[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fear\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fear":32},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,45,0,25,[9,47,77,103,130,162,191,222,252,281,308,337,361,378,404,433,457,485,506,530,550,569,590,620,640],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100643043","the-effect-of-rhythmc-skn-tappng-and-internal-vbraton-appled-proxmal-to-the-procedure-ste-on-pan-and-fear-percepton-durng-pedatrc-perpheral-venpuncture-100643043",false,"NCT07650591","THE EFFECT OF 'RHYTHMİC SKİN TAPPİNG' AND INTERNAL VİBRATİON APPLİED PROXİMAL TO THE PROCEDURE SİTE ON PAİN AND FEAR PERCEPTİON DURİNG PEDİATRİC PERİPHERAL VENİPUNCTURE","THE EFFECT OF 'RHYTHMİC SKİN TAPPİNG' AND INTERNAL VİBRATİON APPLİED PROXİMAL TO THE PROCEDURE SİTE ON PAİN AND FEAR PERCEPTİON DURİNG PEDİATRİC PERİPHERAL VENİPUNCTURE: A RANDOMİZED CONTROLLED TRİAL","Inclusion Criteria:\n\n* Being between 6 and 12 years of age\n\nRequiring a peripheral venipuncture procedure\n\nHaving written informed consent from the parents\n\nHaving verbal assent from the child\n\nBeing able to speak and understand Turkish\n\nHaving a cognitive development level appropriate for age\n\nAbsence of any chronic pain condition\n\nExclusion Criteria:\n\n* Refusing to participate in the study or wishing to withdraw at any stage\n\nDevelopment of complications during the procedure\n\nHaving used analgesics within the last 24 hours\n\nHaving previously participated in the same study\n\nImpaired skin integrity at the procedure site\n\nHaving a neurological or psychiatric diagnosis",true,"ALL","6 Years","12 Years",{"count":22,"type":23},126,"ESTIMATED","INTERVENTIONAL",[26],"NA","What is this study about, in short?\n\nThis study looks at simple, no-cost ways to reduce the pain and fear that children aged 6-12 feel when they have blood drawn at the hospital. Two methods are being tested:\n\n* A nurse lightly and rhythmically tapping with their fingertips just above the spot where the needle will go (\"rhythmic skin tapping\").\n* The child making an \"mmmm\" humming sound while the blood is being drawn (\"internal vibration\" or \"humming\").\n\nThese methods need no medicine and no device, so they can be used easily in any hospital. The study aims to find out whether these two methods really reduce pain and fear, by comparing them with a group that receives no extra method.\n\nWhy is this study being done? Drawing blood is one of the most common painful procedures in children. Fear of needles is very common and can even lead a person to avoid health care later in life. So it matters to make the blood-draw experience easier for children.\n\nSome methods used to reduce pain have practical limits:\n\n* Numbing creams must be applied 30-60 minutes before the procedure; they are not practical in urgent situations and add cost.\n* Special devices that give cold and vibration can work, but they can be expensive, are not always available, and need care for hygiene.\n\nFor these reasons, there is a need for simple methods that cost nothing, need no device, and can be applied easily in any setting. This study tests exactly that.\n\nHow do the methods work? (Simple science) Both methods rest on an idea called the \"Gate Control Theory\": in our body, the sense of touch and vibration competes with the sense of pain on the way to the brain. Gentle touch or mild vibration can act like a \"gate\" that partly blocks the pain signal from reaching the brain.\n\n* Rhythmic skin tapping: Gentle, rhythmic tapping with the fingers may help \"close the gate,\" so the pain is felt less.\n* Internal vibration (humming): The \"mmmm\" sound creates a mild vibration in the body. It can also stimulate the calming part of the nervous system, which may lower the heart rate and stress. Taking an active part in the procedure also gives the child a sense of control.\n\nWho can take part in the study?\n\nCan take part:\n\n* Children aged 6-12 years\n* Children who will have a blood draw\n* Children whose parent has given written permission and who themselves agree verbally\n* Children who can understand and speak Turkish\n* Children whose cognitive development is appropriate for their age\n* Children who do not have an ongoing (chronic) pain condition\n\nCannot take part, or will be withdrawn:\n\n* Children who do not want to take part, or wish to withdraw at any stage\n* Children who develop a complication (an unexpected medical problem) during the procedure\n* Children who have used a painkiller within the last 24 hours\n* Children who have already taken part in this study before\n* Children whose skin is broken at the site where the needle will go\n* Children who have a neurological or psychiatric diagnosis\n\nWhat will happen if my child takes part?\n\nThe blood draw will happen anyway because it is medically needed. The study only adds the method used during the draw and a short measurement afterward. Step by step:\n\n* Your child is placed by computer, at random (like drawing lots), into one of three groups. No one can choose the group in advance; this is called \"randomization\" and it keeps the comparison fair.\n* The blood draw is done as usual. The only difference is the method used, depending on your child's group.\n* Right after the procedure, the child is shown two short picture scales: one for pain, with faces ranging from smiling to crying (0-10), and one for fear, also made of faces (0-4).\n* A short form collects details such as age, sex, and any previous blood-draw experience.\n* No extra needle, medicine, or laboratory test is done beyond the routine blood draw.\n\nThe three groups are:\n\nGroup What is done in this group?\n\n1. Rhythmic skin tapping Gentle, rhythmic tapping with the fingertips just above the needle site.\n2. Internal vibration (humming) The child is asked to make an \"mmmm\" humming sound during the blood draw.\n3. Control group The blood draw is done as usual, with no extra method. This group is the comparison point used to measure the effect of the other two methods.\n\nWhere and when will the study take place?\n\n* Place: Kepez State Hospital Blood Collection Outpatient Clinic (Antalya, Türkiye).\n* Data collection period: June 2026 - June 2027. The total study duration is about 12 months.\n* Planned number of participants: 126 children in total (42 in each group). This number was set in advance by a statistical calculation so the results would be reliable.\n\nTaking part is completely voluntary\n\n* Your child does not have to take part. Even if you agree, you may withdraw at any time without giving a reason.\n* Not taking part, or withdrawing, will not affect the health care your child receives in any way.\n* Your child may also say they do not want the method; the child's decision is",[29,30,31,32,33,34],"Procedural Pain","Acute Pain","Needle-Related Pain and Distress","Fear","Anxiety","Phlebotomy","NOT_YET_RECRUITING","2026-06-12",{"date":38,"type":39},"2026-06-16","ACTUAL",{"date":41,"type":23},"2026-07",{"date":43,"type":23},"2027-06",{"name":45,"class":46},"Akdeniz University","OTHER",{"id":48,"slug":49,"hasResults":12,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":20,"enrollmentInfo":55,"targetDuration":4,"studyType":24,"phases":57,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":70,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100641617","virtual-reality-for-pediatric-perioperative-preparation-100641617","NCT07650695","Virtual Reality for Pediatric Perioperative Preparation","Preoperative Virtual Reality Intervention to Improve the Perioperative Experience in Children Undergoing Elective Surgery: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Children aged 3 to 12 years.\n* Scheduled for elective surgery under anesthesia.\n* Parent or legal guardian owns a mobile phone.\n* Ability to understand simple instructions, according to clinical judgment and developmental level.\n* Sufficient Spanish language proficiency of the child and at least one parent or legal guardian.\n* Written informed consent from parents or legal guardians and child assent when applicable.\n\nExclusion Criteria:\n\n* Emergency or urgent surgery.\n* Moderate to severe neurodevelopmental disorder or intellectual disability limiting understanding of the intervention or study scales.\n* Severe visual or hearing impairment preventing use of virtual reality.\n* History of photosensitive epilepsy, severe vertigo, severe motion sickness, or other conditions that could worsen with virtual reality.\n* Severe decompensated psychiatric disorder.\n* Use of intense sedative premedication before baseline assessment that prevents evaluation of preoperative anxiety.","3 Years",{"count":56,"type":23},56,[26],"This pilot randomized controlled trial will evaluate whether a virtual reality (VR) preparation program can improve the perioperative experience of children aged 3 to 12 years undergoing elective surgery. Children scheduled for surgery at HM Hospital in Madrid, Spain, will be randomly assigned to receive either a VR-based educational experience (NixiKit) or the standard preoperative preparation routinely provided by nursing staff.