[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fluid-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fluid-therapy":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,47,79,116,156,190,224,248,277,300,327,351],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100644754","remimazolam-on-the-incidence-of-postoperative-acute-kidney-injury-100644754",false,"NCT07674719","Remimazolam on the Incidence of Postoperative Acute Kidney Injury","The Effect of Intraoperative Remimazolam Administration on the Incidence of Postoperative Acute Kidney Injury After Hepatobiliary and Pancreatic Surgery : a Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Ages 19 or older and under 85\n* Patients scheduled to undergo elective hepatopancreatic surgery under general anesthesia\n* American Society of Anesthesiologists (ASA) physical grade 1-3\n* Those who voluntarily consented to a written informed consent form prior to participation in the study\n\nExclusion Criteria:\n\n* Patients with hypersensitivity to other benzodiazepine drugs, including remimazolam, and to the components of this drug (e.g., patients with severe hypersensitivity to dextran 40)\n* Patients with hypersensitivity to propofol\n* Patients with underlying conditions: liver, neurological disorders, or acute narrow-angle glaucoma\n* Patients with severe or acute respiratory failure\n* Patients in shock or a coma\n* Patients taking TCA antidepressants\n* Patients with preoperative chronic kidney disease","ALL","19 Years","85 Years",{"count":20,"type":21},78,"ESTIMATED","INTERVENTIONAL",[24],"NA","We hypothesized that in patients undergoing elective hepatobiliary-pancreatic surgery, the group in which anesthesia is induced and maintained with remimazolam during surgery would maintain hemodynamic stability and reduce the incidence of postoperative acute kidney injury compared to propofol. The purpose is to provide practical evidence for perioperative management differentiated from other surgeries for hepatobiliary-pancreatic surgery patients for whom intraoperative fluid therapy is restricted.",[27,28,29,30,31,32,33],"Remimazolam","Propofol","Acute Kidney Injury","Hemodynamic Stability","Hepatobiliary Surgery","Fluid Therapy","Fluid Therapy DURING SURGERY","NOT_YET_RECRUITING","2026-06-24",{"date":37,"type":38},"2026-06-29","ACTUAL",{"date":40,"type":21},"2026-06-26",{"date":42,"type":21},"2028-06-26",{"name":44,"class":45},"Seoul National University Bundang Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":64,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":72,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":46},"100613000","paired-comparison-of-svv-and-pvi-accuracy-100613000","NCT07260890","Paired Comparison of SVV and PVI Accuracy","Diagnostic Accuracy of Stroke Volume Variation (SVV) vs Pleth Variability Index (PVI) for Predicting Fluid Responsiveness in Laparoscopic Major Abdominal Surgery-A Prospective, Paired, Cohort Study","Inclusion Criteria:\n\n* Age ≥18 years\n* ASA physical status I-III\n* Elective laparoscopic major abdominal surgery under general anesthesia\n* Arterial line in place for clinical care\n* Able to provide informed consent\n* Arterial and plethysmographic waveforms adequate for measurement\n\nExclusion Criteria:\n\n* linically significant arrhythmia (e.g., atrial fibrillation with irregular R-R)\n* Severe valvular heart disease or intracardiac shunt\n* Pregnancy\n* Severe right-heart failure or condition where a fluid bolus is unsafe\n* Ongoing hemodynamic instability requiring rapid vasoactive titration at assessment\n* Persistently unreliable arterial\u002Fpleth signals despite optimization\n* Any situation the anesthesiologist judges that the fluid challenge is unsafe",true,{"count":56,"type":21},300,"OBSERVATIONAL","This study will compare two operating-room monitors-stroke volume variation (SVV, from the arterial line) and the Pleth Variability Index (PVI, from the pulse oximeter)-to see which one more accurately predicts whether giving a small fluid bolus will improve the heart's pumping during laparoscopic major abdominal surgery. Adults having elective surgery under general anesthesia will receive two small, timed 250-mL crystalloid infusions as part of routine care (one before and one after creation of the pneumoperitoneum). The