[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"femoral-neck-fractures\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:femoral-neck-fractures":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,22,0,[8,52,87,115,136,161,191,228,250,272,298,320,345,381,410,437,480,522,543,568,591,616],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100611717","mapt-protocol-fixation-versus-arthroplasty-surgical-treatments-for-early-recovery-after-hip-fracture-faster-hip-100611717",false,"NCT07244211","MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)","Musculoskeletal Adaptive Platform Trial (MAPT): Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)","FASTER-HIP","Inclusion Criteria:\n\n* 60 years of age or older undergoing surgery due to a minimally displaced femoral neck fracture\n* The patient has a health condition affecting physical mobility.\n* Complete fracture of the femoral neck (AO\u002FOTA 31B) confirmed with anteroposterior and lateral hip radiographs, computed tomography, or magnetic resonance imaging.\n* Minimally displaced fracture that could be, in the judgment of the attending surgeon, managed with either arthroplasty or in situ internal fixation without reduction.\n* Low energy injury mechanism.\n* Surgeons with expertise in internal fixation and total hip arthroplasty or hemiarthroplasty are available to perform surgery.\n\nExclusion Criteria:\n\n* The patient is not clinically suitable for either compared treatment.\n* Expected injury survival of less than 12 months.\n* Terminal illness with expected survival of less than 12 months.\n* Incarceration.\n* Unable to obtain informed consent due to language barriers.\n* Unable to obtain informed consent because the legally authorized representative was unavailable.\n* Problems, in the judgment of the study personnel, with maintaining follow-up with the patient.\n* Currently enrolled in a study or intervention domain that does not permit co-enrollment.\n* Prior enrollment in the specific platform trial intervention domain.\n* Patient or legally authorized representative did not provide informed consent (declined participation).\n* Eligible patient or legally authorized representative was not approached within the screening window (missed participant).\n* Other reasons to exclude the patient, as approved by the data coordinating center.\n* Associated lower extremity injury that prevents post-operative weight-bearing.\n* Retained hardware around the hip that precludes either study treatment.\n* Infection around the hip (soft tissue or bone).\n* Pathologic fracture with a lytic lesion in the femoral neck that precludes internal fixation.\n* Injury did not occur within 21 days of screening.\n* Patient is too ill, in the judgment of the attending surgeon, for internal fixation.\n* Patient is too ill, in the judgment of the attending surgeon, for arthroplasty.","ALL","60 Years",{"count":20,"type":21},600,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is an intervention domain of the Musculoskeletal Adaptive Platform Trial. The primary goal of this pragmatic, randomized, open-label, comparative effectiveness trial is to evaluate if arthroplasty is superior to internal fixation when used to treat minimally displaced femoral neck fractures in older adults ≥60 years old. We hypothesize that arthroplasty will reduce death, preserve ambulation, increase days alive and out of hospital, and improve health status compared to internal fixation within 4 months and 12 months from randomization.",[27],"Femoral Neck Fractures",[29,30,31,32,33,34,35,36,37,38],"Minimally displaced femoral neck fractures","arthroplasty","hip fractures","femoral fractures","orthopaedic procedures","older adults","patient-centered outcomes","adaptive trial","internal fixation","pragmatic trial","RECRUITING","2026-06-19",{"date":42,"type":43},"2026-06-24","ACTUAL",{"date":45,"type":43},"2026-01-23",{"date":47,"type":21},"2030-01-31",{"name":49,"class":50},"University of Southern California","OTHER",15,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":86},"100641958","post-market-clinical-follow-up-pmcf-study-evaluating-the-safety-and-efficacy-of-tpmed-primary-hip-prosthesis-system-100641958","NCT07651735","Post-Market Clinical Follow-Up (PMCF) Study Evaluating the Safety and Efficacy of Tıpmed™ Primary Hip Prosthesis System","A Multicenter, Prospective, Observational, Post-Market Clinical Follow-Up (PMCF) Study Evaluating the Safety and Efficacy of Tıpmed™ Primary Hip Prosthesis System","Inclusion Criteria:\n\n* Individuals aged 18 years and older,\n* Male or female participants,\n* Subjects who have undergone Primary Hip Arthroplasty (either total or partial) for any indication,\n* Subjects in whose surgical procedure the Tipmed™ Primary Hip Prosthesis System components were utilized.\n* Subjects who are not legally restricted (e.g., military personnel, convicts, or individuals under legal guardianship).\n* Subjects who have voluntarily signed the written Informed Consent Form (ICF).\n\nExclusion Criteria:\n\n* Subjects currently participating in any other interventional clinical trial.","18 Years",{"count":61,"type":21},101,"OBSERVATIONAL","This is a multicenter, prospective, observational, post-market clinical follow-up (PMCF) study designed to evaluate the safety and clinical performance of the Tipmed™ Primary Hip Prosthesis System in adult subjects undergoing primary hip arthroplasty. The study aims to gather real-world clinical evidence on the 24-month post-operative safety profile, potential complications, and functional outcomes of the device during routine clinical practice.",[65,66,67,27,68],"Total Hip Arthroplasty (THA)","Hemiarthroplasty","Osteoarthritis (OA) of the Hip","Joint Diseases",[70,71,72,73,74,75],"Hip Prosthesis","Total Hip Prosthesis","Partial Hip Prosthesis","Primary Hip Arthroplasty","Post-Market Clinical Follow-Up (PMCF)","Harris Hip Score (HHS)","2026-06-10",{"date":78,"type":43},"2026-06-16",{"date":80,"type":43},"2024-03-12",{"date":82,"type":21},"2029-03-31",{"name":84,"class":85},"TIPMED Medical Device Manufacturing Ltd. Co.","INDUSTRY",4,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":22,"phases":97,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":4},"100636565","how-tens-affects-pain-medication-use-and-muscle-function-in-older-adults-with-hip-fractures-100636565","NCT07567339","How TENS Affects Pain, Medication Use, and Muscle Function in Older Adults With Hip Fractures","Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Pain and Analgesic Use and the Association of Clinical and Psychosocial Factors With Muscle Function in Older Adults With Hip Fracture","TENS-HIP","Inclusion Criteria:\n\n* Older adults (male and female) diagnosed with hip fracture\n* Age ≥ 60 years\n* Admitted to the hospital inpatient unit (HPS)\n* Mini-Mental State Examination (MMSE) score ≥ 20\n\nExclusion Criteria:\n\n* Conditions contraindicating electrical stimulation, such as presence of a pacemaker, significant sensory loss in the lower limbs, or skin lesions at the electrode placement site\n* History of neurological or cognitive impairment that may interfere with understanding of the assessments\n* Previous treatment with neuromuscular electrical stimulation (NMES) in the lower limb within the last 3 months",{"count":96,"type":21},32,[24],"The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation (TENS) can reduce perioperative pain in older adults with hip fractures. It will also evaluate its effects on physiological and psychological outcomes. The main questions it aims to answer are:\n\nDoes adding TENS to usual care during the preoperative phase reduce pain intensity and analgesic consumption? Does TENS affect pressure pain threshold and vital signs (blood pressure, heart rate, and respiratory rate)?\n\nResearchers will compare active TENS to sham TENS (no perceptible stimulation) to see if TENS is effective in reducing pain and improving related outcomes.