[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fluid-overload\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fluid-overload":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,20,0,[8,50,88,118,143,172,198,226,262,285,309,335,358,409,446,468,498,528,549,572],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100642154","volume-removal-intolerance-during-net-ultrafiltration-in-acute-kidney-injury-patients-100642154",false,"NCT07643597","Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients","VINKO","Inclusion Criteria:\n\n* Age ≥18 years\n* Admission to an Intensive Care Unit\n* Acute kidney injury according to KDIGO criteria\n* Prescription of continuous renal replacement therapy (CRRT) with net ultrafiltration\n* Clinical stability considered sufficient to initiate net ultrafiltration according to the treating clinical team\n\nExclusion Criteria:\n\n* Chronic kidney replacement therapy prior to ICU admission\n* Pregnancy\n* Limitation of therapeutic effort or goals-of-care decisions at admission or during the observation period\n* Inability to perform hemodynamic or perfusion assessment\n* Extracorporeal membrane oxygenation (ECMO)\n* Refusal to participate in the study","ALL","18 Years",{"count":19,"type":20},128,"ESTIMATED","OBSERVATIONAL","Acute kidney injury (AKI) is common in critically ill patients and is frequently associated with fluid overload, which can worsen clinical outcomes. Continuous renal replacement therapy (CRRT) allows fluid removal through net ultrafiltration (UFNET), but some patients develop hemodynamic instability or signs of poor tissue perfusion during this process.\n\nThe purpose of this prospective observational study is to evaluate tolerance to net ultrafiltration in critically ill patients with AKI receiving CRRT. The study will assess clinical, hemodynamic, ultrasound, perfusion, and biochemical parameters before and during fluid removal to identify factors associated with ultrafiltration intolerance.\n\nThe investigators hypothesize that alterations in hemodynamic, perfusion, and congestion-related parameters can identify patients at increased risk of ultrafiltration intolerance before the development of overt hypotension. The results may help improve individualized fluid removal strategies and optimize the safety of CRRT in critically ill patients.",[24,25,26,27,28],"Acute Kidney Injury","Fluid Overload","Fluid Overload in Dialysis Patients","Critical Illness","Renal Replacement Therapy for Acute Kidney Injury in ICU",[30,31,32,33,34,25,35,36],"Net Ultrafiltration","Continuous Renal Replacement Therapy","Fluid Removal","Ultrafiltration Intolerance","Tissue Hypoperfusion","VExUS","Point-of-Care Ultrasound","NOT_YET_RECRUITING","2026-06-13",{"date":40,"type":41},"2026-06-16","ACTUAL",{"date":43,"type":20},"2026-07-06",{"date":45,"type":20},"2027-12-01",{"name":47,"class":48},"Hospital Las Higueras","OTHER",10,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":83,"leadSponsor":85,"locationsCount":87},"100643185","electric-cardiometry-guided-standard-versus-restricted-fluid-therapy-in-robotic-prostaectomy-100643185","NCT07626151","Electric Cardiometry-Guided Standard Versus Restricted Fluid Therapy In Robotic Prostaectomy","Effect Of Standard Versus Restricted Fluid Therapy Guided By Electric Cardiometry On Tissue Perfuison In Robotic Prostaectomy: A Randomized Controlled Study","Inclusion Criteria:\n\n* Male patient undergoing robotic assisted prostatectomy\n* ASA I-III\n\nExclusion Criteria:\n\n* ASA score more than III\n* BMI more than 40\n* Severe renal disease (GFR between 15 and 29)\n* Previous renal surgery.\n* Decompensated cardiac disease (NYHA class 3 or 4)","MALE","40 Years","80 Years",{"count":61,"type":20},90,"INTERVENTIONAL",[64],"NA","Fluid therapy during surgery is an important factor that is related to long term mortality and morbidity and it's directly related to tissue perfusion as well. The main target in any surgery is what is the optimum fluid therapy to maintain the tissue perfusion and the precise balance between hazardous effects of hypervolemia that may cause delayed wound healing due to surgical anastomosis disruption or being hypovolemic that may cause tissue ischemia as acute kidney injury.\n\nFluid management guidance changed from static methods like central venous pressure into dynamic methods like pulse pressure variation (PPV) and stroke volume variation (SVV), which are now the most famous dynamic measures.\n\nElectrical cardiometry is a non-invasive cardiac output monitor which uses electrical cardiometry, now a commonly used device, to measure SVV which can be used to guide fluid therapy during surgeries.\n\nNow robotic assisted surgery is a common method in preforming many surgeries especially urological, since it's associated with numerous desirable outcomes including shorter post-operative stay and faster return to preoperative function.\n\nWith considerations related to severe Trendelenburg position and increased intra-abdominal pressure due to pneumo-peritoneum, robotic assisted surgeries are associated with many challenges in anesthesia especially the fluid therapy.\n\nFluid therapy in robotic surgeries is an area with growing research focus that need further exploration while there are established guidelines for fluid management in traditional surgeries, the optimal protocols for robotic surgeries are less well defined, needing more research.\n\nWe aim at this study to investigate the impact of liberal versus restricted fluid intake on the tissue perfusion reflected by serum lactate \\& creatinine clearance, while guiding therapy through electrical cardiometry, to reach optimum fluid protocol in prostatic robotic surgeries.",[67,68,25,69],"Prostate Cancer","Surgery","Lactate Blood Increase",[71,72,73,74,75,76,77],"Robotic","Prostatectomy","Sugery","Anesthesia","Fluid","Electric Cardiometry","Tissue Perfusion","RECRUITING","2026-06-05",{"date":81,"type":41},"2026-06-08",{"date":79,"type":41},{"date":84,"type":20},"2026-12",{"name":86,"class":48},"Nazmy Edward Seif",1,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":62,"phases":98,"briefSummary":100,"conditions":101,"keywords":102,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":117},"100376352","phase-4-controlled-fluid-removal-in-critical-ill-patients-with-fluid-overload-in-the-intensive-care-unit-100376352","NCT04180397","Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.","Goal Directed Fluid Removal With Furosemide in Intensive Care Patients With Fluid Overload - A Randomised, Blinded, Placebo-controlled Trial (GODIF).","GODIF","Inclusion Criteria: ALL below must be met.\n\n* Acute admission to the intensive care unit.\n* Age ≥ 18 years of age\n* Fluid overload ≥ 5% of ideal body weight. If possible, all fluids administered before admission to the intensive care unit are to be included in the calculation of cumulative fluid balance.