[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fluid-and-electrolyte-imbalance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fluid-and-electrolyte-imbalance":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,89,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100554485","volume-kinetics-of-fluid-resuscitation-in-early-sepsis-100554485",false,"NCT06499701","Volume Kinetics of Fluid Resuscitation in Early Sepsis","Volume Kinetics of Fluid Resuscitation With 30 ml\u002Fkg Ringer Lactate in Early Sepsis","Inclusion Criteria:\n\nA diagnosis of sepsis, as defined by the Sepsis-3 criteria and exhibiting sepsis-induced hypoperfusion prior to the administration of adequate volume resuscitation:\n\n* hypotension requiring norepinephrine to maintain a mean arterial blood pressure (MAP) either predefined by the clinician or at 65 mm Hg or higher and\u002For\n* a serum lactate level \\>2 mmol\u002FL (18mg\u002FdL) and\u002For\n* acute oliguria defined as urine output \\\u003C0.5mL\u002Fkg\u002Fhr and\u002For\n* mottled skin and\u002For\n* capillary refill time \\> 3 seconds.\n\nExclusion Criteria:\n\n* Administration of at least 1 L of IV fluid in the last 6 hours prior to screening. All crystalloids, colloids and blood products that the patient has received are counted.\n* Known pregnancy.\n* Competing causes of lactic acidosis including: seizures within 3 hours of enrollment, use of linezolid or metformin or anti-retrovirals at the time of enrollment, carbon monoxide or cyanide poisoning, highly suspected or known ischemic bowel, and known mitochondrial disorders.\n* End-stage renal disease that requires chronic dialysis.\n* Concurrent haemorrhagic or obstructive shock.\n* Increased risk of fluid intolerance:\n\n  * Echocardiographic evidence of moderate or severe left ventricular systolic dysfunction.\n  * Echocardiographic evidence of moderate or severe right ventricular systolic dysfunction.\n  * Hypoxemia index \\\u003C 200 mmHg or sonographic evidence of bilateral B or C profile.\n  * Abdominal compartment syndrome.\n* Post-cardiac arrest.","ALL","18 Years",{"count":19,"type":20},15,"ESTIMATED","OBSERVATIONAL","The recommended volume resuscitation for patients with early sepsis-induced hypoperfusion is at least 30 ml\u002Fkg of crystalloid administered within the first three hours. However, this standardized approach does not account for individual patient variability and lacks personalization. Additionally, the effects of administering 30 ml\u002Fkg on intercompartmental fluid shifts between the plasma and interstitial compartments remain unclear. This study aims to describe the volume kinetics of administering 30 ml\u002Fkg of Ringer's Lactate in patients with early sepsis-induced hypoperfusion within the first three hours.",[24],"Fluid and Electrolyte Imbalance",[26,27,28,29,30],"volume kinetics","sepsis","volume resuscitation","crystalloid","Ringer's Lactate","RECRUITING","2026-03-16",{"date":34,"type":35},"2026-03-18","ACTUAL",{"date":37,"type":35},"2024-06-19",{"date":39,"type":20},"2026-07-30",{"name":41,"class":42},"Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu","OTHER",2,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":63,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":5},"100607479","phase-4-creep-and-maintenance-fluid-sodium-chloride-administration-reduction-in-critically-ill-adults-100607479","NCT07189091","CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS","Effect of Reduced Sodium Chloride in Fluid Creep and Maintenance Fluids in Critically Ill Adults: A Randomized Controlled Trial","CRUSADERS","Inclusion criteria\n\n1. At least 18 years of age\n2. Patients who are admitted to the ICU for medical or surgical emergencies, including complications of elective surgery\n3. The treating physician expects the patient will still require ICU care in two days, indicating a severe or complex condition at enrollment\n4. The patient is expected to receive at least 300 mL of fluid creep or at least 1 liter of maintenance fluid according to study-arm during the first 24h after inclusion\n\nExclusion Criteria:\n\n1. A contraindication to hypotonic fluids due to risk of brain edema (including traumatic brain injury, major stroke, intracranial\u002Fsubarachnoid hemorrhage, meningoencephalitis, intracranial malignancies…), with the timing and clinical judgment left at the discretion of the treating physician.