\n\nParticipants will:\n\n* Undergo a standardized baseline assessment, including evaluation of pain, vital signs, anxiety, discomfort, and pressure pain threshold\n* Complete questionnaires assessing quality of life, physical activity, depressive symptoms, anxiety, fear of falling, and pain catastrophizing\n* Be randomly assigned to receive either active TENS or sham TENS\n* Receive a single 45-minute TENS session\n* Have their analgesic use recorded for the 24 hours before and after the intervention.",[100,27,101],"Hip Fractures","Intertrochanteric Femur Fracture",[100,103,104],"TENS","PAIN","NOT_YET_RECRUITING","2026-05-04",{"date":108,"type":43},"2026-05-08",{"date":110,"type":21},"2026-05-22",{"date":112,"type":21},"2027-01-28",{"name":114,"class":50},"University of the Sinos Valley",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":122,"targetDuration":124,"studyType":62,"phases":4,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":4},"100631519","comparison-of-the-direct-anterior-approach-daa-and-the-direct-lateral-approach-dla-in-patients-treated-with-partial-hip-replacement-for-femoral-neck-fracture-based-on-postoperative-functional-status-100631519","NCT07501741","Comparison of the Direct Anterior Approach (DAA) and the Direct Lateral Approach (DLA) in Patients Treated With Partial Hip Replacement for Femoral Neck Fracture Based on Postoperative Functional Status","Impact of Surgical Approach on Post-Fracture Function: A Prospective Hemiarthroplasty Study","Inclusion Criteria:\n\nAdults aged 18 years or older Patients undergoing hemiarthroplasty (partial hip replacement) during the study period at Meir Medical Center Ability to provide informed consent for participation in the study\n\nExclusion Criteria:\n\nRevision surgery performed during the index hospitalization Inability to complete postoperative follow-up Inability to provide informed consent (e.g., dementia or presence of a legal guardian) Pre-injury mobility status of bedbound or wheelchair-bound Polytrauma patients Prior fixation or arthroplasty of the contralateral hip within the previous year",{"count":123,"type":21},100,"1 Year","The goal of this clinical trial is to learn whether the surgical approach used for hemiarthroplasty can improve clinical and functional outcomes in adults with displaced femoral neck fractures.\n\nThe main questions it aims to answer are:\n\n* Does the direct anterior approach (DAA) result in superior postoperative functional recovery compared with the direct lateral approach (DLA)?\n* Are mortality, complications, hospital utilization, and readmission rates different between the two surgical approaches? Researchers will compare hemiarthroplasty performed using the direct anterior approach to hemiarthroplasty performed using the direct lateral approach to determine whether surgical approach influences postoperative function, complications, and survival.\n\nParticipants will:\n\n* Undergo hemiarthroplasty for displaced femoral neck fracture using a randomly assigned surgical approach (DAA or DLA)\n* Complete a baseline functional assessment using the Activities of Daily Living (ADL) questionnaire before surgery\n* Have perioperative data collected during hospitalization, including laboratory values, operative details, blood loss, transfusions, analgesic use, complications, length of stay, and in-hospital mortality\n* Attend follow-up clinic visits at 6 weeks and 3 months after surgery\n* Complete postoperative functional assessment using the Harris Hip Score at both follow-up visits\n* Have demographic data, complications, readmissions, and mortality monitored through review of electronic medical records",[27],"2026-03-24",{"date":129,"type":43},"2026-03-30",{"date":131,"type":21},"2026-05-01",{"date":133,"type":21},"2028-05",{"name":135,"class":50},"Meir Medical Center",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":145,"conditions":146,"keywords":150,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":86},"100491987","observational-study-to-evaluate-long-term-outcome-in-hip-hemiarthroplasty-100491987","NCT05686278","Observational Study to Evaluate Long-Term Outcome in Hip Hemiarthroplasty","A Post-market Clinical Follow-up (PMCF) Study to Evaluate Clinical, Radiographic and Patient Reported Outcomes Following a Hip Hemiarthroplasty Surgery Using Corin Devices","Inclusion Criteria:\n\n1. Both genders.\n2. Adult subjects.\n3. Subjects clinically suitable for a hip hemiarthroplasty surgery with Corin hip devices based on physical examination, medical history and diagnosis such as: non-inflammatory degenerative joint disease including osteoarthritis and avascular necrosis in which the acetabulum does not require replacement, treatment of non-union, femoral neck and trochanteric fractures of the proximal femur, revision of failed partial hip replacements in which the acetabulum does not require replacement.\n4. The subject is willing to comply with the required follow-up visits as per protocol.\n5. The subject, or a designated trusted person in case the subject is unable to do, has signed a Patient Informed Consent Form (PICF), specific to this study, and approved by the local EC.\n\nExclusion Criteria:\n\n1. Subjects with active infection or sepsis or osteomyelitis.\n2. Subjects with unsuitable or insufficient bone support preventing proper fixation of the prosthesis.\n3. Subject with marked bone loss or bone absorption.\n4. Subject with metabolic disorders which may impair bone formation or bone quality.\n5. Subjects under guardianship.\n6. Subjects under jusicial protection\n7. Subjects in the opinion of the Investigator\u002F investigative team who will be unable to comply with study procedures (Examples: recent psychotic or mania disorders, alcohol, drug or substance abusers) and\u002For those unable for any medical or other reason to comply with study procedures\u002Fvisits.",{"count":144,"type":21},368,"This PMCF study is designed to collect safety and efficacy data on hip hemiarthroplasty surgeries with Corin BiPolar-i shell and the Oceane+ or Meije Duo femoral stem up to 10 years.",[100,147,148,149,27],"Hip Hemiarthroplasty","Osteoarthritis, Hip","Avascular Necrosis of Hip",[66,151,100],"Acetabulum","2026-03-17",{"date":154,"type":43},"2026-03-18",{"date":156,"type":43},"2023-06-29",{"date":158,"type":21},"2035-09",{"name":160,"class":85},"Corin",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":18,"enrollmentInfo":169,"targetDuration":4,"studyType":22,"phases":171,"briefSummary":173,"conditions":174,"keywords":176,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":190},"100559575","phase-4-bupivacaine-liposome-plus-bupivacaine-or-ropivacaine-for-pericapsular-nerve-group-block-in-hip-arthroplasty-peng-100559575","NCT06565910","Bupivacaine Liposome Plus Bupivacaine or Ropivacaine for Pericapsular Nerve Group Block in Hip Arthroplasty (PENG)","Bupivacaine Liposome Plus Bupivacaine or Ropivacaine for PENG Block on Post Operative Pain Management in Patients Undergoing Hip Arthroplasty: a Prospective, Randomized, Single Blind, Active Controlled Study","PENG","Inclusion Criteria:\n\n* American Society of Anesthesiologists(ASA) I\\~II\n* Normal coagulation\n* Clinical diagnosis of hip fracture\n\nExclusion Criteria:\n\n* Presence of severe systemic diseases or ASA grade III or higher\n* Allergy to amide local anesthetics",{"count":170,"type":21},60,[172],"PHASE4","The goal of this clinical trial is to study the analgesic effect of liposomal bupivacaine plus bupivacaine for Pericapsular Nerve Group (PENG) block in postoperative pain management following hip replacement surgery. It will also assess the safety of liposomal bupivacaine for this purpose. The main questions it aims to answer are:\n\n1. Is liposomal bupivacaine plus bupivacaine superior to ropivacaine in terms of analgesic efficacy, duration of pain relief, opioid consumption, and patient satisfaction?\n2. What medical problems do participants encounter when using liposomal bupivacaine plus bupivacaine for PENG block in postoperative pain management following hip replacement surgery?\n\nResearchers will compare liposomal bupivacaine plus bupivacaine to ropivacaine (a routinely used regional anesthetic in clinical practice) to determine if liposomal bupivacaine plus bupivacaine is more effective for pain management following hip replacement surgery.