\n* Clinical stable (minimum criteria: MAP \\> 50 mmHg and maximum infusion of 20 microgram\u002Fkg\u002Fminute of noradrenaline and lactate \\\u003C 4.0 mmol\u002FL)\n\nExclusion Criteria:\n\n* Known allergy to furosemide or sulphonamides.\n* Known pre-hospitalization advanced chronic kidney disease (eGFR \\\u003C 30 mL\u002Fminute\u002F1.73 m\\^2 or chronic RRT).\n* Ongoing renal replacement therapy.\n* Anuria \\> 6 hours.\n* Rhabdomyolysis with indication for forced diuresis\n* Ongoing life-threatening bleeding as these patients need specific fluid\u002Fblood product strategies.\n* Acute burn injury of more than 10% of the body surface area as these patients need a specific fluid strategy.\n* Severe dysnatremia (p-Na \\\u003C 120 or \\> 155 mmol\u002FL) as these patients need a specific fluid strategy.\n* Severe hepatic failure as per the clinical team.\n* Patients undergoing forced treatment.\n* Fertile women (women \\\u003C 50 years) with positive urine human chorionic gonadotropin (hCG) or plasma-hCG.\n* Consent not obtainable as per the model approved for the specific trial site.",{"count":97,"type":20},1000,[99],"PHASE4","This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit. Half of the patients will receive furosemide and the other half placebo. The treatment will continue until the excess fluid is excreted.",[25],[103,104,105,106,107],"Fluid overload","Fluid removal","Deresusciation","Diuretics","Fluid accumulation","2026-06-02",{"date":110,"type":41},"2026-06-03",{"date":112,"type":41},"2020-08-17",{"date":114,"type":20},"2028-04-15",{"name":116,"class":48},"Morten H. Bestle",29,{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":126,"minAge":17,"maxAge":4,"enrollmentInfo":127,"targetDuration":4,"studyType":62,"phases":129,"briefSummary":130,"conditions":131,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":87},"100598398","proactive-hemodynamic-management-during-cytoreductive-surgery-and-hipec-100598398","NCT07070973","Proactive Hemodynamic Management During Cytoreductive Surgery and HIPEC","HEMOdynamic Proactive Management During Cytoreductive Surgery and Intraperitoneal hyPErthermic Chemotherapy for Advanced Ovarian Cancer","HEMOPEC","Inclusion Criteria:\n\n* age \\> 18 years\n* patient scheduled for CRS for ovarian cancer\n\nExclusion Criteria:\n\n* patients' refusal\n* cardiac arrythmia\n* pregnancy.","FEMALE",{"count":128,"type":20},52,[64],"Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a complex surgical procedure carried out through laparotomic approach. After CRS-HIPEC morbidity and mortality rates go up to 20%-40% and 3% respectively, and acute kidney injury and pulmonary effusion\u002Foedema are the most frequent postoperative complications.\n\nIntraoperative hypotension and risk of fluid overload are common. Efficient and accurate control of arterial pressure and cardiac output is a major concern during CRS-HIPEC.\n\nThe aim of this study is to perform a pilot study describing a hemodynamic management protocol based on artificial intelligence - derived parameters, that allows to implement the standard goal directed therapy (GDT) protocol in term of amount of IOH and stroke volume (SV) optimization.\n\nSpecifically, this study aims to test the hypotheses that a hemodynamic protocol based on HPI-AFM monitoring compared to standard GDT helps clinicians reduce IOH during surgery and improve the time \"in-target\" range of SV index.\n\nThe study cohort will be compared to an historical cohort of 50 patients underwent to CRS-HIPEC between 2022 and 2024, managed with an institutional goal directed therapy protocol.",[132,133,25],"Ovarian Cancer","Hemodynamic Instability","2026-05-06",{"date":136,"type":41},"2026-05-11",{"date":138,"type":41},"2025-09-01",{"date":140,"type":20},"2027-02-01",{"name":142,"class":48},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":149,"targetDuration":150,"studyType":21,"phases":4,"briefSummary":151,"conditions":152,"keywords":156,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":87},"100606662","concordance-and-discordance-in-the-assessment-of-volume-status-in-home-dialysis-patients-a-comparison-of-modified-medical-research-council-dyspnea-scale-physical-exam-and-point-of-care-ultrasound-pocus-100606662","NCT07178470","Concordance and Discordance in the Assessment of Volume Status in Home Dialysis Patients: A Comparison of Modified Medical Research Council Dyspnea Scale, Physical Exam, and Point of Care Ultrasound (POCUS)","Inclusion Criteria:\n\n1. Age: Greater than 18 years.\n2. Diagnosis: End-stage kidney disease (ESKD).\n3. Treatment: Receiving home dialysis, either peritoneal dialysis (PD) or home hemodialysis (HHD).\n4. Duration of Home Dialysis: At least three months on home dialysis.\n\nExclusion Criteria:\n\n1. Consent: Inability to provide informed consent.\n2. Inclusion Criteria: Not meeting any of the inclusion criteria.\n3. Pregnancy.\n4. Urgent-Start PD.\n5. Any other obvious cause of shortness of breath not related to volume overload including but not limited to pneumonia, pneumothorax, advanced COPD and Interstitial lung disease.",{"count":61,"type":20},"1 Day","Fluid overload, which is when your body has too much fluid, is one of the reasons why people on home dialysis need to go to the hospital. Fluid overload (when body has too much fluid) commonly presents as trouble breathing and leg swelling. Traditionally, doctors check for this by asking patients if they have any symptoms like leg swelling or shortness of breath and by doing a physical exam which includes listening to the lungs or looking for swelling in legs. However, a newer, safe, and non-invasive method called point-of-care ultrasound (POCUS) has become very popular. However, we don't have a lot of research yet on how POCUS and LUS (lung ultrasound) specifically help home dialysis patients, including those on peritoneal dialysis or home hemodialysis. Peritoneal dialysis is a way to clean your blood by putting a special fluid into your belly through a small tube. The fluid uses the natural lining of your belly as a filter to remove waste and extra water. Home hemodialysis is a treatment where a machine acts like an artificial kidney to clean your blood. You get trained to do this yourself at home by connecting to the machine with a couple of needles, which cleans your blood of waste and extra fluid. POCUS, especially a (LUS), has been shown to be useful for dialysis patients in outpatient units.\n\nThis study will compare different 3 different methods of detecting fluid overload: answering various survey questions, completing a physical exam, and a LUS. The study seeks to determine which of these methods is the best method to determine fluid overload.