research team will record SVV and PVI values just before and three minutes after each infusion while keeping these readings hidden from the clinicians so that usual care is not changed. No experimental drugs or devices are used. The main goal is to learn which index better identifies \"fluid responsiveness,\" so future care can be safer and more consistent. Potential risks are minimal and relate to the small fluid boluses (temporary changes in blood pressure or heart rate); the test stops if the anesthesiologist has any safety concerns. There is no direct benefit to participants, but results may help guide fluid therapy for similar patients in the future. The study is being conducted at a single academic hospital in the Republic of Korea and plans to enroll about 300 adults.",[60,32,61,62,63],"Perioperative Care","Monitoring, Physiologic","Hemodynamics","Laparoscopy",[65,66,67,68,69,70],"stroke volume variation; SVV","Pleth Variability Index; PVI","fluid responsiveness","goal-directed fluid therapy; GDFT","pneumoperitoneum","diagnostic accuracy; ROC; AUROC","RECRUITING",{"date":40,"type":38},{"date":74,"type":21},"2026-07-01",{"date":76,"type":21},"2026-08-30",{"name":78,"class":45},"Wonkwang University Hospital",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":46},"100642436","intravenous-fluid-practices-in-turkish-intensive-care-units-tr-fluid-100642436","NCT07649694","Intravenous Fluid Practices in Turkish Intensive Care Units (TR-FLUID)","TR-FLUID: Evaluation of Intravenous Fluid Administration Practices in Turkish Intensive Care Units: A Multicenter, Prospective, Point-Prevalence Observational Study","Inclusion Criteria:\n\n* Aged 18 years or older\n* Present in a participating intensive care unit at the index time (08:00 local time on the center's selected study day); no minimum or maximum ICU length of stay is required\n\nExclusion Criteria:\n\n* Younger than 18 years of age\n* Refusal of study participation by the patient or their legal representative","18 Years",{"count":88,"type":21},400,"Intravenous (IV) fluids-fluids given directly into a vein-are among the most common treatments used in intensive care units (ICUs). They are given for several reasons, such as supporting blood pressure, providing daily water and salts, replacing losses, or diluting medications. However, the type of fluid, the amount given, and the salt (sodium and chloride) load can vary widely between hospitals and doctors. In Turkey, there is currently no up-to-date, multicenter information describing how IV fluids are used in adult ICUs in everyday practice.\n\nThis study, called TR-FLUID, aims to describe IV fluid use in adult ICUs across Turkey. It is an observational study, meaning the researchers only observe and record care that is already being provided. No extra tests, medications, or procedures are added, and the study does not change how patients are treated in any way.\n\nOn a single pre-selected study day at each participating ICU, the research team will identify all adult patients (18 years and older) who are in the ICU at 8:00 a.m. For each patient, the team will record the IV fluids given over the following 24 hours-including the fluid type, the volume, the reason it was given, and the resulting sodium and chloride load-together with the patient's fluid balance. All information is taken from the patient's existing medical records.\n\nThe main goal is to determine what proportion of patients receive fluids for resuscitation and which fluid types are used. The study will also describe the total fluid, sodium, and chloride given by indication; the 24-hour fluid balance; and how fluid use relates to short-term events such as the need for blood-pressure-supporting medications, new kidney injury, and ICU and hospital survival. These relationships will be explored to generate hypotheses and are not intended to prove cause and effect.