[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"flare-up\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:flare-up":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100637480","effect-of-a-herbal-intracanal-medication-on-postoperative-pain-and-flare-up-incidence-in-non-surgical-root-canal-retreatment-100637480",false,"NCT07578311","Effect of a Herbal Intracanal Medication On Postoperative Pain And Flare up Incidence In Non Surgical Root Canal Retreatment","Effect Of Phytotherapeutics As Intracanal Medication On Postoperative Pain And Flare up Incidence In Non Surgical Root Canal Retreatment. (Randomized Clinical Trial)","Inclusion Criteria:\n\n* Failed previously performed endodontic treatment of single-rooted teeth.\n* Presence of a periapical lesion ranging from 1 mm to 2 mm in diameter.\n* Teeth with complete root formation.\n* Teeth without evidence of external or internal root resorption.\n\nExclusion Criteria:\n\n* Pregnant females.\n* Patients with uncontrolled systemic diseases.\n* Patients currently under antibiotic or analgesic administration.\n* Patients presenting with facial swelling.\n* Teeth not indicated for endodontic retreatment (e.g., poor oral hygiene, mobile teeth, or recessed teeth).",true,"ALL",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","The primary objective of this randomized clinical trial is to evaluate and compare the effectiveness of two natural, herbal-based intracanal medications-Propolis and Green Tea Polyphenolics (EGCG)-against the conventional Calcium Hydroxide in reducing postoperative pain and the incidence of flare-ups during non-surgical root canal retreatment.\n\nPostoperative pain is a common complication in endodontics, particularly in retreatment cases where complex bacterial environments and procedural challenges increase the risk of discomfort and acute flare-ups. While Calcium Hydroxide is the traditional gold standard due to its antimicrobial properties, natural phytotherapeutics like Propolis and Green Tea are being investigated for their potent anti-inflammatory, antioxidant, and antibacterial benefits, which may offer superior biocompatibility and symptomatic relief.\n\nForty patients requiring endodontic retreatment of single-rooted teeth will be randomly assigned to one of three groups:\n\nGroup I (Control): Receives Calcium Hydroxide paste.\n\nGroup II: Receives Propolis-based medication.\n\nGroup III: Receives Green Tea Polyphenolic-based medication.\n\nThe study follows a two-visit protocol. During the first visit, the previous root canal filling is removed, the canal is cleaned and shaped, and the assigned medication is placed. Postoperative pain will be assessed using a Visual Analog Scale (VAS) at 6, 12, 24, 48, 72 hours, and 7 days. Flare-up incidence (sudden severe pain or swelling) will also be monitored. In the second visit, the medication is removed, and the canal is permanently sealed using a bioceramic sealer and gutta-percha. The results will help determine if these herbal alternatives can provide a more comfortable treatment experience for patients undergoing root canal retreatment.",[26,27,28],"Postoperative Pain","Flare Up, Symptom","Flare up",[30,31,32,33,34,35],"postoperative pain","flare up","intra-canal medication","calcium hydroxide","propolis","Green Tea Polyphenolics","NOT_YET_RECRUITING","2026-05-05",{"date":39,"type":40},"2026-05-11","ACTUAL",{"date":42,"type":20},"2026-07",{"date":44,"type":20},"2027-02",{"name":46,"class":47},"Minia University","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100598452","postoperative-pain-and-flare-up-rates-in-diabetic-type-ii-patients-following-the-use-of-bioceramic-intracanal-medication-100598452","NCT07071675","Postoperative Pain and Flare-Up Rates in Diabetic Type II Patients Following The Use of Bioceramic Intracanal Medication","Postoperative Pain and Flare-Up Incidence Following the Use of Bio Ceramic Based Intra-Canal Medication in Diabetic Type II Patients (A Randomized Clinical Trial)","Inclusion Criteria:\n\n* Patients with controlled diabetes mellitus type II.\n* Necrotic single rooted teeth:\n\n  * with periapical lesion ranging (1-2mm) in diameter.\n  * with complete root formation.