[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fertilization-in-vitro\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fertilization-in-vitro":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,93,117,152],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100549400","best-size-for-ovulation-triggering-in-poseidon-4-patients-best-4-study-100549400",false,"NCT06433518","BEst Size for Ovulation Triggering in Poseidon 4 Patients (BEST 4 Study)","What Should Be The Optimal Ovulation Triggering Size in Poseidon Group 4 Patients Undergoing Ovarian Stimulation?","BEST","Inclusion Criteria:\n\n* Women age equal to or greater than 35 years\n* Women with low serum AMH (\\\u003C1,2 ng\u002Fml),\n* women with low AFC (\\\u003C5)\n* women Undergoing assisted reproduction with Short antagonist protocol or long -agonist protocol\n* women who used Max daily gonadotropin dose of 300 IU\n\nExclusion Criteria:\n\n* Age \\\u003C35 years.\n* Ovarian reserve parameters not meeting the POSEIDON group 4 definition.\n* Natural or modified natural cycles without controlled ovarian stimulation.\n* In vitro maturation (IVM) cycles.\n* Luteal-phase stimulation or DuoStim protocols.\n* Preimplantation genetic testing (PGT-A, PGT-M, or PGT-SR) cycles, unless prespecified for stratified analyses.\n* Major untreated uterine cavity pathology (e.g., submucosal fibroids, significant intrauterine adhesions, congenital uterine anomalies) or untreated hydrosalpinx.\n* Cycles with missing or incomplete follicular measurement data on the trigger day.\n* Cycles with non-standardized or undocumented trigger-to-oocyte retrieval intervals.","FEMALE","35 Years","44 Years",{"count":21,"type":22},200,"ESTIMATED","9 Months","OBSERVATIONAL","This observational clinical study aims to determine the optimal timing of ovulation triggering in women aged 35 and above with poor ovarian reserve.\n\nFor this purpose, cases undergoing ovarian stimulation for assisted reproductive treatment and planned final oocyte triggering will be evaluated in two separate groups:\n\n1. \\*\\*Experimental Group\\*\\*: Final oocyte triggering will be performed when the follicle or follicles measure between 13-16 mm.\n2. \\*\\*Control Group\\*\\*: Final oocyte triggering will be performed when the follicle or follicles measure greater than 17 mm.\n\nAll triggers will be administered uniformly with 6500 units of recombinant hCG and 0,2 mg triptorelin injections.\n\nThe primary outcome of the study will be the number of mature oocytes. Secondary outcomes will include fertilization rates, embryo counts, and implantation rates.\n\nPrimary and secondary outcomes will be compared between the two groups.",[27,28],"Fertilization","Fertilization in Vitro",[30,31,32,33],"oocyte","IVF","poor responder","ovarian stimulation","RECRUITING","2026-03-17",{"date":37,"type":38},"2026-03-19","ACTUAL",{"date":40,"type":38},"2026-03-15",{"date":42,"type":22},"2026-12-30",{"name":44,"class":45},"Centrum Clinic IVF Center","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":46},"100606439","sister-sibling-oocyte-insemination-with-frozen-sperm-from-third-party-donors-evaluation-of-reproductive-techniques-100606439","NCT07175571","SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques","Prospective Randomized Sibling-Oocyte Trial Comparing Fertilization and Embryo Development Outcomes Between Intracytoplasmic Sperm Injection (ICSI) and Conventional IVF Using Frozen Donor Sperm","SISTER","Inclusion Criteria:\n\n* Female patients undergoing IVF with frozen donor sperm at Shady Grove Fertility Center\n* Normal ovarian reserve (AMH \\> 1 ng\u002FmL, AFC \\> 10)\n* Absence of male factor infertility\n* Post-wash parameters: \\>50% motility, \\>5mil concentration\n* \\> 4 oocytes retrieved at time of transvaginal oocyte retrieval\n\nExclusion Criteria:\n\n* Donor Sperm with significant male factor infertility (e.g., abnormal sperm concentration, motility, or morphology)\n* Any medical condition contraindicating ART",{"count":56,"type":22},95,"INTERVENTIONAL",[59],"NA","The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when using frozen donor sperm in people who do not have male fertility problems. The main questions it aims to answer are:\n\nDoes one method create more usable embryos (blastocysts) than the other?\n\nIs there a difference in how often fertilization does not happen at all?\n\nDo either of the methods lead to better embryo quality or early pregnancy?