[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fluid-responsiveness-predictability\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fluid-responsiveness-predictability":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100632652","comparison-of-acoustic-variability-index-avi-and-pulse-pressure-variation-ppv-for-predicting-fluid-responsiveness-in-mechanically-ventilated-patients-100632652",false,"NCT07516470","Comparison of Acoustic Variability Index (AVI) and Pulse Pressure Variation (PPV) for Predicting Fluid Responsiveness in Mechanically Ventilated Patients","A Prospective, Single-Center, Single-Arm, Paired-Comparison, Open-Label, Non-Inferiority Confirmatory Trial to Evaluate the Efficacy and Safety of ResQ by Comparing Fluid Responsiveness Prediction Performance of the Acoustic Variability Index (AVI) Versus Pulse Pressure Variation (PPV) in Mechanically Ventilated Patients","Inclusion Criteria:\n\nTo participate in this study, individuals must meet all of the following criteria:\n\n* Adults aged 19 years or older.\n* If female, not pregnant or breastfeeding.\n* Scheduled for a planned surgery of major organs in the abdominal, retroperitoneal, or pelvic cavities (e.g., hepatobiliary and pancreatic, small intestine, large intestine, kidney, uterus) under general anesthesia with mechanical ventilation\n* Classified as American Society of Anesthesiologists (ASA) Class I, II, or III. (Note: Excluded regardless of class if any exclusion criteria are met)\n* Scheduled to receive mechanical ventilation in a volume-controlled or pressure-controlled mode in the operating room or intensive care unit, with an anticipated tidal volume of 6-8 mL\u002Fkg (Ideal Body Weight), respiratory rate of 8-14 breaths\u002Fmin, and PEEP of 0-5 cmH2O\n* Scheduled for hemodynamic monitoring to measure the comparison indices during surgery\n* Able to understand the study's purpose and procedures and communicate clearly with the investigator and research staff\n* Voluntarily signed the written informed consent form before participating in the study\n\nExclusion Criteria:\n\nIndividuals meeting any of the following criteria will be excluded from participation:\n\n* Undergoing emergency or unplanned surgery\n* Anticipated to have difficulty with the application of general anesthesia or mechanical ventilation\n* Anticipated to experience massive bleeding of 1 L or more during surgery.\n* Undergoing a reoperation due to the same underlying disease\n* History of severe esophageal damage (e.g., esophageal varices or stricture) that makes inserting the probe difficult\n* Inability to have an arterial catheter inserted, making the measurement of Stroke Volume Variation (SVV) and Pulse Pressure Variation (PPV) difficult\n* Condition where a fluid challenge is contraindicated or considered high risk (e.g., clinical signs of fluid overload, pulmonary congestion, or pulmonary edema; acute exacerbation of heart failure or renal failure; or a hemodynamically unstable state)\n* Body Mass Index (BMI) greater than 30 kg\u002Fm²\n* Uncontrolled coagulopathy prior to surgery (e.g., Platelet count \\\u003C 100,000\u002FμL or INR \\> 2)\n* Arrhythmias, such as atrial fibrillation\u002Fflutter or premature atrial\u002Fventricular contractions (\\>2 per 10 seconds), that make it difficult for the variability index to operate accurately\n* Other cardiovascular history that makes accurate cardiac output measurement impossible (e.g., severe valvular disease, history of intracardiac shunt surgery, or structural heart surgery)\n* Pregnant or lactating women\n* Any other condition deemed unsuitable for study participation by the investigator","ALL","19 Years",{"count":19,"type":20},122,"ESTIMATED","OBSERVATIONAL","The goal of this clinical trial is to learn if a new medical device called ResQ works to predict fluid needs in adults undergoing surgery under general anesthesia. The main questions it aims to answer are:\n\n* Can the Acoustic Variability Index (AVI) measured by ResQ predict if a participant needs more fluids as accurately as the standard arterial blood pressure-based method (PPV)?\n* Is the ResQ device safe to use during surgery? Researchers will compare the new method (AVI) to the standard method (PPV) to see if ResQ provides reliable information for managing patient fluids.\n\nParticipants will:\n\n* Undergo their planned surgery as scheduled.\n* Have a soft probe placed in the esophagus to monitor heart and lung sounds.\n* Receive a set amount of intravenous (IV) fluid as part of their regular surgery care.