[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fluid-balance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fluid-balance":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,55,88,117,145,173,194,219,240],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":4},"100619553","fluid-balance-guided-by-modified-venous-excess-ultrasonography-versus-standard-care-in-patients-with-acute-kidney-injury-receiving-continuous-renal-replacement-therapy-100619553",false,"NCT07346118","Fluid Balance Guided by Modified Venous Excess Ultrasonography Versus Standard Care in Patients With Acute Kidney Injury Receiving Continuous Renal Replacement Therapy","Fluid Balance Guided by Modified Venous Excess Ultrasonography Versus Standard Care in Patients With Acute Kidney Injury Receiving Continuous Renal Replacement Therapy: A Multicentre Randomised Controlled Trial","mVExUS-CRRT","Inclusion Criteria:\n\n* Adults (≥ 18 years of age)\n* Admitted to ICU\n* Acute kidney injury by KDIGO criteria\n* Initiated CRRT by at least one of the following indications for RRT initiation:\n* Serum potassium ≥ 6.0 mmol\u002FL, or\n* pH ≤ 7.20 or serum bicarbonate ≤ 12 mmol\u002FL, or\n* Evidence of severe respiratory failure, based on a PaO2\u002FFiO2 ≤ 200 and clinical perception of volume overload, or\n* Persistent severe AKI (sCr remains \\> 50% the value recorded at randomization) for \\> 72 hours from randomization\n* Participants giving informed consent\n\nExclusion Criteria:\n\n* Refuse to participate\n* Previous diagnosis of end-stage kidney disease (ESKD) currently on kidney replacement therapy\n* Kidney transplant recipient\n* Receive RRT before ICU admission within 90 days\n* Structural kidney diseases which will interfere with intrarenal doppler ultrasound e.g. renal artery stenosis, autosomal dominant polycystic kidney disease\n* Patients with previously known conditions that interfere with portal doppler assessment, namely liver cirrhosis, severe tricuspid regurgitation with structural heart disease or massive ascites.\n* Underlying disease process with a life expectancy less than 90 days\n* Pregnancy\n* Severe cardiac rhythm disturbances (tachyarrhythmia, supraventricular tachycardia)\n* Intra-cardiac shunts; Ventricle septal defect, patent foramen ovale, atrial septal defect\n* Aortic aneurysm\n* Intra-abdominal hypertension (intraabdominal pressure ≥20 mmHg)\n* Expected life expectancy \\\u003C48 hours\n* Receiving extracorporeal membrane oxygenation (ECMO)","ALL","18 Years",{"count":20,"type":21},126,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this randomised controlled trial is to compare the cumulative fluid balance over the first 72 h following inclusion guided by mVExUS versus standard of care in critically ill patients with acute kidney injury receiving CRKT . It will also compare the proportion of CRRT-related complications-including intradialytic hypotension and arrhythmias-between patients managed with mVExUS-guided fluid management and those receiving standard care.\n\nThe main questions it aims to answer are:\n\nDoes fluid removal rate guided by mVExUS will reduce cumulative fluid balance over the course of the first 72 h of CRRT in ICU patients compared to standard care\n\nParticipants will:\n\nGet fluid assessment by mVExUS protocol or a strandard care every 8 hours for 72 hours",[27,28,29,30,31,32,33],"AKI - Acute Kidney Injury","Fluid Balance","Acute Circulatory Failure","Continuous Renal Replacement Therapy (CRRT)","VExUS","Passive Leg Raising","Biomarkers \u002F Blood",[35,36,37,38,39,40,41,42],"Acute kidney injury","Fluid balance","Acute circulatory failure","Continuous kidney replacement therapy","mVExUS","Modified Venous Excess Ultrasound","Passive leg raising","Biomarker","NOT_YET_RECRUITING","2026-05-05",{"date":46,"type":47},"2026-05-07","ACTUAL",{"date":49,"type":21},"2026-07-01",{"date":51,"type":21},"2029-05-01",{"name":53,"class":54},"Chulalongkorn University","OTHER",{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":73,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":87},"100627052","measuring-fluid-buildup-in-cancer-patients-100627052","NCT07443618","Measuring