[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fluid-over-load\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fluid-over-load":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,62,99,131],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100053808","pro-stress-trial-proactive-low-dose-norepinephrine-to-reduce-intraoperative-fluid-administration-in-patients-at-high-risk-for-postoperative-pulmonary-complications-undergoing-laparoscopic-abdominal-surgery-100053808",false,"NCT07627360","PRO STRESS Trial: Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery","Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial","PRO STRESS","Inclusion Criteria:\n\n* Adult patients aged 18 years or older.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Scheduled for elective laparoscopic major abdominal surgery under general anesthesia with an expected duration greater than 2 hours.\n* Patients with ARISCAT score ≥ 45 indicating high risk for postoperative pulmonary complications.\n\nExclusion Criteria:\n\n* Known hypersensitivity to norepinephrine.\n* Severe left ventricular dysfunction with ejection fraction \\\u003C 35%.\n* Significant cardiac arrhythmia.\n* Uncontrolled hypertension defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg.\n* End-stage renal disease.\n* Requirement for vasopressor support before induction of anesthesia.\n* Emergency surgery.","ALL","18 Years",{"count":20,"type":21},130,"ESTIMATED","INTERVENTIONAL",[24],"NA","Intraoperative hypotension is commonly treated with fluid administration; however, excessive fluid therapy may contribute to postoperative pulmonary complications. This randomized double-blind controlled trial evaluates whether proactive administration of fixed low-dose norepinephrine reduces intraoperative crystalloid administration while maintaining hemodynamic stability in high-risk patients undergoing laparoscopic abdominal surgery. One hundred and thirty patients will be randomized to receive either norepinephrine infusion (0.03 µg\u002Fkg\u002Fmin) or placebo from induction until skin closure within a protocolized hemodynamic strategy guided by mean arterial pressure and pulse pressure variation.",[27,28,29],"Intraoperative Hypotension","Postoperative Pulmonary Complications (PPCs)","Fluid Over-load",[31,32,33,34,35],"Norepinephrine","Fluid Therapy","Pulmonary Complications","Abdominal Surgery","Vasopressor","NOT_YET_RECRUITING","2026-07-10",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":21},"2026-07-15",{"date":44,"type":21},"2026-11",{"name":46,"class":47},"Suez Canal University","OTHER",1,{"id":50,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":25,"conditions":53,"keywords":54,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":61,"locationsCount":48},"100639434",{"count":20,"type":21},[24],[27,28,29],[31,32,33,34,35],"2026-05-31",{"date":57,"type":40},"2026-06-04",{"date":59,"type":21},"2026-05-23",{"date":44,"type":21},{"name":46,"class":47},{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":70,"targetDuration":4,"studyType":22,"phases":72,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":48},"100634598","training-medical-residents-in-the-use-of-the-venous-excess-ultrasound-vexus-score-for-bedside-volume-assessment-100634598","NCT07541768","Training Medical Residents in the Use of the Venous Excess UltraSound (VExUS) Score for Bedside Volume Assessment.","Training Medical Residents in the Use of the Venous Excess UltraSound (VExUS) Score for Bedside Volume Assessment: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Medical residents in general internal medicine\n* Basic ultrasound skills (POCUS component 1 or ≥200 scans)\n* Working at study site during study period\n\nExclusion Criteria:\n\n* SGUM certification in abdominal ultrasound\n* Advanced duplex ultrasound experience\n* Prior vascular\u002Fduplex training",true,{"count":71,"type":21},23,[24],"This randomized controlled trial evaluates the effectiveness of two training approaches (in-person versus remote) for teaching medical residents to apply the Venous Excess Ultrasound (VExUS) score for bedside volume assessment in patients with acute heart failure. Resident performance will be compared to that of expert physicians certified in abdominal and duplex sonography.",[75,29,76,77],"Acute Heart Failure (AHF)","Congestion","Congestion, Venous",[79,80,81,82,83,84,85,86,87,88],"Vexus","Venous Excess Ultrasound","Point-of-Care Ultrasound","POCUS","Ultrasound Training","Medical Education","Volume Assessment","Venous Congestion","Duplex Ultrasound","Bedside Ultrasound","RECRUITING","2026-04-16",{"date":92,"type":40},"2026-04-21",{"date":94,"type":40},"2026-03-20",{"date":96,"type":21},"2026-12-31",{"name":98,"class":47},"Insel Gruppe AG, University Hospital Bern",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":110,"conditions":111,"keywords":115,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":48},"100598921","natriuresis-guided-depletion-after-cardiac-surgery-100598921","NCT07077772","Natriuresis-guided Depletion After Cardiac Surgery","Evaluation of Natriuresis-guided Depletion After Cardiac Surgery: a Monocentric, Open-label, Randomized Controlled