\n* Have their heart function checked before and after the fluids are given.",[24,25,26],"Fluid Responsiveness Predictability","Hemodynamic Monitoring","Anesthesia, General",[28,25],"Fluid Responsiveness","RECRUITING","2026-04-23",{"date":32,"type":33},"2026-04-29","ACTUAL",{"date":35,"type":33},"2026-04-13",{"date":37,"type":20},"2026-12",{"name":39,"class":40},"Signal House Co., Ltd.","INDUSTRY",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":70},"100608521","evaluation-of-the-variation-of-the-sub-pulmonary-velocity-time-integral-to-predict-fluid-responsiveness-100608521","NCT07202637","Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness","Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness Prospective Observational Study","Inclusion Criteria:\n\n* Patient with measurable sub-pulmonary VTI in at least one of the two windows: parasternal short-axis or subcostal.\n* Patient with measurable sub-aortic VTI in apical 4-chamber view before and after PLR maneuver.\n* Patient with suspected hypovolemia or whose hemodynamic status justifies vasopressor infusion.\n\nExclusion Criteria:\n\n* Severe left ventricular dysfunction defined by left ventricular ejection fraction (LVEF) \\\u003C 30%.\n* Severe right ventricular dysfunction defined by TAPSE \\\u003C 12 mm.\n* Cardiac arrhythmia or atrial fibrillation.\n* Abdominal compartment syndrome.\n* Amputation of one or both lower limbs.\n* Intracranial hypertension.\n* Pregnant women (ruled out by systematic pregnancy test at ICU admission).\n* Minors.","18 Years",{"count":51,"type":20},205,"Fluid administration is the first-line treatment in hypovolemic states in critically ill patients. Prediction of fluid responsiveness is possible with echocardiography by assessing the variation of the sub-aortic velocity-time integral (AoVTI) during a passive leg raising test (PLR) or Mini-fluid challenge. However, VTI-Ao measurement is not feasible in all patients due to poor echogenicity. Validation of new fluid-responsiveness indices may facilitate the evaluation in this patient population. Among the available indices, variation of the sub-pulmonary VTI is a potential criterion.",[54,24],"Fluid Resuscitation",[56,57,58,59],"fluid responsiveness","echocardiography","Passive Leg Raising","Mini Fluid Challenge","2025-09-23",{"date":62,"type":33},"2025-10-02",{"date":64,"type":33},"2024-11-07",{"date":66,"type":20},"2027-05",{"name":68,"class":69},"Hospital Nord","OTHER",2,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":78,"targetDuration":80,"studyType":21,"phases":4,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100564340","hemodynamic-response-to-the-end-expiratory-occlusion-test-to-titrate-fluid-challenge-in-operating-room-100564340","NCT06627907","Hemodynamic Response to the End-expiratory Occlusion Test to Titrate Fluid Challenge in Operating Room.","FC_EEOT","Inclusion Criteria:\n\n1. Adult patients aged ≥ 18 years\n2. Scheduled for elective supine abdominal laparotomic or neuro surgery, requiring invasive arterial monitoring and continuous hemodynamic monitoring\n3. All the patients must be able to sign an informed consent at the admission\n\nExclusion Criteria:\n\n1. Any recurrent cardiac arrhythmias\n2. Reduced left (ejection fraction \\\u003C30%) or right (systolic peak velocity of tricuspid annular motion \\\u003C0.17 m\u002Fs) ventricular systolic function\n3. Urgent \u002F Emergent surgery\n4. Liver surgery\n5. Laparoscopic surgery",{"count":79,"type":20},300,"1 Day","Personalzing intraoperative anesthetic fluid management may help in preventing fluid accumulation and related complications.\n\nFluids are gine as boluses in operating room (the so-called FC). The response to the FC is due to several physiological conditions related to the \"preload dependency\" (i.e. the intrinsic ability of the heart of increasing the stroke volume - SV - in response to fluid administration).\n\nThe minimal volume required to appropriately \"challenge\" the cardiovascular system is 4 ml\u002Fkg of fluid, but higher volumes (up to 6 ml\u002Fkg may be needed).\n\nPredicting the response to FC administration may be possible by applying a physiological test (called functional hemodynamic test), such as the end-expiratory occlusion test, consisting in interrupping the mechanical ventilation and hence promoting venous return and consequente SV changes. The percentage of SV increase associated to EEOT may predict fluid responsiveness to the FC (patients responders will increase SV to a bigger extent, as compared to non-responders)",[24],[84,85,86,87],"Fluid challenge","End-expiratory occlusion test","FLuid responsiveness","Surgery","NOT_YET_RECRUITING","2024-10-03",{"date":91,"type":33},"2024-10-08",{"date":93,"type":20},"2024-11-01",{"date":95,"type":20},"2026-09-01",{"name":97,"class":69},"Humanitas Clinical and Research Center"]