Fluid Buildup in Cancer Patients","Monitoring of Oedema in Cancer Patients - A Pilot Study","Inclusion Criteria (Outpatient breast cancer patients with lymphoedema after radiotherapy):\n\n* Habile\n* Must be able to speak and read Danish\n* Has received\u002Fis receiving radiotherapy due to breast cancer within the last 6 months\n* Is being followed in the Oncology Outpatient Clinic at Aalborg University Hospital\n* Age ≥ 18 years\n* Visible lymphoedema in at least one upper extremity\n\nInclusion Criteria (Hospitalized cancer patients with peripheral oedema in one or both lower extremities after chemotherapy):\n\n* Habile\n* Must be able to speak and read Danish\n* Has received\u002Fis receiving chemotherapy due to cancer within the last 2 months\n* Hospitalised in the Oncology Ward at Aalborg University Hospital\n* Estimated length of hospital stay of at least 6 days\n* Age ≥ 18 years\n* Visible peripheral oedema in at least one lower extremity\n\nExclusion Criteria (both groups):\n\n* Pregnant or breastfeeding women\n* Amputated limb(s)\n* Pacemaker or implanted cardioverter-defibrillator due to risk of interference from the electrical signal\n* Metallic prostheses due to risk of interference with the device signal\n* Inability to lie still for the duration of the measurement interval (minimum 2 minutes at a time)\n* Inability to stand on a scale, i.e. permanently bedridden.\n* Inability to cooperate with urine collection\n* Receiving dialysis\n* Terminal illness",{"count":63,"type":21},46,"OBSERVATIONAL","The goal of this study is to improve the monitoring of fluid retention in cancer patients. The main question it aims to answer is: Can segmental bioelectrical impedance analysis be used to monitor local fluid retention (edema) in cancer patients? We will include:\n\n* Breast cancer patients with fluid and or lymph retention in one or both arms after radiotherapy (outpatients)\n* Cancer patients with fluid retention in one or both legs after chemotherapy (hospitalized)\n\nParticipants will:\n\n* Have measurements taken using bioelectrical impedance\n* Provide blood samples and 24-hour urine collection\n* Weight monitorering\n* Complete diet and fluid registration (inclusive enteral and parenteral)\n* Have clinical palpatory and measurement assessment of oedema.",[67,68,69,70,71,72,28],"Cancer","Oedema","Bioelectrical Impedance","Lymphoedema","Chemotherapy","Radiotherapy",[74,75,76],"Localized oedema in cancer","Bioelectrical impedance","Post radiation lymphoedema","RECRUITING","2026-04-28",{"date":80,"type":47},"2026-04-29",{"date":82,"type":47},"2026-02-01",{"date":84,"type":21},"2026-07-31",{"name":86,"class":54},"Jens Rikardt Andersen",1,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":98,"conditions":99,"keywords":103,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":4},"100629395","fluid-vs-weight-24-hour-balance-100629395","NCT07474116","Fluid vs Weight 24 Hour Balance","More Than a Number: Why Daily Fluid Balance Alone Should Not Guide Clinical Decision-Making in the ICU: A Prospective Observational Study","Bilance24","Inclusion criteria:\n\n\\- adult (age ≥ 18 years) patients admitted to intensive care unit.\n\nExclusion criteria:\n\n* age \\\u003C18 years\n* pregnancy\n* inability to obtain standardized daily body weight using the ICU bed scale\n* incomplete 24-hour fluid balance data preventing calculation of cumulative balance\n* absence of an indwelling urinary catheter, extracorporeal life support (ECMO) or other extracorporeal circulation\n* open abdomen\n* open chest\n* lavage or irrigation procedures during the assessment interval\n* surgery during the assessment\n* massive bleeding\n* diarrhoea during the assessment period\n* massive transfusion protocol during the 24-hour interval and ICU stay shorter than 24 hours.",{"count":97,"type":21},55,"Daily Fluid Balance vs Weight Change",[100,101,28,102],"Weight Bias","Weight Change","Fluid Accumulation",[104,105,106,107],"fluid balance","weight change","fluid accumulation","fluid deresuscitation","2026-03-11",{"date":110,"type":47},"2026-03-16",{"date":112,"type":21},"2026-05-01",{"date":114,"type":21},"2026-09-01",{"name":116,"class":54},"Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":126,"conditions":127,"keywords":131,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":4},"100618985","fluid-balance-in-acute-kidney-injury-in-critically-ill-patients-100618985","NCT07338734","Fluid Balance in Acute Kidney Injury in Critically Ill Patients","Fluid Balance During Early Hours of Acute Kidney Injury in Critically Ill Patients","Inclusion Criteria:\n\n* Adults aged 18 years or older admitted to the ICU.