\n\nParticipants will:\n\nHave their eggs divided into two groups. One group will be fertilized using ICSI (where a sperm is injected directly into an egg), and the other using conventional IVF (where eggs are mixed with sperm in a dish).\n\nThe fertilization method for each egg will be randomly assigned, with a random process also used to determine the assignment of any extra egg when an odd number is collected.\n\nContinue regular fertility treatment while the study team compares the results of each fertilization method.\n\nThis study includes people with non-male factor infertility and uses frozen donor sperm. It hopes to learn whether ICSI, which is often used even when it may not be needed, truly helps improve outcomes compared to conventional IVF in these cases.",[62,63,28],"Infertility, Female","Reproductive Techniques, Assisted",[65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83],"Intracytoplasmic Sperm Injection (ICSI)","Conventional IVF","Frozen Donor Sperm","Sibling-Oocyte Design","Non-Male Factor Infertility","Blastulation Rate","Total Fertilization Failure (TFF)","Fertilization Outcomes","Embryo Quality","Clinical Pregnancy Rate","Assisted Reproductive Technology (ART)","Embryo Development","In Vitro Fertilization","Oocyte Randomization","Female Infertility","Cryopreserved Sperm","Randomized Controlled Trial (RCT)","Reproductive Medicine","Fertility Treatment","2025-09-09",{"date":86,"type":38},"2025-09-16",{"date":88,"type":22},"2025-09-15",{"date":90,"type":22},"2026-05-01",{"name":92,"class":45},"Shady Grove Fertility Reproductive Science Center",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":57,"phases":103,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":116},"100529733","advantages-of-early-intrauterine-transfer-of-blank-culture-medium-prior-to-1st-or-2nd-transfer-of-thawed-embryos-100529733","NCT06177613","Advantages of Early Intrauterine Transfer of \"Blank\" Culture Medium Prior to 1st or 2nd Transfer of Thawed Embryo(s).","Advantages of Early Intrauterine Transfer of \"Blank\" Culture Medium Prior to 1st or 2nd Transfer of Thawed Embryo(s). Randomized, Single-blind, Multicenter Controlled Trial.","TRABLAN","Inclusion Criteria:\n\n* Having had a first \"fresh\" or frozen embryo transfer, whatever the embryo's stage of development, transfer followed by pregnancy failure ;\n* Frozen embryos must be at least D3 stage;\n* The patient must have given their free and informed consent and signed the consent form\n* The patient must be a member or beneficiary of a health insurance plan\n\nExclusion Criteria:\n\n* The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study\n* The patient is under safeguard of justice or state guardianship",{"count":102,"type":22},1154,[59],"Despite technical advances in Medically Assisted Reproduction (AMP), the success of fertility treatments is sometimes limited by embryo implantation failure. The coordinated development of the embryo and the uterine endometrium requires close communication between the maternal tissue and the embryo. In in vitro fertilization (IVF), embryo transfer generally takes place between the 2nd (D2) and the 6th (D6) day following oocyte fertilization. Recent studies have shown the advantages of sequential transfer (transfer of an embryo on D2\u002FD3 followed by the transfer of another embryo on D5\u002FD6), with higher implantation and clinical pregnancy rate, fewer miscarriages, more live births, and yet no increase in multiple pregnancies. However, the American Society for Reproductive Medicine recommendations continue to prioritize the transfer of a single embryo for all patients aged under 38. To improve pregnancy rates for patients having a single embryo transferred, the study investigators wish to carry out on \"blank\" transfer, based on the principle of sequential transfer. The study investigators hypothesize that a culture medium, placed in the uterus before the time of embryo transfer, will modify immune tolerance. The study will test whether transferring the same culture medium in an equivalent quantity as during the real transfer into the uterus 2\u002F3 days before the embryo transfer will improve tolerance to this foreign medium and, therefore, embryo implantation. The aim of this study is thus to evaluate the impact of a \"blank\" transfer with culture medium alone, on the results of frozen embryo transfers (FET) from IVF.",[106,28],"Single Embryo Transfer","2025-02-19",{"date":109,"type":38},"2025-02-20",{"date":111,"type":38},"2024-02-09",{"date":113,"type":22},"2027-02",{"name":115,"class":45},"Centre