[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"femur-fracture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:femur-fracture":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,72,99,130],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100561133","outpatient-floor-pedal-bike-utilization-100561133",false,"NCT06586190","Outpatient Floor Pedal Bike Utilization","Inclusion Criteria:\n\n* Patients \\>18 years of age\n* Operative fractures of the femur, tibia and select ankle injuries\n* Under the care of an orthopaedic surgeon\n* English or Spanish competent\n* 12 month follow up\n\nExclusion Criteria:\n\n* Type IIIB\u002FC fracture\n* Unable to provide consent\u002Fneed for an LAR\n* Major lower extremity peripheral nerve injury (ex. foot drop, sciatic nerve palsy, etc)","ALL","18 Years",{"count":18,"type":19},20,"ESTIMATED","INTERVENTIONAL",[22],"NA","The goals of this clinical trial are: to test the feasibility of identifying patients and getting patients the floor pedal bikes, to test how well floor pedal bikes help patients with lower body injuries heal, and to test methods of patient self-reported logs for home pedal bike use.\n\nParticipants will be given a floor pedal bike at first post-operative appointment where weightbearing restrictions are lifted (weight-bearing as tolerated) along with instructions on utilization. Participants will be asked to complete patient reported outcome measure surveys at each follow-up visit.",[25,26,27],"Femur Fracture","Tibia Fracture","Ankle Injuries",[29,30,31],"floor pedal bike","lower extremity","rehabilitation","NOT_YET_RECRUITING","2026-05-21",{"date":35,"type":36},"2026-05-26","ACTUAL",{"date":38,"type":19},"2026-08",{"date":40,"type":19},"2028-12",{"name":42,"class":43},"Wake Forest University Health Sciences","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":15,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":20,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100478779","effect-of-remimazolam-and-propofol-on-postoperative-delirium-100478779","NCT05514405","Effect of Remimazolam and Propofol on Postoperative Delirium","Effect of Remimazolam and Propofol on Postoperative Delirium in Elderly Patients Undergoing Hip and Knee Surgery","Inclusion Criteria:\n\n* elderly patients undergoing hip or knee arthroplasty under general anesthesia.\n* body mass index \\>30 kg\u002Fm2\n\nExclusion Criteria:\n\n* moderate to severe liver dysfunction\n* moderate to severe renal dysfunction\n* unable to extubate in the operation room after operation\n* benzodiazepine dependence\n* sensitivity to anesthetic drugs used for study (Benzodiazepines, Propofol, Remifentanil, Fentanyl citrate, Rocuronium bromide, Sugammadex, Flumazenil)\n* acute angle glaucoma\n* received (benzodiazepine, antianxiety drugs, antidepressant, antipsychotic drugs) within 24 hours.\n* acute psychotic depression\n* history stroke or cerebrovascular disease",true,"65 Years","100 Years",{"count":55,"type":19},82,[22],"Remimazolam is an ultra-short acting benzodiazepine agonist which is used widely for general anesthesia and sedation. Remimazolam has several advantages. Remimazolam is rapidly metabolized by tissue esterase that it does not accumulate even after infusion for long periods of time. The presence of reversal agents (flumazenil) is also advantageous. Also, hemodynamic stability compared to propofol gives clinicians preference to use for geriatric anesthesia. However, the study on the effect of remimazolam compared to propofol on postoperative delirium have not been carried out. The purpose of the study is to compare the incidence of postoperative delirium and recovery profile in elderly patients undergoing orthopedic surgery using either remimazolam or propofol.",[59,60,25],"Hip Fractures","Knee Osteoarthritis","RECRUITING","2026-03-24",{"date":64,"type":36},"2026-03-27",{"date":66,"type":36},"2022-08-01",{"date":68,"type":19},"2026-09-30",{"name":70,"class":43},"Inje University",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":98},"100465333","znn-bactiguard-antegrade-femoral-nails-pmcf-study-100465333","NCT05339360","ZNN Bactiguard Antegrade Femoral Nails PMCF Study","Post-Market Clinical Follow-up Study on the ZNN™ Bactiguard ® Antegrade Femoral Nails (Implants and Instrumentation). A Multicenter, Prospective, Consecutive Series","Inclusion Criteria:\n\n* Patient must be 18 or older\n* Patient must have a signed EC-approved informed consent.\n* Patient must have a femoral fracture (open, closed, monolateral, or bilateral) requiring surgical intervention or osteotomy and be eligible for fixation by intramedullary nailing. Patients with delayed treatment (initial treatment by external fixation due to swelling\u002F high energy trauma followed by definitive treatment by intramedullary nail) can also be included.