[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fetal-distress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fetal-distress":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,71,99,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100625093","effect-of-maternal-chocolate-consumption-on-fetal-non-stress-test-nst-reactivity-100625093",false,"NCT07418151","Effect of Maternal Chocolate Consumption on Fetal Non-Stress Test (NST) Reactivity.","Effect of Maternal Consumption of Dark Chocolate on the Reactivity of the Fetal Non-Stress Test (NST): A Single-Blind, Randomized Clinical Trial.","CHOCO-NST","Inclusion Criteria:\n\n* Singleton pregnancy between 36+0 and 41+6 weeks of gestation.\n* Baseline Non-Stress Test (NST) classified as non-reactive after a standard 20-minute recording (absence of ≥2 accelerations of ≥15 beats per minute lasting ≥15 seconds).\n* Intact amniotic membranes and not in active labor (cervical dilation \\\u003C4 cm, with absent or irregular contractions).\n* Ability to provide written, informed consent.\n* Literacy: Ability to read and write (to ensure comprehension of the consent form and study materials).\n* Access to a telephone or electronic device for the 24-hour safety follow-up contact.\n\nExclusion Criteria:\n\n1. Pregnancy-related exclusions:\n\n   * Multiple gestation (twins, triplets, etc.).\n   * Known major fetal malformation.\n   * Diagnosis of severe fetal growth restriction with abnormal umbilical artery Doppler.\n   * Premature rupture of membranes.\n   * Active vaginal bleeding or placenta previa with hemorrhage.\n   * Suspected or confirmed chorioamnionitis.\n2. Maternal medical exclusions:\n\n   * Severe preeclampsia, eclampsia, or HELLP syndrome.\n   * Uncontrolled severe hypertension.\n   * Pregestational diabetes or gestational diabetes requiring insulin or other antihyperglycemic medication.\n   * Capillary blood glucose level \\>140 mg\u002FdL at the time of screening.\n   * Maternal fever ≥38°C or maternal tachycardia \\>120 beats per minute.\n3. Interference with test interpretation:\n\n   * Use of sympathomimetic drugs within 12 hours prior to the study intervention.\n   * Maternal cardiac arrhythmias.\n4. Contraindications to the intervention:\n\n   * Known allergy to cocoa or chocolate.\n   * Severe caffeine intolerance.\n   * Phenylketonuria.\n   * Gastrointestinal conditions that would prevent oral intake (e.g., intractable vomiting, ileus, obstruction).",true,"FEMALE","18 Years","49 Years",{"count":22,"type":23},190,"ESTIMATED","INTERVENTIONAL",[26],"NA","This is a single-blind, randomized, parallel-group, superiority clinical trial. The study aims to determine whether a single intake of 30g of dark chocolate (≥80% cocoa) by pregnant women with a non-reactive fetal non-stress test (NST) increases the conversion rate to a reactive NST within 20 minutes, compared to observation with a sugar-free white chocolate placebo. A total of 190 singleton pregnant women at 36-41 weeks gestation with a non-reactive NST will be recruited at the Hospital General San Felipe, Tegucigalpa, Honduras. Participants will be randomly assigned to either the intervention group (dark chocolate) or the control group (placebo). The primary outcome is the proportion of NSTs that become reactive. Secondary outcomes include changes in specific cardiotocographic parameters, total monitoring time, need for additional tests, and maternal satisfaction.",[29],"Fetal Distress",[31,32,33,34],"Chocolate","Theobromine","Non-Stress Test","Cardiotocography","RECRUITING","2026-02-27",{"date":38,"type":39},"2026-03-03","ACTUAL",{"date":41,"type":23},"2026-02-15",{"date":43,"type":23},"2026-09-30",{"name":45,"class":46},"Universidad Nacional Autonoma de Honduras","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":47},"100491630","maternal-oxygen-supplementation-for-intrauterine-resuscitation-100491630","NCT05681624","Maternal Oxygen Supplementation for Intrauterine Resuscitation","Maternal Oxygen Supplementation for Intrauterine Resuscitation: a Multicenter Randomized Trial","MOXY","Inclusion Criteria:\n\n* Singleton gestation\n* Gestational age\\>=37 weeks\n* Spontaneous labor or induction of labor\n* English or spanish speaking\n* Planned continuous fetal monitoring\n\nExclusion Criteria:\n\n* Preterm gestation\n* Major fetal anomaly\n* Multiple gestation\n* Category III fetal monitoring at time of