\n\nThe VR intervention includes an immersive virtual tour of the preoperative area, operating room, and recovery room, designed to familiarize children with the surgical process in an age-appropriate manner. The control group will receive the usual verbal explanation and support provided by nurses before surgery.\n\nThe study will assess children's fear, preoperative anxiety, cooperation during anesthesia induction, and postoperative pain. Parents' experience and satisfaction with care will also be evaluated. The results of this pilot study will help determine the feasibility and potential effectiveness of VR as a nursing-led preparation strategy for pediatric surgical patients.",[60,32,61,62],"Preoperative Anxiety","Pediatric Surgery","Preoperative Care",[64,61,65,66,67,68,69],"Virtual Reality","Perioperative Care","children","Nursing intervention","fear","anxiety",{"date":38,"type":39},{"date":72,"type":23},"2026-07-01",{"date":74,"type":23},"2027-04-01",{"name":76,"class":46},"Fundación de investigación HM",{"id":78,"slug":79,"hasResults":12,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":12,"sex":18,"minAge":84,"maxAge":20,"enrollmentInfo":85,"targetDuration":4,"studyType":24,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":102},"100643583","effects-of-cartoons-and-mobile-games-on-preoperative-anxiety-and-fear-in-children-with-appendicitis-an-rct-100643583","NCT07640230","Effects of Cartoons and Mobile Games on Preoperative Anxiety and Fear in Children With Appendicitis: An RCT","Apandisit Tanısı Ile Cerrahi Servise Yatırılan Çocuklarda Preoperatif Kaygı ve Korkunun Azaltılmasında Çizgi Film ve Mobil Oyunların Etkisi: Randomize Kontrollü Bir Araştırma","Inclusion Criteria:\n\n* Being hospitalized in the Pediatric Surgery Service with a diagnosis of appendicitis.\n* Being between the ages of 7 and 12 years.\n* Voluntary consent\u002Fassent from both the child and their parents to participate in the study.\n* Absence of any visual, auditory, or cognitive problems that prevent communication.\n* Not having received any analgesics before the intervention.\n\nExclusion Criteria:\n\n* Refusal to participate in the study voluntarily.\n* Having a condition that prevents communication due to vision, hearing, speech, or mental health status.\n* Being in an agitated state or unable to cooperate.\n* Having received analgesics due to pain before the study.","7 Years",{"count":86,"type":23},69,[26],"his study aims to evaluate the effects of cartoon viewing and mobile game playing on preoperative anxiety and fear levels in children aged 7-12 years who are hospitalized for appendicitis surgery. The study is designed as a randomized controlled trial with three groups: a cartoon group, a mobile game group, and a control group receiving routine care.\n\nChildren in the intervention groups will watch a cartoon or play a mobile game for 10 minutes before surgery. Anxiety and fear levels will be measured using validated scales before and after the intervention. The findings of this study are expected to contribute to atraumatic care practices by providing simple and effective non-pharmacological methods to reduce preoperative anxiety and fear in children.",[60,90,91,32],"Children","Appendicitis (Diagnosis)","RECRUITING","2026-06-08",{"date":95,"type":39},"2026-06-10",{"date":97,"type":39},"2025-10-10",{"date":99,"type":23},"2026-05-30",{"name":101,"class":46},"Ankara City Hospital Bilkent",1,{"id":104,"slug":105,"hasResults":12,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":110,"targetDuration":4,"studyType":24,"phases":111,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":102},"100589509","music-and-vr-effects-on-pain-anxiety-and-fear-during-oral-mucositis-care-in-leukaemic-children-100589509","NCT06955338","Music and VR Effects on Pain, Anxiety, and Fear During Oral Mucositis Care in Leukaemic Children","The Effect of Music Recital and Virtual Reality on Pain, Anxiety and Fear During Oral Mucositis Care in Children With Leukaemia: A Randomised Controlled Study","Inclusion Criteria:\n\nThe participant child\n\n* is between the ages of 6-12 years\n* is being followed up as an inpatient in the Paediatric Haematology Clinic\n* is receiving leukaemia treatment only\n* has oral mucositis\n* does not have a systemic infection\n* willing to participate in the study\n* speak Turkish and are open to communication\n* has no visual and hearing problems (not using glasses or hearing aids)\n\nExclusion Criteria:\n\n* Cases not fulfilling the inclusion criteria will be excluded from the study.",{"count":5,"type":23},[26],"Children undergoing leukaemia treatment are exposed to a wide range of chemotherapeutic agents and immunosuppressive therapies during treatment and are therefore at great risk for complications. Mucositis is one of the leading chemotherapy-related complications affecting the quality of life of the child. Although it varies according to the degree of mucositis, oral mucosal erythema, white plaques and ulcers are extremely painful and traumatising procedures for pediatric patients during mucositis care. The pain and fear they experience during the procedure may lead children to delay\u002Fnot perform oral mucositis care or not allow their parents to do so. Since mucositis is a painful condition in children, it is recommended to use distracting nonpharmacological methods that can help reduce the pain and fear of children during mucositis care. In this context, the aim of this study was to determine the effects of music and virtual reality on pain, anxiety and fear during oral mucositis care in children aged 6-12 years receiving leukaemia treatment. Block randomisation (gender (F\u002FM) and age groups (6-9\u002F10-12) will be used to identify participants. Five minutes before the oral mucositis care procedure, all participants, regardless of group, will be assessed with the Child Anxiety Scale-Disposition (CAS-D), Child Fear Scale and Visual Analogue Scale (VAS). The study will be conducted in three groups as control group, VR group and music group. Descriptive characteristics of dependent and independent categorical variables will be given as number and percentage, numerical descriptive characteristics will be given as mean and standard deviation. In examining the relationship between dependent and independent variables, Mann Whitney-Kruskal Wallis or Student t-Anova analyses will be performed according to the result of the analysis of conformity to normal distribution. Bonferroni analysis will be used for pairwise comparisons and Covariance analysis will be used to investigate the effect of variables with children.",[33,114,32],"Pain",[116,117,68,69,118,66,119,120],"leukemia","mucositis","pain","nursing","symptom management","2026-05-16",{"date":123,"type":39},"2026-05-19",{"date":125,"type":23},"2026-12-01",{"date":127,"type":23},"2027-12-01",{"name":129,"class":46},"Ege University",{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":17,"sex":18,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":24,"phases":142,"briefSummary":143,"conditions":144,"keywords":149,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":102},"100626902","comfort-intervention-in-picu-children-100626902","NCT07441668","Comfort Intervention in PICU Children","The Effect of a Kolcaba Comfort Theory-Based Child Comfort Intervention on Comfort, Anxiety, Fear, and Sleep in the Pediatric Intensive Care Unit: A Randomized Controlled Trial","CCI-PICU","Inclusion Criteria:\n\n* Child aged 5-10 years\n* Has not received intravenous sedation or anesthetic medication in the past 12 hours\n* Expected to stay in the Pediatric Intensive Care Unit (PICU) for at least 48-72 hours\n* Conscious and able to communicate\n* Glasgow Coma Scale score of 15\n* No pain as assessed by the Wong-Baker FACES Pain Rating Scale\n* Written informed consent obtained from parent\u002Flegal guardian\n* Child and parent able to communicate in Turkish\n* No medical contraindications to non-pharmacological, non-interactive interventions\n\nExclusion Criteria:\n\n* Mechanically ventilated or intubated\n* Hearing impairment\n* Visual impairment\n* Hand motor limitations\n* Severe or profound intellectual disability\n* Epilepsy or history of seizures\n* Severe underweight\n* Chronic respiratory disease\n* Chronic cardiovascular disease\n* Surgical implants\n* Osteoporosis\n* Diagnosis of sleep disorder\n* Use of sleep medication\n* Any physical or mental health condition that prevents communication","5 Years","10 Years",{"count":141,"type":23},86,[26],"This randomized controlled trial evaluates a family-centered comfort intervention for children hospitalized in a pediatric intensive care unit. The intervention consists of listening to the mother's voice, environmental light regulation, and use of a weighted blanket, delivered in addition to routine nursing care. Outcomes include child comfort, anxiety, fear, and sleep parameters, as well as parental anxiety and satisfaction with care. The study will determine whether the intervention