[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"feeding-difficulties\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:feeding-difficulties":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,55,89,120,138,155],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100628319","premature-infant-oral-motor-intervention-vs-pacifier-for-oral-feeding-transition-in-preterm-infants-100628319",false,"NCT07460089","Premature Infant Oral Motor Intervention vs. Pacifier for Oral Feeding Transition in Preterm Infants","The Effect of the Premature Infant Oral Motor Intervention Versus Pacifier Use in the Transition to Oral Feeding in Preterm Infants","PIOMI","Inclusion Criteria:\n\n1. \\- Preterm infants born at 26-32 weeks of gestational age\n2. \\- Clinically stable (no mechanical ventilation, no major congenital anomalies, no necrotizing enterocolitis)\n3. \\- Birth weight ≥1000 grams\n4. \\- Informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n1. Orofacial malformations (e.g., cleft lip, cleft palate)\n2. Neurological impairment affecting sucking ability (e.g., intraventricular hemorrhage grade III or IV, periventricular leukomalacia)\n3. Infants who received any prior structured oral motor intervention\n4. Major congenital anomalies or genetic syndromes affecting feeding or development\n5. Infants requiring surgical interventions during the study period\n6. Lack of parental consent","ALL","1 Day","28 Days",{"count":21,"type":22},150,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study compares three approaches to help premature babies learn to feed by mouth: a special mouth exercise program (called PIOMI), using a pacifier, and standard care. Premature babies often have difficulty feeding because their sucking, swallowing, and breathing are not yet coordinated, which can lead to longer hospital stays. The study will include 150 premature infants born between 26 and 32 weeks of pregnancy at a hospital in Thi Qar. Babies will be randomly placed into one of three groups: one group will receive a many-day mouth exercise program, another will use a pacifier for many days, and the third will receive routine care. We will measure how quickly each baby learns to feed fully by mouth, how long they stay in the hospital, how much weight they gain, and their feeding skills. The results may help improve care for premature babies and reduce the time they spend in the hospital.",[28,29,30],"Feeding Difficulties","Sucking Behavior","Premature",[32,33,34,28,29,15,35,36,37,38,39,40,41,42],"Premature Infant","Preterm Infant","Oral Feeding","Pacifier Use","Non-nutritive Sucking","Oral Motor Intervention","Neonatal Intensive Care","NICU","Feeding Transition","Weight Gain","Length of Hospital Stay","NOT_YET_RECRUITING","2026-03-06",{"date":46,"type":47},"2026-03-10","ACTUAL",{"date":46,"type":22},{"date":50,"type":22},"2026-05-30",{"name":52,"class":53},"University of Baghdad","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":72,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":88},"100584753","feeding-difficulties-and-quality-of-life-in-children-with-tracheal-cannula-100584753","NCT06893458","Feeding Difficulties and Quality of Life in Children With Tracheal Cannula","Inclusion Criteria: Children below the age of 18 with tracheostomy undergoing follow-up through the Long term Intensive Care Unit at Karolinska University Hospital in Stockholm Sweden between march 2025 and march 2027.\n\nExclusion criteria: Patients that can not undergo full evaluations\u002Fexaminations will not be included.","18 Years",{"count":63,"type":22},80,"OBSERVATIONAL","The over all goal of this observational study is to study if there is an association between the presence of feeding difficulties and self-assessed quality of life in children with tracheal cannula.\n\nThe main questions it aims to answer are\n\n1. What is the incidence of feeding difficulties in children with tracheostomy and what type of feeding difficulties affect these children?\n2. How do children with a tracheal tube and their parents assess their quality of life measured through PedsQL?\n3. Is there an association between the presence of feeding difficulties and self-assessed quality of life in children with tracheal cannula?