\n\nYou were selected as a possible participant because you are over 18 years old, diagnosed with End-stage kidney disease, and have been receiving home dialysis for at least three months.",[25,153,154,155],"POCUS","Lung Ultrasound","Volume Status",[157,158,159,160,161,162],"pocus","fluid overload","lung ultrasound","volume status","modified Medical Research Council Dyspnea Scale","mMRC dyspnea scale","2026-02-24",{"date":165,"type":41},"2026-02-27",{"date":167,"type":41},"2026-01-09",{"date":169,"type":20},"2026-06",{"name":171,"class":48},"Indiana University",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":180,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":182,"conditions":183,"keywords":186,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":197},"100614135","timing-and-dose-of-fluid-deresuscitation-in-critically-ill-patients-100614135","NCT07275658","Timing and Dose of Fluid Deresuscitation in Critically Ill Patients","Timing and Dose of Fluid Deresuscitation in Critically Ill Patients: a Prospective Observational Multicenter Study","TIDE","Inclusion Criteria:\n\n* Admission to one of the participating ICUs;\n* Clinical indication for deresuscitation using diuretics or ultrafiltration as set by the treating physician; first attempt during the ICU stay.\n\nExclusion Criteria:\n\n* Age below 18 years old;\n* Major cardiac shunts;\n* Moderate to severe aortic regurgitation;\n* Morbid Obesisty (BMI \\>40);\n* POCUS impossible or unreliable (i.e. pre-existing interstitial lung disease);\n* PLR or modified form of PLR impossible (i.e. ECMO);\n* Transfer from another ICU;\n* Previous inclusion in this study;\n* Patients who are moribund or facing the end of life;\n* Opt out.",{"count":181,"type":20},150,"Fluid deresuscitation is an important intervention in the Intensive Care Unit (ICU). This study aims to find (1) determinants of successful deresuscitation, (2) the optimal rate (dose) of deresuscitation based on these determinants, and (3) differences in metabolic profiles for a more personalized approach of deresuscitation.\n\nThis study is a multicenter, prospective, observational cohort study in critically ill patients. This study will include ICU patients who have a clinical indication for deresuscitation as set by the treating physician. Clinical, ultrasound and laboratory values will be collected and used for analysis.",[25,184,185],"Critical Care, Intensive Care","Deresuscitation",[187],"ultrasound, RRT, furosemide","2026-01-19",{"date":190,"type":41},"2026-01-21",{"date":192,"type":41},"2025-10-15",{"date":194,"type":20},"2027-02-28",{"name":196,"class":48},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",2,{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":206,"targetDuration":4,"studyType":62,"phases":208,"briefSummary":209,"conditions":210,"keywords":211,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":225},"100502075","early-deresuscitation-strategy-driven-by-tissue-perfusion-in-renal-replacement-therapy-in-patients-with-acute-renal-failure-100502075","NCT05817539","Early Deresuscitation Strategy Driven by Tissue Perfusion in Renal Replacement Therapy in Patients With Acute Renal Failure","Early Deresuscitation Strategy Driven by Tissue Perfusion in Renal Replacement Therapy in Patients With Acute Renal Failure in Intensive Care Unit. A Randomized Study","EarlyDry","Inclusion Criteria:\n\n1. Acute kidney injury treated by continuous renal replacement therapy in ICU less than 7 days,\n2. At least 1 organ failure during ICU in addition to AKI (mechanical ventilation or oxygen therapy or vascular filling \\> 1000ml or vasopressor exposure \\> 12 hours),\n3. Weight loss of less than 3% since starting a net UF or Cumulative UF net less than 2000ml before inclusion,\n4. Norepinephrine \\\u003C 0,5 µg\u002Fkg\u002Fmin,\n5. Absence of hypoperfusion signs defined by the presence of at least 2 out of 4 criteria:\n\n   * TRC \\> 3s at the finger\n   * Marbrure score \\> 2\n   * Lactate \\> 2 mmol\u002FL\n   * ScVO2\\\u003C 60%,\n6. Fluid overload defined as follows :\n\n   * fluid overload \\> 5% of base weight (based on cumulative fluid balance or a weight gain) and\u002For\n   * Obvious oedema of the lumbar region or flanks (oedema \\> 1cm bucket depth).\n\nExclusion Criteria:\n\n1. Chronic renal failure hemodialyzed before admission to the ICU,\n2. Mechanical circulatory support (ECMO, LVAD),\n3. Pregnant, child -bearing age or lactating women,\n4. Stroke based on the combination of central neurological symptoms (aphasia, hemiplegia, hemiparesis) associated with compatible brain imaging, less than 30 days,\n5. Intestinal ischemia less than 7 days documented non-operated,\n6. Interventional study participation or exclusion period on going,that may interfere with the present study\n7. Guardianship, curatorship or safeguard of justice,\n8. Absence of signature of free and informed consent by the patient and\u002For relative,\n9. Patients not affiliated to a social security scheme or beneficiaries of a similar scheme",{"count":207,"type":20},250,[64],"In Intensive Care Unit (ICU) patients with acute kidney injury (AKI) and treated with renal replacement therapy (RRT) often present a fluid overload which is associated with morbidity (mechanical ventilation duration increase, kidney recovery decrease) and mortality.\n\nPatients' prognostic could be improved by correcting the fluid overload with net ultrafiltration (UFnet) however it may lead to harmful iatrogenic hypovolemia responsible of deleterious ischemic lesions.\n\nIn usual practice, UF net prescription are variable and there are different international recommendations. Some observational studies suggest that using a UFnet between 1 et 1.75 mL\u002Fkg\u002Fh in fluid overloaded patient decrease mortality.\n\nFluid overload increases morbidity and mortality, particularly in RRT. Studies without RRT argue for an efficacy of management by decreasing the fluid overload .Cohort studies suggest to use a moderate UFnet instead of a low UFnet. Some data from studies on early versus late RRT that relate the fluid balance or correct the fluid overload during the early strategy argue for a beneficial effect of an early deresuscitation strategy\n\nConsequently, the impact of a moderate UFnet (to decrease the fluid overload) compared to a low UFnet (to stabilize the fluid overload) in a randomized interventional study could be assessed.\n\nThe study hypothesis is that :\n\nan early fluid overload deresuscitation protocol with a high UFnet (2 ml\u002Fkg\u002Fh) targeting both the negativation of cumulated fluid balance to reach a dry weight and the maintenance of tissue perfusion.\n\nCompared to\n\nfluid overload deresuscitation protocol with a low UFnet (between 0 and 1 ml\u002Fkg\u002Fh) to reach a stabilization of cumulated fluid balance without monitoring the tissue perfusion.