[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fluoxetine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fluoxetine":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100606391","phase-2-ssri-antidepressant-fluoxetine-improving-immunotherapy-efficacy-in-advanced-hepatobiliary-malignancy-patients-with-depression-and-anxiety-100606391",false,"NCT07174947","SSRI Antidepressant Fluoxetine Improving Immunotherapy Efficacy in Advanced Hepatobiliary Malignancy Patients With Depression and Anxiety","SSRI Antidepressant Fluoxetine Improving Immunotherapy Efficacy in Advanced Hepatobiliary Malignancy Patients With Depression and Anxiety: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Age: 18 to 80 years old, both male and female are acceptable.\n* The histopathological\u002Fcytological diagnosis is hepatocellular carcinoma or cholangiocarcinoma. Hepatocellular carcinoma can be diagnosed by imaging.\n* Patients with metastatic advanced or locally advanced liver and gallbladder malignancies;\n* No treatment has been received and a first-line treatment regimen including PD-1 inhibitors \u002FPD-L1 inhibitors is planned to be carried out;\n* Patients with a PHQ-9 score of ≥10 or a GAD-7 score of ≥8, that is, those with positive screening for depression or anxiety;\n* At least one lesion measurable by CT or MRI (with a maximum diameter of ≥0.5cm);\n* ECOG: 0-2;\n* Child-Pugh score ≤7 points;\n* The expected survival period is ≥12 weeks.\n* Baseline blood cell count tests and blood biochemistry must meet the following standards:1) White blood cell count ≥3.0×10\\^9\u002FL; Hemoglobin ≥90 g\u002FL;2) Absolute neutrophil count ≥1.5×10\\^9\u002FL;3) Platelet count ≥100×10\\^9\u002FL;4) Alanine aminotransferase (ALT), aspartate aminotransferase (AST) ≤ 2.5 times the upper limit of the normal upper limit (ULN);5) Total bilirubin ≤ twice ULN;6) Serum creatinine ≤ 1.5 times ULN; Albumin ≥30 g\u002FL;\n* The subjects voluntarily joined this study, signed the informed consent form, had good compliance and cooperated with the follow-up.\n\nExclusion Criteria:\n\n* Those with uncorrectable coagulation dysfunction and a distinct bleeding tendency;\n* Patients who currently have unstable or active ulcers or gastrointestinal bleeding;\n* Severe functional insufficiency of vital organs, such as severe cardiopulmonary insufficiency, etc;\n* Patients with hepatic encephalopathy or intractable ascites requiring treatment;\n* A history of mental disorders such as bipolar disorder, schizophrenia, and active suicidal ideation;\n* Patients with active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection (active is defined as a viral load \\> 20,000 IU\u002FmL), or those who are positive for HBV or HCV and refuse to receive standardized antiviral treatment;\n* Unable to swallow oral medication;\n* Patients allergic to fluoxetine;\n* Currently using drugs that may have serious interactions with fluoxetine;\n* The researchers assessed that the patient was unable or unwilling to comply with the requirements of the research protocol.","ALL","18 Years","80 Years",{"count":20,"type":21},240,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","Advanced liver and gallbladder malignancies (including liver cancer, cholangiocarcinoma and gallbladder cancer) are a type of disease that is difficult to treat, and most patients have a short survival period. In recent years, immunotherapy (such as PD-1\u002FPD-L1 inhibitors) has brought new hope to these patients, but still only a small number of patients can benefit.\n\nResearch has found that approximately 40% of patients with liver and gallbladder tumors have symptoms of depression and anxiety, which not only affect their quality of life but may also reduce the therapeutic effect by influencing immune function. Fluoxetine is a commonly used antidepressant. The latest research shows that in addition to improving mood, it may also enhance the anti-tumor effect of immunotherapy. This study aims to explore whether fluoxetine combined with immunotherapy can better control tumors than immunotherapy alone, prolong the survival period of patients, and at the same time improve the depressive and anxious symptoms and quality of life of patients.",[27,28,29,30],"Hepatobiliary Malignancy","Fluoxetine","Anxiety Disorders","Depression Disorders","RECRUITING","2026-03-20",{"date":34,"type":35},"2026-03-24","ACTUAL",{"date":37,"type":35},"2025-10-01",{"date":39,"type":21},"2027-12-01",{"name":41,"class":42},"First Affiliated Hospital of Wenzhou Medical University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":65,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100533123","predicting-treatment-outcomes-in-refractory-constipation-through-brain-connectivity-evaluation-100533123","NCT06221722","Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation","Evaluation of Brain Connectivity Function in Predicting Therapeutic Effects in Patients With Refractory Constipation: a Multicenter, Prospective, Cohort Study","Inclusion Criteria:\n\n* 18≤ age ≤ 45 years old\n* Right-handed\n* Patients diagnosed as functional constipation according to the Rome IV criteria\n* Informed consent of patients\n\nExclusion Criteria:\n\n* Complicated with gastrointestinal organic disease or significant functional abnormalities (tuberculosis, polyps, Crohn's disease, tumors, congenital megacolon, pelvic floor muscle relaxation, abnormal colonic transit test, etc.)\n* Long-term intense exercise (continuous exercise for more than 8 hours per week, such as marathon runners or triathletes)\n* No history of chronic pain, no recent major trauma\n* Drug abuse or tobacco dependence (half a pack or more per day)\n* Combined hypothyroidism and Parkinson's disease\n* Patients with confirmed mental illness or neurological disorders who take psychotropic drugs, analgesics or hormones\n* History of abdominal surgery (appendectomy, hysterectomy, or cholecystectomy)\n* Contraindications to functional magnetic resonance imaging (claustrophobia, metal implants)\n* Pregnant or lactating women with constipation after delivery\n* Patients with other benign and malignant tumors and autoimmune diseases\n* Infectious diseases such as hepatitis B, hepatitis C, AIDS, etc.\n* Heart disease, organ failure and other chronic diseases that require long-term medication or affect the quality of life",true,"45 Years",{"count":54,"type":21},150,"OBSERVATIONAL","The goal of this observational study is to identify the characteristics of brain functional connectivity in refractory constipation and fluoxetine-sensitive patients. The main questions it aims to answer are:\n\n* Investigating the alterations in brain functional connectivity in patients with refractory constipation and fluoxetine-sensitive patients\n* Assessing the predictive value of brain functional connectivity regarding the efficacy of fluoxetine and standard protocol treatments for constipation.\n\nParticipants will receive:\n\n* Standard physiological and psychological assessments of constipation\n* BOLD-fMRI tests\n* Standard protocol and fluoxetine treatment\n\nIf there is a comparison group: Researchers will compare:\n\nRefractory group\u002FFluoxetine sensitive group to see the specific brain alterations.",[58,59,28,60,61,62,63,64],"Constipation - Functional","Refractory Constipation","fMRI","Brain Connectivity","Treatment Efficacy","Somatic Symptom","Mental Symptom",[60,66,67],"functional connectivity","refractory constipation","2025-07-22",{"date":70,"type":35},"2025-07-24",{"date":72,"type":35},"2023-11-01",{"date":74,"type":21},"2026-09-01",{"name":76,"class":42},"Xijing Hospital of Digestive Diseases",3]