\n* Patient has been or is scheduled to be treated with the ZNN Bactiguard System Antegrade Femoral Nail\n* Patient must be able and willing to complete the protocol required for follow-up\n* Patients capable of understanding the surgeon's explanations and following his instructions\n\nExclusion Criteria:\n\nSkeletally immature patients\n\n* Medullary canal obliterated by a previous fracture or tumor\n* Bone shaft having excessive bow or a deformity\n* Lack of bone substance or bone quality, which makes stable seating of the implant impossible\n* All concomitant diseases that can impair the operation, functioning or the success of the implant\n* Insufficient blood circulation\n* Infection\n* Patient is unwilling to give consent.\n* Patient is a vulnerable subject (prisoner, mentally incompetent or unable to understand what participation to the study entails, subjects with alcohol\u002Fdrug addiction, known to be pregnant or breast feeding)\n* Patient anticipated to be non-compliant and\u002For likely to have problems with maintaining follow-up program (e.g. patient with no fixed address, long-distance, plans to move during the course of study)\n* Patients not expected to survive the duration of the follow-up program",{"count":80,"type":19},100,"OBSERVATIONAL","This is a multicenter, prospective, Post-market Clinical Follow-up (PMCF) Study on the ZNN Bactiguard Antegrade Femoral Nails. The objective of this study is to collect data confirming the safety, performance, and clinical benefit of the study device and instrumentation when used for the temporary internal fixation and stabilization of femoral fractures and osteotomies.\n\nThis is a CE-marked device already available on the market and the aim of the study is to comply with the post-market surveillance requirements.",[25,84],"Osteotomy",[86,87],"Intramedullary antegrade femoral nail","Bactiguard","2025-11-19",{"date":90,"type":36},"2025-11-25",{"date":92,"type":36},"2024-01-16",{"date":94,"type":19},"2027-12",{"name":96,"class":97},"Zimmer Biomet","INDUSTRY",2,{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":15,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":20,"phases":110,"briefSummary":113,"conditions":114,"keywords":118,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":71},"100559794","phase-2-comparison-of-eosp-between-usg-guided-s-ficb-vs-usg-guided-peng-block-in-pts-undergoing-femur-fracture-surgery-100559794","NCT06568770","Comparison of EOSP Between Usg Guided S-FICB vs USG Guided PENG Block in Pts Undergoing Femur Fracture Surgery","Comparison of Ease of SPINAL Positioning Between USG Guided Supra-inguinal Fascia Iliaca Block vs USG Guided Pericapsular Nerve Group Block in Patients Undergoing Femur Fracture Surgery","Inclusion Criteria:\n\n* 1\\. Both Genders (Male \u002FFemale). 2. Age between 20 years to 70 years. 3. Radiologically confirmed femur fracture. 4. ASA Class I, II, III.\n\nExclusion Criteria:\n\n1. Patient refusal\n2. Other distracting painful pathology\n3. Any contraindication to Spinal Anesthesia or peripheral nerve blocks\n4. Coagulopathic disorders\n5. H\u002FO ischemic heart disease\n6. Patients on opioids for chronic pain\n7. Patients with significant cognitive impairment\n8. Patients with no pain while sitting by themselves without any support.","20 Years","70 Years",{"count":109,"type":19},70,[111,112],"PHASE2","PHASE3","To compare the immediate and postoperative analgesic efficacy of S-FICB and PENG block will be the objective. The use of ultrasonography in anesthesia has helped the anesthetist to see the nerve, needle and the distribution of the drug, thereby enhancing the chances of a favorable outcome of the nerve block. Grade A recommendation for an ultrasound guided approach to the peripheral nerve blocks is supported by level Ib evidence for a shortened time for the onset of sensory block, decreased performance time and lower drug doses10.\n\nAlthough individually both the blocks have been studied, there are only a handful of studies comparing both techniques under ultrasound guidance for making patient positioning for spinal anesthesia easy. And no local data is available comparing these blocks. So, we want to compare the analgesic efficacy of USG PENG block with USG S-FICB block in patients with fracture femur in reducing pain associated with positioning (sitting) for subarachnoid block, duration of analgesia, opioid sparing effect and complications. So that procedure with better analgesic efficacy and less complications will be included in our local guidelines as a part of multimodal analgesia.",[115,116,117,25],"Post Operative Pain","Bradycardia","Hypotension",[119],"PENG,S-FICB,ASA,EOSP","2025-10-21",{"date":122,"type":36},"2025-10-23",{"date":124,"type":36},"2024-07-10",{"date":126,"type":19},"2026-01-10",{"name":128,"class":129},"Sahiwal medical college sahiwal","OTHER_GOV",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":20,"phases":140,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":4},"100539726","vastus-intermedius-dry-needling-for-knee-stiffness-resulted-from-surgically-managed-femoral-fractures-with-open-reduction--internal-fixation-100539726","NCT06307587","Vastus Intermedius Dry Needling for Knee Stiffness Resulted From Surgically Managed Femoral Fractures With Open Reduction & Internal Fixation.","Vastus Intermedius Dry Needling for Knee Stiffness Resulted From Surgically Managed Femoral Fractures With Open Reduction & Internal Fixation; Randomized Controlled Trial (ORIFDN Trial)","Inclusion Criteria:\n\n* 18 to 55-year-old participants.