\n\nQuality of life will be assessed in an interview using the PedsQL instrument generic module 4.0. Swallowing difficulties will be assessed through evaluations based on The Montreal Children's Hospital Feeding Scale.",[67,68,69,28,70,71],"Quality of Life (QOL)","Tracheostomy","Children in the Pediatric Intensive Care Unit or General Pediatric Care Unit Requiring a Central Venous Catheter","Swallowing Difficulties","Caregiver Quality of Life",[73,74,75,76,77],"pediatric quality of life","caregiver quality of life","swallowing related quality of life","feeding difficulties","pediatric tracheostomy","RECRUITING","2026-02-12",{"date":81,"type":47},"2026-02-13",{"date":83,"type":47},"2025-03-17",{"date":85,"type":22},"2027-03-17",{"name":87,"class":53},"Karolinska Institutet",2,{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":17,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":23,"phases":100,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":4},"100616304","phase-4-the-use-of-high-bile-binding-foods-to-reduce-upper-gastrointestinal-bile-acid-concentrations-aim-2-100616304","NCT07303868","The Use of High Bile-binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 2)","The Use of High Bile-Binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations: A Novel Intervention for Children at Risk for Aspiration-Associated Complications (Aim 2)","Pediatric patients ages 5 to 21 in the randomized arm Inclusion criteria\n\n* receive at least 80% of their nutritional needs via gastrostomy\n* receive blenderized feeds or will start receiving blenderized feeds\n* have no known allergies to ingredients in blenderized feeds;\n* receive their bolus feeds within 30 minutes or less\n* can receive their feeds by syringe push Exclusion criteria\n* have undergone anti-reflux surgery\n* receive post-pyloric feeds\n* are allergic to any component of the administered diets\n* cannot receive their gastrostomy feeds over 30 minutes\n* require a feeding pump for feed administration (as the H-BBB is too thick for pump administration).\n\nPediatric patients ages 5 to 21 in the observational arm Inclusion\n\n* receive at least 80% of their nutritional needs via gastrostomy\n* are taking an amino acid formula\n* have not undergone antireflux surgery Exclusion\n* have undergone anti-reflux surgery\n* receive post-pyloric feeds\n* are not receiving an amino acid-based formula.","5 Years","21 Years",{"count":99,"type":22},66,[101],"PHASE4","Using a four-week randomized, crossover study design, we will assess the impact of 2 weeks of a high bile acid-binding blenderized diet, compared to 2 weeks of a low bile acid-binding blenderized diet, on gastric and salivary bile acid concentrations within individual participants. Four weeks of an amino acid formula will be a comparator group.",[28,104,105],"Gastrostomy","Aspiration",[107,108,109,110],"blenderized","bile acid","gastrostomy","aspiration","2025-12-23",{"date":113,"type":47},"2025-12-26",{"date":115,"type":22},"2026-07",{"date":117,"type":22},"2030-08",{"name":119,"class":53},"Boston Children's Hospital",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":17,"minAge":96,"maxAge":97,"enrollmentInfo":127,"targetDuration":4,"studyType":23,"phases":129,"briefSummary":130,"conditions":131,"keywords":132,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":133,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":137,"locationsCount":54},"100616294","phase-4-the-use-of-high-bile-binding-foods-to-reduce-upper-gastrointestinal-bile-acid-concentrations-aim-1-100616294","NCT07303738","The Use of High Bile-binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 1)","The Use of High Bile-Binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations: A Novel Intervention for Children at Risk for Aspiration-Associated Complications (Aim 1)","Inclusion Criteria:\n\n* receive at least 80% of their nutritional needs by gastrostomy\n* receive either an amino acid-based formula, an International Dysphagia Diet Standardization Initiative level 4 commercial blend, or a home blend\n* can receive bolus feeds of 240 cc within 30 minutes or less\n\nExclusion Criteria:\n\n* have received a fundoplication\n* receive post-pyloric feeds\n* require medication\u002Fflush administration during the four-hour study period\n* are allergic to any component of the study diets.\n\nTo participate in this study, if patients are taking acid suppression or motility medications (e.g., erythromycin, azithromycin, prucalopride), they will need to stop these at least 72 hours prior to participation in this aim.",{"count":128,"type":22},60,[101],"We will perform an acute physiology study comparing three different diets-an amino acid-based formula, a low bile acid-binding blenderized diet, or a high bile acid-binding blenderized diet administered through gastrostomy tube. We will determine the differences in gastric and salivary bile acid concentrations between participants over the 4 hour post-prandial timeframe.