Trial","EASY-CS","Inclusion Criteria:\n\n* Adult patient (age \\> 18 years)\n* Scheduled for cardiac surgery, including mitral valve repair or replacement, aortic valve replacement, coronary artery bypass grafting (CABG), ascending aortic repair, or combined procedures\n* Undergoing surgery with cardiopulmonary bypass (CPB)\n* Eligible to receive intravenous furosemide for fluid overload within 48 hours following surgery, as prescribed by the referring physician\n* Written and oral informed consent obtained\n* Covered by the French national health insurance (Sécurité Sociale)\n\nExclusion Criteria:\n\n* Aortic arch repair requiring deep hypothermic circulatory arrest\n* Active endocarditis\n* Hemodynamic instability requiring vasopressor or inotropic support (norepinephrine, dobutamine, epinephrine, or vasopressin)\n* Failure to wean from CPB requiring mechanical circulatory support\n* Chronic kidney disease with an estimated glomerular filtration rate (eGFR) \\\u003C 60 mL\u002Fmin\n* Chronic use of loop diuretics\n* Known allergy to furosemide\n* Active postoperative bleeding and\u002For reoperation for bleeding\n* Participation in another interventional study that may affect the primary outcome measure\n* Patient deprived of liberty by administrative or judicial decision, or placed under legal protection (guardianship or curatorship)",{"count":108,"type":21},102,[24],"Fluid overload (FO) is a common complication after cardiac surgery, associated with increased morbidity and mortality. Loop diuretics, especially furosemide, are routinely used to manage FO, but their use is often empirical. Recent data suggest that natriuresis-guided furosemide titration using point-of-care urinary sodium sensors (LAQUAtwin NA-11, Horiba) may improve the efficiency and safety of fluid removal, but no randomized trial has yet evaluated this approach in postoperative cardiac surgery patients\n\nOur goal is to assess the clinical impact, safety, and feasibility of a natriuresis-guided furosemide protocol after cardiac surgery requiring cardiopulmonary bypass.",[112,113,77,114,29],"Cardiac Surgery","Diuresis","Sodium Depletion",[116,117,118,119,120,121],"natriuresis","fluid overload","cardiac surgery","furosemide","venous congestion","loop diuretics","2026-01-19",{"date":124,"type":40},"2026-01-21",{"date":126,"type":40},"2025-06-25",{"date":128,"type":21},"2027-10",{"name":130,"class":47},"Centre Hospitalier Universitaire, Amiens",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":147,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":162},"100588171","effect-of-dynamic-arterial-elastance-and-assisted-fluid-management-software-guided-resuscitation-in-septic-shock-pilot-study-100588171","NCT06937918","Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Shock: Pilot Study","Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Adjustment of Vasopressor and Fluid Therapy in Septic Shock Resuscitation; A Pilot Study","DAFM shock","Inclusion Criteria:\n\n* All Thai consecutive patients older than 18 years with a diagnosis of sepsis or septic shock in medical ICU, defined by clinically suspected or confirmed infection and MAP \\\u003C65 mmHg according to the criteria of the Surviving Sepsis Campaign 2021(11)with onset of shock in less than 24 hours.\n* Already receiving or planning for mechanical ventilation\n* Already receiving or planning for arterial catheter placement for invasive arterial pressure monitoring\n* All patients will receive an echocardiogram with a cut point of LVEF \\> 30% to be included in the study\n\nExclusion Criteria:\n\n* Active, immediate, life-threatening cardiac arrhythmia, defined as ventricular tachycardia and ventricular fibrillation\n* Acute cerebral vascular event, including both acute ischemic stroke or intracranial hemorrhage\n* Acute coronary syndrome\n* cardiogenic shock, acute heart failure\n* Severe asthma exacerbation\n* Fluid intolerance: hypoxemia (P:F ratio \\\u003C 150)\n* Life-threatening gastrointestinal hemorrhage\n* Pregnancy\n* Requirement for immediate surgery within 2 hours of randomization\n* Advanced-stage cancer with predicted survival of less than 6 months\n* Oliguric AKI with signs of volume overload\n\nWithdrawal or termination criteria\n\n* The patient and legal representative request for withdrawal\n* The attending physician requested a withdrawal",{"count":140,"type":21},60,[24],"To investigate the benefit of using the AFM and Eadyn-guided fluid and vasopressor therapy in septic shock resuscitation for mechanically ventilated patients compared with the standard of care. The investigators hypothesize that using the AFM and Eadyn-guided fluid\u002Fvasopressor titration in septic shock patients who underwent mechanical ventilation might reduce the time to shock reversal.",[144,29,145,146],"Critical Illness","Dynamic Arterial Elastance","Septic Shock",[148,149,150,117,151,152],"critical illness","dynamic arterial elastance","stroke volume change prediction","ischemic complication","septic shock","2025-04-22",{"date":155,"type":40},"2025-04-27",{"date":157,"type":21},"2025-04-23",{"date":159,"type":21},"2028-04-08",{"name":161,"class":47},"Mahidol University",3]