\n* Distal one third femur fractures classified as type 33 with AO\u002FOTA classification.\n* Three months post ORIF surgery to the distal femoral fracture,\n* Experience postoperative limitation in knee flexion range of motion of less than 90 degrees.\n\nExclusion Criteria:\n\n* Neuropathic pain in the lower limb.\n* Lumbosacral radiculopathy,\n* Saphenous nerve entrapment,\n* Meralgia paresthetica,\n* Rheumatoid or systemic conditions,\n* Other surgeries,\n* Post-surgery complications (i.e., thrombosis or osteomyelitis) or use of heparin during DN.\n* Knee surgery,\n* Periprosthetic fractures,\n* Scraw fixation only,\n* Intermedullary nail fixation,\n* non-union,\n* Isolated medial or lateral condyle femoral fractures,\n* Underwent manipulation under anesthesia.","50 Years",{"count":139,"type":19},44,[22],"Orthopedic traumatic injuries are considered a major health epidemic, challenged by high morbidity, mortality, and socioeconomic burden. The management of traumatic orthopedic injuries is challenging and complex, with high resources utilization. Particularly, the prevalence of femoral fractures in Kuwait is 8.8%, being one of the most prevalent injuries. Open reduction and internal fixation (ORIF) is a common surgical procedure for the management of femoral fractures demonstrating successful outcome for allowing minimally invasive percutaneous plate osteosynthesis, early union of 93% to 100%, and low infection rate of only 0% to 2%. Yet, one of the major complications post ORIF is knee stiffness and reduced function, which brings many inconveniences to patients' daily lives, lead to disability, and could seriously threaten the functional activities of patients. The incidence of knee stiffness requiring surgical intervention is 14.5%. Particularly, the potential loss of knee flexion is 30 to 40 degrees, 13% of the patients failed to reach 90 degrees of knee flexion, and only 48% of patients reached \\>120 degrees of flexion. Ultimately, knee stiffness in flexion forms a major issue in distal femoral fractures. Various reasons could explain such complication including intrinsic adhesions, fibrosis and shortening of the vastus intermedius muscle.\n\nThere are various surgical procedures which could be used to manage knee stiffness. However, there is no consensus regarding the ideal approach and strategy with many postoperative complications including deep sepsis, quadricep tendon rupture, skin dehiscence and infection, delayed wound healing, patella fracture, lateral femoral condyle fracture and extension lag. In contrast, dry needling (DN) is a minimal invasive intervention for the management of musculoskeletal dysfunction, and it could be used to reduce the adhesion and fibrosis between the vastus intermedius and the femoral bone. However, there is limited research investigating the effect of DN on the vastus intermedius muscle after ORIF of the femoral fractures. The effectiveness of DN was explored for the management of various musculoskeletal conditions, and a systematic review addressing DN in the lower quarter concluded that DN is an effective procedure (Morihisa et a,., 2016). In ACL reconstruction, DN for the vastus medialis improved ROM at short-term and improved function at both short and long term. DN has been proposed as a useful addition to the rehabilitation of ACL reconstructed in reducing pain intensity, increasing knee flexion range, and modifying the mechanical properties of the quadriceps muscle during the late-stage of rehabilitation. DN has also altered the passive mechanical properties of the quadriceps muscle where decrement and resistance of the vastus medialis were significantly reduced. It is hypothesized that releasing the adhesions and fibrosis of the vastus intermedius could play an important role in managing knee stiffness post ORIF of the distal femur fractures. Therefore, the aim of this project is to identify the incidence rate and risk factors of knee stiffness resulted from surgically managed femoral fractures with open reduction and internal fixation in Kuwait, and to investigate the effect of DN on the vastus intermedius muscle in improving knee joint range of motion and function after ORIF of the distal femur using single blind randomized controlled trial (RCT).",[25],"2024-07-29",{"date":145,"type":36},"2024-07-30",{"date":147,"type":19},"2024-09-01",{"date":149,"type":19},"2027-03-12",{"name":151,"class":129},"Al-Razi Hospital"]