[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"flexor-tendon-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:flexor-tendon-injury":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,79,109,137],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100580365","registry-randomized-comparison-of-rehabilitation-regimens-after-flexor-tendon-injury-in-the-thumb-100580365",false,"NCT06836349","Registry-randomized Comparison of Rehabilitation Regimens After Flexor Tendon Injury in the Thumb","Registry-randomized Comparison of Rehabilitation Regimens After Flexor Pollicis Longus Injury in the Thumb","Inclusion Criteria:\n\nComplete laceration of the thumb flexor tendon (Flexor Pollicis Longus; FPL) within zone 1 and 2.\n\nAge over 15 years. Minors (\\\u003C18 years) are considered to have sufficient maturity to understand the implications of the research.\n\nSwedish-speaking \u002F able to understand spoken and written Swedish. Surgery performed within 14 days from the time of injury.\n\nExclusion Criteria:\n\nTendon injury with a defect requiring tendon grafting. Another complete tendon injury in the same hand. Extensive associated injuries, such as fracture, vascular injury with circulatory impairment, large skin defect, or preoperative signs of infection. Patient deemed unsuitable for early active motion therapy due to factors such as lack of cooperation, cognitive impairment, or substance abuse issues.\n\nPatient declines follow-up in the HAKIR quality registry. Wound infection making early active motion therapy inappropriate.","ALL","15 Years",{"count":19,"type":20},380,"ESTIMATED","INTERVENTIONAL",[23],"NA","Flexor tendon injuries in the thumb occur across all ages and genders. Each year, approximately 400 patients undergo surgery for a flexor tendon injury in Sweden. These injuries are exclusively treated at one of the seven specialized hand surgery clinics, as the surgery is technically demanding, and postoperative rehabilitation is critical, specialized, and requires expertise from hand therapists. To prevent tendon adhesions and stiffness in the thumb or fingers, controlled active motion therapy is usually initiated within a few days after surgery. Studies on finger flexor tendon injuries have shown that early active movement therapy leads to better mobility compared to immobilization. Consequently, early active training is now the standard treatment following flexor tendon repair. However, during postoperative rehabilitation, the repaired flexor tendon may rupture, often necessitating revision surgery.\n\nThe rupture rate after flexor tendon repair in the thumb is approximately three times higher than in other fingers (10% vs. 3%). While most studies on flexor tendon injuries focus on finger tendons, research on the outcomes of thumb flexor tendon injuries is limited. The biomechanics and anatomy of the thumb's flexor tendon differ significantly from those of finger tendons.\n\nThe objective of this study is to determine whether the rupture rate following thumb flexor tendon surgery can be reduced by immobilizing the thumb in a cast for four weeks postoperatively, compared to standard early active motion therapy, without negatively affecting joint mobility and thumb strength. Additionally, the study will evaluate patient-reported outcomes one year post-surgery for both rehabilitation regimens (immobilization vs. mobilization).\n\nThis study is a registry-randomized clinical trial (RRCT) involving five hand surgery clinics in Sweden. Data following randomization between the two rehabilitation protocols will be collected through follow-up in the Swedish National Hand Surgery Quality Registry (HAKIR).",[26,27,28,29],"Flexor Tendon Injury","Rehabilitation Program","Flexor Tendon Rupture","Thumb Injury",[31,32,33,34,35,36],"Flexor pollicis longus injury","RRCT","Early active motion","flexor tendon injury","Thumb","Immobilisation","RECRUITING","2026-05-31",{"date":40,"type":41},"2026-06-03","ACTUAL",{"date":43,"type":41},"2025-05-01",{"date":45,"type":20},"2031-12-31",{"name":47,"class":48},"Karolinska Institutet","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100637720","comparing-two-skin-incisions-for-flexor-tendon-repair-100637720","NCT07596017","Comparing Two Skin Incisions for Flexor Tendon Repair","Prospective Randomized Controlled Trial to Compare Bruner Incision With Modified Midlateral Bruner Incision for Flexor Tendon Repair","Inclusion Criteria:\n\n* flexor tendon injury in the hand in zone 2\n\nExclusion Criteria:\n\n* complex injuries with fracture and\u002For skin defect\n* previous injury with functional deficit of the finger or the contralateral control finger\n* incapable to follow the training protocol for flexor tendon injuries\n* not proficient in swedish or english language\n* active substance abuse","18 Years",{"count":58,"type":20},70,[23],"Flexor tendons injuries in the fingers are common and often require surgery. During surgery, the surgeon needs to make an incision in the skin on the inside of the finger to access the damaged tendon.\n\nA comparison will be done between two types of skin incisions in the fingers:\n\n* Bruner zig-zag incision\n* modified Bruner midlateral zig-zag incision\n\nResearch questions:\n\n* Is there a difference in pain between the types of incisions?\n* Is there a difference in swelling between the types of incisions?\n* Does the type of incision affect the final result in term of motion?\n\nPatients who will undergo surgery for a flexor tendon injury in a finger will be asked to participate and be randomized to one type of skin incision. All other parts of the surgery will be carried out as usual.\n\nAn occupational therapist and nurse will measure swelling and motion. The participant will report pain on a daily basis.\n\nThe results for pain, swelling, motion in the fingers and sensibility in the fingers will be statistically compared between the two types of incisions on a group level.