\n\nThe findings will provide a national picture of current fluid practice in Turkish ICUs, help identify where practice differs from guidelines, and serve as a foundation for future quality-improvement and research efforts.",[91,32,92],"Critical Illness","Practices",[94,95,96,97,98,99,100,101,102,103,104,105,106],"TR-FLUID","Intravenous fluid therapy","Fluid resuscitation","Resuscitation fluid","Balanced crystalloids","Normal saline","Albumin","Fluid creep","Maintenance fluids","Fluid balance","Chloride load","Fluid stewardship","Critical care","2026-06-10",{"date":109,"type":38},"2026-06-16",{"date":111,"type":21},"2026-09-01",{"date":113,"type":21},"2027-09-01",{"name":115,"class":45},"Ondokuz Mayıs University",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":16,"minAge":123,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":127,"briefSummary":128,"conditions":129,"keywords":133,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":155},"100377988","effect-of-giving-reduced-fluid-in-children-after-trauma-100377988","NCT04201704","Effect of Giving Reduced Fluid in Children After Trauma","Effect of Restricted Fluid Management Strategy on Outcomes in Critically Ill Pediatric Trauma Patients: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* Trauma patients older than 6 months and younger than 15 years admitted to the pediatric intensive care unit (PICU)\n* Patients admitted to the PICU directly from the Emergency Department (ED)\n* Patients admitted to the PICU from the operating room (OR)\n* Patients transferred to PICU from outside facility ED (need to have been in ED 12 hours or less)\n\nExclusion Criteria:\n\n* Patients transferred to PICU from outside PICU or inpatient floor\n* Patients transferred to PICU from outside facility ED if \\>12 hours\n* Patients expected to be discharged from the PICU within 24 hours\n* Patient with congenital heart disease as defined by a congenital cardiac defect requiring surgery or medication\n* Patient with diagnosis of chronic cardiac condition (e.g. hypertension, cardiac arrhythmia)\n* Patients with chronic kidney disease as defined by an abnormality of kidney structure or function, present for more than 3 months, with implications to health\n* Post-operative transplant, cardiac, and neurosurgical patients\n* Patients with traumatic brain injury\n* Patients with any disease that may affect baseline blood pressure and heart rate (endocrine disorders, certain genetic disorders, mitochondrial diseases)\n* Hypotension requiring vasopressor therapy\n* If massive transfusion protocol initiated","6 Months","15 Years",{"count":126,"type":21},250,[24],"This study is designed to help decide how much intravenous (IV) fluid should be given to pediatric trauma patients. No standard currently exists for managing fluids in critically ill pediatric trauma patients, and many fluid strategies are now in practice. For decades, trauma patients got high volumes of IV fluid. Recent studies in adults show that patients actually do better by giving less fluid. The investigators do not know if this is true in children and this study is designed to answer that question and provide guidelines for IV fluid management in children after trauma.",[91,130,131,32,132],"Pediatrics","General Surgery","Wounds and Injuries",[32,134,135,132,136,137,138,139,62,140,141,142,143,144,145],"Intensive Care Units, Pediatric","Critical Care","Multiple Trauma","Treatment Outcome","Postoperative Complications","Resuscitation","Infusions, Intravenous","Isotonic Solutions","Crystalloid Solutions","Diuretics","Organism Hydration Status","Body Water","2026-05-04",{"date":148,"type":38},"2026-05-07",{"date":150,"type":38},"2018-08-27",{"date":152,"type":21},"2027-09",{"name":154,"class":45},"Columbia University",4,{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":16,"minAge":163,"maxAge":164,"enrollmentInfo":165,"targetDuration":167,"studyType":57,"phases":4,"briefSummary":168,"conditions":169,"keywords":172,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":155},"100633122","fluid-responsiveness-assessment-simplified-by-electric-cardiometry-in-children-100633122","NCT07522580","Fluid-responsiveness Assessment Simplified by Electric Cardiometry in Children","FAST","Inclusion Criteria:\n\n* Age less than or equal to 8 years old\n* Hospitalization in a pediatric intensive care unit\n* Prescription by the attending physician of a fluid expansion of 10ml\u002Fkg\n* Use of a non-invasive cardiac output monitoring device (electrical cardiometry) as part of routine care\n\nExclusion Criteria:\n\n* Patient less than 37 weeks' corrected gestational age\n* Hemodynamic instability making the delay necessary for any test dangerous\n* Supine