\n\ncould improve overall, renal, hemodynamic and respiratory prognosis in fluid overloaded patients with renal replacement therapy in ICU",[24,25],[212,213,185,214,103,215],"Renal Replacement Therapy (RRT)","Ultrafiltration","Fluid balance","Tissue perfusion","2026-01-07",{"date":218,"type":41},"2026-01-08",{"date":220,"type":41},"2023-12-15",{"date":222,"type":20},"2028-01-15",{"name":224,"class":48},"Hospices Civils de Lyon",14,{"id":227,"slug":228,"hasResults":11,"nctId":229,"briefTitle":230,"officialTitle":231,"acronym":232,"eligibilityCriteria":233,"healthyVolunteers":11,"sex":16,"minAge":234,"maxAge":4,"enrollmentInfo":235,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":236,"conditions":237,"keywords":250,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":87},"100478094","interview-study-of-adult-and-child-patients-and-parents-of-children-with-swelling-due-to-nephrotic-syndrome-100478094","NCT05505500","Interview Study of Adult and Child Patients and Parents of Children With Swelling Due to Nephrotic Syndrome.","Preparing a Clinical Outcomes Assessment Set for Nephrotic Syndrome","Prepare-NS","Criteria for the Observer Reported Outcomes (ObsRO) cohort of the study:\n\nInclusion Criteria:\n\n1. Parents\u002Fguardians must be able to read and understand English;\n2. Parents\u002Fguardians must be caring for a child (ages 2-11.999) with a medically documented diagnosis of idiopathic (primary) Nephrotic Syndrome (NS) or primary or monogenic NS associated kidney disease. Populations with Primary NS Conditions: Focal segmental glomerulosclerosis (FSGS), Minimal Change Disease (MCD), Immunoglobulin M (IgM) Nephropathy, Membranous Nephropathy (MN), and childhood - onset nephrotic syndrome not biopsied;\n3. The child must have a current NS-associated edema\n4. The child must have native kidney function\n5. Parents\u002Fguardians must provide informed consent.\n\nExclusion Criteria:\n\n1\\. Index case with dialysis dependence throughout the 3-month pre-enrollment period\n\nCriteria for the Patient Reported Outcomes (PRO) cohort of the study:\n\nInclusion Criteria:\n\n1. ≥8 years of age\n2. Able to read and understand English\n3. Primary (idiopathic) kidney disease that causes NS or monogenic NS associated kidney disease.\n\n   i. Populations with Primary Nephrotic Syndrome (NS) Conditions include: FSGS, MCD, IgM nephropathy, MN, and childhood - onset nephrotic syndrome not biopsied\n4. Current NS-associated edema\n5. Kidney function with most recent estimated Glomerular Filtration Rate (eGFR) \\> 25 ml\u002Fmin\u002F1.73m2\n6. Informed Consent: For patients ≥8 to \\\u003C18 years of age: a parent or legal guardian provide informed consent and the patient must provide assent. Patients ≥18 years of age must provide informed consent.\n\nExclusion Criteria:\n\n1. Native kidney disease participant with dialysis dependence during the 3-month pre-enrollment period\n2. Co-existing significant chronic or severe acute health condition that has the potential to influence how the participant feels or functions as related to fluid overload in NS","2 Years",{"count":181,"type":20},"Researchers from the University of Michigan and Northwestern University are studying people's experiences with swelling caused by Nephrotic Syndrome. Interviews with patients (child and adult) and parents of young children will be conducted. The information collected from the interviews will be used to develop a survey to use when testing new medications for Nephrotic Syndrome.\n\nPlease consider participating in a 1-hour long interview with the Prepare-NS research study to discuss children and adults experiences with swelling.",[25,238,239,240,241,242,243,244,245,246,247,248,249],"Glomerulosclerosis, Focal Segmental","Edema","Membranous Nephropathy","Minimal Change Disease","Minimal Change Nephrotic Syndrome","IgM Nephropathy","Nephrotic Syndrome","Glomerular Disease","Nephrotic Syndrome, Minimal Change","Nephrotic Syndrome in Children","Nephrotic Syndrome With Edema (Diagnosis)","FSGS",[244,251,252,25,239,249,241,240,243],"Child","Adult","2025-12-15",{"date":255,"type":41},"2025-12-22",{"date":257,"type":41},"2022-04-18",{"date":259,"type":20},"2026-04-30",{"name":261,"class":48},"University of Michigan",{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":268,"eligibilityCriteria":269,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":270,"targetDuration":4,"studyType":62,"phases":271,"briefSummary":272,"conditions":273,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":284},"100453711","lung-ultrasound-guided-fluid-deresuscitation-in-icu-patients-100453711","NCT05188092","Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients","Effect of Lung Ultrasound-Guided Fluid Deresuscitation on Duration of Ventilation in Intensive Care Unit Patients (CONFIDENCE)","CONFIDENCE","Inclusion Criteria:\n\n* Admission to one of the participating ICUs;\n* Invasively ventilated for less than 24 hours at randomization;\n* Expected to be under invasive ventilation for longer than 24 hours after randomization.\n\nExclusion Criteria:\n\n* Age below 18 years old;\n* Suspected or confirmed pregnancy;\n* Participation in other interventional trials with similar endpoints;\n* Use of long term home mechanical ventilation;\n* Neurological condition that can prolong duration of mechanical ventilation (i.e.Guillain-Barré syndrome, high spinal cord lesion, amyotrophic lateral sclerosis, multiple sclerosis, or myasthenia gravis);\n* Conditions in which LUS cannot be performed or correctly interpreted (i.e. chest wall abnormalities, morbid obesity, and pre-existing interstitial lung disease);\n* Conditions in which targeting a negative fluid balance is discouraged (i.e. subarachnoid bleeding, severe rhabdomyolysis (CK \\> 20.000);\n* Previous participation in this RCT;\n* Patients transferred from another center and invasively ventilated for longer than 24 hours.",{"count":97,"type":20},[64],"Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients. Lung ultrasound (LUS) is an easy to learn, safe, cheap and noninvasive bedside imaging tool with high accuracy for pulmonary edema and pleural effusions in ICU patients. The aim of this study is to assess the effect of LUS-guided deresuscitation on duration of invasive ventilation in ICU patients. The investigators hypothesize that LUS-guided fluid deresuscitation is superior to routine fluid deresuscitation (not using LUS) with regard to duration of invasive ventilation.