[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fissure-sealant\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fissure-sealant":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,71,97],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100593247","the-effect-of-different-deproteinizing-agents-on-the-clinical-success-of-fissure-sealants-in-primary-teeth-100593247",false,"NCT07003958","The Effect of Different Deproteinizing Agents on the Clinical Success of Fissure Sealants in Primary Teeth","Evaluation of the Effect of Different Deproteinizing Agents on the Clinical Success of Fissure Sealants in Primary Teeth: Splint Mouth Clinical Study","Inclusion Criteria:\n\n* Patients between the ages of 4-6 who do not have any systemic problems\n* Have a score of 3 and 4 on the Frankl Behavior Scale\n* Do not have a habit of clenching and\u002For grinding their teeth\n* Have lower second primary molars without caries\n* Have an indication for fissure sealant application\n\nExclusion Criteria:\n\n* Teeth with fissure sealants\n* Teeth with developmental defects such as hypoplasia\n* Teeth with approximal or incipient caries lesions on one or both mandibular second primary molars",true,"ALL","4 Years","6 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","Investigation of the effect of deproteinization agents on the clinical success of non-invasive fissure sealant application, which is a non-invasive method used to prevent caries formation or to stop the progression of initial caries lesions limited to enamel on tooth surfaces thought to be at high risk of caries.",[28],"Fissure Sealant",[30,31,32,33,34],"deproteinization agents","sodium hypochlorite","hypochlorous acid","fissure sealent","Primary Teeth","RECRUITING","2025-05-26",{"date":38,"type":39},"2025-06-04","ACTUAL",{"date":41,"type":39},"2024-08-05",{"date":43,"type":22},"2026-08-05",{"name":45,"class":46},"Tokat Gaziosmanpasa University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":17,"minAge":19,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":26,"conditions":58,"keywords":59,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":47},"100592028","the-effect-of-different-deproteinising-agents-on-the-clinical-success-of-fissure-sealants-in-permanent-teeth-100592028","NCT06988098","The Effect of Different Deproteinising Agents on the Clinical Success of Fissure Sealants in Permanent Teeth","Evaluation of the Effect of Different Deproteinizing Agents on the Clinical Success of Fissure Sealants in Permanent Teeth: Splint Mouth Clinical Study","Inclusion Criteria:\n\n* Patients between the ages of 6-9 who do not have any systemic problems\n* Have a score of 3 and 4 on the Frankl Behavior Scale\n* Do not have a habit of clenching and\u002For grinding their teeth\n* Have newly erupted permanent lower first molars without caries\n* Have an indication for fissure sealant application\n\nExclusion Criteria:\n\n* Teeth with fissure sealants\n* Teeth with developmental defects such as hypoplasia\n* Teeth with approximal or incipient caries lesions on one or both mandibular first permanent molars\n* Children who are not systemically healthy\n* Uncooperative children with scores of 1 and 2 on the Frankl Behavior Scale\n* Children and parents who refuse to attend follow-up appointments\n* Children with parafunctional habits such as teeth grinding","9 Years",{"count":21,"type":22},[25],[28],[60,61,62,33],"Deproteinization Agents","Sodium Hypochlorite","Hypochlorous Acid","2025-05-16",{"date":65,"type":39},"2025-05-23",{"date":67,"type":39},"2024-08-01",{"date":69,"type":22},"2027-08-01",{"name":45,"class":46},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":23,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":4},"100582316","caries-arrest-using-silver-diamine-fluoride-versus-fissure-sealant-in-occlusal-dental-carious-lesions-randomized-controlled-trial-100582316","NCT06861725","CARIES ARREST USING SILVER DIAMINE FLUORIDE VERSUS FISSURE SEALANT in OCCLUSAL DENTAL CARIOUS LESIONS: RANDOMIZED CONTROLLED TRIAL","Inclusion Criteria:\n\n1. Patient consulting in the outpatient clinic.\n2. Patients with enamel caries in molars permanent teeth, according to ICDAS 1 and 2.\n3. Provide informed consent.\n4. Co-operative patients approving to participate in the trial.\n5. Patient age (20-45 years old).\n\nExclusion Criteria:\n\n1. Tooth mobility.\n2. Signs of pulpal infection.\n3. Severe medical conditions that would not allow management in the clinic.\n4. Hereditary developmental defects, such as amelogenesis imperfecta or dentinogenesis imperfecta.\n5. Known allergies or sensitivities to dental materials, including SDF and fissure sealant.\n6. Inability to return for recall visits.