\n* Patients with no AKI at ICU admission.\n* AKI secondary to (prerenal cause-renal and post renal with manifestation of hypovolemia)-postoperative settings-On top of CKD up to Stage 111b-Compansated heart failure with indication of fluid therapy\n\nExclusion Criteria:\n\n* Patients with pre-existing end-stage renal disease requiring dialysis.\n* Patients with known chronic kidney disease stage 4 or higher.\n* ICU readmissions during the same hospitalization.\n* Patients who received renal replacement therapy before ICU admission\n* Patients with AKI with manifestation of over load as pulmonary edema- pulmonary embolism-Acute decompensated heart failure",{"count":125,"type":21},120,"This prospective observational cohort study evaluates if fluid balance in the first 48 hours of ICU admission is linked to acute kidney injury (AKI) in critically ill adults. Patients without AKI at entry will have fluids tracked hourly via charts, weights, and labs to assess AKI risk by KDIGO criteria within 7 days. Findings may guide better fluid management to lower AKI rates.",[28,128,129,130],"Acute Kidney Injury","Critically Ill Acute Kidney Injury","Critically Ill",[28,132,133,134,135],"acute kidney injury","AKI","critically ill","KDIGO criteria","2026-01-04",{"date":138,"type":47},"2026-01-14",{"date":140,"type":21},"2026-01",{"date":142,"type":21},"2027-02",{"name":144,"class":54},"Assiut University",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":151,"sex":17,"minAge":18,"maxAge":152,"enrollmentInfo":153,"targetDuration":4,"studyType":22,"phases":155,"briefSummary":156,"conditions":157,"keywords":158,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":87},"100609688","effects-of-a-glycerol-electrolyte-beverage-on-fluid-balance-in-healthy-euhydrated-men-and-women-100609688","NCT07217834","Effects of a Glycerol-Electrolyte Beverage on Fluid Balance in Healthy Euhydrated Men and Women","Inclusion Criteria:\n\n* Subject is male or female\n* If female, subject is not pregnant\n* Subject is 18-50 years of age, inclusive\n* Subject is at least recreationally active (engaged in light to moderate intensity, intermittent, or steady-state exercise at least 3 days per week for at least 30 min at a time)\n* Subject does not smoke (or has quit for at least 6 months)\n* Subject is not taking medication that may interfere with the study (e.g., diuretics, laxatives, weight loss drugs)\n* Subject has no health conditions that would interfere with the study (e.g. cardiovascular, renal, or metabolic diseases)\n* Subject is not allergic to fuji apple pear flavoring\n* Subject is not allergic to Stevia\n* Subject is willing to avoid alcohol consumption 24 hours prior to visits\n* Subject is willing to fast overnight (\\~8-10 hours) prior to visits\n* Subject is willing to refrain from vigorous exercise for 24 hours\n* Subject is willing to eat the exact same food the day prior to each study session.\n* Willing and able to provide signed informed consent to participate in the study and to comply with all study procedures and scheduled visits.