\n\nParticipants will:\n\n1. Receive liposomal bupivacaine plus bupivacaine or ropivacaine as a regional anesthetic for PENG block under ultrasound guidance.\n2. Undergo hip replacement surgery under spinal anesthesia.\n3. Have pain relief, opioid analgesic consumption, and incidence of complications assessed at multiple time points within 72 hours after surgery.",[27,175,100],"Femur Head Necrosis",[177,178,179,180],"Bupivacaine Liposome","PENG block","Hip Arthroplasty","Randomized Controlled Trial","2026-03-11",{"date":183,"type":43},"2026-03-13",{"date":185,"type":43},"2024-12-04",{"date":187,"type":21},"2026-07-01",{"name":189,"class":50},"Huazhong University of Science and Technology",1,{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":17,"minAge":198,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":22,"phases":201,"briefSummary":202,"conditions":203,"keywords":206,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":227},"100549791","evaluating-a-strategy-to-improve-pre-anesthesia-care-discussions-my-anesthesia-choice-hip-fracture-100549791","NCT06438640","Evaluating a Strategy to Improve Pre-Anesthesia Care Discussions (My Anesthesia Choice-Hip Fracture)","Implementation and Evaluation of a Strategy to Improve Pre-Anesthesia Care Discussions (My Anesthesia Choice-Hip Fracture)","Inclusion:\n\nAge 50 and older Planned surgery to treat a hip fracture\n\nExclusion:\n\nContraindication to spinal anesthesia: current anticoagulant therapy or coagulopathy Contraindication to spinal anesthesia: critical aortic stenosis Contraindication to spinal anesthesia: skin infection over the lumbar spine","50 Years",{"count":200,"type":21},1881,[24],"The objective of this study is to assess the implementation process for and the effectiveness of a quality improvement (QI) strategy to increase shared decision-making around anesthesia options for hip fracture surgery at 6 US hospitals. The QI strategy is to be facilitated by a clinician-administered 1-page bedside conversation aid designed to improve the quality of physician-patient communication, paired with brief clinician training. The evaluation will occur via a stepped wedge, cluster randomized trial to be carried out over a period of 34 months.",[100,27,204,205],"Intertrochanteric Fractures","Subtrochanteric Fractures",[207,208,209,210,211,212,213,214,215,216,217],"hip fracture","femoral neck","intertrochanteric","subtrochanteric","fracture","anesthesia","observational study","survey","shared decision making","My Anesthesia Choice","MAC-HF","2026-03-09",{"date":220,"type":43},"2026-03-12",{"date":222,"type":43},"2024-08-15",{"date":224,"type":21},"2028-06-15",{"name":226,"class":50},"University of Pennsylvania",6,{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":11,"sex":17,"minAge":198,"maxAge":235,"enrollmentInfo":236,"targetDuration":4,"studyType":22,"phases":238,"briefSummary":239,"conditions":240,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":190},"100441056","phase-4-this-is-a-study-to-verify-if-periarticular-hip-injection-of-corticosteroid-after-hip-replacement-reduce-the-pain-and-the-hospitalisation-time-100441056","NCT05023369","This is a Study to Verify if Periarticular Hip Injection of Corticosteroid After Hip Replacement Reduce the Pain and the Hospitalisation Time","Periarticular Administration of Dexamethasone to Improve Post-operative Pain, Function, Nausea, Hospitalization Length, and Risk of Complications in Patients Undergoing Hip Arthroplasty - A Randomized Trial","Inclusion Criteria:\n\n* Patients undergoing unilateral cemented hip endoprosthesis for femoral neck fracture\n* Patients aged 50-90 years old\n* Patients with a BMI \\>18.5 and \\\u003C35\n* Patients able to provide informed consent and follow all the study procedures as indicated by the protocol\n* Informed Consent as documented by signature\n\nExclusion Criteria:\n\n* Contraindications to steroids\n* Revision endoprosthesis\n* Active steroid or immunosuppressive therapy in the last 30 days before the operation\n* Pregnant or breast-feeding women\n* Presence of other clinically significant concomitant disease states (ASA IV)\n* Uncontrolled diabetes mellitus\n* Contraindications to NSAIDs\n* Chronic systemic diseases as immunodeficiency, autoimmune disease (Systemic Lupus Erythematosus, SLE), gout, rheumatic arthritis\n* Known or suspected non-compliance, drug or alcohol abuse\n* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant.\n* Participation in another study with investigational drug within the 30 days preceding and during the present study\n* Previous enrolment into the current study\n* Enrolment of the investigator, his\u002Fher family members, employees and other dependent persons.","90 Years",{"count":237,"type":21},110,[172],"The investigators are going to evaluate if periarticular corticosteroid injection during endoprothesis implantation can lead to any advantage to the patients, namely if it can reduce post-operative pain, lenght and cost of hospitalisation, use of analgesics drugs.",[27],"2026-03-03",{"date":243,"type":43},"2026-03-05",{"date":245,"type":43},"2021-12-10",{"date":247,"type":21},"2026-11-01",{"name":249,"class":50},"Ente Ospedaliero Cantonale, Bellinzona",{"id":251,"slug":252,"hasResults":11,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":4,"eligibilityCriteria":256,"healthyVolunteers":11,"sex":17,"minAge":198,"maxAge":235,"enrollmentInfo":257,"targetDuration":4,"studyType":22,"phases":259,"briefSummary":260,"conditions":261,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":190},"100626983","sacral-espb-vs-peng-block-for-hip-hemiarthroplasty-analgesia-100626983","NCT07442721","Sacral ESPB vs. PENG Block for Hip Hemiarthroplasty Analgesia","Sacral Erector Spinae Plane Block Versus Pericapsular Nerve Group Block For Analgesia In Hip Hemi Arthroplasty: A Randomized Comparative Study","Inclusion Criteria:\n\n* Patients with ages from 50 to 90 years of either gender, with diagnosis of intracapsular neck of femur fracture scheduled for elective hip hemiarthroplasty • Patients with an American Society of Anesthesiologists (ASA) physical status I to III.\n\nExclusion Criteria:\n\n* • Patient refusal.\n\n  * Allergy to local anesthetics and patient with infection at the injection site of block\n  * Patient with contraindication to spinal anesthesia.\n  * Coagulopathy as INR≥1.5 or platelets ≤80\\*103 \u002F microliter)\n  * Patients with body mass index\\>35 kg \u002F m2\n  * Patients with peripheral neuropathy or diabetic neuropathy\n  * Patients receiving opioids for chronic analgesic therapy (cancer, addiction).\n  * Cognitive impairment preventing pain scoring.\n  * Chronic renal failure requiring dose modification.\n  * Bilateral hip fracture or previous ipsilateral hip surgery",{"count":258,"type":21},80,[24],"Sacral erector spinae plane block(S-ESPB) has been recently described. Case reports are showing that it is useful in various types of surgery. In case presentations, it has been reported as effective in providing analgesia in the posterior branches of the sacral nerves in pilonidal sinus surgery, in the treatment of radicular pain at the L5 - S1 level, after a sex reassignment operation and hypospadias surgery, and its use in combination with lumbar ESPB for analgesia was reported after hip prosthesis surgery . Described in 2018, pericapsular nerve group (PENG) block selectively targets the articular branches of the femoral and accessory obturator nerves thereby providing potential motorsparing analgesia for hip surgery\n\n. Recent studies found that PENG block targets the articular branches of the femoral and accessory obturator nerves, only anesthetizes the anterior hip joint sparing posterior part , as well as there was a motor impairment after block which is from local anesthetic (LA) diffusion to the femoral nerve\n\n. Motor-sparing regional anesthesia techniques have emerged as a safer alternative, balancing effective pain relief with the preservation of quadriceps function . These techniques align with Enhanced Recovery After Surgery (ERAS) protocols, which emphasize multimodal pain control, opioid minimization, and early mobility to reduce complications such as venous thromboembolism (VTE) and postoperative