admission\n* Maternal hypoxia \\\u003C95%\n* Planned or scheduled cesarean delivery Excluded from randomization if receiving nitrous oxide for analgesia at time of randomization.",{"count":57,"type":23},2124,[26],"More than 80% of the 3 million women who labor and deliver each year in the United States undergo continuous electronic fetal monitoring (EFM) during labor in order to fetal hypoxia and prevent the transition to acidemia, expedited operative delivery, and\u002For neonatal morbidity. Category II EFM is the most commonly observed group of fetal heart rate features in labor. One common response to Category II EFM is maternal oxygen (O2) supplementation. The theoretic rationale for O2 administration is that it increases O2 transfer to a hypoxic fetus. There are conflicting national guidelines regarding O2 administration - the American College of Obstetricians and Gynecologists suggest O2 is ineffective, whereas the Association of Women's Health, Obstetric, and Neonatal Nurses recommend continued use given lack of definitive data on safety and efficacy. A recent national survey of nearly 600 Labor \\& Delivery providers in February 2022 revealed that 49% still use O2 . Thus, there remains equipoise on the topic and high-quality data on the safety of intrapartum O2 is needed. None of the trials to date have studied the effect of intrapartum O2 on important clinical measures of neonatal or maternal morbidity. This safety data is imperative because the field of obstetrics must hold supplemental O2 to the same rigorous standards applied to any drug used in pregnancy. Without data on these definitive outcomes, it will be challenging to implement evidence-based recommendations for supplemental O2 use on Labor \\& Delivery. The investigators will conduct a large, multicenter, randomized noninferiority trial of O2 supplementation versus room air in patients with Category II EFM in labor.",[29,61,62],"Fetal Hypoxia","Labor and Delivery Complication","2026-02-25",{"date":36,"type":39},{"date":66,"type":39},"2023-05-22",{"date":68,"type":23},"2028-12-31",{"name":70,"class":46},"Washington University School of Medicine",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":47},"100530453","fetal-assessment-of-the-myocardium-and-evaluation-of-the-neonate-100530453","NCT06186973","Fetal Assessment of the Myocardium and Evaluation of the Neonate","FAME-n","Inclusion Criteria:\n\nWomen admitted for labor and newborn infants will be included after written consent from both parents (if applicable). The final inclusion criterion is that CTG with STAN is used for fetal surveillance at clinician's discretion.\n\nExclusion Criteria:\n\nPerinatal asphyxia fulfilling the criteria for therapeutic hypothermia, major malformations and stillbirth, known chromosomal anomalies or congenital heart defects other than a patent ductus arteriosus.","ALL","0 Hours","1 Hour",{"count":82,"type":23},220,"OBSERVATIONAL","FAME-n aims to improve perinatal care by introducing new approaches to fetal and neonatal heart assessment. Better identification of high-risk deliveries requiring intervention will reduce perinatal asphyxia-related illness and death. Neonatal hemodynamics may be improved by early detection of instability of the heart and circulation. Innovative use of technology enables characterization of normal and abnormal cardiovascular transition in a significantly larger number of fetuses and newborn infants than what was previously possible. The methods used may have broad generalizability and applicability in perinatal, neonatal and pediatric medicine.\n\nIn September 2023, the project was expanded with an obstetric arm called Epidural analgesia: Fetal Oxygenation and Maternal Oxygenation (Epi-FOMO). In Epi-FOMO, the relationship between maternal breathing and arterial blood gases during labour, and umbilical cord blood gases and neonatal outcomes (as specified in FAME-n) will be investigated.",[86,87,88,29,89],"Newborn Asphyxia","Hemodynamic Instability","Myocardium; Ischemic","Labor Pain","2025-03-17",{"date":92,"type":39},"2025-03-18",{"date":94,"type":39},"2022-11-14",{"date":96,"type":23},"2035-12-31",{"name":98,"class":46},"Oslo University Hospital",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":4},"100578635","monitored-effects-of-physical-activity-on-fetal-heart-rate-by-using-a-wireless-non-invasive-device-100578635","NCT06813859","Monitored Effects of