position contraindicated or deleterious\n* Impairment of echocardiographic acoustic window or restless patient making ultrasonography impossible\n* Opposition to participate expressed by the patient or by a parent or legal guardian\n* Intra-abdominal hypertension, painful abdominal palpation or abdominal surgery in the last 15 days","0 Days","8 Years",{"count":166,"type":21},42,"28 Days","In this study of diagnostic accuracy, the investigators aim to validate a faster, simpler, and noninvasive test of fluid-responsiveness in critically ill children. This test is based on an assessment of the hemodynamic effects of a standardized abdominal compression, using electrical cardiometry. This would help physicians to identify more easily which patient could benefit from a volume expansion, thus avoiding a potentially useless or even dangerous fluid expansion that could lead to fluid overload. To this end, the diagnostic accuracy of electrical cardiometry-based stroke volume (SV) variation induced by a standardized abdominal compression to predict fluid responsiveness (define as a 15% increase in echocardiographically measured SV after volume expansion) will be measured.",[170,171,32],"Circulatory Failure","Shock State",[173,135,174,175,176,177,178,179,180],"Circulatory failure","Echocardiography","Electrical Cardiometry","Fluid therapy","Fluid responsiveness","Goal-directed fluid management","pediatrics","volume expansion","2026-04-03",{"date":183,"type":38},"2026-04-13",{"date":185,"type":38},"2025-07-22",{"date":187,"type":21},"2027-08-19",{"name":189,"class":45},"University Hospital, Bordeaux",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":196,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":198,"enrollmentInfo":199,"targetDuration":4,"studyType":22,"phases":201,"briefSummary":202,"conditions":203,"keywords":207,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":223},"100543100","efficacy-of-intraoperative-use-of-20-albumin-combined-with-ringer-lactate-versus-ringer-lactate-during-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-100543100","NCT06351475","Efficacy of Intraoperative Use of 20% Albumin Combined With Ringer Lactate Versus Ringer Lactate During Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy","Evaluation de l'efficacité du Remplissage Vasculaire Par de l'ALBUmine Humaine 20% + Ringer Lactate comparé au Ringer Lactate Seul Chez Les Patients opérés Par cytoréduction Avec CHimiothérapie Intrapéritonéale hyPerthermique","ALBUCHIP","Inclusion Criteria:\n\n* Male and female patients aged 18 years old and older\n* Planned cytoreductive surgery with HIPEC for peritoneal carcinomatosis (from gynaecological or digestive origin)\n* Patient volunteer for the study and provided written informed consent\n* Patient affiliated to the French Health Insurance\n\nExclusion Criteria:\n\n* Adults \\>75 years old\n* Functional status rendering the patient ineligible for cytoreduction with CHIP (ECOG \\> 2 or Karnofsky index \\\u003C 75)\n* Pre-existing preoperative conditions affecting albuminemia (hepatic cirrhosis, nephrotic syndrome, exudative enteropathy, malnutrition)\n* Severe preoperative hypoalbuminemia (albuminemia \\\u003C 20 g\u002FL)\n* History of chronic left heart failure with reduced left ventricular ejection fraction (left ventricular ejection fraction \\\u003C 40%)\n* Patients at high risk of perioperative and postoperative pulmonary complications (atelectasis, significant pleural effusions)\n* Significant ascites with preoperative respiratory repercussions\n* Uncontrolled diabetes (HbA1c \\> 8.5%)\n* Allergy to exogenous human albumin and its excipients.\n* Contraindication to the administration of Ringer's lactate (history of allergy)\n* Hyperkalemia \\> 6.0 mmol\u002FL\n* Hypercalcemia (total calcium \\> 2.60 mmol\u002FL)\n* Chronic use of digitalis and hyperkalemic diuretics\n* Pregnancy, breastfeeding\n* Known preoperative renal failure (GFR \\\u003C 30 mL\u002Fmin\u002F1.73m2 or extrarenal purification)\n* Recent brain trauma \\\u003C 6 months (traumatic, ischemic, or hemorrhagic)\n* Participation in another interventional study involving human subjects or being in the exclusion period following a previous study involving human subjects, if applicable\n* Patient deprived of liberty\n* Patient under