\n\nExclusion Criteria:\n\n* Subject has participated in a clinical trial within the past 30 days\n* Subject has participated in any PepsiCo trial within past 3 months\n* Subject has a condition or is taking medication that the investigator believes would interfere with his\u002Fher ability to provide informed consent, comply with the study protocol, which might confound the interpretation of the study results, or put the person at undue risk\n* Subject is employed by, or has a parent, guardian, or other immediate family member employed by a company that manufactures any products that compete with any Gatorade product. If subject is unsure if a company would be considered a competitor to Gatorade, they will be asked to please let the study investigator know the name of the other company and the nature of their relationship to that company before they sign the informed consent.",true,"50 Years",{"count":154,"type":21},30,[24],"Glycerol and sodium are osmotically-active ingredients that promote fluid retention via renal water reabsorption. The purpose of this study is to compare the effects of a glycerol-electrolyte beverage on fluid balance in healthy euhydrated men and women",[28],[159,160,161,162],"hydration","electrolytes","glycerol","beverage","2025-10-13",{"date":165,"type":47},"2025-10-20",{"date":167,"type":47},"2025-10-01",{"date":169,"type":21},"2025-12-12",{"name":171,"class":172},"PepsiCo Global R&D","INDUSTRY",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":151,"sex":17,"minAge":18,"maxAge":152,"enrollmentInfo":179,"targetDuration":4,"studyType":22,"phases":181,"briefSummary":182,"conditions":183,"keywords":184,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":193},"100581758","effects-of-beverage-volume-glycerol-concentration-and-sodium-concentration-on-fluid-balance-in-healthy-euhydrated-men-and-women-at-rest-100581758","NCT06854471","Effects of Beverage Volume, Glycerol Concentration, and Sodium Concentration on Fluid Balance in Healthy Euhydrated Men and Women at Rest","Inclusion Criteria:\n\n* Subject is male or female\n* If female, subject is not pregnant\n* Subject is 18-50 years of age, inclusive\n* Subject is at least recreationally active (engaged in light to moderate-intensity, intermittent, or steady-state exercise at least 3 days per week for at least 30 min at a time)\n* Subject does not smoke (or has quit for at least 6 months)\n* Subject is not taking medication that may interfere with the study (e.g., diuretics)\n* Subject has no health conditions that would interfere with the study (e.g. cardiovascular, renal, or metabolic diseases)\n* Subject is willing to avoid alcohol consumption 24 hours prior to visit(s)\n* Subject is willing to fast overnight (\\~8-12 hours)\n* Subject is willing to refrain from vigorous exercise for 24 hours\n* Subject is willing to eat the exact same food the day prior to each visit to the laboratory\n* Provision of written consent to participate\n\nExclusion Criteria:\n\n* Subject has participated in a clinical trial within the past 30 days\n* Subject has participated in any PepsiCo trial within past 6 months\n* Subject has a condition or is taking medication that the investigator believes would interfere with his\u002Fher ability to provide informed consent, comply with the study protocol, which might confound the interpretation of the study results, or put the person at undue risk\n* Subject is employed by, or has a parent, guardian, or other immediate family member employed by a company that manufactures any products that compete with any Gatorade product. If subject is unsure if a company would be considered a competitor to Gatorade, they will be asked to please let the study investigator know the name of the other company and the nature of their relationship to that company before they sign the informed consent.",{"count":180,"type":21},80,[24],"The presence of certain ingredients such as sodium and glycerol can facilitate retention of the fluid consumed via renal water reabsorption. To maintain overall whole-body fluid balance, it is important that ingested fluid is retained in the body instead of losing it through urination.