improves child and parent outcomes compared with routine care.",[145,146,147,32,148],"Pediatric Intensive Care Unit","Comfort","Anxiety in Children","Sleep",[150,151,152,33,32,148],"Pediatric intensive care","Child comfort","Kolcaba Comfort Theory","2026-05-09",{"date":155,"type":39},"2026-05-12",{"date":157,"type":39},"2026-02-20",{"date":159,"type":23},"2027-07-01",{"name":161,"class":46},"Ankara Yildirim Beyazıt University",{"id":163,"slug":164,"hasResults":12,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":12,"sex":169,"minAge":170,"maxAge":171,"enrollmentInfo":172,"targetDuration":4,"studyType":24,"phases":174,"briefSummary":175,"conditions":176,"keywords":177,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":4},"100634536","the-effect-of-motvatonal-intervewng-on-cancer-fear-and-partcpaton-in-cervcal-cancer-screenngs-among-women-lvng-in-rural-areas-100634536","NCT07540962","The Effect Of Motıvatıonal Intervıewıng On Cancer Fear And Partıcıpatıon In Cervıcal Cancer Screenıngs Among Women Lıvıng In Rural Areas","The Effect Of A Motıvatıonal Intervıew Based Nursıng Care Program On Health Belıefs And Fear Of Cancer Related To Cervıcal Cancer And Screenıng In Rural Women: A Randomızed Controlled Study","Inclusion Criteria:\n\n* The individual must be registered with the Sivaslı Community Health Center affiliated with the Uşak Provincial Health Directorate\n* Reside in a rural area\n* Be within the age range (30-65) suitable for the national screening program\n* Have an intellectual disability.\n\nExclusion Criteria:\n\n* Having a condition that prevents communication (unable to speak or understand Turkish, having a speech disorder)\n* being illiterate.","FEMALE","30 Years","65 Years",{"count":173,"type":23},80,[26],"This research was conducted to determine the effect of a motivational interview-based nursing care program on health beliefs and cancer fears related to cervical cancer and screening in rural women.",[32],[178,179,180,181],"CERVICAL CANCER","FEAR","CANCER SCREENING","MOTIVATIONAL INTERVIEW","2026-04-17",{"date":184,"type":39},"2026-04-21",{"date":186,"type":23},"2026-06-27",{"date":188,"type":23},"2026-09-02",{"name":190,"class":46},"Ozge Aslan Koyutürk",{"id":192,"slug":193,"hasResults":12,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":17,"sex":169,"minAge":199,"maxAge":200,"enrollmentInfo":201,"targetDuration":4,"studyType":24,"phases":203,"briefSummary":204,"conditions":205,"keywords":208,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":102},"100635170","hbm-based-solution-focused-birth-program-on-fear-of-childbirth-in-primigravidas-100635170","NCT07549204","HBM-Based Solution-Focused Birth Program on Fear of Childbirth in Primigravidas","The Effect of a Health Belief Model-Based Solution-Focused Childbirth Preparation Program on Fear of Childbirth, Belief in Normal Birth, Pregnancy Stress, and Mode of Delivery in Primigravid Women","Primigravida","Inclusion Criteria:\n\n* Being 18 years of age or older\n* Having at least a primary school level of education\n* Being able to understand and speak Turkish\n* Having a singleton pregnancy\n* Being a primigravida\n* Being between 28 and 32 weeks of gestation at the time of the intervention.\n\nExclusion Criteria:\n\n* Having a high-risk pregnancy (e.g., preeclampsia, diabetes, cardiovascular disease, placenta previa, oligohydramnios)\n* Having a chronic and\u002For psychiatric disorder\n* Having conceived through infertility treatment","18 Years","49 Years",{"count":202,"type":23},72,[26],"Pregnancy is a period characterized by significant physiological and psychosocial changes, during which women adapt to new roles. While some women experience this period with excitement and hope, others may experience anxiety, uncertainty, and fear. Fear of childbirth (tokophobia) is a common condition that can negatively affect women's quality of life, birth preferences, and childbirth experiences. High levels of fear of childbirth have been associated with increased cesarean section rates, negative birth perceptions, and postpartum psychological problems.\n\nThis randomized controlled trial aims to evaluate the effect of a solution-focused childbirth preparation education program based on the Health Belief Model on fear of childbirth and belief in normal birth among primigravida women. Secondary outcomes include pregnancy-related stress and mode of delivery.\n\nParticipants will be randomly assigned to either an intervention group receiving structured education or a control group receiving routine prenatal care. Data will be collected before and after the intervention using validated measurement tools, and delivery outcomes will be recorded after birth. The findings are expected to contribute to improving maternal psychological well-being and promoting positive childbirth experiences.",[32,206,207],"Stress (Psychology)","Pregnancy",[207,32,209,210,211,212,213],"Health Belief Model","Solution-Focused Approach","Antenatal Education","Mode of Delivery","Randomized Controlled Trial",{"date":215,"type":39},"2026-04-24",{"date":217,"type":23},"2026-05-15",{"date":219,"type":23},"2026-12-15",{"name":221,"class":46},"Ordu University",{"id":223,"slug":224,"hasResults":12,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":17,"sex":18,"minAge":229,"maxAge":230,"enrollmentInfo":231,"targetDuration":4,"studyType":24,"phases":233,"briefSummary":234,"conditions":235,"keywords":240,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":246,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":250,"locationsCount":102},"100634533","effect-of-mbsr-training-on-childbirth-fear-bonding-and-breastfeeding-in-adolescent-pregnant-women-100634533","NCT07540923","Effect of MBSR Training on Childbirth Fear, Bonding and Breastfeeding in Adolescent Pregnant Women","Effect of Mindfulness-Based Stress Reduction Training on Fear of Childbirth, Maternal and Paternal Bonding and Breastfeeding Success in Adolescent Pregnant Women and Their Partners","Inclusion Criteria:\n\n1. Being between 15-19 years of age\n2. Being in the third trimester of pregnancy (30-33 weeks of gestation)\n3. Being primiparous\n4. Having no history of miscarriage, abortion or similar obstetric problems during pregnancy\n5. Not having a high-risk pregnancy diagnosis\n6. Being literate\n7. Partner accepting to actively participate in the parenting process\n\nExclusion Criteria:\n\n1. Having a chronic disease\n2. Having physical or psychological health problems\n3. Having a psychiatric diagnosis in the participant or their partner\n4. Having a detected health problem or congenital anomaly in the fetus\n5. Having previously received Mindfulness-Based Stress Reduction (MBSR) training\n6. Not completing the planned training program\n7. Voluntarily withdrawing from the study","15 Years","19 Years",{"count":232,"type":23},54,[26],"This randomized controlled study aims to evaluate the effect of Mindfulness-Based Stress Reduction (MBSR) training given to adolescent pregnant women and their partners on fear of childbirth, maternal and paternal bonding, and breastfeeding success. Adolescent pregnancy is associated with increased stress, fear of childbirth and parenting anxiety, which negatively affect mother-infant and father-infant bonding and breastfeeding outcomes. MBSR training is expected to reduce fear of childbirth, strengthen maternal and paternal bonding, and improve breastfeeding success in adolescent pregnant women and their partners compared to the control group receiving routine care.",[236,32,237,238,239],"Pregnancy in Adolescence","Mother-Child Relations","Mindfulness","Breastfeeding",[241,242,243,244,245,239],"Adolescent Pregnancy","Fear of Childbirth","Maternal Bonding","Paternal Bonding","Mindfulness-Based Stress Reduction",{"date":184,"type":39},{"date":248,"type":39},"2025-12-01",{"date":99,"type":23},{"name":251,"class":46},"Inonu University",{"id":253,"slug":254,"hasResults":12,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":12,"sex":259,"minAge":19,"maxAge":139,"enrollmentInfo":260,"targetDuration":4,"studyType":24,"phases":262,"briefSummary":263,"conditions":264,"keywords":268,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":102},"100633338","the-effect-of-progressive-relaxation-exercises-with-therapeutic-clown-100633338","NCT07525388","The Effect of Progressive Relaxation Exercises With Therapeutic Clown","The Effect of Progressive Relaxation Exercises With Therapeutic Clown in Preoperative Period on Fear Anxiety and Physiological Parameters in Children","Inclusion Criteria:\n\n* Aged between 6 and 10 years,\n* Willing to participate in the study,\n* Admitted to the clinic for elective circumcision surgery,\n* Accessible prior to surgery,\n* With no cognitive impairments,\n* With no vision or hearing problems were included in the study.