\n\nThe results of this study may lead to guidelines for skin incisions in acute flexor tendon repair, allowing patients to experience less pain and swelling. This may facilitate the rehabilitation program and improve the final functional outcome.",[26,62],"Incision, Surgical",[64,65,66,67,68],"incision","Bruner","midlateral incision","flexor tendon","modified Bruner","NOT_YET_RECRUITING","2026-05-19",{"date":72,"type":41},"2026-05-22",{"date":74,"type":20},"2026-06-01",{"date":76,"type":20},"2028-06-01",{"name":78,"class":48},"Sahlgrenska University Hospital",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":21,"phases":89,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":4},"100630558","effects-of-different-wrist-positions-in-dorsal-blocking-orthoses-after-flexor-tendon-repair-100630558","NCT07489235","Effects of Different Wrist Positions in Dorsal Blocking Orthoses After Flexor Tendon Repair","Effects of Different Wrist Positions in 3D-Printed Dorsal Blocking Orthoses on Clinical and Functional Outcomes After Zone I-II Flexor Tendon Repair: A Randomized Controlled Study","Inclusion Criteria:\n\n* Individuals aged 16 years and older\n* Patients who underwent zone I or II flexor tendon repair using at least a four--strand suture technique\n* Referral to physiotherapy within the first 10 days after surgery\n* Eligibility for a controlled early active mobilization protocol\n* Ability to understand and complete Turkish assessment questionnaires\n* Adequate cognitive function (Montreal Cognitive Assessment score \\>21)\n* Voluntary participation with written informed consent\n\nExclusion Criteria:\n\n* Thumb tendon repairs\n* Multiple or complex injuries (e.g., concomitant peripheral nerve injury, fractures requiring immobilization, joint dislocation, extensor tendon injury)\n* Active infection\n* Severe edema preventing orthosis use\n* Dermatological conditions or allergies preventing orthosis application\n* Systemic diseases that may affect rehabilitation (e.g., diabetes mellitus, -peripheral neuropathy, stroke, advanced rheumatoid arthritis)\n* Pre-existing wrist pain or deformity prior to injury\n* Inability to attend follow-up assessments\n* Non-compliance with the home exercise program","16 Years",{"count":88,"type":20},64,[23],"This randomized controlled study aims to compare the effects of three different wrist positions (30° extension, neutral, and 30° flexion) used in dorsal blocking orthoses during early active mobilization after zone I-II flexor tendon repair. A total of 54 patients will be randomly assigned into three groups. All participants will receive the same rehabilitation protocol. Clinical and functional outcomes including total active motion, pain, complications, functional status, and orthosis satisfaction will be evaluated at 6, 8, and 12 weeks by a blinded assessor.",[26,92],"Tendon Injury - Hand",[67,94,95,96,97,98,99],"orthosis","splint","3D printing","therapy","rehabilitation","immobilization","2026-03-28",{"date":102,"type":41},"2026-04-02",{"date":104,"type":20},"2026-04-20",{"date":106,"type":20},"2028-08-06",{"name":108,"class":48},"Sedanur Güngör",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":118,"phases":4,"briefSummary":119,"conditions":120,"keywords":124,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":4},"100622328","evaluation-of-eight-strand-flexor-tendon-repair-without-splinting-100622328","NCT07382193","Evaluation of Eight-Strand Flexor Tendon Repair Without Splinting","Evaluation of the Eight - Strand Repair of Flexor Tendon Injuries Without Splinting a Prospective Cohort Study","Inclusion Criteria:\n\n* Adult patients (18+ years).\n* Single or multiple clean-cut flexor tendon injuries.\n* Primary repair performed within 2 weeks.\n* Patients with concurrent digital nerve injuries will include if the nerve could be directly repaired.\n\nExclusion Criteria:\n\n* Crush or avulsion injuries.\n* Associated fractures or neurovascular compromise.\n* Recurrent or chronic tendon injuries.",{"count":117,"type":20},40,"OBSERVATIONAL","This prospective cohort study evaluates functional outcomes of primary eight-strand flexor tendon repair in zone II without postoperative splinting in 40 adults (≥18 years) at Assiut University Hospitals. Patients undergo wide-awake local anesthesia no tourniquet (WALANT) surgery followed by immediate gentle active motion. Primary outcome: total active motion via Strickland score at 6 weeks and 6 months. Secondary: grip strength, DASH score, patient satisfaction.",[26,121,122,123],"Splints","Flexor Tendon Repair","Flexor Tendon",[125,126,127],"Eight-strand repair","Flexor tendon injury","no splint","2026-01-26",{"date":130,"type":41},"2026-02-02",{"date":132,"type":20},"2026-03",{"date":134,"type":20},"2027-04",{"name":136,"class":48},"Assiut University",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":21,"phases":147,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":159},"100604671","task-oriented-exercises-and-mirror-therapy-after-flexor-tendon-repair-100604671","NCT07152548","Task-oriented Exercises and Mirror Therapy After Flexor Tendon Repair","Impact of Task-oriented Exercises and Mirror Therapy on Hand Functions Post Flexor Tendon Repair","Inclusion Criteria: - Ages of patients will range from 18 to 45 years. - All patients were working individuals before injury. - All patients will undergo zones of flexor tendon primary direct repair technique. - All patients will be referred by a surgeon before starting the study procedure. - All patients will enter the study having their informed consent. Exclusion Criteria: - Patients with associated vascular injuries requiring arterial repair. - Patients with associated soft tissue loss. - Patients with associated nerve injuries or bone fractures. - Patients with preexisting problems limiting joint motion. - Patients with tendon injuries in both hands. - Patients with diminished cognitive capacity. - Patients with a history of previously failed repair.","45 Years",{"count":146,"type":20},66,[23],"The main objective of the study is to explore the effect of intervention with task-oriented exercises and mirror therapy on the outcomes of hand function post flexor tendon repair.",[26],"2025-09-10",{"date":152,"type":41},"2025-09-16",{"date":154,"type":20},"2025-09-15",{"date":156,"type":20},"2026-09-15",{"name":158,"class":48},"Cairo University",1]