\n\nParticipants who regularly receive an amino acid-based formula will receive an amino acid-based formula during the study and participants who regularly receive a blenderized feed will receive a blenderized feed during the study. Only participants who regularly receive blenderized feeds will be randomized to receive either the high or low bile acid binding blenderized feed.",[28,105,104],[107,108,109,110],{"date":113,"type":47},{"date":135,"type":47},"2025-12-01",{"date":117,"type":22},{"name":119,"class":53},{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":17,"minAge":96,"maxAge":97,"enrollmentInfo":145,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":147,"conditions":148,"keywords":149,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":153,"leadSponsor":154,"locationsCount":4},"100586303","the-use-of-high-bile-binding-foods-to-reduce-upper-gastrointestinal-bile-acid-concentrations-aim-3-100586303","NCT06913621","The Use of High Bile-Binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 3)","The Use of High Bile-Binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations: A Novel Intervention for Children at Risk for Aspiration-Associated Complications (Aim 3)","Inclusion Criteria:\n\n* receive at least 80% of their nutritional needs via gastrostomy\n* receive an International Dysphagia Diet Standardization Initiative level 4 commercial blend, home blend or amino acid-based formula\n* receive their bolus feeds within 30 minutes or less.\n\nExclusion Criteria:\n\n* have undergone anti-reflux surger\n* receive post-pyloric feeds\n* receive regular daily prophylactic antibiotics.",{"count":146,"type":22},138,"Using a longitudinal cohort design, we will compare the impact of a high BA-binding blenderized diet compared to a low BA-binding blenderized diet and an amino acid-based formula, on gastrointestinal and pulmonary hospitalization and emergency room visit rates over six months.",[28,104,105],[107,108,109,110],{"date":151,"type":47},"2025-12-30",{"date":115,"type":22},{"date":117,"type":22},{"name":119,"class":53},{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":23,"phases":164,"briefSummary":165,"conditions":166,"keywords":168,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":54},"100586840","stereotypic-behaviors-and-feeding-difficulties-in-adults-with-developmental-disabilities-100586840","NCT06920615","Stereotypic Behaviors and Feeding Difficulties in Adults With Developmental Disabilities","Stereotypi in Motor-, Vocal- and Feeding Behaviors: Novel Extensions to Adults","Inclusion Criteria:\n\n* Participants will be recruited through referrals at the Department of Neurohabilitation, or from other hospitals in the Oslo Region.\n* be 18 years or older,\n* have a DD, autism spectrum disorder or a PDD-NOS diagnosis\n* and be referred to the specialist habilitation service for adults.\n\nExclusion Criteria:\n\n* If there are medical causes of the participant's behavioral problem or\n* a reasonable possibility that the referred problem is caused by medical variables\n* if the client participant receives communal care services and if those are not in accordance with Norwegian standards of services for individuals with DD.\n* This could include inappropriate staff-to-client ratio,\n* lack of stimulating activities,\n* or if on-site training is insufficient.\n* the exclusion criteria do not exclude health care from The Oslo University Hospital.",{"count":163,"type":22},8,[25],"Adults with developmental disabilities (DD) and autism represent a vulnerable demographic that transitions into adulthood with diverse etiologies, exhibiting a significantly higher prevalence of various challenging behaviors. These problematic behaviors can lead to adverse health outcomes and a diminished quality of life. Addressing these issues often necessitates an interdisciplinary approach to continuity of care, focusing on enhancing functional skills, empowerment, and independence, as well as preventing and mitigating challenging behaviors. The current research proposal comprises of three studies designed to evaluate the efficacy of behavioral interventions for problematic behaviors in adults with DD and autism. If left unaddressed, these behaviors may worsen over time, potentially hindering community involvement, educational opportunities, and employment prospects. These include harmful stereotypies and feeding difficulties.",[167,28],"Harmful Stereotypies",[169],"Feeding difficulties, stereotypic behavior, challenging behavior, autism, developmental disabilities","2025-04-10",{"date":172,"type":47},"2025-04-15",{"date":174,"type":22},"2025-04-08",{"date":176,"type":22},"2030-08-26",{"name":178,"class":53},"Oslo University Hospital"]