\n\nThis study is an international multicenter randomized clinical trial (RCT) in invasively ventilated ICU patients.This study will include 1,000 consecutively admitted invasively ventilated adult ICU patients, who are expected not to be extubated within the next 24 hours after randomization. Patients are randomly assigned to the intervention group, in which fluid deresuscitation is guided by repeated LUS, or the control group, in which fluid deresuscitation is at the discretion of the treating physician (not using LUS).",[274,25,185,275],"Mechanical Ventilation","Ventilator-free Days","2025-11-28",{"date":278,"type":41},"2025-12-05",{"date":280,"type":41},"2021-12-22",{"date":282,"type":20},"2026-06-01",{"name":196,"class":48},3,{"id":286,"slug":287,"hasResults":11,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":291,"eligibilityCriteria":292,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":293,"targetDuration":295,"studyType":21,"phases":4,"briefSummary":296,"conditions":297,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":87},"100334101","timing-of-renal-replacement-therapy-in-the-critically-ill-patients-100334101","NCT03629977","Timing of Renal Replacement Therapy in the Critically Ill Patients","Early vs Late CRRT, a Propensity Matched Multicenter Cohort Study","TORRT","Inclusion Criteria:\n\n\\*Critically ill patients admitted to intensive care units in Stockholm at: Karolinska University Hospital (Solna and Huddinge) and at Södersjukhuset.\n\n\\*Patients over 18 years of age\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years\n* Patients with DNAR (do not attempt resuscitation)-orders\n* Patients dying within 12 hours of commencing renal replacement therapy.",{"count":294,"type":20},50000,"1 Year","Background: Severe acute kidney injury (AKI) among critically ill patients is sometimes treated with renal replacement therapy (RRT), and in Sweden continuous RRT (CRRT) is the dominant modality used in this population.\n\n* The optimal timing of renal replacement therapy (RRT) initiation in critically ill patients with acute kidney injury (AKI) is unknown\n* No consensus to guide clinical practice on this issue\n* Lack of consistency regarding outcome measurements; should we look at morbidity or mortality?\n* Wide variability in the timing of RRT initiation in the intensive care unit (ICU) population\n\nHypothesis: This is an important knowledge gap in the support of critically ill patients with AKI and we hypothesize that early initiation of RRT is beneficial.\n\nMethods: The present study aims to test this hypothesis by using a large scale high resolution intensive care database, the Clinisoft repository. In this database, we have information on \\>60 000 patients from three different hospitals and five ICUs, during the years 2005 up until today. The repository will be crossmatched, using the unique Swedish national ID number, with hospital records; to gather information on preexisting illnesses, chronic medication and post-ICU outcomes. It is likely that over 5%, more than 3000 patients, have been treated with RRT. We will categorize these patients into \"early\" and \"late\" groups using both biomarker data and clinical data. Importantly, early and late RRT can be categorized using biomarkers, like urea and creatinine; using degree of fluid accumulation, by level of pH in blood and just by using hours-days after ICU admission. All possible definitions of early\u002Flate RRT initiation can be tested in this study.\n\nOutcomes: Our primary outcome is 90 day mortality. Secondary outcomes include: mortality at 30, 60, 180 and 365 days. Two- and three year mortality.\n\nMorbidity, measured as end-stage renal disease (ESRD) for 90-day survivors. ICU length of stay, hospital length of stay.",[24,298,25,299,27],"Uremia","Dialysis; Complications","2025-08-26",{"date":302,"type":41},"2025-09-03",{"date":304,"type":20},"2025-11-01",{"date":306,"type":20},"2027-04-01",{"name":308,"class":48},"Karolinska University Hospital",{"id":310,"slug":311,"hasResults":11,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":315,"eligibilityCriteria":316,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":317,"targetDuration":318,"studyType":21,"phases":4,"briefSummary":319,"conditions":320,"keywords":323,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":334},"100535960","fluid-administration-and-fluid-accumulation-in-the-intensive-care-unit-100535960","NCT06258616","Fluid Administration and Fluid Accumulation in the Intensive Care Unit","Fluid Administration and Fluid Accumulation in the Intensive Care Unit (FLUID-ICU) - an International Inception Cohort Study","FLUID-ICU","Inclusion Criteria:\n\n* Acute admission to the ICU during the 14-day inception period.\n* Adults (≥ 18 years).\n\nExclusion Criteria:\n\n* Patients previously included in the FLUID-ICU study.\n* Patients with major burns (≥ 10% of body surface)",{"count":97,"type":20},"90 Days","The goal of this international inception cohort study is to describe fluid administration during admittance to the intensive care unit (ICU), and provide contemporary epidemiological data on fluid accumulation, risk factors, management and outcome in critically ill adult patients.",[321,322,25],"Fluid Accumulation","Fluid Therapy",[25,321,324],"Fluid Administration","2025-02-05",{"date":327,"type":41},"2025-02-06",{"date":329,"type":41},"2024-04-01",{"date":331,"type":20},"2025-09",{"name":333,"class":48},"Nordsjaellands Hospital",21,{"id":336,"slug":337,"hasResults":11,"nctId":338,"briefTitle":339,"officialTitle":340,"acronym":341,"eligibilityCriteria":342,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":343,"targetDuration":4,"studyType":62,"phases":345,"briefSummary":346,"conditions":347,"keywords":348,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":356,"locationsCount":87},"100527909","ultrafiltration-rate-induced-cardiac-strain-ulrica---study-100527909","NCT06153888","ULtrafiltration-Rate Induced CArdiac Strain (ULRICA) - Study","The Effect of Hemodialysis on proBNP","ULRICA","Inclusion Criteria:\n\n* Adult HD patients with an intra-dialytic weight gain (IDWG) ≥2.5% of target weight over the long interval (3 days) prior to inclusion.\n* Patients need to be able to understand the study information\n* Patients need to be able to give consent.\n\nExclusion Criteria:\n\n* Active systemic inflammatory state such as extensive malignancy or acute septic infection.\n* Uncontrolled hyperphosphatemia decided by the local routine of the physician (due to somewhat decreased efficacy of the low flux filter to eliminate phosphate)",{"count":344,"type":20},40,[64],"Patients performing chronic hemodialysis (HD) retain more or less water between dialyses. The water is removed by ultrafiltration and usually during the cleansing of waste products - the HD. The length of HD is usually the same as the time of fluid removal while sometimes this may differ. There is no clear guideline. In previous research the investigator noted that the heart releases more NT-pro-BNP during HD in numerous of the patients.