Physical Activity on Fetal Heart Rate by Using a Wireless Non-invasive Device","Inclusion Criteria:\n\n* Presence of signed informed consent form\n* healthy pregnant active female over the age of 18 years and below 45 years\n* sporting activity \\>4h\u002Fweek on 2 or more weekdays\n* single pregnancy, between 28+0 and 34+0 weeks of pregnancy\n\nExclusion Criteria:\n\n* No signed informed consent form or revocation of consent\n* pre-existing pregnancy complications","45 Years",{"count":107,"type":23},20,"Effect of acute exercise testing in pregnant athletes on maternal and fetal heart rate, fetal\u002Fmaternal bloodflow and cardiotocogramm assessment.",[29],"NOT_YET_RECRUITING","2025-02-04",{"date":113,"type":39},"2025-02-07",{"date":115,"type":23},"2025-02-01",{"date":117,"type":23},"2027-02-27",{"name":119,"class":46},"Balgrist University Hospital",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":17,"sex":18,"minAge":127,"maxAge":105,"enrollmentInfo":128,"targetDuration":4,"studyType":24,"phases":130,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":47},"100562860","application-of-electronic-endoscope-in-fetal-distress-100562860","NCT06608654","Application of Electronic Endoscope in Fetal Distress","The New Application of Electronic Endoscope in the Visual Diagnosis and Treatment of Intrauterine Fetal Distress During Labor","Inclusion Criteria:\n\n1. Subjects aged 20-45 years with single pregnancy;\n2. Intrauterine fetal distress occurs during labor (during the first stage of labor), and the fetal membrane was already broken;\n3. Fetal heart monitoring category II, after stopping oxytocin, oxygen inhalation, change of position, intravenous fluid and other measures can not improve;\n4. Understand the research procedures, be able to follow the procedures of the research protocol, and voluntarily sign a written consent.\n\nExclusion Criteria:\n\n1. Type III fetal heart monitoring for pregnant women who require emergency c-section\n2. Pregnant women with GBS positive\n3. Pregnant women suspected of chorioamniotic infection\n4. Pregnant women have signs of reproductive system infection (vaginal inflammation, cervicitis, uterine infection)\n5. Pregnant women suspected of uterine rupture\n6. Pregnant women with abnormal contractions: excessive strong contractions\n7. Check the fetus for serious deformities during pregnancy\n8. Check pregnant women with serious abnormal functions of cardiovascular system, urinary system, digestive system, reproductive system and other organs","20 Years",{"count":129,"type":23},15,[26],"Fetal distress is a common emergency in obstetrics, which refers to the combined symptoms of fetal health and life in utero due to acute or chronic hypoxia, with an incidence of 2.7% to 38.5%. Fetal distress is mainly related to abnormal amniotic fluid, umbilical cord entanglement and compression, which is an important reason for the increase of cesarean section rate during delivery. At present, the diagnosis of fetal distress mainly relies on electronic monitoring of fetal heart, and the false positive rate is high. Intrauterine pressure catheter has not been widely used because of the little effect of intrauterine treatment and the increase of infection. Endoscopy has been widely used in the diagnosis and treatment of various specialties at present, but the diagnosis and treatment during childbirth are still in a blind area. The characteristics of endoscopic visualization provide a new idea for the diagnosis and treatment of fetal distress during delivery, especially for the etiological diagnosis and treatment of umbilical cord factors. The use of intraauterine endoscope during delivery can make up for the defects of intrauterine pressure catheter, realize the visual diagnosis of the causes of fetal distress such as oligoamniotic fluid, meconium contamination of amniotic fluid, umbilical cord compression caused by entangling and true junction, etc. At the same time, it can also improve the intrauterine environment by perfusion of saline for the causes of fetal embarrassment, correct fetal distress, and extend the observation time during labor. It is beneficial to reduce caesarean section during labor.",[29,61],"2024-09-19",{"date":135,"type":39},"2024-09-23",{"date":137,"type":23},"2024-10-01",{"date":139,"type":23},"2026-08-25",{"name":141,"class":46},"The First Affiliated Hospital with Nanjing Medical University"]