[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fluid-accumulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fluid-accumulation":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,81,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100643525","dry-weight-reduction-intervention-via-extra-ultrafiltration-100643525",false,"NCT07637110","Dry Weight Reduction Intervention Via Extra Ultrafiltration","DRIVE-UF","Inclusion Criteria:\n\n* Receiving thrice weekly in-center hemodialysis treatments for end stage kidney disease for at least four weeks and clinical suspicion of volume excess based on either:\n\n  1. Persistent hypertension defined by three consecutive pre-dialysis systolic blood pressures ≥140 mmHg or three consecutive pre-dialysis systolic blood pressures 130-140 mmHg plus use of at least two anti-hypertensive medications that can be tapered.\n\n     OR\n  2. Symptoms of congestion defined by a 12-item Kidney Modified Kansas City Cardiomyopathy Questionnaire (KM-KCCQ) score \\\u003C75.\n\n     Exclusion Criteria:\n* Age \\\u003C18 years\n* Receiving hemodialysis treatments for acute kidney injury\n* Receiving hemodialysis treatments for less than four weeks\n* Planned switch to peritoneal or home dialysis within next three months\n* Current or planned incremental hemodialysis (less than 3 treatments per week)\n* Current or planned intensive hemodialysis (four or more treatments per week)\n* Scheduled kidney transplantation\n* Major cardiovascular or bleeding event within previous 90 days\n* Receiving chemotherapy or radiation treatment for cancer\n* History of cirrhosis with ascites\n* Inability to complete 24-hour ambulatory blood pressure measurement\n* Wheelchair dependance or other inability to complete six-minute walk test\n* Pre-dialysis systolic blood pressure \\\u003C100 mmHg\n* Scheduled use of midodrine with hemodialysis treatments\n* History of non-adherence with dialysis treatments\n* Pregnancy\n* Institutionalized\n* Current or pending enrollment in hospice care\n* Inappropriate for enrollment based on investigator or nephrologist discretion","ALL","18 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"NA","Most patients who receive hemodialysis treatments have excess fluid in their body that has slowly built up over the course of kidney disease. This extra fluid is the main cause of high blood pressure in dialysis and leads to stress on the heart and lungs.that causes debilitating symptoms and frequent hospitalizations.\n\nThis trial will test whether a focused program of 4 or 8 weeks of extra ultrafiltration treatments can remove most of this extra fluid. We believe that getting rid of large amounts of extra fluid will result in sustained improvements in blood pressure and symptoms. Ultrafiltration is a gentler type of dialysis that removes fluid but does not clean the blood.",[26,27,28],"Fluid Accumulation","Blood Pressure Management","End Stage Renal Disease (ESRD)",[30,31,32,33,34,35,36,37],"ESRD","Volume overload","Fluid accumulation","End stage renal disease","Congestion","Chronic dialysis","Blood Pressure (High)","Blood pressure management","NOT_YET_RECRUITING","2026-06-03",{"date":41,"type":42},"2026-06-09","ACTUAL",{"date":44,"type":20},"2026-06",{"date":46,"type":20},"2030-11",{"name":48,"class":49},"University of Washington","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100629395","fluid-vs-weight-24-hour-balance-100629395","NCT07474116","Fluid vs Weight 24 Hour Balance","More Than a Number: Why Daily Fluid Balance Alone Should Not Guide Clinical Decision-Making in the ICU: A Prospective Observational Study","Bilance24","Inclusion criteria:\n\n\\- adult (age ≥ 18 years) patients admitted to intensive care unit.\n\nExclusion criteria:\n\n* age \\\u003C18 years\n* pregnancy\n* inability to obtain standardized daily body weight using the ICU bed scale\n* incomplete 24-hour fluid balance data preventing calculation of cumulative balance\n* absence of an indwelling urinary catheter, extracorporeal life support (ECMO) or other extracorporeal circulation\n* open abdomen\n* open chest\n* lavage or irrigation procedures during the assessment interval\n* surgery during the assessment\n* massive bleeding\n* diarrhoea during the assessment period\n* massive transfusion protocol during the 24-hour interval and ICU stay shorter than 24 hours.",{"count":60,"type":20},55,"OBSERVATIONAL","Daily Fluid Balance vs Weight Change",[64,65,66,26],"Weight Bias","Weight Change","Fluid Balance",[68,69,70,71],"fluid balance","weight change","fluid accumulation","fluid deresuscitation","2026-03-11",{"date":74,"type":42},"2026-03-16",{"date":76,"type":20},"2026-05-01",{"date":78,"type":20},"2026-09-01",{"name":80,"class":49},"Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":21,"phases":91,"briefSummary":93,"conditions":94,"keywords":99,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":5},"100607479","phase-4-creep-and-maintenance-fluid-sodium-chloride-administration-reduction-in-critically-ill-adults-100607479","NCT07189091","CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS","Effect of Reduced Sodium Chloride in Fluid Creep and Maintenance Fluids in Critically Ill Adults: A Randomized Controlled Trial","CRUSADERS","Inclusion criteria\n\n1. At least 18 years of age\n2. Patients who are admitted to the ICU for medical or surgical emergencies, including complications of elective surgery\n3. The treating physician expects the patient will still require ICU care in two days, indicating a severe or complex condition at enrollment\n4. The patient is expected to receive at least 300 mL of fluid creep or at least 1 liter of maintenance fluid according to study-arm during the first 24h after inclusion\n\nExclusion Criteria:\n\n1. A contraindication to hypotonic fluids due to risk of brain edema (including traumatic brain injury, major stroke, intracranial\u002Fsubarachnoid hemorrhage, meningoencephalitis, intracranial malignancies…), with the timing and clinical judgment left at the discretion of the treating physician.