pneumonia\n\n.",[179,262,27,263],"Hip Fracture Surgeries","Postoperative Pain","2026-02-28",{"date":241,"type":43},{"date":267,"type":43},"2026-02-01",{"date":269,"type":21},"2027-08-01",{"name":271,"class":50},"Fayoum University Hospital",{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":279,"enrollmentInfo":280,"targetDuration":4,"studyType":22,"phases":282,"briefSummary":283,"conditions":284,"keywords":286,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":86},"100556175","evaluation-of-fracture-migration-after-internal-fixation-of-femoral-neck-fractures-in-younger-adults-a-clinical-rct-using-rsa-100556175","NCT06521671","Evaluation of Fracture Migration After Internal Fixation of Femoral Neck Fractures in Younger Adults: A Clinical RCT Using RSA","Evaluation of Femoral Neck Fracture Migration After Internal Fixation With an Angle Stable Implant Compared With Gold Standard Cannulated Cancellous Screws in Young Adults: Study Protocol for a Clinical RCT Using Radiostereometric Analysis","Inclusion Criteria:\n\n* Femoral neck fracture (DS720)\n* Age 18-64 years\n* Ability to speak and read Danish\n* Willingness to participate\n\nExclusion Criteria:\n\n* Pathological, basicervical or transcervical fracture\n* Clinical Frailty Scale ≥5, indicating mild to severe frailty prior to the fracture\n* Cognitive impairment that hinders informed consent\n* Previous fracture in the ipsilateral femur\n* Patients who are unwilling or incapable of following post-operative care instructions.\n* Comorbidities making the participant ineligible for internal fixation such as:\n\n  * Material sensitivity, documented or suspected\n  * Active or suspected latent infection, sepsis or marked local inflammation in or around the surgical area\n  * Compromised vascularity, inadequate skin or neurovascular status\n  * Compromised bone stock that cannot provide adequate support and\u002For fixation of the device due to disease, infection or prior implantation\n  * Other physical, mental, medical or surgical conditions that would preclude the potential benefit of surgery.","65 Years",{"count":281,"type":21},75,[24],"The goal of the clinical trial is to compare different surgical methods for internal fixation of femoral neck fractures in younger adults.\n\nThe main question it aims to answer is:\n\nIs internal fixation with the novel implant consisting of three angle stable screws locked together by a plate equal to internal fixation with cancellous screws or a sliding hip screw in younger adults under 65 years of age in terms of fracture migration?\n\nThe study will examine how stable the fracture remains during healing. This will be measured by assessing how much the fracture moves after surgery using a highly precise imaging method called radiostereometric analysis (RSA). The study will also record complications and evaluate pain, health related quality of life, and hip function over time.\n\nThe participants will be treated with either a novel angle stable implant (Dynaloc), cannulated cancellous screws or sliding hip screw and followed up at 6 weeks, 12 weeks, 6 months and 12 months. Recruitment will continue until 75 participants, 25 in each group, have completed the 12-week follow-up for the primary outcome.",[27,285,100],"Internal Fixation; Complications",[287,288,207,37],"femoral neck fracture","radiostereometric analysis","2026-01-24",{"date":291,"type":43},"2026-01-27",{"date":293,"type":43},"2025-06-16",{"date":295,"type":21},"2028-12",{"name":297,"class":50},"Odense University Hospital",{"id":299,"slug":300,"hasResults":11,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":4,"eligibilityCriteria":304,"healthyVolunteers":11,"sex":17,"minAge":279,"maxAge":4,"enrollmentInfo":305,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":307,"conditions":308,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":190},"100616102","population-pharmacokinetics-and-pharmacodynamics-of-ciprofol-100616102","NCT07301242","Population Pharmacokinetics and Pharmacodynamics of Ciprofol","Population Pharmacokinetic\u002FPharmacodynamic Modeling of Ciprofol in Elderly Patients Undergoing Orthopedic Limb Surgery","Inclusion Criteria:\n\n* Age ≥65 years;\n* BMI: 18-30 kg\u002Fm²;\n* ASA physical status classification I-III;\n* Scheduled for elective orthopedic limb surgery under general anesthesia;\n* Expected duration of surgery \\>30 minutes;\n* Willing to participate and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Known allergy to ciprofol or related medications, or any contraindication to their use;\n* Preoperative cognitive impairment;\n* History of severe cerebrovascular disease or related complications;\n* History of neuromuscular system diseases or psychiatric disorders;\n* History of sedative medication use;\n* History of alcohol abuse or substance use disorder;\n* Bradycardia (heart rate \\\u003C60 beats per minute);\n* Hypotension (mean arterial pressure \\\u003C55 mmHg);\n* QT interval prolongation;\n* Uncooperative or unable to communicate effectively.",{"count":306,"type":21},50,"The goal of this observational study is to learn how the anesthetic drug ciprofol works in older adults who are having limb surgery under general anesthesia at Shanghai Geriatric Medical Center. The study will help researchers build a population model to better understand how the drug moves through the body (PK) and how it affects patients (PD). This model may help doctors use a Target-Controlled Infusion (TCI) system to adjust the drug dose more precisely.\n\nThe main question it aims to answer is: Does ciprofol work safely and effectively in older adults during orthopedic surgery?\n\nParticipants already receiving ciprofol as part of their regular anesthesia care will:\n\n1. Provide blood samples at different time points during and after surgery.\n2. Have their vital signs and anesthesia-related data recorded before, during, and after surgery.\n3. Be monitored for side effects and recovery indicators such as the Aldrete score and signs of postoperative delirium.\n\nResearchers will use this information to:\n\n1. Build and test a population PK\u002FPD model for ciprofol.\n2. Simulate recommended TCI dosing plans.\n3. Explore how individual responses to ciprofol relate to recovery and safety outcomes.\n\nThis study may help improve anesthesia care for elder adults by making drug dosing safer and more effective.",[309,310,27],"Hip Fractures (ICD-10 72.01-72.2)","Osteoarthritis, Knee and Hip","2025-12-10",{"date":313,"type":43},"2025-12-24",{"date":315,"type":43},"2025-10-28",{"date":317,"type":21},"2026-12",{"name":319,"class":50},"Shanghai Geriatric Medical Center",{"id":321,"slug":322,"hasResults":11,"nctId":323,"briefTitle":324,"officialTitle":325,"acronym":4,"eligibilityCriteria":326,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":327,"targetDuration":4,"studyType":22,"phases":329,"briefSummary":330,"conditions":331,"keywords":332,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":86},"100588111","artificial-intelligence-assisted-vs-surgeon-planned-trajectories-in-freehand-femoral-neck-screw-fixation-100588111","NCT06937138","Artificial Intelligence-Assisted vs Surgeon-Planned Trajectories in Freehand Femoral Neck Screw Fixation","Comparison of AI-Assisted vs Surgeon-Planned Trajectories in Freehand Femoral Neck Screw Fixation: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years;\n* Radiologically confirmed diagnosis of femoral neck fracture (displaced or non-displaced);\n* Scheduled to undergo internal fixation with cannulated screws as the initial treatment strategy during the study period;\n* Capable of understanding the study procedures and providing informed consent;\n* Willing and able to adhere to the prescribed postoperative follow-up schedule and rehabilitation instructions.