\n\nThe present study aims to clarify if the speed of fluid removal during HD is a factor that may alter the release of cardiac markers during HD. If so the recommendations for the prescription of HD can be updated.",[25,299],[349],"dialysis prescription","2024-12-10",{"date":352,"type":41},"2024-12-16",{"date":354,"type":41},"2023-03-20",{"date":259,"type":20},{"name":357,"class":48},"Umeå University",{"id":359,"slug":360,"hasResults":11,"nctId":361,"briefTitle":362,"officialTitle":363,"acronym":4,"eligibilityCriteria":364,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":365,"targetDuration":366,"studyType":21,"phases":4,"briefSummary":367,"conditions":368,"keywords":372,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":197},"100569686","muscle-and-subcutaneous-tissue-variation-by-ultrasound-and-impedance-linked-to-fluid-balance-in-icu-patients-100569686","NCT06697470","Muscle and Subcutaneous Tissue Variation by Ultrasound and Impedance Linked to Fluid Balance in ICU Patients","Cross-sectional Study on the Variation of Muscle Thickness and Subcutaneous Tissues by Ultrasound and Bioelectrical Impedance in Association with the Fluid Balance of Patients in Intensive Care","Inclusion Criteria:\n\n* Adults aged over 18 years.\n* Patients present and admitted to the ICU at Epicura Hornu Hospital between October 14, 2024, and November 15, 2024 (to be updated).\n* Informed consent to participate in the study has been signed by the patient or their legal representative.\n\nExclusion Criteria :\n\n* Patients in post-operative or other surveillance with an expected ICU stay of less than 48 hours.\n* Patients for whom a decision to withdraw therapy has been made prior to inclusion.\n* Presence of skin conditions (e.g., wounds or ulcers) that hinder ultrasound measurements or the application of skin electrodes.\n* Pregnancy.\n* Presence of an implanted pacemaker or defibrillator.",{"count":344,"type":20},"5 Days","This cross-sectional study aims to investigate the relationship between variations in muscle thickness and subcutaneous tissue, measured by ultrasound, and fluid compartments, evaluated using bioelectrical impedance analysis (BIA), in critically ill patients in the intensive care unit (ICU). Critically ill patients frequently experience muscle wasting and tissue edema due to a combination of inflammation, immobilization, and aggressive fluid resuscitation protocols designed to counteract hemodynamic instability.\n\nUltrasound is widely used to monitor muscle thickness because it is fast, non-invasive, and repeatable. However, muscle thickness measurements during the first days of ICU admission may be influenced by fluid overload, which causes edema and might lead to an overestimation of actual muscle mass. Bioelectrical impedance analysis (BIA) is a complementary tool that assesses both intra- and extracellular fluid compartments. This study aims to correlate daily fluid balance with changes in muscle thickness and subcutaneous tissue measured by ultrasound, and to determine if BIA can accurately reflect fluid status and potentially identify edema in these patients.\n\nFurthermore, at ICU discharge, patients' muscle strength will be assessed using both the MRC-sum score (0-60) and handgrip strength (using a Jamar dynamometer), to investigate whether the presence of edema at discharge correlates with muscle strength deficits. Data collection will occur daily, tracking fluid balance, clinical parameters, and body weight, alongside ultrasound and BIA measurements in a standardized position. The study will help clarify the interactions between fluid management, muscle mass changes, and clinical outcomes in critically ill patients, providing valuable insight into early rehabilitation strategies.",[369,370,239,25,27,371],"Weakness Acquired in the ICU","Muscle Wasting","Intensive Care Unit (ICU) Patients",[373,374,375,376,377,214,378,379,380,381,382,383,384,385,386,387,388,389,390,391,392,393,394,395,396,397,398,399],"Muscle thickness","Subcutaneous tissue","Ultrasound","Bioelectrical impedance analysis","BIA","ICU (intensive care unit)","Muscle strength","MRC-sum score","Grip strength","Edema assessment","Critical care","Skeletal muscle","Hydration status","Muscle echogenicity","ICU-acquired weakness","Fluid compartments","Extracellular water","Intracellular water","Body composition","Bedside ultrasound","Fluid management","Early mobilization","Volume overload","Tissue edema","Body water compartments","Length of ICU stay","Muscle quality","2024-11-17",{"date":402,"type":41},"2024-11-20",{"date":404,"type":41},"2024-10-21",{"date":406,"type":20},"2024-11-15",{"name":408,"class":48},"Dr F Duprez",{"id":410,"slug":411,"hasResults":11,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":4,"eligibilityCriteria":415,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":416,"targetDuration":418,"studyType":21,"phases":4,"briefSummary":419,"conditions":420,"keywords":428,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":437,"lastUpdatePostDateStruct":438,"startDateStruct":440,"completionDateStruct":442,"leadSponsor":444,"locationsCount":87},"100500545","comparing-the-diagnostic-sensitivity-and-specificity-of-pleural-fluid-n-terminal-pro-b-type-natriuretic-peptide-nt-probnp-and-other-biochemical-gradient-criteria-in-distinguishing-heart-failure-and-non-heart-failure-related-pleural-effusions-centre-study-100500545","NCT05797649","Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)","Comparing N-terminal-proB-type Natriuretic Peptide with Other Diagnostic Criteria in Discriminating Heart Failure-associated from Non-heart Failure-associated Pleural Effusions","Inclusion Criteria:\n\n* Patients hospitalized for heart failure and pleural effusion\n* Pleural tapping indicated for pleural fluid analysis.\n* Aged 18 years old or above\n\nExclusion Criteria:\n\n* History of intrapleural therapy (including talc and fibrinolytic) in the ipsilateral pleural space.\n* History of surgical decortication or pleurodesis in the ipsilateral pleural space.\n* Ipsilateral thoracic or cardiac surgery in the past 3 months.