\n\nExclusion Criteria:\n\n* Children who wished to withdraw from the study during the study period were excluded.","MALE",{"count":261,"type":23},162,[26],"This study was conducted to investigate the effects of progressive relaxation exercises, performed with the assistance of a therapeutic clown during the pre-operative period, on fear, anxiety and physiological parameters in children. This randomised controlled trial included children aged 6-10 years undergoing circumcision surgery. The children were randomised into three groups: a progressive relaxation exercise group led by a therapeutic clown, a progressive relaxation group led by a nurse, and a control group. Fear, anxiety and physiological parameters (heart rate, respiratory rate, blood pressure, oxygen saturation) were assessed before and after the procedure.",[265,266,33,32,267],"Therapeutic Clown","Relaxation Exercise","Surgery",[269,270,68,69,271],"therapeutic clown","relaxation exercise","surgery","2026-04-07",{"date":274,"type":39},"2026-04-13",{"date":276,"type":39},"2025-03-25",{"date":278,"type":23},"2026-06-30",{"name":280,"class":46},"Ataturk University",{"id":282,"slug":283,"hasResults":12,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":287,"eligibilityCriteria":288,"healthyVolunteers":12,"sex":18,"minAge":199,"maxAge":4,"enrollmentInfo":289,"targetDuration":4,"studyType":24,"phases":291,"briefSummary":292,"conditions":293,"keywords":294,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":102},"100631974","the-effect-of-a-stress-ball-applied-before-retrograde-intrarenal-surgery-on-anxiety-surgical-fear-and-hemodynamic-parameters-100631974","NCT07507656","The Effect of a Stress Ball Applied Before Retrograde Intrarenal Surgery on Anxiety, Surgical Fear, and Hemodynamic Parameters","The Effect of a Stress Ball Applied Before Retrograde Intrarenal Surgery on Anxiety, Surgical Fear, and Hemodynamic Parameters: A Randomized Controlled Trial","Stress ball","Inclusion Criteria:\n\nPatients to be included in the study are those who:\n\n* Are scheduled to undergo Retrograde Intrarenal Surgery (RIRS),\n* Are 18 years of age or older,\n* Are conscious and cooperative,\n* Speak and understand Turkish,\n* Have stable general condition and hemodynamic parameters,\n* Are scheduled for an elective surgical procedure,\n* Have no psychiatric diagnosis,\n* Are not using psychiatric and\u002For local neuromuscular blocking medications,\n* Provide informed consent to participate in the study (have signed the Informed Consent Form).\n\nExclusion Criteria:\n\nPatients who will not be included in the study are those who:\n\n* Are under 18 years of age,\n* Are not conscious or cooperative,\n* Do not speak or understand Turkish,\n* Have unstable general condition or hemodynamic parameters,\n* Are undergoing emergency surgical procedures,\n* Have an existing psychiatric diagnosis,\n* Are using psychiatric and\u002For local neuromuscular blocking medications,\n* Do not consent to participate in the study (have not signed the Informed Consent Form).",{"count":290,"type":23},66,[26],"This study was designed as a randomized controlled trial to determine the effect of a stress ball applied before retrograde intrarenal surgery on patients' anxiety levels, surgical fear, and hemodynamic parameters.",[33,32],[295,296,69,297,298],"Retrograde intrarenal surgery","stress ball","surgical fear","hemodynamic parameters","2026-04-02",{"date":301,"type":39},"2026-04-08",{"date":303,"type":23},"2026-04-16",{"date":305,"type":23},"2027-04-16",{"name":307,"class":46},"Mersin University",{"id":309,"slug":310,"hasResults":12,"nctId":311,"briefTitle":312,"officialTitle":313,"acronym":4,"eligibilityCriteria":314,"healthyVolunteers":17,"sex":18,"minAge":138,"maxAge":84,"enrollmentInfo":315,"targetDuration":4,"studyType":24,"phases":317,"briefSummary":318,"conditions":319,"keywords":322,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":102},"100627534","ai-avatar-video-vs-tell-show-do-for-reducing-anxiety-and-improving-cooperation-in-children-during-local-anesthesia-100627534","NCT07449884","AI Avatar Video vs. Tell-Show-Do for Reducing Anxiety and Improving Cooperation in Children During Local Anesthesia","Artificial Intelligence-driven Avatar-based Video vs. Tell-show-do for Reducing Anxiety and Improving Cooperation in Children During Local Anesthesia: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Inclusion Criteria:\n\n  * Children aged 5 to 7 years\n  * Medically healthy (ASA I)\n  * Cooperative behavior during dental examination\n  * No known allergy to local anesthetics\n  * Require non-urgent dental treatment under local anesthesia\n  * First-time experience receiving local anesthesia\n  * Able to understand and communicate\n\nExclusion Criteria:\n\n* History of epilepsy\n* Diagnosed anxiety or behavioral disorders\n* Cognitive or developmental delay\n* Hearing or visual impairment\n* Previous experience with dental anesthesia\n* Require inferior alveolar nerve block anesthesia\n\nExclusion Criteria:\n\n\\-",{"count":316,"type":23},70,[26],"This randomized clinical trial aims to compare two behavior guidance techniques used to reduce anxiety in children during local anesthesia injections in dental treatment. The study evaluates the traditional Tell-Show-Do (TSD) technique versus an artificial intelligence (AI)-driven, avatar-based video method called the \"Mini Dentist.\"\n\nChildren aged 5 to 7 years who require local anesthesia for routine dental treatment will be randomly assigned to one of two groups. The control group will receive the conventional Tell-Show-Do explanation from the pediatric dentist. The experimental group will watch a short animated video featuring an AI-generated avatar that explains and demonstrates the procedure in a child-friendly manner before the injection.\n\nAnxiety and behavior will be assessed using heart rate monitoring, behavioral observation (FLACC scale), and a self-reported pain scale (Wong-Baker FACES). The goal is to determine whether the AI-based method improves cooperation and reduces anxiety compared to the traditional approach.\n\nParticipation is voluntary, and all procedures follow ethical research standards.",[33,32,320,321],"Local Anesthesia","Pediatric Dentistry",[323,324,325,326,327],"Artificial intelligence","Child behavior","Dental anxiety","Local anesthesia.","Randomized Controlled trial","2026-03-24",{"date":330,"type":39},"2026-03-30",{"date":332,"type":39},"2026-02-16",{"date":334,"type":23},"2027-05-30",{"name":336,"class":46},"Saint-Joseph University",{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":4,"eligibilityCriteria":343,"healthyVolunteers":17,"sex":18,"minAge":199,"maxAge":344,"enrollmentInfo":345,"targetDuration":4,"studyType":24,"phases":347,"briefSummary":348,"conditions":349,"keywords":350,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":359,"locationsCount":102},"100405872","social-support-and-enhanced-fear-extinction-100405872","NCT04565041","Social Support and Enhanced Fear Extinction","Can Social Support Figures Enhance Fear Extinction in Patients With Social Anxiety?","Inclusion Criteria:\n\n* healthy adults 18 to 55\n* fluent in English\n* no history of mental illness (healthy participants: including anxiety, depression, phobia, or any other mental health related disorder diagnosed by a mental health professional)\n* diagnosis of social anxiety disorder (anxious participants: allowed co-morbid disorders include depression, other anxiety disorders, and PTSD)\n\nExclusion Criteria:\n\n* pregnant or planning to become pregnant during the experiment period\n* presence of chronic mental illness (healthy participants: as determined by the report of a past diagnosis of mental illness by a physician or psychologist and\u002For the prescription of medication related to mental health disorder; including anxiety, depression, phobia, or any other diagnosed psychological disorder)\n* presence of non-allowed co-morbid disorders (anxious participants: including, bipolar disorder, psychosis, substance use disorder, neurological disorder, and\u002For obsessive-compulsive disorder)\n* current and regular use of prescription medications related to mental health disorders","55 Years",{"count":346,"type":23},100,[26],"University of California, Los Angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the ability of social support figure reminders to enhance the extinction of fear in healthy participants extends to those with anxiety disorders.