[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fibrin-blood-clot\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fibrin-blood-clot":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100614121","pregnancy-and-fibrin-clot-properties-100614121",false,"NCT07275476","Pregnancy and Fibrin Clot Properties","Fibrin Clot Properties and Thrombin Generation in Pregnancy Women With and Without Obstetric Complications.","Inclusion Criteria:\n\nI. age 18-40 years; II. natural conception (without assisted reproductive techniques).\n\nExclusion Criteria:\n\nI. use of hormonal therapy (i.e., oral contraceptives, progestogens) within 3 months before or during pregnancy; II. use of anticoagulants oral\u002Fsubcutaneous within 3 months before or during pregnancy; III. increased risk factors of VTE (i.e., obesity - body mass index \\>30 kg\u002Fm2; smoking) or history of VTE; IV. Concomitant diseases, i.e: severe hypertension, diabetes mellitus, autoimmune diseases (i.e., systemic lupus erythematosus, antiphospholipid syndrome); V. congenital or acquired thrombophilia (i.e., mutation factor V Leiden, prothrombin mutation).",true,"FEMALE","18 Years","40 Years",{"count":21,"type":22},100,"ESTIMATED","OBSERVATIONAL","1. The structure of fibrin clot and thrombin generation may vary between trimesters of pregnancy.\n2. Unfavorably altered fibrin clot properties along with enhanced thrombin generation may lead to the development of complications during pregnancy such as TE and hypertensive disorders.\n3. The application of machine learning techniques may help to identify previously undetected phenotypes with increased risk of TE and hypertensive disorders during pregnancy.",[26,27,28],"Fibrin Blood Clot","Pregnancy","Pregnancy Complicated by Cardiovascular Disorders as Postpartum Condition, Delivered During Previous Episode",[30,31,32],"fibrinolysis","fibrin clot","thrombin generation","RECRUITING","2025-11-28",{"date":36,"type":37},"2025-12-10","ACTUAL",{"date":34,"type":37},{"date":40,"type":22},"2027-12",{"name":42,"class":43},"Jagiellonian University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":44},"100375311","ovarian-hyperstimulation-and-fibrin-clot-properties-100375311","NCT04166825","Ovarian Hyperstimulation and Fibrin Clot Properties.","The Impact of Different Ovarian Hyperstimulation Protocols on Coagulation and Fibrinolysis.","Inclusion Criteria:\n\n* infertility defined based on the WHO 2010 criteria\n\nExclusion Criteria:\n\n* ovarian involvement\n* oral contraceptives use within previous 3 months\n* dienogest therapy within 3 months until ART\n* thrombotic events in the medical history\n* severe hypertension\n* diabetes mellitus\n* the presence of known VTE risk factors, including obesity, recent major surgery with prolonged immobilization or trauma,\n* deficiency of antithrombin, protein C or protein S,\n* antiphospholipid syndrome,\n* known malignancy,\n* any chronic inflammatory diseases (e.g. rheumatoid arthritis)\n* advanced chronic renal disease (estimated glomerular filtration rate \\[eGFR\\] \\\u003C30 ml\u002Fmin),\n* international normalized ratio (INR) more than 1.2 at the day of blood draw\n* pregnancy.",{"count":53,"type":22},300,"INTERVENTIONAL",[56],"NA","The impact evaluation of ovarian hyperstimulation on coagulation and fibrinolysis in infertile women.\n\nComparative analysis between different ovarian stimulation protocols on thrombin formation and efficiency of fibrinolysis in women diagnosed with infertility.",[26,59,60],"Infertility, Female","Endometriosis",[62,30,63,64],"coagulation","ovarian hyperstimulation","infertility",{"date":66,"type":37},"2025-12-05",{"date":68,"type":37},"2019-11-18",{"date":70,"type":22},"2026-01",{"name":42,"class":43},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":80,"minAge":18,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":54,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":99},"100557718","fibrine-clot-augmented-repair-of-longitudinal-meniscus-tears-100557718","NCT06541756","Fibrine Clot-augmented Repair of Longitudinal Meniscus Tears","Fibrine Clot-augmented Repair of Longitudinal Meniscus Tears - A Prospectively Randomized Controlled Trial","FCAR","Inclusion Criteria:\n\n* Presenting with a painful meniscus (lateral or medial) longitudinal tear\n* Being between the ages of 18 and 50\n* Not having undergone surgery on the same knee before\n* Having an MRI taken at the end of the 1st year post-surgery\n\nExclusion Criteria:\n\n* Having additional collateral ligamentous damage along with the meniscus tear (such as MCL or LCL)\n* Incomplete clinical scores at the end of the study\n* A history of previous surgery on the same knee\n* Having an active infection\n* Not having a control MRI at the end of the 1st year","ALL","50 Years",{"count":83,"type":22},120,[56],"Longitudinal meniscal tears are a type of meniscal injury characterized by a displaced fragment of the meniscus that flips over into the joint, often resembling a buckle or handle. These tears typically occur in the medial meniscus and are often associated with traumatic knee injuries, particularly in athletes.\n\nThe displaced meniscal fragment can cause mechanical symptoms such as locking, clicking, or catching of the knee, as well as pain and swelling. If not properly treated, buckle-handle meniscal tears can lead to further complications, including chronic knee instability, increased risk of osteoarthritis, and persistent joint pain.Repairing a longitudinal meniscal tear offers several advantages over partial meniscectomy, particularly in preserving knee function and preventing long-term complications.\n\nMeniscal repair aims to restore the integrity of the meniscus, which plays a crucial role in load distribution, shock absorption, and joint stability.\n\nUtilizing a fibrin clot during the repair of a buckle-handle meniscal tear can enhance the healing process and improve surgical outcomes. Fibrin clots act as a biological scaffold, promoting tissue regeneration by providing a matrix that facilitates cellular migration and proliferation.\n\nThe purpose of this study was to compare longitudinal meniscal tear repair reinforced with fibrin clot with routine end-to-end repair in a prospective randomized controlled trial.",[87,88,26,89],"Meniscus Tear","Meniscus Lesion","Knee Injuries","2025-09-29",{"date":92,"type":37},"2025-10-02",{"date":94,"type":37},"2024-07-25",{"date":96,"type":22},"2029-07-31",{"name":98,"class":43},"Ankara City Hospital Bilkent",2]