guardianship or curatorship","80 Years",{"count":200,"type":21},140,[24],"Introduction Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is considered as the standard of care for the treatment of peritoneal metastases. Cytoreductive surgery with HIPEC is characterized by large intra operative fluid shift secondary to surgical resection, peritoneal inflammation and capillary shifts, requesting high volume of intra operative fluid therapy. Previous studies found a strong association between intra operative hypovolemia or volume overload with post operative outcomes. Albumin as an intravenous fluid has been widely studied in critical ill patients, but evaluation of its efficacy during major surgery on post operative clinical outcomes are lacking. We hypothesize that a reduction of intra operative crystalloid volume infusion by using 20% albumin during CRS with HIPEC could improve patients' prognosis. The aim of this study will be to assess the efficacy of 20% albumin combined with Ringer Lactate versus Ringer Lactate for fluid therapy during CRS with HIPEC on post operative outcome at 28 day.\n\nMethods and analysis The study protocol has been designed and written in accordance with the Prospective randomised, comparative, controlled, prospective, open-label, with parallel group and multicentre clinical trial.\n\nRecruitment, randomisation and allocation Information on the study and screening of patients will be conducted during the consultation of anaesthesia (= selection visit), 2 months at 3 days before the surgery. Information notice and consent form will be delivered. The day before the surgery, anaesthesiologist who will conduct the pre anaesthetic visit will be able to include patients in the study (=inclusion visit). Randomisation will be done at the inclusion visit after information and signature of consent form of voluntary patients. A randomization number will be assigned. The 1:1 randomisation will be centralized via an online interface ensuring secret group assignment, and based on predefined randomisation lists with variable-size permutation blocks, stratified by center. Randomisation will be accomplished using a computer-generated random sequence.\n\nRandomized Open, Blinded endpoint (PROBE) design. This study is a randomised, comparative, controlled, prospective, open-label, with parallel group and multicentre clinical trial.\n\nIntervention\n\n* 20% Albumin + Ringer Lactate group (intervention group) Per-operative fluid therapy consisting in Ringer Lactate combined with 20% albumin. Patients will receive a bolus of 3 mL\u002Fkg on one hour of 20% albumin from anaesthetic induction. Then, infusion of 20% albumin (100 mL, 20g) will be administered for each 1200 mL of vascular filling by Ringer Lactate. Dosage of intra operative albuminemia will be realized 2 hours after the end of the bolus or infusion to ensure albuminemia is within the target concentrations (35-45 g\u002FL). Use of 20% albumin will be realized for the entire duration of the surgery and stopped at the end of the surgery.\n* Control group Ringer Lactate for intra operative fluid management based on the latest scientific recommendations. As the the study is an open labelled randomized clinical trial, placebo use is not planned.\n\nOutcome measures The primary outcome will be the Comprehensive Complication Index (CCI score) at day 28 after CRS with HIPEC. Secondary outcomes are mortality at day 28, CCI score at day 7, volume of intra operative and post operative (48h) post operative fluid therapy, cumulated incidence of surgical post operative complications, cumulated incidence of medical post operative complications, need for mechanical ventilation, renal replacement therapy between surgery and day 28, SOFA score variation between pre operative period and 48h after surgery, number of days alive out of intensive care unit and out of hospital until day 28\n\nSample size calculation To ensure a power of 80%, a number of patients 130 (65 patients by group) will be necessary with a reduction of 13.6 (SD 24) points of the CCI score at day 28 in the intervention group. Because of a risk of neoplastic evolution between anaesthetic consultation and randomisation (10% of early cancellation), a total of 146 patients (73 by group) will be included in the study.