\n\nAfter being recruited from the UCLA community (healthy participants, n = 50) or referred by treatment providers at the Anxiety and Depression Research Center at UCLA (anxious participants, n = 50) and undergoing a telephone screening and in-person screening, 100 participants will be enrolled in the study, with an expected recruited 150 to reach this number. During the experiment, all participants will undergo the same procedures: undergoing a fear extinction procedure in which threatening cues--cues that predict electric shock--will be paired with either an image of a social support figure (provided by participants) or an image of a smiling stranger. These pairings will be presented repeatedly in the absence of shock in order for fear extinction to occur. Participants will return for a follow-up test to determine if fear extinction was successful.",[32,33],[351,352],"social support","fear extinction","2026-03-16",{"date":355,"type":39},"2026-03-18",{"date":357,"type":39},"2022-02-01",{"date":72,"type":23},{"name":360,"class":46},"University of California, Los Angeles",{"id":362,"slug":363,"hasResults":12,"nctId":364,"briefTitle":365,"officialTitle":342,"acronym":4,"eligibilityCriteria":366,"healthyVolunteers":17,"sex":18,"minAge":199,"maxAge":344,"enrollmentInfo":367,"targetDuration":4,"studyType":24,"phases":368,"briefSummary":369,"conditions":370,"keywords":371,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":373,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":377,"locationsCount":102},"100405867","social-support-and-reduced-fear-acquisition-100405867","NCT04564976","Social Support and Reduced Fear Acquisition","Inclusion Criteria:\n\n* healthy adults 18 and 35\n* fluent in English\n* no history of mental illness (healthy participants: including anxiety, depression, phobia, or any other mental health related disorder diagnosed by a mental health professional)\n* diagnosis of social anxiety disorder (anxious participants: allowed co-morbid disorders include depression, other anxiety disorders, and PTSD)\n\nExclusion Criteria:\n\n* pregnant or planning to become pregnant during the experiment period\n* presence of chronic mental illness (healthy participants: as determined by the report of a past diagnosis of mental illness by a physician or psychologist and\u002For the prescription of medication related to mental health disorder; including anxiety, depression, phobia, or any other diagnosed psychological disorder)\n* presence of non-allowed co-morbid disorders (anxious participants: including, bipolar disorder, psychosis, substance use disorder, neurological disorder, and\u002For obsessive-compulsive disorder)\n* current and regular use of prescription medications related to mental health disorders",{"count":346,"type":23},[26],"University of California, Los Angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the ability of social support figure reminders to prevent the acquisition of fear in healthy participants extends to those with anxiety disorders.\n\nAfter being recruited from the UCLA community (healthy participants, n = 50) or referred by treatment providers at the Anxiety and Depression Research Center at UCLA (anxious participants, n =50) and undergoing a telephone screening and in-person screening, 100 participants will be enrolled in the study. During the experiment, all participants will undergo the same procedures: undergoing fear acquisition procedures--the repeated pairing of a neutral image with a mild electric shock that ultimately leads to the association of threat of shock with the image--in the presence of an image of a social support figure (provided by participants) and an image of a smiling stranger.",[32,33],[351,372],"fear acquisition",{"date":355,"type":39},{"date":375,"type":39},"2022-02-09",{"date":72,"type":23},{"name":360,"class":46},{"id":379,"slug":380,"hasResults":12,"nctId":381,"briefTitle":382,"officialTitle":383,"acronym":4,"eligibilityCriteria":384,"healthyVolunteers":12,"sex":18,"minAge":138,"maxAge":20,"enrollmentInfo":385,"targetDuration":4,"studyType":24,"phases":387,"briefSummary":388,"conditions":389,"keywords":390,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":102},"100628944","effect-of-helfer-skin-tap-and-vibration-on-pain-and-fear-in-children-during-intramuscular-injection-100628944","NCT07468227","Effect of Helfer Skin Tap and Vibration on Pain and Fear in Children During Intramuscular Injection","The Effect of Helfer Skin Tap and Vibration Techniques on Pain and Fear During Intramuscular Injection in Children Aged 5-12 Years in the Pediatric Emergency Department: A Randomized Controlled Trial","Inclusion Criteria:\n\n* The child must be in the 5-10 age group\n* Intramuscular injection must be performed,\n* The child must be able to communicate in Turkish,\n* Verbal\u002Fwritten consent must be obtained from the parents\u002Flegal guardians\n\nExclusion Criteria:\n\n* Known neurological disorders,\n* Inability to communicate cognitively,\n* Chronic pain syndrome\n* Acute and life-threatening clinical condition",{"count":386,"type":23},186,[26],"Intramuscular injection is one of the most common invasive procedures in childhood and is frequently associated with pain and fear. These negative experiences may affect children's attitudes toward healthcare and complicate nursing care. Therefore, using non-pharmacological methods is essential for promoting child-friendly services. This study aims to evaluate the effects of the Helfer Skin Tap and vibration techniques on pain and fear levels in children aged 5-10 years during intramuscular injections.\n\nThe study is designed as a parallel, three-arm randomized controlled trial conducted in the Pediatric Emergency Clinic of Ege University Hospital. Participants will be allocated by simple randomization to Helfer Skin Tap, vibration, or standard care. Sample size was calculated with G\\*Power 3.1 using a repeated-measures within-between interaction model with two time points (T0-T1), α=0.05, and power=0.80. Assuming a medium effect size (f=0.25) based on previous studies, at least 159 children are required. Allowing for 15% attrition, the final sample will include 186 participants (62 per group).\n\nData will be collected using a Child Information Form including sociodemographic characteristics and prior injection experiences. A Procedure Record Form will document randomization, assigned group, medication, dose, injection site, duration, child's position, and parental presence.\n\nPain and fear will be assessed immediately before (T0) and after (T1) the injection. Pain will be measured with the Wong-Baker FACES Pain Rating Scale (0-10) and fear with the Children's Fear Scale (0-4). Ratings will be obtained independently from the child, parent, and observing nurse.\n\nThe procedure will be video-recorded to enable objective evaluation of behavioral responses. Recordings will be scored by an independent blinded expert using standardized criteria. Videos will be used only for research purposes, with identifying features concealed, stored in coded format, and destroyed after study completion.",[114,32],[391,392,393,394,395],"pediatric emergency","intramuscular injection","Helfer Skin Tap","vibration","randomized controlled trial","2026-03-11",{"date":398,"type":39},"2026-03-12",{"date":400,"type":23},"2026-05-01",{"date":402,"type":23},"2027-05-01",{"name":129,"class":46},{"id":405,"slug":406,"hasResults":12,"nctId":407,"briefTitle":408,"officialTitle":409,"acronym":410,"eligibilityCriteria":411,"healthyVolunteers":12,"sex":18,"minAge":199,"maxAge":4,"enrollmentInfo":412,"targetDuration":4,"studyType":24,"phases":414,"briefSummary":415,"conditions":416,"keywords":420,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":431,"locationsCount":102},"100627756","stress-ball-use-during-cataract-surgery-effects-on-pain-fear-and-satisfaction-100627756","NCT07452770","Stress Ball Use During Cataract Surgery: Effects on Pain, Fear and Satisfaction","The Effect of Stress Ball Use on Patients' Pain, Fear and Satisfication\" During Cataract Surgery","SBUDCS","Inclusion Criteria:\n\n* Individuals aged 18 years or older,\n* Without hearing or cognitive impairments,\n* Without any neurological conditions that would prevent squeezing a stress ball,\n* Without any physical limitations in the hands or arms that would prevent squeezing a stress ball,\n* Individuals undergoing cataract surgery for the first time will be included.\n\nExclusion Criteria:\n\n* Under 18 years of age,\n* Change in anesthesia type during surgery (from topical anesthesia to general anesthesia)\n* Patients scheduled for cataract surgery under general anesthesia,\n* Patients with psychiatric disorders,\n* Patients diagnosed with uncontrolled hypertension,\n* Patients who used any analgesic or anxiolytic prior to surgery will not be included in the study.",{"count":413,"type":23},60,[26],"The aim of this study is to determine the effect of stress ball use during cataract surgery on patients' pain, fear, and satisfaction levels.",[114,32,417,418,419],"Stress Ball","Nursing","Cataract Surgery",[421,422,119,423,424],"pain management","Surgical fear","cataract surgery","satisfaction","2026-03-05",{"date":427,"type":39},"2026-03-06",{"date":429,"type":39},"2025-09-01",{"date":217,"type":23},{"name":432,"class":46},"Bezmialem Vakif University",{"id":434,"slug":435,"hasResults":12,"nctId":436,"briefTitle":437,"officialTitle":437,"acronym":4,"eligibilityCriteria":438,"healthyVolunteers":12,"sex":259,"minAge":19,"maxAge":439,"enrollmentInfo":440,"targetDuration":4,"studyType":24,"phases":441,"briefSummary":442,"conditions":443,"keywords":445,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":455,"locationsCount":4},"100624822","the-effect-of-a-drama-based-coloring-storybook-on-childrens-fear-anxiety-and-pain-management-in-the-perioperative-process-alicans-brave-journey-100624822","NCT07414628","The Effect of a Drama-Based Coloring Storybook on Children's Fear, Anxiety, and Pain Management in the Perioperative Process: \"Alican's Brave Journey\"","Inclusion Criteria:\n\n* Children aged 6-9 years.