[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fluid-management\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fluid-management":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,43,74,102,125,153],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100643751","phase-4-phenotype-guided-vasoactive-medication-during-kidney-transplantation-100643751",false,"NCT07633600","Phenotype Guided Vasoactive Medication During Kidney Transplantation","Intraoperative Circulation Phenotyping to Guide Vasoactive Medication in Kidney Transplant Recipients","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Undergoing kidney transplantation at Cedars-Sinai Medical Center\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Patients unable to provide informed consent\n* Patients with contraindications to protocol vasoactive medications, as determined by the treating anesthesiologist\n* Patients in whom required intraoperative monitoring cannot be performed","ALL","18 Years",{"count":19,"type":20},255,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The goal of this clinical trial is to learn if vasopressin improves the body's response to intravenous fluids during kidney transplantation in patients who have relaxed blood vessels. Researchers will compare the results of vasopressin to those who received calcium chloride.",[26,27],"Kidney Transplant","Fluid Management",[29,26],"Vasoactive Management","NOT_YET_RECRUITING","2026-06-04",{"date":33,"type":34},"2026-06-08","ACTUAL",{"date":36,"type":20},"2026-06-01",{"date":38,"type":20},"2027-12-01",{"name":40,"class":41},"Jennifer Cutler","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":60,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":42},"100596975","association-of-microcirculation-vexus-score-and-femoral-vein-doppler-in-patients-on-the-icu-after-non-emergency-cardiac-surgery-100596975","NCT07052461","Association of Microcirculation, Vexus Score and Femoral Vein Doppler in Patients on the ICU After Non-emergency Cardiac Surgery","VeMic","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Elective or urgent (need for definitive procedure during hospitalisation, but not emergency intervention) cardiac surgery\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Pregnant women\n* Known severe chronic kidney disease (estimated glomerular filtration rate \\\u003C15 mL\u002Fmin per 1.73 m2 or dialysis)\n* Renal or liver transplantation\n* Any known condition interfering with Doppler evaluation of the portal system (including known or suspected cirrhosis or portal vein thrombosis or huge abdominal emphysema).\n* Inability to consent to study\n* Emergency cardiac surgery",{"count":51,"type":20},40,"OBSERVATIONAL","The aim of the VeMic study is to explore if venous congestion is linked with microcirculatory impairment in elective cardiac surgery patients in the postoperative ICU stay.",[55,56,57,58,27,59],"Microcirculatory Diffusion","Microcirculatory Convection Capacity","Venous Congestion","Postoperative Cardiac Surgery","Haemodynamic Coherence",[61,62,63],"vexus score","femoral vein doppler","intensive care unit","RECRUITING","2026-04-15",{"date":67,"type":34},"2026-04-20",{"date":69,"type":34},"2026-04-14",{"date":71,"type":20},"2027-09-30",{"name":73,"class":41},"University Hospital, Basel, Switzerland",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100620771","oral-versus-intravenous-fluid-therapy-in-the-emergency-department-100620771","NCT07361952","Oral Versus Intravenous Fluid Therapy in the Emergency Department","OVID-B","Inclusion Criteria:\n\n* Age 18 or above\n* At least 1000 ml of crystalloid fluid therapy prescribed by the physician\n\nExclusion Criteria:\n\n* Altered mental state prohibiting oral fluid intake (Glasgow Coma Scale ≤ 12)\n* Pregnancy\n* Oral fluids contraindicated (e.g. bowel obstruction)\n* Severe hyponatremia (sodium \\\u003C120 mEq\u002FL)\n* Requiring treatment in the intensive care unit",{"count":82,"type":20},250,[84],"NA","The goal of this randomized clinical feasibility trial is to determine whether oral fluid therapy can achieve prescribed fluid volumes as effectively as intravenous fluid therapy in adult patients admitted to the emergency department who require fluid treatment.\n\nThe main questions it aims to answer are:\n\nAre patients receiving oral fluids equally likely to achieve the prescribed fluid volume compared with patients receiving intravenous fluids?