\n\nDiscussion In summary, ALBUCHIP study will be the first randomized clinical trial assessing efficacy of intraoperative use of 20% albumin combined with Ringer Lactate versus Ringer Lactate during CRS with HIPEC. Results yielded from this study will be helpful for vascular filling during CRS with HIPEC but, thanks to ancillary studies, to improve pathophysiological understanding of this surgery.",[204,205,206,32,138],"Peritoneal Neoplasms","Hyperthermic Intraperitoneal Chemotherapy","Intraoperative Care",[208,209,210,176,211,212,213],"Cytoreductive surgery","Hyperthermic intraperitoneal chemotherapy","Albumin administration","Post operative prognosis","Randomized clinical trial","Open label clinical trial","2025-11-28",{"date":216,"type":38},"2025-12-05",{"date":218,"type":38},"2025-09-03",{"date":220,"type":21},"2027-10",{"name":222,"class":45},"Assistance Publique - Hôpitaux de Paris",7,{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":16,"minAge":163,"maxAge":124,"enrollmentInfo":232,"targetDuration":167,"studyType":57,"phases":4,"briefSummary":234,"conditions":235,"keywords":237,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":247},"100612583","metabolic-fluid-responsiveness-in-children-100612583","NCT07255469","Metabolic Fluid Responsiveness in Children","Parameters Associated With Metabolic Response to Volume Expansion in Children Post-operative of Cardiac Surgery","METAFRIC","Inclusion Criteria:\n\n* Age less than or equal to 15 years old\n* Hospitalization in a pediatric intensive care unit after cardiac surgery\n* Prescription by the attending physician of a fluid expansion of 10ml\u002Fkg\n* Prescription of arterial and venous blood gas before and after the volume expansion to help manage acute circulatory failure\n* Patient implanted with a functioning arterial line\n* Patient implanted with a functioning central venous line in the superior vena cava territory\n\nExclusion Criteria:\n\n* Patient less than 37 weeks' corrected gestational age\n* Hemodynamic instability making the delay necessary for any test dangerous\n* Supine position contraindicated or deleterious\n* Impairment of echocardiographic acoustic window or restless patient making ultrasonography impossible\n* Opposition to participate expressed by the patient or by a parent or legal guardian",{"count":233,"type":21},110,"The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery. This would allow physicians to identify which patient could benefit the most from fluid expansion, thus avoiding useless and potentially dangerous fluid expansions that could lead to fluid overload. To this end, The investigators will evaluate the diagnostic accuracy of the ratio of central venous to arterial carbon dioxide tension (Pv-aCO2) to arteriovenous oxygen content (CavO2), a simple biological marker of anaerobic metabolism, for the diagnosis of metabolic fluid responsiveness defined as a significant increase in oxygen consumption (VO2) after fluid expansion.",[236,32],"Circulatory Failure \u002F Shock State",[173,135,174,176,177,178,238,179,180],"oxygen consumption","2025-11-19",{"date":241,"type":38},"2025-12-01",{"date":243,"type":38},"2025-03-21",{"date":245,"type":21},"2027-04-18",{"name":189,"class":45},8,{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":4,"enrollmentInfo":255,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":257,"conditions":258,"keywords":262,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":46},"100594658","urine-output-response-to-fluid-and-diuretic-therapy-in-cardiac-icu-patients-monitored-with-fize-kuo-100594658","NCT07022314","Urine Output Response to Fluid and Diuretic Therapy in Cardiac ICU Patients Monitored With FIZE kUO®","FIZE kUO® Real-Time Measurement of Urine Output Response to Fluid Therapy and Diuretics in Cardiovascular Surgery Patients: A Prospective Post-Market Study","Inclusion Criteria:\n\n1. Adults aged 18 years and older scheduled for CABG or valve surgery and expected postoperative admission to CTICU\n2. Ability to provide informed consent\n\nExclusion Criteria:\n\n1. Pregnancy\n2. Preoperative dialysis (chronic or acute)\n3. Enrollment in other interventional trials assessing urine output or AKI",{"count":256,"type":21},45,"This prospective observational study evaluates the real-time urine output response to fluid