\n* Children scheduled for surgery due to circumcision.\n* Children who have not undergone previous surgery.\n* Children without vision, hearing, or speech problems.\n\nExclusion Criteria:\n\n* Children who have undergone previous surgery.\n* Children with vision, hearing, or speech problems.","9 Years",{"count":202,"type":23},[26],"This randomized controlled study aims to evaluate the effect of a drama-based coloring storybook on children's fear, anxiety, and pain management during the perioperative process. The study will be conducted with children aged 6-9 years who are scheduled for elective surgery. Participants will be randomly assigned to either an intervention group receiving the drama-based coloring storybook or a control group receiving routine preoperative care. Levels of fear, anxiety, and pain will be assessed using validated measurement tools at predefined perioperative time points. The findings are expected to contribute to evidence-based, child-centered perioperative care practices.",[60,444,32],"PAİN",[446,447,448,114,33],"Drama","Storybook","Pediatric","2026-02-12",{"date":451,"type":39},"2026-02-17",{"date":453,"type":23},"2026-02-01",{"date":219,"type":23},{"name":456,"class":46},"Bingol University",{"id":458,"slug":459,"hasResults":12,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":4,"eligibilityCriteria":463,"healthyVolunteers":12,"sex":18,"minAge":199,"maxAge":171,"enrollmentInfo":464,"targetDuration":4,"studyType":24,"phases":466,"briefSummary":467,"conditions":468,"keywords":473,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":479,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":484,"locationsCount":102},"100624171","nonpharmacological-management-of-pain-and-fear-during-hormone-injection-in-breast-cancer-patients-100624171","NCT07406165","Nonpharmacological Management of Pain and Fear During Hormone Injection in Breast Cancer Patients","ShotBlocker and Helfer Technique in the Management of Pain and Fear During Hormone Injection in Patients With Breast Cancer: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years.\n* Patients diagnosed with breast cancer.\n* Requirement of intramuscular (IM) injection of premenopausal or postmenopausal hormonal medications as part of their prescribed treatment.\n* Cognitive competence to provide informed consent for the injection procedure. Intact skin integrity and normal sensory perception at the injection site (gluteal region).\n\nExclusion Criteria:\n\n* History of chronic pain disorders, neuropathic pain syndrome, or any disease requiring regular analgesic use.\n* Presence of neurological or cognitive disorders that may alter pain or fear perception.\n* Use of analgesics within the last 24 hours (or a specific timeframe relevant to your study).",{"count":465,"type":23},99,[26],"This randomized controlled study will compare the effects of the ShotBlocker device and the Helfer Skin Tap Technique on pain and fear during intramuscular hormone injections in premenopausal and postmenopausal breast cancer patients. Ninety-nine participants will be randomly assigned to three groups (ShotBlocker, Helfer, control). All injections will be administered by the same nurse using standardized procedures. Pain will be assessed with the Visual Analog Scale, and fear with the Injection Fear Scale. The study aims to identify effective nonpharmacological methods to enhance patient comfort, support treatment adherence, and improve nursing care quality.",[469,470,32,471,472],"Breast Cancer","Pain Management","Injection Fear","Injection Pain Prevention",[474,475,476,114,477],"Breast cancer","Hormone therapy","Intramuscular injection","Injection fear","2026-02-11",{"date":480,"type":39},"2026-02-13",{"date":482,"type":23},"2026-02-10",{"date":41,"type":23},{"name":251,"class":46},{"id":486,"slug":487,"hasResults":12,"nctId":488,"briefTitle":489,"officialTitle":490,"acronym":4,"eligibilityCriteria":491,"healthyVolunteers":17,"sex":18,"minAge":199,"maxAge":4,"enrollmentInfo":492,"targetDuration":4,"studyType":24,"phases":494,"briefSummary":495,"conditions":496,"keywords":498,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":482,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":505,"locationsCount":4},"100625083","effects-of-cold-spray-and-buzzy-device-an-pain-and-fear-during-penicillin-injection-100625083","NCT07418021","Effects of Cold Spray and Buzzy Device an Pain and Fear During Penicillin Injection","The Effect of Innovative Cold Applications (Cold Spray and Buzzy Device) on Pain and Fear Associated With Penicillin Injection: A Randomized Controlled Trial","Eligibility Criteria\n\nInclusion Criteria:\n\nAdults aged 18 years and older\n\nIndividuals scheduled to receive intramuscular penicillin injection\n\nAble to communicate and report pain and fear levels\n\nWilling to participate in the study\n\nProvided written informed consent\n\nExclusion Criteria:\n\nKnown allergy or hypersensitivity to cold applications\n\nSkin lesions, infection, or injury at the injection site\n\nNeurological or psychiatric conditions that may affect pain or fear perception\n\nUse of analgesic or anxiolytic medication prior to injection\n\nPrevious adverse reaction to intramuscular injections",{"count":493,"type":23},90,[26],"This study investigates the effect of cold spray and Buzzy devices on pain and fear experienced during penicillin injections. There are three groups: a cold spray and Buzzy device, and a control group. Penicillin injections are commonly used in clinical practice and can cause discomfort, pain, and fear, particularly in patients receiving intramuscular injections.\n\nCold spray and Buzzy devices are non-pharmacological methods that can help reduce pain and fear by providing a cooling effect and vibration at the injection site. Participants will be randomly assigned to one of the study groups, and their pain and fear levels during injection will be assessed using standardized measurement tools.\n\nThe results of this study are expected to contribute to improving patient comfort and supporting the use of simple, non-invasive methods to reduce pain and fear during injections.",[497,470,32],"Injection",[114,497,477],{"date":500,"type":39},"2026-02-18",{"date":502,"type":23},"2026-02-05",{"date":504,"type":23},"2026-05-05",{"name":251,"class":46},{"id":507,"slug":508,"hasResults":12,"nctId":509,"briefTitle":510,"officialTitle":511,"acronym":4,"eligibilityCriteria":512,"healthyVolunteers":17,"sex":18,"minAge":84,"maxAge":20,"enrollmentInfo":513,"targetDuration":4,"studyType":24,"phases":515,"briefSummary":516,"conditions":517,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":502,"lastUpdatePostDateStruct":521,"startDateStruct":523,"completionDateStruct":525,"leadSponsor":527,"locationsCount":529},"100543026","the-effect-of-animated-movies-and-storybooks-on-fear-and-anxiety-levels-in-children-with-type-1-diabetes-100543026","NCT06350513","The Effect of Animated Movies and Storybooks on Fear and Anxiety Levels in Children With Type 1 Diabetes","The Effect of Animated Film and Storybook on Fear and Anxiety Levels in Children With Newly Diagnosed Type 1 Diabetes: Randomized Controlled Study","Inclusion Criteria:\n\n* Volunteering to participate in the study,\n* Parental approval\n* Being between the ages of 7-12,\n* Being diagnosed with T1D for the first time,\n* Being literate and able to communicate in Turkish\n\nExclusion Criteria:\n\n* Having a mental, visual, hearing or communication impairment,\n* Having mental and spiritual health problems,",{"count":514,"type":23},64,[26],"This study aims to evaluate the effects of animated films and story books on the fear and anxiety levels of children with newly diagnosed type 1 diabetes.",[518,519,33,32,520],"Diabetes Mellitus, Type 1","Child, Only","Nurse",{"date":522,"type":39},"2026-02-09",{"date":524,"type":39},"2024-02-25",{"date":526,"type":23},"2026-07-25",{"name":528,"class":46},"Selverhan Yurttutan",3,{"id":531,"slug":532,"hasResults":12,"nctId":533,"briefTitle":534,"officialTitle":535,"acronym":4,"eligibilityCriteria":536,"healthyVolunteers":17,"sex":18,"minAge":537,"maxAge":19,"enrollmentInfo":538,"targetDuration":4,"studyType":24,"phases":539,"briefSummary":540,"conditions":541,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":542,"lastUpdatePostDateStruct":543,"startDateStruct":545,"completionDateStruct":547,"leadSponsor":549,"locationsCount":102},"100622082","the-effect-of-therapeutic-play-applied-before-intramuscular-injection-100622082","NCT07378995","The Effect of Therapeutic Play Applied Before Intramuscular Injection","The Effect of Therapeutic Play Applied Before Intramuscular Injection on Fear, Anxiety and Pain in Pre-school Children","Inclusion Criteria:\n\n* Children aged 4-6 years,\n* Those who will receive intramuscular injections,\n* Those who have been prescribed Desefin flk 1x1 IM,\n* Children whose parents have given consent will be included in the study.