\n\nExclusion Criteria:\n\n* Evidence of avascular necrosis of the femoral head on the affected side prior to surgery;\n* Inability to tolerate the surgical intervention;\n* Severe physical illnesses, cognitive problems (such as memory loss), or mental health conditions that may impair the ability to comply with medical instructions or attending scheduled follow-up appointments.",{"count":328,"type":21},334,[24],"The goal of this clinical trial is to compare two different methods of screw path planning-AI-assisted versus surgeon-directed-in freehand percutaneous femoral neck fracture fixation surgery. The study will include adult patients diagnosed with femoral neck fractures who are eligible for cannulated screw fixation under fluoroscopic guidance.The main questions it aims to answer are:\n\nDoes AI-assisted screw path planning improve the radiographic accuracy of screw placement (screw deviation, tip position, and inter-screw parallelism)? Does AI-assisted planning reduce operative time, number of intraoperative fluoroscopy exposures, intraoperative blood loss (mL) and surgeon workload compared with surgeon-directed planning? Does AI-assisted planning reduce postoperative complications and improve functional outcomes compared to surgeon-directed planning? Researchers will compare the AI-assisted planning group to the surgeon-directed planning group to determine whether AI guidance contributes to enhanced surgical precision, reduced intraoperative burden, and improved recovery outcomes.\n\nParticipants will:\n\nUndergo freehand percutaneous internal fixation of femoral neck fractures with either AI-assisted or surgeon-directed screw path planning, Receive standardized perioperative care and follow-up at defined intervals, Be evaluated through clinical assessments, imaging studies, and documentation of intraoperative and postoperative metrics over a 12-month follow-up period.",[27],[333,334,335],"Screw Placement Accuracy","Artificial Intelligence in Surgical Planning","Femoral Neck Fracture","2025-11-13",{"date":338,"type":43},"2025-11-17",{"date":340,"type":43},"2025-11-14",{"date":342,"type":21},"2027-06-15",{"name":344,"class":50},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology",{"id":346,"slug":347,"hasResults":11,"nctId":348,"briefTitle":349,"officialTitle":350,"acronym":4,"eligibilityCriteria":351,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":352,"targetDuration":4,"studyType":22,"phases":354,"briefSummary":355,"conditions":356,"keywords":361,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":190},"100602937","phase-4-preoperative-use-of-peripheral-nerve-blocks-in-elderly-patients-with-hip-fractures-100602937","NCT07130006","Preoperative Use of Peripheral Nerve Blocks in Elderly Patients With Hip Fractures","Preoperative Use of Peripheral Nerve Blocks in Elderly Patients With Hip Fractures: a Factorial Randomized Clinical Trial","Inclusion Criteria:\n\n* both sexes\n* 60 years old and older\n* diagnosed with a hip fracture resulting from low-energy trauma\n* scheduled surgery.\n\nExclusion Criteria:\n\n* polytraumatized patients\n* dementia and acute psychosis patients\n* patients for whom spinal anesthesia is contraindicated\n* patients with severe renal failure\n* patients for whom intravenous administration of tranexamic acid is contraindicated\n* patients with proven allergy and contraindications to dexamethasone, non-steroidal anti-rheumatic drugs, opioid analgesics, magnesium sulfate.",{"count":353,"type":21},256,[172],"The goal of this clinical trial is to explore the effects of different peripheral nerve blocks in older adults with hip fractures. It will also explore the safety of preoperative administration of peripheral nerve blocks. The main questions this trial aims to answer are:\n\n* which peripheral nerve block is the best regarding analgesia\n* which peripheral nerve block eases positioning and decrease time necessary for applying spinal anesthesia?\n* which peripheral nerve block is associated with reduced intake of analgesics, both oral and intravenous?\n* which peripheral nerve block lasts long enough but does not interfere with the start of physical therapy?\n* what medical problems do respondents have during their hospitalization, after administration of peripheral nerve blocks, spinal anesthesia and surgery?\n* what medical problems arise as a consequence of their complex medical history? Researchers will compare respondents who receive peripheral nerve blocks to those who do not. Those who do not receive blocks will be given fentanyl preoperatively, which was until recently standard at our institution.\n\nAll respondents will, in addition to obligatory intraoperative monitoring,:\n\n* be thoroughly examined by anesthesiologists before surgery\n* be closely monitored after surgery, until their hospital discharge.",[357,27,204,205,358,359,360],"Fractures, Hip","Aged","Frail Older Adults","Elderly",[362,363,364,365,366,367,368,369,370,371],"elderly","ultrasound-guided","peripheral nerve blocks","intravenous fentanyl","spinal anaesthesia","EQ-5D-5L","visual analog scale","pain at rest","dynamic pain","hip fracture surgery","2025-08-11",{"date":374,"type":43},"2025-08-19",{"date":376,"type":21},"2025-08-30",{"date":378,"type":21},"2026-03-31",{"name":380,"class":50},"University Hospital of Split",{"id":382,"slug":383,"hasResults":11,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":387,"eligibilityCriteria":388,"healthyVolunteers":11,"sex":17,"minAge":389,"maxAge":4,"enrollmentInfo":390,"targetDuration":4,"studyType":22,"phases":392,"briefSummary":393,"conditions":394,"keywords":398,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":408,"locationsCount":190},"100527779","functional-outcome-after-orif-or-arthroplasty-for-femoral-neck-fracture-100527779","NCT06152198","Functional Outcome After ORIF or Arthroplasty for Femoral Neck Fracture","Internal Fixation Versus Hip Replacement in Older Adults with an Garden I\u002FII Femoral Neck Fracture: Physical Function and Pain in Elderly Patients - a Substudy of the Hipsther Trial","HipFunct","Inclusion Criteria:\n\n* Undisplaced (Garden I-II) femoral neck fracture (within 72h)\n* Treated at participating unit\n* Informed consent\n* Amenable for both treatment options\n* Included in the Hipsther trial\n\nExclusion Criteria:\n\n* No informed consent\n* Pathological or stress fracture\n* Peri-implant fracture\n* Previous inclusion of a contralateral Garden 1 or 2 femoral neck fracture","75 Years",{"count":391,"type":21},340,[24],"Aim To investigate the effect of internal fixation versus hip arthroplasty on physical function and pain in elderly patients.\n\nMethods This is a substudy of an on-going nationwide multicenter registry-based RCT named HipSTHeR- (Hip Screws or Total Hip replacement or undisplaced femoral neck fracture in elderly patients) \\[21\\]. The aim is to recruit 340 patients with undisplaced or minimally displaced femoral neck fracture, Garden 1 or 2, are randomized to surgery either with internal screw fixation or hip arthroplasty.\n\nThis substudy aims to investigate the potential differences between internal fixation versus hip arthroplasty regarding physical function and pain 4- and 12- months after surgery. Those included in the main study will be contacted by letter a few weeks after the surgery to be invited to participate in a further study. The assessor will then contact the person by telephone to answer further questions and to obtain informed consent. The follow-ups will be conducted over telephone and mail at 4 and 12 months. During the follow-up the participants will answer questions about their functional level.\n\nInformation on randomisation and fracture data will be acquired from the Swedish Fracture Register and treatment data from the Swedish Hip Arthroplasty Register.\n\nPrimary outcome The New Mobility Score will be used as the primary outcome with follow-up at 4- and 12 months.\n\nSecondary outcome WOMAC will be used as an additional hip specific patient reported outcome.\n\nActivities of daily living will be assessed with Katz ADL index to evaluate the patients' performance and the need of assistance in ADL.\n\nPatients' cognitive status will be assessed ALFI-MMSE, adapted from Adult Lifestyles and Function Interview (ALFI-MMSE).\n\nThe Geriatric Depression Scale (GDS-15), which are developed to identify depressive symptoms.