\n2. Hyponatremia below 131 mmol\u002FL at admission\n3. Admission solely for treatment of fluid accumulation due to cardiac decompensation, without other acute medical conditions requiring ICU-level care. Note: Patients with heart failure as a comorbidity, those on chronic diuretic therapy, or presenting with edema\u002Fbilateral lung infiltrates due to other conditions (e.g., sepsis, pneumonia) are not excluded.\n4. Patient's death is deemed imminent and inevitable, admission for palliative care or admission solely for organ donation\n5. Patient receiving chronic renal replacement therapy\n6. Patients referred after a stay of more than 24 hours in another ICU\n7. Patients randomized in CRUSADERS before\n8. Patient is co-enrolled in an unapproved concomitant ICU-trial or in any trial with an intervention that affects fluid administration or fluid balance\n\nAdditional exclusion criteria for the SALADIN nested substudy\n\n1. Patients expected to require renal replacement therapy within 24 hours\n2. Increased insensible fluid losses: burns, extensive wounds or skin defects or massive diarrhea,…\n3. Patients without a urine catheter\n4. Patients expected to require bladder irrigation within 24 hours\n5. Patients on chronic treatment with loop or thiazide diuretics (including combination preparations)",{"count":90,"type":20},640,[92],"PHASE4","This study is enrolling adult patients who require a prolonged stay in the intensive care unit (ICU). These patients often receive large amounts of intravenous fluids, which can contain more salt (sodium and chloride) than the body normally needs. Extra salt and water can build up in the body and may delay recovery.\n\nThe study will test two strategies:\n\nFluid creep: These are fluids used to dilute medications or keep intravenous lines open. Usually, the choice is based on habit. In the intervention group, a salt-free glucose 5% solution will be used (if the responsible pharmacist confirms it is compatible with the medication).\n\nMaintenance fluids: These fluids cover daily needs for water and electrolytes. In the intervention group, a lower-salt solution (NaCl 0.3% in glucose 3.3%) will be given, with volume decided by the treating physician.\n\nThe comparison group will receive usual care: NaCl 0.9% (commonly called \"normal saline\") for fluid creep, and an isotonic solution (PlasmaLyte) for maintenance fluids.\n\nThe main outcome is the number of days patients are alive and free of life support (such as ventilator or dialysis) during the first 90 days. Other outcomes include abnormal sodium, chloride, or glucose levels, fluid balance and need for diuretics, kidney injury, use of dialysis, time on the ventilator, survival, and length of ICU and hospital stay.\n\nA smaller substudy (SALADIN) will measure in detail how the body handles sodium, chloride, and water using additional calculation on blood tests, urine collections, body weight, and bioimpedance analysis",[95,26,96,97,98],"Critical Care, Intensive Care","Fluid and Electrolyte Imbalance","Critical Illness","Fluid Balance Outcomes",[100,101,97,102,103,104,105,106,107,108,109,110,111,112,113,114,115],"Intensive Care Unit","Critically Ill","Intravenous fluids","Maintenance fluids","Fluid Creep","Sodium chloride reduction","Salt reduction","Hypotonic fluids","Saline (NaCl 0.9%)","Fluid balance","Electrolyte disorders","Glycemic control","Acute kidney injury","Mechanical ventilation","Organ support","Hyponatremia","RECRUITING","2026-01-30",{"date":119,"type":42},"2026-02-03",{"date":121,"type":42},"2025-10-07",{"date":123,"type":20},"2028-07-30",{"name":125,"class":49},"University Hospital, Antwerp",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":134,"targetDuration":136,"studyType":61,"phases":4,"briefSummary":137,"conditions":138,"keywords":141,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":152},"100535960","fluid-administration-and-fluid-accumulation-in-the-intensive-care-unit-100535960","NCT06258616","Fluid Administration and Fluid Accumulation in the Intensive Care Unit","Fluid Administration and Fluid Accumulation in the Intensive Care Unit (FLUID-ICU) - an International Inception Cohort Study","FLUID-ICU","Inclusion Criteria:\n\n* Acute admission to the ICU during the 14-day inception period.\n* Adults (≥ 18 years).\n\nExclusion Criteria:\n\n* Patients previously included in the FLUID-ICU study.\n* Patients with major burns (≥ 10% of body surface)",{"count":135,"type":20},1000,"90 Days","The goal of this international inception cohort study is to describe fluid administration during admittance to the intensive care unit (ICU), and provide contemporary epidemiological data on fluid accumulation, risk factors, management and outcome in critically ill adult patients.",[26,139,140],"Fluid Therapy","Fluid Overload",[140,26,142],"Fluid Administration","2025-02-05",{"date":145,"type":42},"2025-02-06",{"date":147,"type":42},"2024-04-01",{"date":149,"type":20},"2025-09",{"name":151,"class":49},"Nordsjaellands Hospital",21]