\n\nExclusion Criteria:\n\n* Those experiencing pain,\n* Those with hearing problems and communication barriers,\n* Those with chronic illnesses,\n* Those with mental and physical disabilities,\n* Those who have taken analgesics within the last 6 hours,\n* Children who have previously been hospitalised will not be included in the study.","4 Years",{"count":173,"type":23},[26],"This research aims to evaluate the effectiveness of a therapeutic toy doll developed to reduce the levels of fear, anxiety and pain experienced by children aged 4-6 during intramuscular injection procedures.\n\nChildren, especially at an early age, show great sensitivity towards medical procedures, and these processes can often cause pain, anxiety and fear. This research aims to evaluate the effectiveness of a therapeutic toy doll developed to reduce the levels of fear, anxiety and pain experienced by children aged 4-6 during intramuscular injection procedures. Children, especially at an early age, show great sensitivity to medical procedures, and these processes can often cause pain, anxiety, and fear. This research aims to discover methods of managing and improving children's responses to medical procedures through therapeutic games.\n\nThis study, to be conducted at the Emergency Department of Atatürk University Research Hospital in Erzurum, will be carried out using a randomised controlled design. Participants will be randomly assigned to intervention and control groups. Children in the intervention group will prepare using the therapeutic toy doll, while children in the control group will receive an intramuscular injection at the clinic using routine application methods.\n\nData collection tools will include the Socio-demographic Information Form, the Children's Fear Scale (CFS), the Children's Anxiety Scale-State (CAS-D), and the Wong-Baker Facial Expression Rating Scale.",[519,32,114],"2026-01-23",{"date":544,"type":39},"2026-01-30",{"date":546,"type":39},"2025-12-30",{"date":548,"type":23},"2027-12-30",{"name":280,"class":46},{"id":551,"slug":552,"hasResults":12,"nctId":553,"briefTitle":554,"officialTitle":555,"acronym":4,"eligibilityCriteria":556,"healthyVolunteers":17,"sex":18,"minAge":84,"maxAge":557,"enrollmentInfo":558,"targetDuration":4,"studyType":24,"phases":559,"briefSummary":560,"conditions":561,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":542,"lastUpdatePostDateStruct":563,"startDateStruct":564,"completionDateStruct":566,"leadSponsor":568,"locationsCount":102},"100622084","mindfulness-based-emotion-regulation-training-for-hospitalized-children-100622084","NCT07379021","Mindfulness-Based Emotion Regulation Training for Hospitalized Children","The Effect of Mindfulness-Based Emotion Regulation Training on Fear and Emotion Regulation in Hospitalized Children","Inclusion Criteria:\n\n* Be aged between 7 and 11 years old,\n* Have a planned hospital stay of at least four days,\n* Be able to speak and understand Turkish,\n* Be able to read and write (to complete questionnaires),\n* The child and parent must be willing to participate in the study.\n\nExclusion Criteria:\n\n* The child has a hearing\u002Fspeech problem that prevents them from communicating,\n* The child has severe pain or acute respiratory distress that prevents them from participating,\n* The child has a known psychiatric diagnosis,\n* The child has previously received similar mindfulness training","11 Years",{"count":232,"type":23},[26],"Hospitalization and medical procedures are a significant source of stress and anxiety for school-age children aged 7-11, who, due to their cognitive development, can perceive events but lack the capacity to cope effectively. The main objective of this project is to examine the effect of Mindfulness-Based Emotion Regulation Training, which will be applied to children aged 7-11 hospitalized in the pediatric clinic, on developing children's emotion regulation skills and reducing their fear levels related to the hospital. The research is a randomized controlled trial to be conducted between April 2026 and April 2027. Data will be collected using the \"Child and Parent Introduction Form,\" the \"Emotion Regulation Scale for Children and Adolescents,\" and the \"Medical Procedure Fear Scale.\" While distraction techniques frequently used in the literature offer a quick and effective solution at the time of the procedure, this project differs in that it aims to provide children with sustainable emotion regulation skills that they can use not only at that moment but also in later stages of the illness and in future life events. As a result of the project, it is expected that the implemented training will increase adaptive emotion regulation strategies in children, significantly reduce medical fear and anxiety, and provide an evidence-based nursing intervention that will facilitate children's compliance with treatment.",[32,519,562],"Hospitalism in Children",{"date":544,"type":39},{"date":565,"type":39},"2025-12-26",{"date":567,"type":23},"2027-12-26",{"name":280,"class":46},{"id":570,"slug":571,"hasResults":12,"nctId":572,"briefTitle":573,"officialTitle":574,"acronym":4,"eligibilityCriteria":575,"healthyVolunteers":12,"sex":18,"minAge":199,"maxAge":171,"enrollmentInfo":576,"targetDuration":4,"studyType":24,"phases":577,"briefSummary":578,"conditions":579,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":565,"lastUpdatePostDateStruct":582,"startDateStruct":584,"completionDateStruct":586,"leadSponsor":588,"locationsCount":4},"100611751","hologram-burn-dressing-on-pain-anxiety-fear-patient-satisfaction-and-physiological-parameters-100611751","NCT07244653","Hologram Burn Dressing on Pain, Anxiety, Fear, Patient Satisfaction, and Physiological Parameters","Effect of Hologram Application During Burn Dressing on Pain, Anxiety, Fear, Patient Satisfaction, and Physiological Parameters: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Between the ages of 18 and 65,\n* Able to read, write, and speak Turkish,\n* Not participating in any other clinical trials at the same time,\n* Patients who were decided to be admitted to a burn unit,\n* No infected cases,\n* Patients who did not undergo minor and\u002For major surgical procedures that could affect the wound healing process,\n* No chronic illness other than burns,\n* No cognitive, sensory, or other problems that would prevent verbal communication and understanding the information given,\n* Second-degree burn with a total body surface area (TBSA) of less than 20%; Patients were included in the study if their burn rate was below 15% (20% in Grade 2 patients; sedation was required in Grade 3 patients with burn rates above 15%),\n* 2nd and 3rd degree burns in the granulation stage (2nd and 3rd degree burns requiring granulation treatment and experiencing high pain),\n* No burns on the head, ears, or face,\n* Daily dressing changes with a frequency of 1-15 dressing changes,\n* No complaints that would prevent participation in the study, such as respiratory problems,\n* No vision or hearing problems.\n\nExclusion Criteria:\n\n* Those with a pain intensity between 8 and 10 points (sedation is required when the pain intensity is 8 or higher),\n* Those under the influence of various non-pharmacological treatment methods that may affect pain,\n* Patients requiring advanced surgical procedures such as fasciotomy, escharotomy, or amputation,\n* Patients receiving sedation during the dressing,\n* Patients interrupting the hologram video during the dressing,\n* First-degree burns,\n* Those with neurological, psychological, or psychiatric illnesses,\n* Patients receiving sedation during the dressing,\n* Patients interrupting the hologram video during the dressing",{"count":316,"type":23},[26],"Burn injuries are a significant global health problem, leading to serious physical, psychological, and social challenges for affected individuals. The literature emphasizes that dressing changes are among the most painful and anxiety-provoking procedures, negatively impacting treatment adherence and patient well-being. Although pharmacological methods are used to alleviate pain and anxiety, they are often insufficient due to potential side effects and addiction risks.\n\nIn recent years, advancements in digital technologies-particularly virtual reality (VR), augmented reality (AR), and hologram applications-have offered promising distraction-based approaches. Hologram technology, through three-dimensional and interactive visuals, can divert the patient's attention from traumatic stimuli, thereby reducing pain, anxiety, and fear in an innovative way. However, there is limited scientific evidence regarding the use of hologram applications during burn dressing changes.