\n\nThe purpose of this study is to determine the effect of sodium and glycerol concentrations at various fluid intake volumes on fluid balance in healthy, euhydrated men and women.",[28],[159,160,161,162],"2025-07-14",{"date":187,"type":47},"2025-07-17",{"date":189,"type":47},"2025-04-09",{"date":191,"type":21},"2025-12-15",{"name":171,"class":172},3,{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":22,"phases":205,"briefSummary":206,"conditions":207,"keywords":208,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":217,"locationsCount":4},"100588350","caval-aorta-index-for-fluid-optimization-in-traumatic-brain-injury-100588350","NCT06940258","Caval Aorta Index for Fluid Optimization in Traumatic Brain Injury","Efficacy of Caval Aorta Index for Fluid Optimization in Critically Ill Patients With Traumatic Brain Injury","CAI for fluids","Inclusion Criteria:\n\nTraumatic brain injury diagnosed by computed tomography scan Glasgow coma score ≥ 4\n\nExclusion Criteria:\n\nInability to get consent. Pregnant and lactating women Traumatic subarachnoid hemorrhage Spinal cord injury Increased intra-abdominal pressure Abdominal aortic aneurysm Inferior vena cava (IVC) thrombus Portal hypertension Acute corpulmonale Congestive heart failure chronic hemodialysis Surgical intervention other than neurological one within the first 7 days Mechanical ventilation need during first 7 days Cardiac arrest during the first 7 days","60 Years",{"count":204,"type":21},92,[24],"Traumatic brain injury is a leading cause of death and disability in trauma patients. As the primary injury cannot be reversed; management strategies must focus on preventing secondary injury by avoiding hypotension and hypoxia besides, maintaining appropriate cerebral perfusion pressure, which is a surrogate for cerebral blood flow.",[28],[209,210],"caval aorta index","traumatic brain injury","2025-04-25",{"date":213,"type":47},"2025-04-29",{"date":215,"type":21},"2025-05-01",{"date":84,"type":21},{"name":218,"class":54},"Mansoura University",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":151,"sex":17,"minAge":18,"maxAge":152,"enrollmentInfo":225,"targetDuration":4,"studyType":22,"phases":227,"briefSummary":228,"conditions":229,"keywords":230,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":87},"100566390","effect-of-adding-glycerol-to-electrolyte-beverages-on-fluid-balance-in-healthy-euhydrated-men-and-women-at-rest-100566390","NCT06654557","Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest","Inclusion Criteria:\n\nSubject is male or female\n\n* If female, subject is not pregnant (based on self-report)\n* Subject is 18-50 years of age, inclusive Subject is at least recreationally active (engaged in light to moderate intensity, intermittent, or steady-state exercise at least 3 days per week for at least 30 min at a time)\n* Subject does not smoke (or has quit for at least 6 months)\n* Subject is not taking medication that may interfere with the study (e.g., diuretics)\n* Subject has no health conditions that would interfere with the study, As indicated on the general health questionnaire (GHQ), e.g. cardiovascular, renal, or metabolic diseases\n* Subject is not allergic to adhesives (e.g., medical tape)\n* Subject is not allergic to kiwi-strawberry flavoring\n* Subject is willing to avoid alcohol consumption 24 hours prior to visit(s)\n* Subject is willing to fast overnight (\\~8-12 hours)\n* Subject is willing to refrain from vigorous exercise for 24 hours (light physical activity only)\n* Subject is willing to eat the exact same food the day prior to each visit to the laboratory\n* Able to speak, write, and read English\n* Provision of written consent to participate\n\nExclusion Criteria:\n\n* Subject has participated in a clinical trial within the past 30 days\n* Subject has participated in any PepsiCo trial within past 6 months\n* Subject has a condition or is taking medication that the investigator believes would interfere with his\u002Fher ability to provide informed consent, comply with the study protocol, which might confound the interpretation of the study results, or put the person at undue risk\n* Subject is employed by, or has a parent, guardian, or other immediate family member employed by a company that manufactures any products that compete with any Gatorade product. If subject is unsure if a company would be considered a competitor to Gatorade, they will be asked to please let the study investigator know the name of the other company and the nature of their relationship to that company before they sign the informed consent.",{"count":226,"type":21},95,[24],"The results of a prior study PEP-2311 suggested there was a positive dose-response effect of glycerol and sodium on fluid balance and fluid retention. In addition, inclusion of glycerol resulted in an upward shift in the relationship between sodium concentration and fluid balance. The practical interpretation is that addition of glycerol enables a reduction in sodium concentration compared with a 0% glycerol drink.