\n\nThe Philadelphia Geriatric Center Morale Scale (PGCMS) and have been used in several studies including frail people living in residential care facilities and can be used among patients with cognitive impairment.",[100,27,395,396,285,397],"Undisplaced Fracture","Treatment Complication","Arthroplasty Complications",[207,287,399,400,37],"treatment","hip arthroplasty","2024-11-28",{"date":403,"type":43},"2024-12-03",{"date":405,"type":43},"2021-06-20",{"date":407,"type":21},"2027-09-01",{"name":409,"class":50},"Uppsala University",{"id":411,"slug":412,"hasResults":11,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":416,"eligibilityCriteria":417,"healthyVolunteers":11,"sex":17,"minAge":389,"maxAge":4,"enrollmentInfo":418,"targetDuration":4,"studyType":22,"phases":420,"briefSummary":421,"conditions":422,"keywords":423,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":430,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":436},"100359947","hips-screws-or-total-hip-replacement-for-undisplaced-femoral-neck-fractures-in-elderly-patients-hipsther-100359947","NCT03966716","Hips Screws or (Total) Hip Replacement for Undisplaced Femoral Neck Fractures in Elderly Patients (HipSTHeR)","HipSTHeR - a Registerbased Randomized Controlled Trial - Hip Screws or (Total) Hip Replacement for Undisplaced Femoral Neck Fractures in Elderly Patients.","HipSTHeR","Inclusion Criteria:\n\n* Undisplaced (Garden I-II) femoral neck fracture (within 72h)\n* treated at participating unit\n* informed consent\n* amenable for both treatment options\n\nExclusion Criteria:\n\n* no informed consent\n* pathological or stress fracture\n* peri-implant fracture",{"count":419,"type":21},1440,[24],"A registerbased RCT will investigate whether arthroplasty can decrease the reoperation rate compared to internal fixation for patients with an undisplaced femoral neck fracture (Garden I-II).",[27,395],[424,179,425,426,427,428,429],"Internal Fixation","Reoperation Rate","Mortality","Health Economy","External validity","Adverse events",{"date":403,"type":43},{"date":432,"type":43},"2019-09-16",{"date":434,"type":21},"2026-09-01",{"name":409,"class":50},25,{"id":438,"slug":439,"hasResults":11,"nctId":440,"briefTitle":441,"officialTitle":441,"acronym":442,"eligibilityCriteria":443,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":444,"enrollmentInfo":445,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":447,"conditions":448,"keywords":460,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":477,"locationsCount":479},"100566684","prospective-validation-study-of-the-cd8temra-cells-as-a-prognostic-biomarker-of-healing-outcome-after-fracture-100566684","NCT06658379","Prospective Validation Study of the CD8+TEMRA Cells As a Prognostic Biomarker of Healing Outcome After Fracture","BioBone","Inclusion Criteria:\n\n* male or female subjects\n* subjects \\> 18 to 80 years of age at the time of screening\n* closed fractures\n* fractures of the humerus-shaft, forearm-shaft, femur and tibia\n* Subjects suffering monotrauma or comparable with monotrauma, due to comparable post-surgery mobilisation\n* osteosynthesis\n* subject has signed an informed consent form\n* legal capacity\n\nExclusion Criteria:\n\n* cancer related fractures\n* periprosthetic fractures\n* known active Hepatitis B virus or Hepatitis C virus infection at screening\n* known human immunodeficiency virus (HIV) infection, severe uncontrolled inflammatory disease or severe uncontrolled autoimmune disease (e.g., ulcerative colitis, Crohn's disease\n* active malignancy or history of malignancy within 5 years prior to screening\n* known diagnosis of moderate to severe dementia based on subject's medical history or severe psychiatric disorder\n* known history of drug or alcohol abuse in the past 12 months, based on self-report or medical record\n* history of autologous\u002Fallogeneic bone marrow (BM) or solid organ transplantation\n* exposure to allogeneic cell-based therapy in the past or exposure to autologous cell therapy in the last 12 months before screening\n* pregnancy\n* subject is currently enrolled in an investigational device or drug trial, or has not yet completed a period of at least 30 days since ending other investigational device or drug trial(s).\n* subject is detained or institutionalized under a court order or administrative order\n* in the opinion of the investigator, the subject is unsuitable for participating in the study (patient compliance).","80 Years",{"count":446,"type":21},640,"In approx. 10-15% of all fracture patients, there is a prolonged healing time or even a complete absence of fracture healing (non-union). As a result, these patients require further surgical interventions, combined with renewed or prolonged hospitalisation\u002Frehabilitation and incapacity to work. To summarise, this therefore represents a serious socio-economic problem. At present, there is no prognostic method for the early prediction of patients at risk of a disturbed healing process. However, if these patients are successfully stratified, there are already a variety of therapeutic strategies available to additionally stimulate fracture healing. Therefore, the aim is to conduct a prospective clinical study to validate CD8+ TEMRA cells as a prognostic marker of impaired fracture healing. The investigators assume that preoperative CD8+ TEMRA cell expression represents a prognostic biomarker with high diagnostic precision for differentiating between a) normal healing patients, b) delayed healing patients and c) pseudarthrosis patients. Furthermore, the sensitivity and specificity should be high enough, health-economically significant and realisable in clinical routine.",[449,450,451,452,453,27,454,455,456,457,458,459],"Fracture Non Union","Fracture Healing","Long Bone Delayed-Union Fracture","Humerus Shaft Fracture","Forearm Fracture","Femur Distal Fracture","Pertrochanteric Fracture of Femur","Femoral Shaft Fracture","Proximal Tibia Fracture","Tibial Shaft Fracture","Distal Tibia Fracture",[461,462,463,464,465,466,467,468,469],"long bone fracture","impaired fracture healing","fracture non-union","prognosis","prognostic biomarker","Immune system","T cells","radiology","bone fracture healing","2024-10-23",{"date":472,"type":43},"2024-10-26",{"date":474,"type":43},"2016-12",{"date":476,"type":21},"2025-06",{"name":478,"class":50},"Charite University, Berlin, Germany",7,{"id":481,"slug":482,"hasResults":11,"nctId":483,"briefTitle":484,"officialTitle":485,"acronym":4,"eligibilityCriteria":486,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":487,"targetDuration":4,"studyType":22,"phases":489,"briefSummary":490,"conditions":491,"keywords":511,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":514,"lastUpdatePostDateStruct":515,"startDateStruct":516,"completionDateStruct":518,"leadSponsor":520,"locationsCount":190},"100522111","opioid-free-pain-treatment-in-trauma-patients-100522111","NCT06078371","Opioid-Free Pain Treatment in Trauma Patients","Peri-operative Opioid-free Analgesic Protocol for Orthopedic Trauma Patients","Inclusion Criteria:\n\n* Patient is over the age of 18 years old\n* Underwent surgical treatment for the injuries of interest (stated elsewhere) by an Orthopedic Traumatology Attending Physician at the University of Kansas Hospital\n\nExclusion Criteria:\n\n* Patients that are unable to provide informed consent due to sustaining a head injury or incoherence from narcotics given to them post-injury\n* Chronic opioid use\n* Under the age of 18 years old\n* Undergoing revision surgery\n* Did not undergo surgical fixation\n* Pregnant\u002Fnursing women\n* Vulnerable populations as defined by the University of Kansas Medical Center IRB\n* Did not experience one of the following fractures listed in D.1. above.