[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"filter-clotting\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:filter-clotting":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100593368","ultrasound-guided-microbubble-removal-and-filter-lifespan-during-crrt-a-pilot-crossover-study-100593368",false,"NCT07005531","Ultrasound-Guided Microbubble Removal and Filter Lifespan During CRRT: A Pilot Crossover Study","Impact of Ultrasound-Guided Microbubble Clearance During CRRT Circuit Priming on Filter Lifespan: A Randomized Crossover Pilot Trial","Inclusion Criteria:\n\n* Age ≥18 years, regardless of sex;\n* Admission to the intensive care unit (ICU) with a diagnosis of acute kidney injury (AKI) or chronic kidney disease (CKD) requiring continuous renal replacement therapy (CRRT);\n* Expected to receive at least two sessions of CRRT;\n* Written informed consent obtained from the patient or their legally authorized representative.\n\nExclusion Criteria:\n\n* Presence of severe coagulopathy (such as disseminated intravascular coagulation, DIC) or platelet count \\\u003C30×10\\^9\u002FL;\n* Contraindications to anticoagulation therapy;\n* Change in APACHE II score \\>5 points, or changes in coagulation parameters and platelet count exceeding 20% between the two treatment sessions;\n* Any other condition deemed unsuitable for participation by the investigators.","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","What is this study about? This study is designed to evaluate whether ultrasound-guided removal of microbubbles during circuit priming in Continuous Renal Replacement Therapy (CRRT) can extend the filter lifespan for critically ill patients who require CRRT. The investigators aim to determine if this technique improves the duration of effective filter use and reduces complications related to filter clotting.\n\nWho can join? Adults (18 years or older) admitted to the Intensive Care Unit (ICU) and diagnosed with acute kidney injury (AKI) or chronic kidney failure (CKD) who require CRRT and are expected to undergo at least two sessions of CRRT treatment.\n\nParticipants or their legal representatives must provide signed informed consent.\n\nWho cannot join? Patients with severe coagulation disorders, platelet count \\\u003C30×10\\^9\u002FL, contraindications to anticoagulation, significant changes in clinical scores or blood tests between CRRT sessions, or any other condition deemed unsuitable by the investigator.\n\nWhat will happen during the study?\n\nTwo Treatment Methods:\n\nConventional Priming (Control): The CRRT circuit will be primed following the standard visual bubble inspection protocol.\n\nUltrasound-Guided Priming (Intervention): The circuit will be primed using real-time ultrasound to detect and remove microbubbles from key locations.\n\nEach participant will receive both interventions in random order, separated by a washout period of at least 24 hours.\n\nSafe and Routine Monitoring:\n\nUltrasound scans will be performed on the filter and circuit to guide microbubble removal.\n\nStandardized CRRT treatment protocols, including filter type and anticoagulation regimen, will be used for all sessions.\n\nOther Data Collection:\n\nPatient information (e.g., age, sex, medical history, APACHE II score) CRRT treatment details (e.g., filter lifespan, filter clotting incidence, coagulation parameters) Monitoring of adverse events and clinical outcomes (including 28-day survival and treatment costs) What are the benefits and risks? Benefits: This study may provide evidence for a simple, non-invasive method to reduce filter clotting, improve CRRT efficiency, and enhance patient outcomes.\n\nRisks: Ultrasound monitoring is non-invasive and does not add risk beyond standard care. All procedures are standard clinical practice.\n\nYour Rights and Safety Voluntary Participation: Participation is voluntary; withdrawal is allowed at any time without affecting clinical care.\n\nEthical Approval: The study protocol is reviewed and approved by the hospital's ethics committee.\n\nConfidentiality: All personal information and test results will be kept confidential.",[26,27,28,29,30],"Acute Kidney Injury","Continuous Renal Replacement Therapy (CRRT)","Filter Clotting","Microbubbles","Ultrasound-Guided Microbubble Removal",[27,32,29,33,28,34,35,36],"Filter Lifespan","Ultrasound Guidance","Circuit Priming","Critical Care","Randomized Crossover Trial","NOT_YET_RECRUITING","2025-06-03",{"date":40,"type":41},"2025-06-05","ACTUAL",{"date":43,"type":20},"2025-06-30",{"date":45,"type":20},"2026-06-29",{"name":47,"class":48},"First Affiliated Hospital of Wannan Medical College","OTHER"]