\n2. Hyponatremia below 131 mmol\u002FL at admission\n3. Admission solely for treatment of fluid accumulation due to cardiac decompensation, without other acute medical conditions requiring ICU-level care. Note: Patients with heart failure as a comorbidity, those on chronic diuretic therapy, or presenting with edema\u002Fbilateral lung infiltrates due to other conditions (e.g., sepsis, pneumonia) are not excluded.\n4. Patient's death is deemed imminent and inevitable, admission for palliative care or admission solely for organ donation\n5. Patient receiving chronic renal replacement therapy\n6. Patients referred after a stay of more than 24 hours in another ICU\n7. Patients randomized in CRUSADERS before\n8. Patient is co-enrolled in an unapproved concomitant ICU-trial or in any trial with an intervention that affects fluid administration or fluid balance\n\nAdditional exclusion criteria for the SALADIN nested substudy\n\n1. Patients expected to require renal replacement therapy within 24 hours\n2. Increased insensible fluid losses: burns, extensive wounds or skin defects or massive diarrhea,…\n3. Patients without a urine catheter\n4. Patients expected to require bladder irrigation within 24 hours\n5. Patients on chronic treatment with loop or thiazide diuretics (including combination preparations)",{"count":53,"type":20},640,"INTERVENTIONAL",[56],"PHASE4","This study is enrolling adult patients who require a prolonged stay in the intensive care unit (ICU). These patients often receive large amounts of intravenous fluids, which can contain more salt (sodium and chloride) than the body normally needs. Extra salt and water can build up in the body and may delay recovery.\n\nThe study will test two strategies:\n\nFluid creep: These are fluids used to dilute medications or keep intravenous lines open. Usually, the choice is based on habit. In the intervention group, a salt-free glucose 5% solution will be used (if the responsible pharmacist confirms it is compatible with the medication).\n\nMaintenance fluids: These fluids cover daily needs for water and electrolytes. In the intervention group, a lower-salt solution (NaCl 0.3% in glucose 3.3%) will be given, with volume decided by the treating physician.\n\nThe comparison group will receive usual care: NaCl 0.9% (commonly called \"normal saline\") for fluid creep, and an isotonic solution (PlasmaLyte) for maintenance fluids.\n\nThe main outcome is the number of days patients are alive and free of life support (such as ventilator or dialysis) during the first 90 days. Other outcomes include abnormal sodium, chloride, or glucose levels, fluid balance and need for diuretics, kidney injury, use of dialysis, time on the ventilator, survival, and length of ICU and hospital stay.\n\nA smaller substudy (SALADIN) will measure in detail how the body handles sodium, chloride, and water using additional calculation on blood tests, urine collections, body weight, and bioimpedance analysis",[59,60,24,61,62],"Critical Care, Intensive Care","Fluid Accumulation","Critical Illness","Fluid Balance Outcomes",[64,65,61,66,67,68,69,70,71,72,73,74,75,76,77,78,79],"Intensive Care Unit","Critically Ill","Intravenous fluids","Maintenance fluids","Fluid Creep","Sodium chloride reduction","Salt reduction","Hypotonic fluids","Saline (NaCl 0.9%)","Fluid balance","Electrolyte disorders","Glycemic control","Acute kidney injury","Mechanical ventilation","Organ support","Hyponatremia","2026-01-30",{"date":82,"type":35},"2026-02-03",{"date":84,"type":35},"2025-10-07",{"date":86,"type":20},"2028-07-30",{"name":88,"class":42},"University Hospital, Antwerp",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":54,"phases":100,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":4},"100603866","bia-guided-vs-conventional-fluid-resuscitation-in-icu-patients-100603866","NCT07142083","BIA-Guided