\n* Patients with CKD and\u002For cirrhosis will be excluded from the opioid-free pain block (block 2) and will only qualify for the standard of care opioid group (Block 1)",{"count":488,"type":21},250,[24],"Analgesic drug study that will compare pain outcomes of opioid analgesia and opioid-free analgesia in post-operative orthopedic patients.",[27,204,456,492,493,494,495,496,497,498,499,500,501,502,503,504,505,506,507,508,509,510],"Distal Femur Fracture","Patella Fracture","Tibial Shaft Fracture with or Without Associated Fibula Fracture","Ankle Fracture (bimalleolar Equivalent, Bimalleolar, or Trimalleolar)","Tibial Pilon Fracture","Talar Head, Neck, Body, or Process Fractures","Calcaneus Fractures","Lisfranc Injuries","Isolated or Multiple Metatarsal Fractures","Phalanx Fractures of the Foot, Single or Multiple","Clavicle Fractures","Proximal Humerus Fractures","Humeral Shaft Fractures","Distal Humerus Fractures (intra or Extra-articular)","Olecranon Fractures","Radial Head or Neck Fractures","Elbow Fractures Involving a Combination of Fractures of the Radius and Uln","Forearm Fractures (both Bone Forearm Fractures, Isolated Ulnar Shaft, Isolated Radial Shaft)","Distal Radius Fractures",[512,513],"Surgical Intervention","Trauma","2024-10-22",{"date":472,"type":43},{"date":517,"type":43},"2023-11-01",{"date":519,"type":21},"2026-10",{"name":521,"class":50},"University of Kansas Medical Center",{"id":523,"slug":524,"hasResults":11,"nctId":525,"briefTitle":526,"officialTitle":527,"acronym":4,"eligibilityCriteria":528,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":529,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":530,"conditions":531,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":534,"lastUpdatePostDateStruct":535,"startDateStruct":537,"completionDateStruct":539,"leadSponsor":541,"locationsCount":190},"100565653","monitoring-bleeding-of-patients-using-noac-anticoagulation-therapy-in-proximal-femoral-fracture-internal-fixation-surgery-without-waiting-we-measure-bleeding-in-surgery-and-the-levels-of-noac-drug-in-blood-we-will-try-to-compare-to-regular-pateints-later-100565653","NCT06644976","Monitoring Bleeding of Patients Using NOAC Anticoagulation Therapy in Proximal Femoral Fracture Internal Fixation Surgery Without Waiting. We Measure Bleeding in Surgery and the Levels of Noac Drug in Blood. We Will Try to Compare to Regular Pateints Later","Bleeding of Patients Using NOAC Anticoagulation Therapy in Proximal Femoral Fracture Internal Fixation Surgery","Inclusion Criteria:\n\nabove 18 y.o femoral neck fracture NOAC capable of making inform consent primary surgery\n\n\\-\n\nExclusion Criteria:\n\n* under 18 y.o\n* anti platelet therapy (aspirin is not included)\n* creatinine clearance under 50\n* active anti cancer therapy\n* ITP patients\n* non capable of making inform consent\n* patients which decide not to proceed with the expeirment",{"count":123,"type":21},"until today we waited at least 24 hours before surgery of femoral neck fractures in patients who take anticouagolation . in our new reasearch we belive that patients who take NOAC can go under surgery earlier with minimal risk",[532,27,533],"Osteoperosis","Anticoagulant Therapy","2024-10-14",{"date":536,"type":43},"2024-10-16",{"date":538,"type":43},"2024-08-20",{"date":540,"type":21},"2025-12",{"name":542,"class":50},"Meir Hospital, Kfar Saba, Israel",{"id":544,"slug":545,"hasResults":11,"nctId":546,"briefTitle":547,"officialTitle":547,"acronym":4,"eligibilityCriteria":548,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":549,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":551,"conditions":552,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":558,"lastUpdatePostDateStruct":559,"startDateStruct":561,"completionDateStruct":563,"leadSponsor":565,"locationsCount":567},"100456771","safety-and-performance-assessment-of-the-symbol-range-of-medical-devices-in-patients-underlying-total-hip-arthroplasty-100456771","NCT05227924","Safety and Performance Assessment of the SYMBOL Range of Medical Devices in Patients Underlying Total Hip Arthroplasty","Inclusion Criteria:\n\n* Patient age \\> 18 years at implantation.\n* Patient who will undergo, during the study's period of inclusion, a total hip arthroplasty (primary or revision) with at least one SYMBOL medical device (DEDIENNE Santé).\n* Patient informed of his\u002Fher participation and willing to participate in the study.\n* Patient able to read, write and understand French.\n\nExclusion Criteria:\n\n* Patient deprived of freedom, under guardianship\u002Fcuratorship or placed under judicial protection\n* Patient unable to follow study procedures.\n* Patient who has already been included in the study for a total hip arthroplasty (primary or revision) with at least one SYMBOL medical device.",{"count":550,"type":21},747,"The purpose of this post-market clinical follow up study is to assess the safety and effectiveness of the SYMBOL range of medical devices. The study will evaluate the outcome of Total Hip Arthroplasty using medical devices from SYMBOL range over a period of 10 years.",[553,554,555,27,556,557],"Degenerative Hip Joint Disease","Post-traumatic Osteoarthritis","Hip Arthritis","Avascular Necrosis of the Femoral Head","Failure of Prosthetic Joint Implant","2024-08-26",{"date":560,"type":43},"2024-08-27",{"date":562,"type":43},"2021-09-21",{"date":564,"type":21},"2034-09",{"name":566,"class":85},"Dedienne Sante S.A.S.",9,{"id":569,"slug":570,"hasResults":11,"nctId":571,"briefTitle":572,"officialTitle":573,"acronym":4,"eligibilityCriteria":574,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":575,"targetDuration":577,"studyType":62,"phases":4,"briefSummary":578,"conditions":579,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":583,"lastUpdatePostDateStruct":584,"startDateStruct":586,"completionDateStruct":587,"leadSponsor":589,"locationsCount":190},"100495703","promis-evaluation-study-100495703","NCT05734651","PROMIS Evaluation Study","Prospective Evaluation of the PROMIS Stem for Primary Total Hip Arthroplasty","Inclusion Criteria:\n\n* Primary total hip arthroplasty with the PROMIS stem\n\nExclusion Criteria:\n\n* n\u002Fa",{"count":576,"type":21},200,"20 Years","A total of 250 total hip arthroplasties (THA) are performed at the Bezirkskrankenhaus St. Johann. In a majority of those, implants from the company Falcon Medical (Austria) are used. Those implants are undergoing constant development and improvement. To guarantee their clinical performance, this clinical study is evaluating safety and efficacy of all implants produced by Falcon Medical.\n\nThe purpose of this study is to evaluate the effcacy and safety of implants produced and distributed by Falcon Medical. All patients with primary THA and usage of a Falcon Medical implant are included. The outcome measures include intra-operative complications, early post-operative complications, revision for any cause and patient reported outcome (WOMAC questionnaire). All data is prospectively collected in a standardized fashion.",[580,148,581,582,27],"Hip Arthropathy","Perthes Disease","Osteonecrosis","2023-02-09",{"date":585,"type":43},"2023-02-21",{"date":583,"type":43},{"date":588,"type":21},"2042-02-09",{"name":590,"class":50},"Bezirkskrankenhaus St. Johann in Tirol",{"id":592,"slug":593,"hasResults":11,"nctId":594,"briefTitle":595,"officialTitle":596,"acronym":4,"eligibilityCriteria":597,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":598,"targetDuration":4,"studyType":22,"phases":600,"briefSummary":601,"conditions":602,"keywords":603,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":607,"lastUpdatePostDateStruct":608,"startDateStruct":610,"completionDateStruct":612,"leadSponsor":614,"locationsCount":190},"100397980","a-prospective-multicenter-cohort-study-about-internal-fixation-using-fns-versus-mcs-for-femoral-neck-fracture-100397980","NCT04462172","A Prospective Multicenter Cohort Study About Internal Fixation Using FNS Versus MCS for Femoral Neck Fracture","A Prospective Multicenter Cohort Study About Internal Fixation Using Synthes Femoral Neck System (FNS) Versus Multiple Cancellous Screws (MCS) for Femoral Neck Fracture","Inclusion Criteria:\n\n1. Age ≥18 years\n2. Patients with unilateral femoral neck fractures that will be treated with internal fixation\n3. According to AO fracture classification, subjects with the fracture type (31-B)\n4. Subjects (with the help of relatives) can understand the informed documents and patient questionnaires.\n5. Subjects (with the help of relatives) voluntarily provide written informed consent to participate in the clinical study and authorize the transfer of their information to the sponsor.\n6. The investigator believes that the subject can understand the clinical study, is willing and able to complete all research procedures and follow-up visits and can cooperate with the research procedures.