therapy and diuretics in cardiothoracic intensive care unit (CTICU) patients monitored with the FIZE kUO® device. The study aims to assess how continuous urine output monitoring can inform fluid management and improve patient outcomes post-cardiac surgery.",[259,260,32,261,138],"AKI - Acute Kidney Injury","Cardiac Surgery","Hemodynamic Instability",[263,264,265,143,266],"FIZE kUO","Urine Output","Fluid Management","Cardiothoracic Surgery","2025-06-12",{"date":269,"type":38},"2025-06-15",{"date":271,"type":21},"2025-07",{"date":273,"type":21},"2026-06",{"name":275,"class":276},"FIZE Medical ltd","INDUSTRY",{"id":278,"slug":279,"hasResults":11,"nctId":280,"briefTitle":281,"officialTitle":282,"acronym":4,"eligibilityCriteria":283,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":4,"enrollmentInfo":284,"targetDuration":4,"studyType":22,"phases":286,"briefSummary":287,"conditions":288,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":46},"100485858","the-impact-of-intra-operative-fluid-infusion-rate-on-microcirculation-100485858","NCT05606536","The Impact of Intra-operative Fluid Infusion Rate on Microcirculation","The Impact of Intra-operative Fluid Infusion Rate on Hemodilution and Microcirculation Prospective Observational Pilot Study","Inclusion Criteria:\n\n* elective recumbent and laparoscopic surgery\n* informed consent\n\nExclusion Criteria:\n\n* blood loss over 250 ml\n* hemodynamic instability requiring noradrenaline infusion",{"count":285,"type":21},80,[24],"Intraoperative fluid therapy (IFT) is an integral part of anesthesia care during surgery. Its main indication is the optimization of oxygen supply to the tissues. For elective surgery that is not associated with higher blood loss and a long period of preoperative fasting, including fluids IFT is dosed to cover the basal daily need for fluids. However, it is not clear whether this fluid dose is optimal. Surgery is a stress factor that leads, among other things, to damage of the endothelial glycocalyx (EG). EG binds a significant amount of plasma, which is released during EG destruction and causes relative hemodilution.\n\nIsovolumic hemodilution is an established intraoperative procedure that serves to better control bleeding in procedures where bleeding is expected. However, partial hemodilution occurs even with standard IFT, and even when fluids are hardly given at all. Flow parameters in microcirculation have not yet been described depending on IFT conduction. The parameters of the microcirculation reflect its functioning, which will consequently affect the postoperative phase of the patient's moaning and clinical outcome.",[32,289,290],"Microcirculation","Hemodilution","2025-03-24",{"date":293,"type":38},"2025-03-27",{"date":295,"type":38},"2022-10-01",{"date":297,"type":21},"2025-12-31",{"name":299,"class":45},"University Hospital Hradec Kralove",{"id":301,"slug":302,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":306,"eligibilityCriteria":307,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":4,"enrollmentInfo":308,"targetDuration":310,"studyType":57,"phases":4,"briefSummary":311,"conditions":312,"keywords":315,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":326},"100535960","fluid-administration-and-fluid-accumulation-in-the-intensive-care-unit-100535960","NCT06258616","Fluid Administration and Fluid Accumulation in the Intensive Care Unit","Fluid Administration and Fluid Accumulation in the Intensive Care Unit (FLUID-ICU) - an International Inception Cohort Study","FLUID-ICU","Inclusion Criteria:\n\n* Acute admission to the ICU during the 14-day inception period.\n* Adults (≥ 18 years).\n\nExclusion Criteria:\n\n* Patients previously included in the FLUID-ICU study.