\n7. Patients with bad oral hygiene\n8. Refuse to participate in the study.","20 Years","45 Years",{"count":80,"type":22},76,[25],"The goal of this randomized clinical trial is to evaluate if Silver Diamine Fluoride (SDF) is a more conservative and effective treatment in preventing the progression of mild occlusal caries compared to fissure sealant in patients aged 20-45 years with incipient molar caries. The main question it aims to answer is:\n\nIs SDF more effective in arresting caries progression than fissure sealant? Does SDF prevent the formation of new caries compared to fissure sealant? Researchers will compare SDF treatment to fissure sealant application to see if SDF results in better caries arrest and fewer new carious lesions.\n\nParticipants will:\n\nBe randomly assigned to receive either SDF or fissure sealant. Have follow-up assessments at 1, 3, 6, and 12 months for caries progression, arrest, and new caries formation.\n\nUndergo clinical evaluations using visual and tactile examinations to assess caries arrest and progression and using DIAGNOdent laser fluorescence system .",[84,85,86,28],"Dental Caries","Caries Arrested","Silver Diamine Fluoride","NOT_YET_RECRUITING","2025-03-01",{"date":90,"type":39},"2025-03-06",{"date":92,"type":22},"2025-04-01",{"date":94,"type":22},"2026-05-01",{"name":96,"class":46},"Cairo University",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":16,"sex":17,"minAge":19,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":23,"phases":108,"briefSummary":109,"conditions":110,"keywords":111,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":47},"100562853","the-effect-of-an-adhesive-system-on-the-retention-and-caries-prevention-for-fissure-sealants-in-permanent-molars-100562853","NCT06608563","The Effect of an Adhesive System on the Retention and Caries Prevention for Fissure Sealants in Permanent Molars","The Effect of an Adhesive System on the Retention and Caries Prevention for Fissure Sealants in Permanent Molars: a 2-year Randomised Clinical Trial","ResinFS","Inclusion criteria:\n\n1. 6 to 12 years of age;\n2. Referred for dental treatment at the Dublin Dental University Hospital DDUH) or that are ongoing patients of the Paediatric dentistry clinic;\n3. With first permanent molars that are caries free or present caries lesions restricted to enamel (ICDAS 1 to 3) indicated for glass ionomer sealants.\n4. Whose parents agreed and consent to participate in the present research;\n\nExclusion criteria:\n\n1. Presence of any developmental defects\n2. Presence of any type of restorative\u002Fsealant material in the selected tooth;\n3. Presence of a dentine shadow (ICDAS 4) or dentine cavitation (ICDAS 5\u002F6) detected clinically and\u002For radiographically14;\n4. Insufficient cooperation to achieve adequate moisture control using cotton roll isolation","12 Years",{"count":107,"type":22},100,[25],"Background: Resin-based fissure sealants (FS) are recommended to prevent pit-and-fissure caries development or prevent the progression of enamel caries lesion to frank cavitation into dentine. There is still limited clinical evidence on the use of adhesive system beneath fissure sealants in permanent molars and its effect on FS retention and caries progression.\n\nAim: The aim of this randomised clinical trial is to evaluate the clinical efficacy of fissure sealants placed with and without prior use of an adhesive system in terms of retention and caries prevention in permanent molars over the period of 2 years.\n\nStudy design: Children (6-12 years of age) with high caries risk that require sealants in their first permanent molars (ICDAS 0-3) will be selected at the Dublin Dental University Hospital (DDUH). Molars will be stratified according to presence of caries lesions (ICDAS 0 or ICDAS1-3) and randomly allocated according to the study groups (Test group: 17% phosphoric acid + adhesive system + FS; Control group: 17% phosphoric acid + FS). The randomisation unit will be the tooth and more than one tooth can be included per child. All children will be evaluated after 12 and 24 months by calibrated independent examiners. The primary outcome of the present trial is sealant retention over time. Clinical variables such as age, gender, tooth position (upper\u002Flower), caries experience (DMFT\u002Fdmft), stage of eruption (erupted\u002Fpartially erupted) and children's behavior (Frankl scale) will be collected.",[84,28],[112,113,114,115,116,117,118],"fissure sealant","first permanent molar","retention","adhesive system","children","clinical trial","caries","2024-11-06",{"date":121,"type":39},"2024-11-08",{"date":123,"type":39},"2024-06-05",{"date":125,"type":22},"2027-06-05",{"name":127,"class":46},"University of Dublin, Trinity College"]