\n7. In-label use of the MCS and FNS.\n\nExclusion Criteria:\n\n1. Subject does not provide voluntary consent to participate in the study.\n2. The researcher believes that the subjects have conditions that affect the participation and follow-up of this study. (for example, the patient lives in a remote area or has difficulty in going back to the hospital for follow-up or does not cooperate with the medical guidance and suggestions of the surgeon.)\n3. The subjects were pregnant or lactating women.\n4. The researchers believe that the subjects have psychological disorders, which may affect the treatment outcome.\n5. Garden classification III and IV of femoral neck fracture patients older than 65 years\n6. Concurrent hip osteoarthritis.\n7. Fractures where the operative treatment will occur more than three weeks after the primary injury\n8. Patients combined with other bone fractures.\n9. Pathological fracture (e.g., primary or metastatic tumor)\n10. Serious soft tissue injury, judged by the investigator, will impact the union of the fracture, combined open fractures, vascular injury, and combined osteofascial compartment syndrome\n11. Multiple systemic injuries judged by researchers not suitable for enrollment.\n12. Revision surgeries (for example, due to malunion, nonunion or infection)\n13. Concurrent medical conditions judged by researchers not suitable for enrollment, such as: metabolic bone disease, post-polio syndrome, poor bone quality, prior history of poor fracture healing, etc\n14. Patients with anaesthetic and surgical contraindications\n15. Patients known to be allergic to implant components\n16. Patients who are currently using chemotherapeutics or accepting radiotherapy, use systematically corticosteroid hormone or growth factor, or long-term use sedative hypnotics (continuous use over 3 months) or non-steroidal anti-inflammatory drugs (continuous use over 3 months)\n17. Intemperance judged by researchers not suitable for enrollment (e.g., excessive daily drinking or smoking, drug abuse);\n18. Subjects participated in other clinical studies in the past 3 months, which may affect the outcome and follow-up according to the judgment of researchers.\n19. Subjects have significant neurological or musculoskeletal disorders or may have adverse effects on gait or weight-bearing (e.g., muscular dystrophy, multiple sclerosis, cerebral infarction, hemiplegia, Charcot arthropathy, avascular necrosis of the femoral head).",{"count":599,"type":21},290,[24],"This prospective multicenter cohort study is to compare the post-operative implant failure rate between the patients with femoral neck fracture (AO classification 31-B) using Femoral Neck System (FNS) versus Multiple Cancellous Screws (MCS) at 2-year follow up. The patients are divided into the FNS group and the MCS group according to the internal fixation they choose. The internal fixation failure rate (IFFR) and differences in fracture prognosis of the two groups will be compared. Obtain clinical data of FNS in the Chinese population, and verify the safety and efficacy of FNS for patients with femoral neck fracture.",[27],[287,37,604,605,606],"FNS and MCS","multicenter randomized controlled clinical trial","internal fixation failure rate","2021-10-20",{"date":609,"type":43},"2021-10-22",{"date":611,"type":43},"2021-09-30",{"date":613,"type":21},"2024-12-31",{"name":615,"class":50},"Peking University Third Hospital",{"id":617,"slug":618,"hasResults":11,"nctId":619,"briefTitle":620,"officialTitle":621,"acronym":4,"eligibilityCriteria":622,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":623,"targetDuration":4,"studyType":22,"phases":624,"briefSummary":625,"conditions":626,"keywords":627,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":631,"lastUpdatePostDateStruct":632,"startDateStruct":634,"completionDateStruct":636,"leadSponsor":638,"locationsCount":190},"100429227","three-cancellous-screws-versus-four-cancellous-screws-for-femoral-neck-fixation-100429227","NCT04869332","Three Cancellous Screws Versus Four Cancellous Screws for Femoral Neck Fixation","A Prospective Randomised Controlled Clinical Trial: Three Cancellous Screws Versus Four Cancellous Screws for Fixation of Femoral Neck Fractures","Inclusion Criteria:\n\n* Age ≥18 years\n* Patients with unilateral femoral neck fractures that will be treated with internal fixation\n* According to AO fracture classification, subjects with the fracture type (31-B)\n* Subjects (with the help of relatives) can understand the informed documents and patient questionnaires.\n* Subjects (with the help of relatives) voluntarily provide written informed consent to participate in the clinical study and authorize the transfer of their information to the sponsor.\n* The investigator believes that the subject can understand the clinical study, is willing and able to complete all research procedures and follow-up visits and can cooperate with the research procedures.\n* In-label use of the MCS.\n\nExclusion Criteria:\n\n* Subject does not provide voluntary consent to participate in the study.\n* The researcher believes that the subjects have conditions that affect the participation and follow-up of this study. (for example, the patient lives in a remote area or has difficulty in going back to the hospital for follow-up or does not cooperate with the medical guidance and suggestions of the surgeon.)\n* The subjects were pregnant or lactating women.\n* The researchers believe that the subjects have psychological disorders, which may affect the treatment outcome.\n* Garden classification III and IV of femoral neck fracture patients older than 65 years\n* Concurrent hip osteoarthritis.\n* Fractures where the operative treatment will occur more than three weeks after the primary injury\n* Patients combined with femoral head fractures(31-C), femoral shaft fractures(32-A\u002FB\u002FC) or femoral trochanteric area fracture (31-A1\u002FA2\u002FA3).\n* Pathological fracture (e.g., primary or metastatic tumor)\n* Serious soft tissue injury, judged by the investigator, will impact the union of the fracture, combined vascular injury, and combined osteofascial compartment syndrome\n* Multiple systemic injuries judged by researchers not suitable for enrollment.\n* Revision surgeries (for example, due to malunion, nonunion or infection)\n* Concurrent medical conditions judged by researchers not suitable for enrollment, such as: metabolic bone disease, post-polio syndrome, poor bone quality, prior history of poor fracture healing, etc\n* Patients with anaesthetic and surgical contraindications\n* Patients known to be allergic to implant components\n* Patients who are currently using chemotherapeutics or accepting radiotherapy, use systematically corticosteroid hormone or growth factor, or long-term use sedative hypnotics (continuous use over 3 months) or non-steroidal anti-inflammatory drugs (continuous use over 3 months)\n* Intemperance judged by researchers not suitable for enrollment (e.g., excessive daily drinking or smoking, drug abuse);\n* Subjects participated in other clinical studies in the past 3 months, which may affect the outcome and follow-up according to the judgment of researchers.\n* Subjects have significant neurological or musculoskeletal disorders or may have adverse effects on gait or weight-bearing (e.g., muscular dystrophy, multiple sclerosis, cerebral infarction, hemiplegia, Charcot arthropathy, avascular necrosis of the femoral head).",{"count":599,"type":21},[24],"This study is a prospective randomized controlled clinical study. Patients with femoral neck fracture (AO classification 31-B) will be randomly divided into three-screw fixation group and four-screw fixation group. The internal fixation failure rate (IFFR) and functional outcomes of the two groups will be compared and the patients will be followed up to 2 years after surgery.",[27,424],[628,629,630],"femoral neck fractures","multiple cancellous screws","RCT","2021-04-30",{"date":633,"type":43},"2021-05-03",{"date":635,"type":43},"2021-04-08",{"date":637,"type":21},"2026-12-31",{"name":615,"class":50}]