\n  * Without calcified root canals.\n  * Without root caries.\n  * Without external or internal root resorption.\n  * Without anatomical abnormalities such as fusion.\n\nExclusion Criteria:\n\n* Pregnant females.\n* Patients with other systemic diseases in combination with diabetes mellitus.\n* Patients under antibiotic or analgesic administration.\n* Patients with facial swelling.\n* Teeth that are not indicated for endodontic treatment: bad oral hygiene, mobile teeth, or recessed teeth.\n* Previously endodontically treated teeth.\n* Teeth with sinus tract.",{"count":56,"type":20},56,[23],"The goal of this randomized clinical trial is to evaluate the Postoperative Pain and Flare-Up incidence following the use of Bio-Ceramic Based Intra-Canal Medication in Diabetic type II Patients compared to the Calcium Hydroxide based Intra-canal medicament.\n\nThe main questions it aims to answer are:\n\n1. Is there any difference between using the two intracanal medicaments in the aspects of postoperative pain and flare-up incidence in diabetic type II patients?\n2. Do intracanal medications reduce postoperative pain and flare-up incidence in diabetic type II patients?\n\nParticipants will be divided into two groups:\n\n( both groups will receive root canal treatment in single rooted teeth) then: First group: will receive \"Calcium Hydroxide based\" intracanal medicament Second group: will receive \"Bio-Ceramic Based\" intracanal medicament\n\nPostoperative pain will be assessed using:\n\n* visual analog scale (VAS), A scale from (0 to 10) where \"0\" means no pain and \"10\" means a severe pain that has never faced before.\n* Patients will be contacted by phone at 6, 12, 24, 48, 72 hours and 7 days after the first visit to collect the postoperative pain data.\n\nFlare-up is assessed:\n\n\\- by asking the patient to notify the investigator if any sudden severe pain or swelling takes place.",[26,27,28,60],"Diabete Type 2",[30,31,62,63,64,33],"diabetes type II","Intra-Canal medication","bioceramic","2025-07-16",{"date":67,"type":40},"2025-07-20",{"date":69,"type":20},"2025-09-01",{"date":71,"type":20},"2026-09",{"name":46,"class":47},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100599415","impact-of-integrating-two-nano-based-irrigants-with-two-activation-techniques-in-treatment-of-teeth-with-acute-pulpitis-on-postoperative-pain-and-flare-up-incidence-100599415","NCT07084194","Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence","Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence: A Randomized Clinical Study","Inclusion Criteria:\n\n* Age 18-60 (adults only)\n* multiple-rooted with multiple root canal.\n* Permanent teeth with mature apex and complete root formation.\n* Without root caries.\n* Tooth must be restorable.\n* Without anatomical abnormalities such as fusion.\n* Healthy patient category I according to ASA.\n* Vital tooth, with acute irreversible pulpitis and without peri-apical periodontitis.\n* No periapical radiolucency.\n* Consent Patients for who consent to participate and attend follow-up appointments.\n\nExclusion Criteria:\n\n* single root canals or double root.\n* Root canal calcifications.\n* Root resorption or fracture.\n* Previously root canal treated teeth.\n* immunocompromised patients.\n* Pregnant females\n* Patients with systemic diseases as diabetic or hypertension patients.\n* Patients with facial swelling.\n* patients who use analgesics or antibiotics within 48-72 hours.\n* Allergy to any materials used (e.g., irrigants or anesthetics).\n* psychiatric illness\n* Teeth that are not indicated for endodontic treatment: bad oral hygiene, mobile teeth, or recessed teeth.\n* Previously endodontically treated teeth.\n* Teeth with sinus tract.",{"count":81,"type":20},64,[23],"This study aimed to evaluate and compare impact of integrating passive ultrasonic activation and laser activation with nano-chitosan and aloe vera in terms of postoperative pain and flare-up incidence in a randomized clinical trial.",[26,28,27],[30,31,86,87,88,89],"nano-technology","irrigation","chitosan","aloe-vera",{"date":91,"type":40},"2025-07-24",{"date":93,"type":20},"2025-09-10",{"date":95,"type":20},"2026-08-10",{"name":46,"class":47}]