vs. Conventional Fluid Resuscitation in ICU Patients","Comparison of the Effects of Bioelectrical Impedance Analysis-Guided Versus Conventional Fluid Resuscitation Strategies on 28-Day Mortality in Intensive Care Unit Patients After Major Surgery","BIA-FLUID","Inclusion Criteria:\n\n* Undergoing major surgery under general anesthesia(Major surgery defined as: vascular clamping or organ ischemia, intraoperative blood loss \\>1000 mL, need for \\>10 mcg\u002Fmin norepinephrine infusion, surgery duration \\>4 hours, or requirement for perioperative blood transfusion)\n* Admission to the intensive care unit (CU) after surgery\n* Informed consent obtained\n\nExclusion Criteria:\n\n* Refusal to participate or failure to provide informed consent\n* Undergoing laparoscopic or emergency surgery\n* Severe major organ dysfunction:Acute kidney injury stage 2 or 3 (KDIGO 2012) • Acute or chronic liver failure (ALT \\>3x or Child A-C cirrhosis\n* Conditions preventing accurate BIA measurement: • Limb amputation • Metallic cardiac or joint prostheses • Pacemakers or intracardiac stents\n* Body mass index \\>35 kg\u002Fm or \\\u003C 18 kg\u002Fm\n* Contraindications to lactated Ringer's solution (e.g. hypercalcemia, increased intracranial pressure)","60 Years",{"count":99,"type":20},80,[101],"NA","In this study aimed to compare bioelectrical impedance analysis (BIA)-guided fluid resuscitation with conventional fluid management strategies in patients admitted to the intensive care unit (ICU) following major surgery. The primary objective is to evaluate whether BIA-guided fluid therapy reduces 28-day mortality by optimizing fluid balance and preventing volume-related complications. Secondary outcomes include cumulative fluid balance, ICU and hospital length of stay, duration of mechanical ventilation, and need for vasopressor or inotropic support. This study is expected to provide evidence for the clinical utility and applicability of BIA in guiding postoperative fluid therapy in critically ill patients.",[24,104],"Anesthesia",[106,107,108,109],"Bioelectrical impedance analysis","Intensive Care","Fluid Resuscitation","Postoperative Fluid Management","NOT_YET_RECRUITING","2025-09-01",{"date":113,"type":35},"2025-09-08",{"date":115,"type":20},"2025-09-15",{"date":117,"type":20},"2026-12-01",{"name":119,"class":42},"Ondokuz Mayıs University",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":16,"minAge":127,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":54,"phases":131,"briefSummary":132,"conditions":133,"keywords":136,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":146},"100456216","bio-impedance-monitoring-as-a-tool-to-assess-fluid-status-in-the-pediatric-surgical-patient-pedfluid-study-100456216","NCT05220709","Bio Impedance Monitoring as a Tool to Assess Fluid Status in the Pediatric Surgical Patient? (PedFluid Study)","Bio Impedance Monitoring as a Tool to Assess Fluid Status in the Pediatric Surgical Patient: Can we Measure a Fluid Shift","Inclusion Criteria:\n\n* Scheduled for elective surgery or investigation under general anesthesia\n* Day care or inpatient hospitalisation\n\nExclusion Criteria:\n\n* If sedation is needed instead of general anesthesia\n* Critically ill patients for urgent surgery\n* Patients who cannot lie still for performing correct measurements on the bio impedance monitor\n* No informed consent obtained","1 Month","16 Years",{"count":130,"type":20},100,[101],"The baseline infusion rate during surgery for pediatric patients still is the 'Holliday and Segar' rule (also known as the 4\u002F2\u002F1 rule) The question arises if this rule is not outdated, since it was calculated based on the caloric need of the pediatric population, calculated for cow milk. The study tends to validate the use of bio impedance measurements for registering fluid shifts in the pediatric surgical patients.",[24,134,135],"Body Weight Changes","Children, Only",[137],"bio impedance spectroscopy","2025-03-04",{"date":140,"type":35},"2025-03-05",{"date":142,"type":35},"2022-04-05",{"date":144,"type":20},"2026-05-31",{"name":88,"class":42},1]