\n\nIs it feasible to conduct a randomized trial of oral versus intravenous fluid therapy in the emergency department, based on recruitment rate and protocol adherence?\n\nResearchers will compare oral tap water administration with standard intravenous crystalloid therapy to assess whether oral fluids are non-inferior in achieving prescribed fluid volumes and to evaluate feasibility outcomes.\n\nParticipants will:\n\nBe randomized to receive either oral tap water or intravenous crystalloid fluids during their stay in the emergency department\n\nReceive a fluid volume and administration rate determined by the treating physician\n\nBe monitored according to standard clinical practice during the emergency department stay\n\nHave fluid intake, vital signs, and clinical outcomes recorded, with follow-up through routine health records up to 30 days after inclusion",[27],[88,89,90,91],"oral fluids","Emergency department","intravenous fluids","fluid management","2026-01-22",{"date":94,"type":34},"2026-01-23",{"date":96,"type":34},"2025-10-03",{"date":98,"type":20},"2026-07",{"name":100,"class":41},"Esbjerg Hospital - University Hospital of Southern Denmark",3,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":21,"phases":112,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":42},"100621095","hemodynamic-optimization-using-an-artificial-intelligenze-system-100621095","NCT07366164","Hemodynamic Optimization Using an Artificial Intelligenze System","The Assisted Fluid Management For High-Risk Patients During Colorectal Surgery: A Randomised Controlled Clinical Trial","SIMPLY","Inclusion Criteria:\n\n\\- patients \\>18 years old and ASA 3 scheduled for laparoscopic colorectal surgery\n\nExclusion Criteria:\n\n* Refusal of consent\n* Body Mass Index \\> 35 kg\u002Fm2\n* urgent cases\n* pregnancy",{"count":111,"type":20},80,[84],"This study will investigate the impact of using an automated fluid management system on intraoperative fluid therapy in patients undergoing colorectal surgery. The aim is to evaluate whether automated guidance can optimize hemodynamic stability and reduce the incidence of arterial hypotension,",[115,27],"Hemodynamic (MAP) Stability","2026-01-16",{"date":118,"type":34},"2026-01-26",{"date":120,"type":34},"2025-10-01",{"date":122,"type":20},"2027-01-01",{"name":124,"class":41},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":132,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":21,"phases":135,"briefSummary":136,"conditions":137,"keywords":142,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":42},"100612845","effect-of-vexus-ultrasound-protocol-venous-excess-ultrasound-on-perioperative-fluid-management-on-the-incidence-of-postoperative-pulmonary-complications-and-postoperative-acute-kidney-injury-in-patients-undergoing-thoracic-surgery-100612845","NCT07258875","Effect of VExUS Ultrasound Protocol (Venous Excess Ultrasound) on Perioperative Fluid Management, on the Incidence of Postoperative Pulmonary Complications and Postoperative Acute Kidney Injury in Patients Undergoing Thoracic Surgery","VEXUS","Inclusion Criteria:\n\n* Adults \\>18 years undergoing video assisted thoracic surgery\u002F lobectomy requiring one-lung ventilation.\n\nExclusion Criteria:\n\n* Refusal to participate.\n* Pneumonectomy.\n* Young athletes (risk of physiologically large IVC \\>2 cm).\n* Moderate-severe tricuspid regurgitation, moderate to severe pulmonary hypertension\n* Heart failure with reduced ejection fraction, EF\\\u003C35%\n* Portal hypertension, portal vein thrombosis, or liver cirrhosis.\n* Stage 4 or end-stage chronic kidney disease (eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m² or dialysis).\n* Transfusion with more than 2 packed red blood cells unit perioperatively (intraoperatively, in the PACU, in the ward)",true,{"count":134,"type":20},230,[84],"This study aims to investigate the effect of a VExUS ultrasound guided protocol of perioperative fluid management within a goal-directed therapy framework, on postoperative respiratory complications, and the occurrence of acute kidney injury (AKI) in patients undergoing thoracic surgery.",[138,139,27,140,141],"Thoracic Surgery With One-lung Ventilation","VExUS","Acute Kidney Injury","Postoperative Pulmonary Complications (PPCs)",[143],"VExUS, fluid management, pulmonary complications, acute kidney injury, thoracic surgery, one lung