\n* Patients with major burns (≥ 10% of body surface)",{"count":309,"type":21},1000,"90 Days","The goal of this international inception cohort study is to describe fluid administration during admittance to the intensive care unit (ICU), and provide contemporary epidemiological data on fluid accumulation, risk factors, management and outcome in critically ill adult patients.",[313,32,314],"Fluid Accumulation","Fluid Overload",[314,313,316],"Fluid Administration","2025-02-05",{"date":319,"type":38},"2025-02-06",{"date":321,"type":38},"2024-04-01",{"date":323,"type":21},"2025-09",{"name":325,"class":45},"Nordsjaellands Hospital",21,{"id":328,"slug":329,"hasResults":11,"nctId":330,"briefTitle":331,"officialTitle":331,"acronym":332,"eligibilityCriteria":333,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":198,"enrollmentInfo":334,"targetDuration":335,"studyType":57,"phases":4,"briefSummary":336,"conditions":337,"keywords":340,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":46},"100535264","evaluation-of-fluid-responsiveness-with-recruitment-maneuver-after-sternotomy-in-coronary-artery-bypass-surgery-100535264","NCT06249568","Evaluation of Fluid Responsiveness With Recruitment Maneuver After Sternotomy in Coronary Artery Bypass Surgery","fluidresponse","* Inclusion Criteria:\n* 1-ASA2-3 patients between the ages of 18-80 who will undergo elective coronary bypass surgery under general anesthesia\n* Exclusion Criteria:\n* 1\\. Be younger than 18 years old, be over 80 years old\n* 2\\. Patients with an ASA score greater than 3\n* 3\\. EF\\\u003C40%\n* 4\\. Those with contraindications to anesthetic drugs\n* 5\\. Patients with BMI\\>30\n* 6\\. Patients who did not want to participate in the study\n* 7\\. Right ventricular dysfunction\n* 8\\. COPD(Chronic obstructive pulmonary disease)\n* 9\\. Bullous lung disease\n* 10\\. Moderate to severe PHT\n* 11\\. Severe kidney or liver disease\n* 12\\. Patients with hemodynamic instability in the perioperative period\n* 13\\. Pregnancy",{"count":256,"type":21},"1 Day","Assuming that the basic reliability of dynamic indices will increase with the application of functional hemodynamic tests after sternotomy and protective lung ventilation in patients undergoing elective coronary artery bypass surgery, it is useful to predict fluid responsiveness after sternotomy in coronary artery bypass surgery patients ventilated with 6 ml\u002Fkg PBW (ideal body weight). We aimed to reveal the sensitivity and specificity of PPV and SVV changes by applying a lung opening maneuver.",[32,338,339],"Coronary Artery Bypass Surgery Patients","Lung Recruitment Maneuver",[341,338,339],"fluid therapy","2024-07-15",{"date":344,"type":38},"2024-07-16",{"date":346,"type":38},"2023-06-01",{"date":348,"type":21},"2024-08-20",{"name":350,"class":45},"Ankara City Hospital Bilkent",{"id":352,"slug":353,"hasResults":11,"nctId":354,"briefTitle":355,"officialTitle":355,"acronym":356,"eligibilityCriteria":357,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":198,"enrollmentInfo":358,"targetDuration":4,"studyType":22,"phases":359,"briefSummary":361,"conditions":362,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":372},"100467652","early-phase-1-mini-bolus-for-fluid-challenge-responsiveness-in-the-emergency-department-100467652","NCT05369559","Mini Bolus for Fluid Challenge Responsiveness in the Emergency Department","MIBORED","Inclusion Criteria:\n\n* Patients with spontaneous breathing\n* Patients in whom a fluid challenge is indicated because they present acute circulatory failure (which is defined as systolic blood pressure less than 90 mmHg or the need for vasopressors (norepinephrine more than 0.1 µg\u002Fkg\u002Fmin) to maintain a systolic blood pressure more than 90 mmHg (14), and at least one sign of inadequate tissue perfusion:\n\n  * urine output of below 0.5ml\u002Fkg per hour over 1 hour\n  * tachycardia (heart rate of greater than 100 beats per minute)\n  * mottled skin.\n  * lactate \\> 2 mmol\u002Fl\n\nExclusion Criteria:\n\n* Cardiac arrest\n* Acute respiratory distress syndrome\n* Coma Glasgow Scale \\\u003C 14\n* Age of less than 18 years\n* Moribund patients\n* Pregnant patients\n* impossibility to perform passive leg raising (PLR) (trauma patients, lower extremity amputees, and prone patients)\n* Patients with cardiac arrhythmias\n* Patients with cardiogenic pulmonary oedema",{"count":309,"type":21},[360],"EARLY_PHASE1","Intravascular volume expansion is a common intervention in critically ill patients with acute circulatory failure.we test the hypothesis that a mini-bolus fluid challenge, of either 50 ml , can predict fluid responsiveness in spontaneously breathing patients with hemodynamic instability.",[32],"2024-07-04",{"date":365,"type":38},"2024-07-09",{"date":367,"type":38},"2022-03-03",{"date":369,"type":21},"2025-05-22",{"name":371,"class":45},"University of Monastir",2]