\n\nThis study aims to examine the effects of hologram applications on pain, anxiety, fear, patient satisfaction, and physiological parameters during burn dressing procedures. The research will be conducted at Erzurum City Hospital Burn Center, with a total of 70 patients assigned to experimental and control groups using simple randomization. Data collection tools will include the Visual Analogue Scale (VAS), the State-Trait Anxiety Inventory (STAI), the Burn Specific Pain Anxiety Scale, satisfaction and fear VAS assessments, and physiological parameter recording forms. The study will be carried out between November 2025 and May 2026. The results are expected to provide evidence-based insights into the feasibility and effectiveness of hologram technology as a non-pharmacological, innovative intervention in burn care.",[33,580,581,32],"Burn Pain","Burn Patients",{"date":583,"type":39},"2025-12-29",{"date":585,"type":23},"2025-12-31",{"date":587,"type":23},"2026-07-20",{"name":589,"class":46},"Gamze BULUT",{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":595,"acronym":596,"eligibilityCriteria":597,"healthyVolunteers":12,"sex":18,"minAge":199,"maxAge":171,"enrollmentInfo":598,"targetDuration":4,"studyType":24,"phases":600,"briefSummary":601,"conditions":602,"keywords":606,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":612,"lastUpdatePostDateStruct":613,"startDateStruct":614,"completionDateStruct":616,"leadSponsor":618,"locationsCount":102},"100584442","effects-of-education-and-exercise-on-pain-psychosocial-factors-and-upper-limb-function-in-non-specific-neck-pain-100584442","NCT06889389","Effects of Education and Exercise on Pain, Psychosocial Factors, and Upper Limb Function in Non-specific Neck Pain.","Effects of Pain Neuroscience Education and Therapeutic Exercise on Pain, Catastrophizing, Kinesiophobia and Upper Limb Function in Patients With Non-specific Neck Pain.","PNE-EXNP","Inclusion Criteria:\n\n* Subjects aged between 18 and 65 years\n* Subjects with non-specific neck pain at the time of the intervention, scoring at least 3 on the NPRS scale.\n\nExclusion Criteria:\n\n* Pregnancy\n* Severe illnesses: diabetes, cancer, neurological conditions, depression, etc.\n* Subjects impairments or disorders\n* Subjects who have received physiotherapy treatment within the last month\n* Subjects currently undergoing concurrent physiotherapy treatment for this condition\n* Subjects with specific neck pain, such as any traumatic pathology, whiplash, or diagnoses associated with neurological compromise or peripheral nerve damage\n* Physiotherapy students or professional physiotherapists",{"count":599,"type":23},81,[26],"Pain neuroscience education is currently one of the techniques being explored in physiotherapy for pain management. The benefits of this technique are gradually becoming evident in various published studies. So far, it has been widely studied for its short-term effects, but the education provided has typically been generic, not focused on exercise. However, it is suggested that this technique should be combined with exercise to achieve the expected outcomes. Therefore, pain education should be tailored to the specific physical activities the subject will perform to maximise its effectiveness. The primary aim of this study is to analyse the outcome of combining exercise with tailored pain neuroscience education on aspects such as pain, kinesiophobia, catastrophizing, exercise conceptualization, and upper limb function in subjects with neck pain. The secondary aim is to evaluate the relationship between kinesiophobia and catastrophizing and their impact on the results of various upper limb performance tests. Finally, the effects of therapeutic exercise alone will be compared with those of therapeutic exercise combined with pain neuroscience education, focusing on pain, kinesiophobia, catastrophizing, and exercise conceptualization. A double-blind, randomised clinical trial has been designed, in which three intervention protocols will be applied to 81 subjects with non-specific neck pain: education with exercise, exercise alone, and placebo alone. Subjects with non-specific neck pain who meet the inclusion criteria will be enrolled. Demographic characteristics of the subjects, as well as pain, kinesiophobia, catastrophizing, and upper limb performance test scores, will be assessed. This study aims to explore the potential relevance of a pain neuroscience education session prior to therapeutic exercise, as well as to influence the clinical recommendations made by clinicians during treatment.",[603,604,605,32,114],"Neck Pain","Patient Education","Exercise Therapy",[607,608,609,610,611],"Neck pain","Pain neuroscience education","Exercise therapy","Kinesiophobia","Pain catastrophizing","2025-12-19",{"date":583,"type":39},{"date":615,"type":39},"2025-03-28",{"date":617,"type":23},"2026-10-30",{"name":619,"class":46},"Universidad Miguel Hernandez de Elche",{"id":621,"slug":622,"hasResults":12,"nctId":623,"briefTitle":624,"officialTitle":625,"acronym":4,"eligibilityCriteria":626,"healthyVolunteers":17,"sex":18,"minAge":138,"maxAge":139,"enrollmentInfo":627,"targetDuration":4,"studyType":24,"phases":629,"briefSummary":630,"conditions":631,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":633,"lastUpdatePostDateStruct":634,"startDateStruct":635,"completionDateStruct":636,"leadSponsor":638,"locationsCount":4},"100616935","the-effect-of-two-different-types-of-hourglasses-on-pain-fear-and-anxiety-100616935","NCT07312084","The Effect of Two Different Types of Hourglasses on Pain, Fear, and Anxiety","The Effect of Two Different Types of Hourglasses on Pain, Fear, and Anxiety During Blood Collection in Children: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Being between 5 and 10 years old,\n* Agreeing to participate in the research by applying to the blood collection unit,\n* Written consent being obtained from the parent,\n* Physical and mental development being appropriate for the age.\n\nExclusion Criteria:\n\n* Being outside the specified age range,\n* Having a serious chronic disease or hematological disorder,\n* Having developed serious trauma or intense anxiety due to a previous blood draw,\n* Refusal to participate in the study or failure to obtain parental consent,\n* Psychiatric or neurological disorders that may affect the implementation of the study.",{"count":628,"type":23},120,[26],"This research will be conducted as a pre-test-post-test parallel group randomized controlled experimental study to determine the effects of two different types of hourglasses (liquid gel-based hourglass and sand-based hourglass) used for distraction during blood collection in children aged 5-10 years on pain, fear, and anxiety and the comparative effectiveness of these methods.\n\nResearch Hypotheses H1: The mean pain, fear, and anxiety scores of children who used a liquid gel-based hourglass during blood collection were significantly lower than the mean scores of children in the control group.\n\nH2: The mean pain, fear, and anxiety scores of children who used a sand-based hourglass during blood collection were significantly lower than the mean scores of children in the control group.\n\nH3: The use of a liquid gel-based hourglass and a sand-based hourglass during blood collection had different effects on the mean pain, fear, and anxiety scores of children.",[114,32,33,632,29],"Procedural Anxiety","2025-12-16",{"date":585,"type":39},{"date":453,"type":23},{"date":637,"type":23},"2026-12-31",{"name":639,"class":46},"Hakkari Universitesi",{"id":641,"slug":642,"hasResults":12,"nctId":643,"briefTitle":644,"officialTitle":644,"acronym":4,"eligibilityCriteria":645,"healthyVolunteers":17,"sex":18,"minAge":199,"maxAge":646,"enrollmentInfo":647,"targetDuration":4,"studyType":24,"phases":648,"briefSummary":649,"conditions":650,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":654,"lastUpdatePostDateStruct":655,"startDateStruct":656,"completionDateStruct":658,"leadSponsor":659,"locationsCount":661},"100448529","intracranial-neurophysiological-signatures-of-fear-and-anxiety-in-humans-100448529","NCT05120635","Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans","Inclusion Criteria:\n\n* 18 years of age or older\n* Has undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement\n* Willing to provide informed consent and participate in the study\n* Ability to read and write English fluently\n\nExclusion Criteria:\n\n* Unwilling to provide informed consent\n* Has not undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement\n* Pregnant women\n* Participants with active psychosis\n* Participants with suicidal ideation\n* Participants with substance abuse issues","70 Years",{"count":173,"type":23},[26],"Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments.\n\nThe purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. To accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. Some of the tasks will also use a virtual reality headset and transport the patient in a video game-like environment. These tasks will expose the participants to various levels of fear-provoking images. Participants with responsive neurostimulation (RNS) implants will be enrolled under Pro00117931 at Duke, but their results for fear and anxiety tasks will be reported under NCT05120635.",[32,651,652,653],"GAD","Emotional Memory","PTSD","2025-12-11",{"date":633,"type":39},{"date":657,"type":39},"2021-10-01",{"date":278,"type":23},{"name":660,"class":46},"Duke University",2]