[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fluid-resuscitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fluid-resuscitation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,72,96,123,155],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100635262","role-of-echocardiography-and-ultrasound-indices-in-resuscitation-of-septic-shock-patients-100635262",false,"NCT07550400","Role of Echocardiography and Ultrasound Indices in Resuscitation of Septic Shock Patients","Echocardiographic Left Ventricular End Diastolic Area Versus Carotid Artery Duplex as a Sensitive Indicator for Guiding Fluid Resuscitation in Septic Shock Patients . A Prospective Cohort Study","Inclusion Criteria:\n\n* ▪ Age:18-50 years old\n\n  * Sex: both males \\&females.\n  * Patients diagnosed with septic shock according to SOFA score more than or equal 1\n  * Presence of at least one sign of acute circulatory failure from:\n\n    1. Low blood pressure (mean arterial pressure \\\u003C65 mmHg and \u002F or systolic \\\u003C90 mmHg).\n    2. Tachycardia\\> 120 bpm without other obvious cause of circulatory failure.\n    3. Oliguria \\\u003C1 ml \u002F kg during the last hour suggestive of circulatory failure.\n    4. Blood hyperlactatemia \\> 2mmol \u002F l without other obvious cause a systemic circulatory failure.\n    5. Another sign justifying, for example vascular increase capillary refill time more than 2 seconds.\n\nExclusion Criteria:\n\n* ▪ Known significant valvular heart disease (sever aortic insufficiency or stenosis)\n\n  * Known carotid artery stenosis \\>50% or previous carotid surgery\n  * Clear contraindication to the carotid artery Doppler such as wound or infection or complete or partial occlusion of the carotid artery.\n  * Arrhythmias affect stroke volume assessment (atrial fibrillation, frequent PVCs)\n  * Dilated cardiomyopathy.\n  * Poor transthoracic echocardiographic window\n  * Patient refusal","ALL","18 Years","50 Years",{"count":20,"type":21},40,"ESTIMATED","1 Day","OBSERVATIONAL","Fluid replacement is considered the cornerstone of hemodynamic management in critically ill patients especially in patients with septic shock. However, only about 50% of critically ill hemodynamically unstable patients are responsive to fluids. Consequently, the resuscitation of critically ill patients requires an accurate assessment of the patients' intravascular volume status and their volume responsiveness. In this study, we will compare the efficacy of carotid artery flow to echo left ventricular end diastolic volume as a predictive value for fluid resuscitation in septic shock patients.",[26,27],"Septic Shock","Fluid Resuscitation",[29,30,31],"End diastolic diameter","carotid artery duplex","septic shock","RECRUITING","2026-04-18",{"date":35,"type":36},"2026-04-24","ACTUAL",{"date":38,"type":21},"2026-05-03",{"date":40,"type":21},"2026-11-12",{"name":42,"class":43},"Ain Shams University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100608521","evaluation-of-the-variation-of-the-sub-pulmonary-velocity-time-integral-to-predict-fluid-responsiveness-100608521","NCT07202637","Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness","Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness Prospective Observational Study","Inclusion Criteria:\n\n* Patient with measurable sub-pulmonary VTI in at least one of the two windows: parasternal short-axis or subcostal.\n* Patient with measurable sub-aortic VTI in apical 4-chamber view before and after PLR maneuver.\n* Patient with suspected hypovolemia or whose hemodynamic status justifies vasopressor infusion.\n\nExclusion Criteria:\n\n* Severe left ventricular dysfunction defined by left ventricular ejection fraction (LVEF) \\\u003C 30%.\n* Severe right ventricular dysfunction defined by TAPSE \\\u003C 12 mm.\n* Cardiac arrhythmia or atrial fibrillation.\n* Abdominal compartment syndrome.\n* Amputation of one or both lower limbs.\n* Intracranial hypertension.\n* Pregnant women (ruled out by systematic pregnancy test at ICU admission).