[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fistula-perianal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fistula-perianal":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100553328","efficacy-of-minimally-invasive-approach-in-the-surgical-treatment-of-complex-perianal-fistula-100553328",false,"NCT06484660","Efficacy Of Minimally Invasive Approach In The Surgical Treatment Of Complex Perianal Fistula","Efficacy Of Minimally Invasive Approach In The Mucosal Advancement Flap Technique For The Surgical Treatment Of Previously Untreated Complex Perianal Fistula","Inclusion Criteria:\n\n* Age older than 18.\n* Present with a complex perianal fistula not surgically treated with curative intention.\n* Present only one main fistulous tract.\n* Mucosal advancement flap as the chosen technique for the treatment of the fistula.\n* Patient has given informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Non-cryptoglandular internal fistulous orifice (IFO).\n* Extrasphincteric fistula.\n* Coexistence of anal fissure.\n* Coexistence of hemorrhoids tributary to surgery.\n* Coexistence of anal or rectal prolapse.\n* Coexistence of inflammatory bowel disease.\n* Coexistence of anal or colorrectal cancer.","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to study whether the minimally invasive approach in the mucosal advancement flap technique for the treatment of complex perianal fistula improves the healing rate compared to non-minimally invasive surgery.\n\nThe main question it aims to answer is:\n\n\\- Does the healing rate of patients undergoing minimally invasive approach in the mucosal advancement flap technique improve compared to patients undergoing non-minimally invasive surgery?\n\nResearchers will also compare minimally invasive approach in the mucosal advancement flap technique to the non-minimally invasive approach in terms of postoperative pain, fecal incontinence and healing time.\n\nQuality of life and global morbidity will also be analyzed.\n\nParticipants will:\n\n* Undergo surgical treatment of complex perianal fistula performed by mucosal advancement flap performed by a minimally invasive technique.\n* Attend control visits and fill in symptom forms one week, one month, three months and six months after the surgical procedure.",[26],"Fistula Perianal",[28,29,30],"Perianal Fistula","Mucosal Advancement Flap","Minimally Invasive Approach","RECRUITING","2025-08-26",{"date":34,"type":35},"2025-09-03","ACTUAL",{"date":37,"type":35},"2021-08-01",{"date":39,"type":20},"2025-12-31",{"name":41,"class":42},"Hospital Son Llatzer","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100559785","phase-2-human-placenta-mesenchymal-stem-cells-derived-exosomes-injection-for-treatment-of-complex-anal-fistula-100559785","NCT06568653","Human Placenta Mesenchymal Stem Cells Derived Exosomes Injection for Treatment of Complex Anal Fistula","The Efficacy of Human Placenta Mesenchymal Stem Cells Derived Exosomes Injection for Treatment of Complex Anal Fistula in Colorectal Surgery Department of Imam Khomeini Hospital Complex: A Non-randomized Clinical Trial.","Inclusion Criteria:\n\n* participants with complex perianal fistula\n* provided written informed consent\n\nExclusion Criteria:\n\n* participants with any inflammatory bowel diseases\n* pregnant or lactating participants\n* participants with contraindications for surgery\n* participants with hepatitis\n* participants with uncontrolled diabetes\n* participants with alcohol or substance abuse","70 Years",{"count":19,"type":20},[54],"PHASE2","The goal of this clinical trial is to learn if human placenta mesenchymal stem cells (MSC)-derived exosomes work to treat complex perianal fistula in adults without Crohn's disease. The safety of this treatment will also be learned. The main questions it aims to answer are:\n\n* Does treatment with MSC-derived exosomes lower the number of fistula recurrences in participants?\n* Is treatment with MSC-derived exosomes safe? We will compare treatment with MSC-derived exosomes to the routine treatment which is fistulotomy (surgery to close the fistula) alone to see if MSC-derived exosomes work better to treat complex fistula.\n\nParticipants will:\n\n* Undergo fistulotomy plus MSC-derived exosome injections or fistulotomy alone.\n* Visit the clinic the week after surgery and then every 4 weeks for checkups and tests",[26],[58],"fistula, perianal fistula, non-Crohn's disease, exosome, mesenchymal stem cell, human placenta stem cell","NOT_YET_RECRUITING","2024-08-22",{"date":62,"type":35},"2024-08-23",{"date":64,"type":20},"2024-09-15",{"date":66,"type":20},"2025-02-15",{"name":68,"class":42},"Tehran University of Medical Sciences"]