Hospitalier Universitaire de Nīmes",7,{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":124,"sex":17,"minAge":125,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":57,"phases":129,"briefSummary":131,"conditions":132,"keywords":139,"overallStatus":143,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":148,"leadSponsor":150,"locationsCount":4},"100565054","phase-4-protocol-with-progestin-primed-ovarian-stimulation-ppos-from-the-beginning-of-stimulation-versus-protocol-with-gnrh-antagonists-for-ovarian-stimulation-in-patients-undergoing-duostim-with-embryo-accumulation-for-pgt-a-100565054","NCT06637189","Protocol with Progestin-primed Ovarian Stimulation (PPOS) from the Beginning of Stimulation Versus Protocol with GnRH Antagonists for Ovarian Stimulation in Patients Undergoing DUOSTIM with Embryo Accumulation for PGT-A.","PPDUO","Inclusion Criteria:\n\n* Regular menstrual cycles between 21 and 35 days, inclusive.\n* Indication of IVF with PGT-A.\n* Both ovaries present.\n* Ability to participate and complete the study.\n* Give and sign the consent to participate in the study.\n\nExclusion Criteria:\n\n* Endometriosis grade III\u002FIV\n* Concurrent participation in another study",true,"18 Years","43 Years",{"count":128,"type":22},144,[130],"PHASE4","The PPOS protocol (Progestin-primed Ovarian Stimulation) involves avoiding ovulation during ovarian stimulation with progesterone. It is a reliable and safe protocol that has been widely used in recent years for in vitro fertilization, as it reduces the number of injections needed during controlled ovarian stimulation and is more cost-effective for patients.\n\nThe aim of this study is to compare two methods of ovarian stimulation for in vitro fertilization: the PPOS protocol (Group A) and the conventional protocol with injected antagonists (Group B). The goal is to determine whether both methods are equally effective in obtaining euploid embryos in the context of double ovarian stimulation.",[133,134,135,136,28,137,138],"Stimulation in the Ovary","Embryo","Oocyte","Oocyte Retrieval","Blastocyst","PGT-A",[140,33,141,142,138],"duostim","progesterone","GnRH antagonists","NOT_YET_RECRUITING","2024-10-10",{"date":146,"type":38},"2024-10-15",{"date":146,"type":22},{"date":149,"type":22},"2025-12-31",{"name":151,"class":45},"Ginefiv",{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":124,"sex":17,"minAge":125,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":57,"phases":162,"briefSummary":163,"conditions":164,"keywords":167,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":46},"100526428","does-sexual-intercourse-affect-the-outcomes-of-frozen-thawed-embryo-transfer-100526428","NCT06134609","Does Sexual Intercourse Affect the Outcomes of Frozen-thawed Embryo Transfer?","Does Sexual Intercourse Affect the Outcomes of Frozen-thawed Embryo Transfer? Randomized Controlled Trial","Inclusion Criteria:\n\n1. Women age 18-41yrs.\n2. BMI (body mass index) of 18-35 kg\u002Fm².\n3. Patients undergoing one of their first four frozen embryo transfers.\n4. Patients transferring a good quality embryo, either a cleavage stage embryo or a day 5 blastocyst.\n\nExclusion Criteria:\n\n1. Patients age above 42.\n2. Moderate or poor-quality embryos.\n3. Patients with hydrosalpinx or uterus malformations.\n4. Patients who are not able or are not interested in having vaginal intercourse (same sex couples for example).\n5. Couples undergoing preimplantation genetic diagnosis when natural cycle frozen embryo transfer is planned (as they are instructed to avoid intercourse).","41 Years",{"count":161,"type":22},656,[59],"The goal of this clinical trial is to test whether sexual intercourse the night after embryo transfer affects thawed embryo implantation rates. Women undergoing one of their first four frozen embryo transfers with a good quality embryo will be randomly assigned to two groups. The study group is subjected to have intercourse without using a condom at the evening\u002Fnight after the embryo transfer, while the control group will abstain from intercourse for the next 48 hours after the transfer. Researchers will compare the ongoing pregnancy rates between the intervention group and the control group.",[165,28,166],"Embryo Transfer","Coitus",[31,165,168,166,169],"Sexual intercourse","Pregnancy","2023-11-16",{"date":172,"type":38},"2023-11-18",{"date":174,"type":38},"2023-11-13",{"date":176,"type":22},"2026-11",{"name":178,"class":179},"Sheba Medical Center","OTHER_GOV"]