\n* Minors.",{"count":53,"type":21},205,"Fluid administration is the first-line treatment in hypovolemic states in critically ill patients. Prediction of fluid responsiveness is possible with echocardiography by assessing the variation of the sub-aortic velocity-time integral (AoVTI) during a passive leg raising test (PLR) or Mini-fluid challenge. However, VTI-Ao measurement is not feasible in all patients due to poor echogenicity. Validation of new fluid-responsiveness indices may facilitate the evaluation in this patient population. Among the available indices, variation of the sub-pulmonary VTI is a potential criterion.",[27,56],"Fluid Responsiveness Predictability",[58,59,60,61],"fluid responsiveness","echocardiography","Passive Leg Raising","Mini Fluid Challenge","2025-09-23",{"date":64,"type":36},"2025-10-02",{"date":66,"type":36},"2024-11-07",{"date":68,"type":21},"2027-05",{"name":70,"class":43},"Hospital Nord",2,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":4},"100607041","impact-of-fluid-resuscitation-on-venous-congestion-in-cardiac-critically-ill-patients-100607041","NCT07183397","Impact of Fluid Resuscitation on Venous Congestion in Cardiac Critically-ill Patients","VExUS-CS","Inclusion Criteria:\n\n* Age above 18 years\n* Admission to cardiac intensive care unit",{"count":80,"type":21},250,"The objective of this study is to assess how fluid resuscitation, in the context of fluid responsiveness, affects the incidence and progression of systemic venous congestion in critically ill cardiac patients. Additionally, the study aims to evaluate the impact on clinical outcomes, with a particular focus on acute kidney dysfunction. This assessment will utilize the VExUS score in conjunction with comprehensive bedside echocardiographic evaluations.",[83,84,85,27],"Cardiac and Aortic Surgery","Cardiac Anaesthesia","Venous Congestion","NOT_YET_RECRUITING","2025-09-14",{"date":89,"type":36},"2025-09-19",{"date":91,"type":21},"2025-09-15",{"date":93,"type":21},"2027-12",{"name":95,"class":43},"Medical University of Vienna",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":104,"targetDuration":106,"studyType":23,"phases":4,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":44},"100589776","evolution-of-tissue-perfusion-and-venous-congestion-markers-in-fluid-responsive-septic-shock-patients-100589776","NCT06958809","Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients","Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients: Evaluating the Benefit-Risk Balance of Fluid Resuscitation","FLUID-IMPACT","Inclusion Criteria:\n\n* Septic shock (sepsis-3 criteria)\n* Under mechanical ventilation\n* Central venous catheter in the superior vena cava territory and arterial catheter in place\n* Response to fluid resuscitation as per standard definition (i.e., an increase in cardiac output \\>10% assessed by subaortic velocity time integral \\[VTI\\] using echocardiography)\n\nExclusion Criteria:\n\n* Patient under 18 years of age\n* Lack of social security coverage \u002F adult under legal protection\n* Pregnant woman\n* Inability to obtain non-opposition consent",{"count":105,"type":21},200,"28 Days","Septic shock remains a leading cause of mortality in intensive care, and while fluid resuscitation (FR) is a cornerstone of early management, its benefit-risk balance is highly variable. Excessive fluid administration can cause venous congestion and organ dysfunction, while insufficient resuscitation risks hypoperfusion. Current strategies often rely on fluid responsiveness (i.e., increased cardiac output after fluids), but this does not guarantee improved outcomes, particularly if congestion ensues.\n\nThis prospective, multicenter, observational study aims to assess the clinical impact of FR in septic shock patients who are fluid responsive. The primary objective is to evaluate changes in tissue perfusion and venous congestion markers following FR. Patients will be categorized into four response profiles based on the presence or absence of perfusion improvement and congestion worsening.\n\nSecondary objectives include exploring the prognostic implications of each profile (organ dysfunction, mortality), identifying pre-FR predictors of adverse responses, evaluating changes in congestion markers after passive leg raising (PLR), and performing phenotypic clustering and mediation analyses.\n\nEligible patients are adults with septic shock requiring vasopressors and mechanical ventilation, with confirmed fluid responsiveness via echocardiography. Each patient will undergo standardized pre- and post-FR assessments, including cardiac ultrasound, Doppler of hepatic\u002Fportal veins (VeXUS), CVP, perfusion markers, and blood gases.\n\nData on SOFA scores, organ support duration, and 28-day mortality will be collected. Approximately 170 patients will be enrolled across five ICUs experienced in advanced hemodynamic monitoring. Statistical analyses will include multivariate modeling, clustering, ROC curves, and mediation analyses.