ventilation","2025-11-20",{"date":146,"type":34},"2025-12-02",{"date":148,"type":34},"2024-11-27",{"date":150,"type":20},"2029-11-01",{"name":152,"class":41},"University of Crete",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":21,"phases":164,"briefSummary":165,"conditions":166,"keywords":175,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":42},"100591559","importance-of-arterial-measurement-sites-ipams-on-intraoperative-hemodynamic-management-100591559","NCT06982001","ImPortance of Arterial Measurement Sites (IPAMS) on Intraoperative Hemodynamic Management","Importance of Arterial Measurement Sites on Intraoperative Hemodynamic Management of Major Abdominal Surgeries and Artificial Intelligence-based Prediction of Arterial Gradient Using Peripheral Radial Pressure Waveform Analysis","IPAMS","Inclusion Criteria:\n\n* Patients between 18 and 90 years of age;\n* Major abdominal surgery via laparoscopy or laparotomy under general anesthesia - with or without concomitant use of regional or neuraxial anesthesia;\n* Expected anesthesia time of more than 120 minutes.\n\nExclusion Criteria:\n\n* Known peripheral severe vascular disease with subclavian artery stenosis,\n* Significant arterial gradient between arms with preoperative non-invasive bloop pressure measurements (\\>25 mm Hg of systolic blood pressure or 10 mm Hg of mean arterial pressure);\n* Inability or contraindications to insert arterial line on either arm (arteriovenous fistula, surgical sterility);\n* Known allergies, intolerance, other medical conditions that precludes the use of prescribed general anesthesia protocol for this trial;\n* Inability to communicate in French or English.","90 Years",{"count":163,"type":20},204,[84],"The goal of this clinical trial is to demonstrate the importance of arterial pressure measurement sites during major abdominal surgeries. This randomized controlled trial will compare arterial pressure measurements obtained from radial artery catheterization (the current standard method of monitoring) with those obtained from brachial artery catheterization (a more accurate reflection of central arterial pressure). At the end of the study, we are looking to answer the following questions:\n\n1. Does arterial pressure measurement sites influence the amount of vasopressors that is administered during major abdominal surgeries?\n2. What are the instances where there is a difference between peripheral (radial catheter) and central (brachial catheter) monitoring and what are the risk factors leading to the appearance of this radial-brachial pressure gradient?\n3. With the data collected, can artificial intelligence based analysis help predict the reliability of a radial monitoring and help guide clinicians on choosing a peripheral versus central arterial pressure monitoring site? All adult participants who are scheduled for elective major abdominal surgeries and meeting our inclusion criteria will be approached and included if they consent. Participants will be randomized 1:1 in the intervention group and the standard of care group. In the intervention group, the brachial arterial line will be used intraoperatively to guide vasopressor and fluid administration. A radial line will also be installed to measure the radial arterial pressure simultaneously, but will not be used to guide hemodynamic management. In the standard of care group, both lines will be installed just like in the intervention group, however, it is the radial arterial line that will guide fluid and vasopressor administration. In both groups, the anesthesia protocol will be standardized and the anesthesiologist will be blinded to the arterial pressure measurement site.",[167,168,169,170,171,172,27,173,174],"Perioperative Care","Hemodynamics","Monitoring Blood Pressure","Arterial Lines","Anesthesia","Vasopressor","Artificial Intelligence in Operating Room","Artificial Intelligence (AI)",[176,177,178,179,180],"Comparison of arterial catheterization sites on hemodynamic monitoring","Incidence of radial-brachial pressure gradient","Risk factors of radial-brachial pressure gradient","Effect of arterial catheterization sites on hemodynamic management","Effect of peripheral vs central arterial pressure measurements in intraoperative hemodynamic management","2025-05-13",{"date":183,"type":34},"2025-05-21",{"date":185,"type":20},"2025-09",{"date":187,"type":20},"2028-12",{"name":189,"class":41},"Ciusss de L'Est de l'Île de Montréal"]