\n* Failure to obtain informed consent due to the patient's refusal or cognitive impairment.",{"count":417,"type":20},120,"24 Months","To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).",[421,422,423,25,424,425,426,427],"Pleural Effusion","Heart Failure","Malignant Neoplasm","Hypoalbuminemia","Renal Failure","Cirrhosis","Infections",[429,430,431,432,433,434,435,436],"pleural fluid","heart failure","malignancy","cancer","echocardiography","infection","tuberculosis","respiratory medicine","2024-11-11",{"date":439,"type":41},"2024-11-13",{"date":441,"type":41},"2023-07-01",{"date":443,"type":20},"2025-11-30",{"name":445,"class":48},"Chinese University of Hong Kong",{"id":447,"slug":448,"hasResults":11,"nctId":449,"briefTitle":450,"officialTitle":451,"acronym":4,"eligibilityCriteria":452,"healthyVolunteers":11,"sex":126,"minAge":4,"maxAge":4,"enrollmentInfo":453,"targetDuration":4,"studyType":62,"phases":454,"briefSummary":455,"conditions":456,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":87},"100557508","inferior-vena-cava-collapsibility-index-guide-for-preoperative-fluid-therapy-in-preeclampsia-100557508","NCT06539026","Inferior Vena Cava Collapsibility Index Guide for Preoperative Fluid Therapy in Preeclampsia","Ultrasound Assessment of Inferior Vena Cava Collapsibility Index (IVCCI) to Guide Pre-operative Fluid Management in Critically Ill Pre-eclamptic Patients in Comparison with the Standard Fluid Management","Inclusion Criteria:\n\n* Critically ill pre-eclamptic patients for cesarean section\n\nExclusion Criteria:\n\n* Patient refusal\n* severe cardiovascular disease ( ejection fraction \\\u003C 40 mmHg ), tricuspid regurge.\n* contraindication for spinal anesthesia.\n* failure to perform spinal anesthesia.\n* severe hepatic.\n* renal dysfunction",{"count":61,"type":20},[64],"The routine assessment of fluid status depends on clinical evaluation and invasive monitoring. The clinical assessment lacks objectivity and the invasive monitoring carries risks. Point of care ultrasound (POCUS) parameters can be useful as early markers of fluid status and were used in safe fluid assessment in term pregnancy and preeclampsia.",[457,458,25],"Pre-Eclampsia","Hypotension","2024-10-26",{"date":461,"type":41},"2024-10-29",{"date":463,"type":41},"2024-08-15",{"date":465,"type":20},"2024-12-20",{"name":467,"class":48},"Ain Shams University",{"id":469,"slug":470,"hasResults":11,"nctId":471,"briefTitle":472,"officialTitle":472,"acronym":473,"eligibilityCriteria":474,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":475,"enrollmentInfo":476,"targetDuration":4,"studyType":62,"phases":477,"briefSummary":478,"conditions":479,"keywords":482,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":284},"100565617","the-efficient-picu-fluid-care-evaluation-100565617","NCT06644508","The Efficient PICU Fluid Care Evaluation","LESSER-2","Inclusion Criteria:\n\n* Age \\\u003C 10 years and weight \\\u003C 35 kg\n* Receiving invasive mechanical ventilation (IMV) due to respiratory failure\n* Inclusion possible within 24 hours of start of IMV\n* Expected duration of IMV \\> 48 hours\n\nExclusion Criteria:\n\n* Preterm (\\\u003C37weeks gestational age)\n* Preexistent (clinical) diagnosis of kidney disease\n* Congenital cardiac defect with hemodynamic consequences or reduced cardiac function\n* (Ongoing) shock with need for fluid resuscitation and\u002For vasoactive drugs\n* Cardiovascular (including diuretics) drug use on admission (home medication)\n* Pre-existent (clinical) diagnosis of liver failure\n* Right of left heart failure\n* Pulmonary hypertension\n* ECMO treatment\n* Receiving total parenteral nutrition on admission which won't be stopped\n* Failure to include within 12 hours after start of IMV\n* Expected duration of IMV \\\u003C 48 hours\n* Parents or caretakers unable to understand\u002Fspeak Dutch language\n* Surgery \\\u003C 48 hours","10 Years",{"count":61,"type":20},[64],"The goal of this clinical trial is to evaluate and prevent fluid overload in critically ill, mechanically ventilated children. The main questions it aims to answer are:\n\n1. What is the effect of a restrictive fluid strategy on cumulative fluid balance on day three of invasive mechanical ventilation?\n2. What is the feasibility (e.g. adherence to target intake, fluid balance and nutritional goals) of maintaining a neutral fluid balance?\n\nResearchers will compare the effects of strict adherence to the European Society of Paediatric and Neonatal Intensive Care (ESPNIC) guidelines regarding fluid balance (i.e. restricting fluid intake and preventing a positive fluid balance) to current local practice.\n\nFrom the start to the end of invasive mechanical ventilation participants will be treated according to local practice or with the strict aim to prevent a positive fluid balance. Aiming to prevent a positive fluid balance, if this is possible given the clinical context, is at descretion of the attending physician. Minimal caloric intake requirements must be met.\n\nParticipants are studied for ten days during invasive mechanical ventilation or until discharge from the intensive care",[480,25,481],"Respiratory Insufficiency Requiring Mechanical Ventilation","Fluid Balance",[483,484,485,481,239,25,486,487,488],"Respiratory Insufficiency","Mechanical ventilation","Fluids","Lenght of mechanical ventilation","Childeren","Maintenance fluids","2024-10-14",{"date":491,"type":41},"2024-10-16",{"date":493,"type":20},"2024-10",{"date":495,"type":20},"2025-05",{"name":497,"class":48},"Radboud University Medical Center",{"id":499,"slug":500,"hasResults":11,"nctId":501,"briefTitle":502,"officialTitle":502,"acronym":503,"eligibilityCriteria":504,"healthyVolunteers":505,"sex":16,"minAge":17,"maxAge":58,"enrollmentInfo":506,"targetDuration":4,"studyType":62,"phases":508,"briefSummary":511,"conditions":512,"keywords":516,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":519,"lastUpdatePostDateStruct":520,"startDateStruct":522,"completionDateStruct":524,"leadSponsor":526,"locationsCount":4},"100564269","phase-1-investigation-of-novel-and-established-therapies-in-a-human-intravenous-lipopolysaccharide-model-of-sepsis-100564269","NCT06626984","Investigation of Novel and Established Therapies in a Human Intravenous Lipopolysaccharide Model of Sepsis","INITIALISE","Inclusion Criteria:\n\n1. Healthy adult volunteers aged between 18 and 40 years of age\n2. Informed consent to participate\n\nExclusion Criteria:\n\n1. Current participation in a clinical trial\n2. Pregnant or breastfeeding\n3. Current history of smoking\n4. Alcohol intake \\> 21 units per week\n5. Regular intake of any relevant prescription or over-the-counter medication. Any regular medication use will be reviewed on a case-by-case basis as to (a) risk and (b) potential confounding effect.\n6. Oxygen saturation \\\u003C95% breathing room air\n7. Abnormal findings on history, examination or laboratory tests suggestive of underlying illness (in the opinion of the clinician undertaking screening)\n8. History of recurrent vaso-vagal episodes\n9. Allergy to Imatinib\n10. Positive or equivocal hepatitis B or C serology result",true,{"count":507,"type":20},65,[509,510],"PHASE1","PHASE2","Sepsis is a common and life-threatening condition caused by a dysregulated host immune response to infection. Given the prominent role of endothelial breakdown and dysfunction in sepsis, therefore, there is an urgent need to establish strategies to protect the endothelium and preserve microcirculatory function.