\n\nBy identifying phenotypes of fluid-responsive but fluid-intolerant patients, the study aims to refine fluid management strategies and improve outcomes through more personalized care in septic shock.",[26,27,109],"Congestion, Venous",[31,111,112,113],"fluid resuscitation","venous congestion","tissue perfusion","2025-04-25",{"date":116,"type":36},"2025-05-06",{"date":118,"type":21},"2026-02-01",{"date":120,"type":21},"2027-08-01",{"name":122,"class":43},"Hospital Ambroise Paré Paris",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":132,"phases":133,"briefSummary":135,"conditions":136,"keywords":139,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":44},"100580263","dextran-40-plus-ringers-lactate-vs-ringers-lactate-alone-for-fluid-resuscitation-in-acute-pancreatitis-100580263","NCT06835023","Dextran 40 Plus Ringer's Lactate Vs. Ringer's Lactate Alone for Fluid Resuscitation in Acute Pancreatitis","A Randomized Controlled Trial Evaluating Fluid Resuscitation in Acute Pancreatitis: Dextran 40 and Ringer's Lactate (1:3 Ratio) Versus Ringer's Lactate Alone","Inclusion Criteria:\n\n* adults (≥18 years) diagnosed with mild or moderate acute pancreatitis\n* must provide written informed consent for study participation.\n\nExclusion Criteria:\n\n* patients who decline to provide informed consent.\n* patients are non-compliant with treatment and follow-up visits.\n* pregnant individuals.\n* patients requiring concomitant treatment that is contraindicated within the study protocol.\n* patients who develop conditions that contraindicate the administration of the investigational medication.\n* patients experiencing severe adverse reactions necessitating treatment discontinuation.",{"count":131,"type":21},100,"INTERVENTIONAL",[134],"NA","This clinical trial aims to learn if a combination of Dextran 40 and Ringer's lactate solution can improve fluid resuscitation in mild and moderate acute pancreatitis (AP) and prevent complications. The main questions it aims to answer are:\n\nDoes early fluid resuscitation with Dextran 40 plus Ringer's lactate improve patient outcomes compared to Ringer's alone? Does this treatment reduce inflammation, organ failure, and the need for intensive care unit (ICU) admission? Researchers will compare Dextran 40 plus Ringer's lactate to Ringer's alone to see if the combination therapy is more effective in reducing disease severity and complications.\n\nParticipants will:\n\nReceive either Dextran 40 plus Ringer's lactate (1:3 ratio) or Ringer's lactate alone.\n\nHave blood tests every 24 hours to measure inflammation and organ function. Be monitored for changes in disease severity, need for ICU admission, and hospitalization duration.\n\nThis study will help determine the best fluid resuscitation strategy for treating mild and moderate acute pancreatitis.",[137,138,27],"Acute Pancreatitis (AP)","Acute Pancreatic Fluid Collection",[140,141,142,143,144],"Fluid resuscitation","Acute pancreatitis","Dextran","Ringer Lactat solution","combination colloid-crystalloid","2025-02-18",{"date":147,"type":36},"2025-02-20",{"date":149,"type":36},"2022-01-10",{"date":151,"type":21},"2025-05-12",{"name":153,"class":154},"Satu Mare County Emergency Hospital","OTHER_GOV",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":165,"conditions":166,"keywords":4,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":4},"100474105","restricted-or-liberal-fluid-for-haemodynamic-resuscitation-in-sepsis-100474105","NCT05453565","Restricted or Liberal Fluid for Haemodynamic Resuscitation in Sepsis","Fluid Restricted Resuscitation in Sepsis With Hypotension Meta-Analysis (FRESHLY): Individual Patient Data Met-analysis of the ARISE FLUIDS, CLASSIC, CLOVERS and EVIS Trials","FRESHLY","Inclusion Criteria:\n\nParticipants of the ARISE FLUIDS, CLASSIC, CLOVERS \\& EVIS trials who had:\n\n* Suspected or proven infection\n* Systolic blood pressure (SBP) \\\u003C100 mm Hg OR mean arterial pressure (MAP) \\\u003C65 mm Hg\n* Lactate ≥ 2.0 mmol\u002FL\n* Requirement for vasopressors to meet perfusion targets\n\nExclusion criteria:\n\nParticipants not in the ARISE FLUIDS, CLASSIC, CLOVERS \\& EVIS trials",{"count":164,"type":21},7838,"A prospective, individual patient data meta-analysis (IPDMA) of four multicentre, open-label, randomised clinical trials of initial haemodynamic resuscitation in patients with septic shock.",[26,27],"2025-01-01",{"date":169,"type":36},"2025-01-03",{"date":171,"type":21},"2025-11",{"date":173,"type":21},"2026-11",{"name":175,"class":43},"Australian and New Zealand Intensive Care Research Centre"]