\n\nIn this follow-up study, the investigators hypothesize that 1) fluid balance will be sustained (greater than or not different from baseline) and significantly greater than placebo for 120 min after drinking the test no\u002Flow\u002Fmoderate carbohydrate beverages and 2) fluid balance will not differ between the carbohydrate-electrolyte beverages, but both will be greater than placebo.",[28],[159,160,161,231,162],"carbohtydrate","2025-02-07",{"date":234,"type":47},"2025-02-11",{"date":236,"type":47},"2024-09-30",{"date":238,"type":21},"2025-05-30",{"name":171,"class":172},{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":244,"acronym":245,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":247,"enrollmentInfo":248,"targetDuration":4,"studyType":22,"phases":250,"briefSummary":251,"conditions":252,"keywords":255,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":193},"100565617","the-efficient-picu-fluid-care-evaluation-100565617","NCT06644508","The Efficient PICU Fluid Care Evaluation","LESSER-2","Inclusion Criteria:\n\n* Age \\\u003C 10 years and weight \\\u003C 35 kg\n* Receiving invasive mechanical ventilation (IMV) due to respiratory failure\n* Inclusion possible within 24 hours of start of IMV\n* Expected duration of IMV \\> 48 hours\n\nExclusion Criteria:\n\n* Preterm (\\\u003C37weeks gestational age)\n* Preexistent (clinical) diagnosis of kidney disease\n* Congenital cardiac defect with hemodynamic consequences or reduced cardiac function\n* (Ongoing) shock with need for fluid resuscitation and\u002For vasoactive drugs\n* Cardiovascular (including diuretics) drug use on admission (home medication)\n* Pre-existent (clinical) diagnosis of liver failure\n* Right of left heart failure\n* Pulmonary hypertension\n* ECMO treatment\n* Receiving total parenteral nutrition on admission which won't be stopped\n* Failure to include within 12 hours after start of IMV\n* Expected duration of IMV \\\u003C 48 hours\n* Parents or caretakers unable to understand\u002Fspeak Dutch language\n* Surgery \\\u003C 48 hours","10 Years",{"count":249,"type":21},90,[24],"The goal of this clinical trial is to evaluate and prevent fluid overload in critically ill, mechanically ventilated children. The main questions it aims to answer are:\n\n1. What is the effect of a restrictive fluid strategy on cumulative fluid balance on day three of invasive mechanical ventilation?\n2. What is the feasibility (e.g. adherence to target intake, fluid balance and nutritional goals) of maintaining a neutral fluid balance?\n\nResearchers will compare the effects of strict adherence to the European Society of Paediatric and Neonatal Intensive Care (ESPNIC) guidelines regarding fluid balance (i.e. restricting fluid intake and preventing a positive fluid balance) to current local practice.\n\nFrom the start to the end of invasive mechanical ventilation participants will be treated according to local practice or with the strict aim to prevent a positive fluid balance. Aiming to prevent a positive fluid balance, if this is possible given the clinical context, is at descretion of the attending physician. Minimal caloric intake requirements must be met.\n\nParticipants are studied for ten days during invasive mechanical ventilation or until discharge from the intensive care",[253,254,28],"Respiratory Insufficiency Requiring Mechanical Ventilation","Fluid Overload",[256,257,258,28,259,254,260,261,262],"Respiratory Insufficiency","Mechanical ventilation","Fluids","Edema","Lenght of mechanical ventilation","Childeren","Maintenance fluids","2024-10-14",{"date":265,"type":47},"2024-10-16",{"date":267,"type":21},"2024-10",{"date":269,"type":21},"2025-05",{"name":271,"class":54},"Radboud University Medical Center"]