\n\nThis study is a randomised clinical study investigating intravenous fluid therapy and oral imatinib therapy in healthy human volunteers exposed to intravenous lipopolysaccharide (LPS).\n\nThe objective of the study is to investigate the biological effects of fluid and imatinib therapy on LPS-induced microcirculatory dysfunction.",[513,25,514,515],"Sepsis","Endothelial Dysfunction","Microcirculation",[517,518],"Intravenous Fluid Therapy","Imatinib","2024-10-02",{"date":521,"type":41},"2024-10-04",{"date":523,"type":20},"2024-12-01",{"date":525,"type":20},"2026-07-01",{"name":527,"class":48},"Belfast Health and Social Care Trust",{"id":529,"slug":530,"hasResults":11,"nctId":531,"briefTitle":532,"officialTitle":533,"acronym":534,"eligibilityCriteria":535,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":536,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":538,"conditions":539,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":542,"lastUpdatePostDateStruct":543,"startDateStruct":545,"completionDateStruct":547,"leadSponsor":548,"locationsCount":87},"100561097","association-between-venous-excess-ultrasound-grading-system-and-acute-kidney-injury-in-the-icu-population-100561097","NCT06585722","Association Between Venous Excess Ultrasound Grading System and Acute Kidney Injury in the ICU Population","The Association Between Venous Excess Ultrasound, the Lung Ultrasound Score and Acute Kidney Injury and Death in the Intensive Care Unit Population","VExUS ICU","Inclusion Criteria:\n\n* all patients admitted to the ICU 18 years or older expected to stay in the ICU for more than 24 hours\n\nExclusion Criteria:\n\n* any obstruction between the righ atrium and structures assessed by VExUS\n* a medical history of: Major cardiac shunts (e.g. atrial septum defect), Tricuspid regurgitation, dialysis, portal hypertension, pulmonary hypertension, interstitial lung disease, recipients of a kidney of liver transplant.\n* patients in whom an ultrasound assesment is unfeasible e.g. a BMI over 40",{"count":537,"type":20},136,"Fluid resuscitation is one of the cornerstones of treatment in ICU patients. Nonetheless, excessive fluid administration can lead to fluid overload which has been associated with worse outcomes in the ICU. To prevent this, assessments of fluid responsiveness are commonly employed. However, fluid responsiveness does not take fluid tolerance into account. Fluid tolerance is the idea that a patient might still be fluid responsive but might already be at risk of the detrimental effects of fluid therapy. Recent developments in point of care ultrasound e.g. the Venous excess ultrasound might help identify patients at risk of fluid overload. However its association with patient relevant outcomes in the ICU remains unclear.",[25,540,541],"Kidney Injury","Make-30","2024-09-04",{"date":544,"type":41},"2024-09-05",{"date":546,"type":41},"2023-02-01",{"date":544,"type":20},{"name":196,"class":48},{"id":550,"slug":551,"hasResults":11,"nctId":552,"briefTitle":553,"officialTitle":554,"acronym":555,"eligibilityCriteria":556,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":557,"enrollmentInfo":558,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":560,"conditions":561,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":563,"lastUpdatePostDateStruct":564,"startDateStruct":566,"completionDateStruct":568,"leadSponsor":570,"locationsCount":197},"100560119","thoracic-fluid-content-during-stabilization-and-therapeutic-de-escalation-in-septic-shock-100560119","NCT06572995","Thoracic Fluid Content During Stabilization and Therapeutic De-escalation in Septic Shock","Assessment of Intra-thoracic Water by Bio Reactance During Stabilization and Therapeutic De-escalation in Septic Shock: A Prospective, Multicenter, Observational Study","TFC-SEPSIS","Inclusion Criteria:\n\n* Adult (Age \\>18 years old)\n* Septic shock according to Sepsis-3 definition:\n\n  * A suspected or confirmed infection\n  * Persisting hypotension, despite adequate fluid resuscitation, requiring vasopressor to maintain a Mean Arterial Pressure (MAP) ≥ 65 mmHg\n  * Lactate level \\> 2 mmol\u002Fl\n* Predictive ICU length of stay \\> 3 days\n\nExclusion Criteria:\n\n* Admission in ICU for more than 3 days\n* Refusal to participate\n* Moribund patients\n* Decision of therapeutic withdrawal\n* Curators","99 Years",{"count":559,"type":20},50,"In ICU, fluid challenge represents one of the cornerstones of hemodynamic care. However, fluid overload due to an excessive and\u002For inappropriate fluid administration could be associated with morbidity or mortality. Unfortunately, there is currently no continuous non-invasive devices to monitor fluid content at bedside. Bio reactance is a non-invasive, rapid and continuous technology developed in order to measure body fluid compartment. Monitoring devices functioning with such technology are promising to evaluate fluid overload in ICU.",[513,562,133,25],"Septic Shock","2024-08-26",{"date":565,"type":41},"2024-08-27",{"date":567,"type":41},"2023-06-01",{"date":569,"type":20},"2025-06-01",{"name":571,"class":48},"University Hospital, Brest",{"id":573,"slug":574,"hasResults":11,"nctId":575,"briefTitle":576,"officialTitle":577,"acronym":578,"eligibilityCriteria":579,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":580,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":581,"conditions":582,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":585,"startDateStruct":587,"completionDateStruct":589,"leadSponsor":591,"locationsCount":87},"100554383","fluid-status-and-body-composition-analysis-by-bioelectrical-impedance-in-patients-after-cardiac-surgery-flubiacs-100554383","NCT06498375","Fluid Status and Body Composition Analysis by Bioelectrical Impedance in Patients After Cardiac Surgery (FLUBIACS)","Fluid Status and Body Composition Analysis in Patients After Cardiac Surgery Assessed by Bioelectrical Impedance Method and Its Impact on Postoperative Morbidity and Mortality","FLUBIACS","Inclusion criteria\n\n1. Elective cardiovascular surgery (on-pump or off-pump)\n2. Age ≥ 18 years\n3. ASA 3 or 4\n4. Provided verbal and written informed consent\n\nExclusion criteria\n\n1. Refusal to participate in the research\n2. \\\u003C 18 years\n3. Renal failure requiring replacement treatment with hemodialysis\n4. Amputation of a limb\n5. Pregnancy\n6. Emergency Procedures\n7. Reoperation\n8. Pacemaker\u002Fimplantable cardioverter-defibrillator",{"count":181,"type":20},"Evaluation of fluid status in cardiac surgery patients using bioelectrical impedance and its impact on postoperative morbidity and mortality",[583,25],"Cardiopulmonary Disease","2024-07-04",{"date":586,"type":41},"2024-07-12",{"date":588,"type":20},"2024-07",{"date":590,"type":20},"2026-07",{"name":592,"class":48},"University Medical Centre Ljubljana"]