[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"food-reward\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:food-reward":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":38,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":65},"100625406","long-term-effects-of-walnut-consumption-on-brain-function-100625406",false,"NCT07422220","Long-Term Effects of Walnut Consumption on Brain Function","Long-Term Effects of Walnut Consumption on Brain Function in Men and Women With Abdominal Obesity","WalBrain","Inclusion Criteria:\n\n* Men and women, aged between 45-75 years\n* Women postmenopausal: two or more years after last menstruation\n* Waist circumference of ≥102 cm for men and ≥88 cm for women (abdominal obesity)\n* Fasting plasma glucose \\\u003C 7.0 mmol\u002FL\n* Fasting serum total cholesterol \\\u003C 8.0 mmol\u002FL\n* Fasting serum triacylglycerol \\\u003C 4.5 mmol\u002FL\n* Systolic blood pressure \\\u003C 160 mmHg and diastolic blood pressure \\\u003C 100 mmHg\n* Stable body weight (weight gain or loss \\\u003C 3 kg in the past three months)\n* Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study\n* No difficult venipuncture as evidenced during the screening visit\n\nExclusion Criteria:\n\n* Allergy or intolerance to walnuts\n* Left-handedness (effects on brain function differ between left- and right-handed adults)\n* Current smoker, or smoking cessation \\\u003C 12 months\n* Diabetic patients\n* Familial hypercholesterolemia\n* Abuse of drugs\n* More than 3 alcoholic consumptions per day\n* Use of products or dietary supplements (e.g., dietary fiber or antioxidant dietary supplements (vitamin C and E), fish or seaweed oil capsules) known to interfere with the main outcomes as judged by the principal investigators\n* Use of medication to treat blood pressure, lipid, or glucose metabolism\n* Use of an investigational product within another biomedical intervention trial within the previous 1-month\n* Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases, and rheumatoid arthritis\n* Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident\n* Contra-indications for MRI imaging (e.g., pacemaker, surgical clips\u002Fmaterial in body, metal splinter in eye, claustrophobia)",true,"ALL","45 Years","75 Years",{"count":22,"type":23},55,"ESTIMATED","INTERVENTIONAL",[26],"NA","Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation. It is therefore important to investigate the specific effects of walnuts on cerebral blood flow responses before and after intranasal insulin administration, as well as their associated functional benefits. The investigators hypothesize that long-term walnut consumption improves vascular function and insulin-sensitivity in the brain, thereby enhancing cognitive performance and appetite control in abdominally obese men and women. Objective: The primary objectives are to investigate in abdominally obese adults the effects of 24-week walnut consumption on (regional) vascular function and insulin-sensitivity in the brain, while the investigators will also assess changes in cognitive performance and appetite-related brain reward activity (secondary objectives). Cerebral blood flow responses before (brain vascular function) and after the administration of intranasal insulin spray (brain insulin-sensitivity) will be quantified by the non-invasive gold standard magnetic resonance imaging (MRI)-perfusion method Arterial Spin Labeling (ASL). Study design: This intervention study will have a randomized, controlled parallel design. The total study duration will be 24 weeks. Study population: Fifty-five abdominally obese men and (postmenopausal) women (aged 45-75 years) without a history of cardiovascular diseases or complaints will participate. This study population is expected to have a decreased cerebral blood flow at baseline and are also at increased risk of cognitive impairment, allowing for improvement by the intervention. Intervention: Study participants will receive daily 50 g (about 15% of energy) of raw walnuts (walnut intervention) or no walnuts (control intervention) for 24 weeks. Main study parameters\u002Fendpoints: At baseline and after 24 weeks (follow-up), participants will visit the research facilities for assessments. The primary endpoint is the difference in the cerebral blood flow response before and after intranasal insulin administration between the walnut and control intervention. Cognitive performance will be assessed, while the investigators will also focus on appetite-related brain reward activity (secondary outcomes).",[29,30,31,32,33,34,35,36,37],"Healthy","Brain Insulin Sensitivity","Cerebral Blood Flow","Brain Vascular Function","Satiety and Food Intake","Food Reward","Cognitive Performance","Abdominal Obesity","Cognitive Decline",[39,40,41,42,43,44,45,46,47,48,49,50,51,52],"Walnuts","Juglans","Brain vascular function","Brain insulin sensitivity","Satiety","Food reward mechanisms","Cognitive performance","Abdominal obesity","Cognitive decline","pCASL MRI","fMRI","CANTAB","Intranasal insulin","Food cues","NOT_YET_RECRUITING","2026-02-18",{"date":56,"type":57},"2026-02-19","ACTUAL",{"date":59,"type":23},"2026-02",{"date":61,"type":23},"2027-08",{"name":63,"class":64},"Maastricht University Medical Center","OTHER",1,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":17,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":24,"phases":78,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":65},"100558300","timing-and-resistance-exercise-impact-on-eating-and-metabolism-100558300","NCT06549322","Timing and Resistance Exercise: Impact on Eating and Metabolism","The Efficacy of Exercise Timing - Effects of Resistance Exercise on Eating Behavior and Energy Metabolism","Inclusion Criteria:\n\n* Age: 20-30\n* weight stable for at least 6 months\n\nExclusion Criteria:\n\n* Obesity (BMI \\> 30 kg\u002Fm² or body fat percentage \\> 25%)\n* Hypertension (blood pressure over 140\u002F90 mmHg)\n* Heart disease\n* Cancer\n* Liver or kidney diseases\n* Any other conditions that could potentially influence the study's outcomes","MALE","20 Years","30 Years",{"count":77,"type":23},18,[26],"Exercise timing (morning or evening) for optimal weight control is a research topic urgently addressed by scholars in the relevant field. Due to the better control of energy metabolism and physical activity levels in the morning, existing research on resistance exercise and eating behavior primarily focuses on experiments conducted in the morning, with only one study in the afternoon. No research has yet compared the potential differences between morning and evening resistance exercise. A one-year study aims to investigate the impact of morning and evening resistance exercise on physiological metabolism and eating behavior. Eighteen healthy male participants will be randomly assigned to a crossover design study, including AM exercise, PM exercise, and control (rest condition) trials. Variables including subjective appetite, appetite hormones (ghrelin, peptide YY), food preferences, ad libitum eating, dietary records, energy expenditure, and PBMCs circadian rhythm genes will be measured. This preliminary study through a multidimensional observation, the results will contribute to understanding the potential differences and mechanisms of morning and evening resistance exercise on physiological metabolism and eating behavior. In practical applications, conducting resistance exercise in the evening or at night aligns better with current lifestyles. The findings of this study can support the optimization of exercise benefits by validating the choice of exercise timing.",[81,82,83,34],"Circadian Rhythm","Energy Balance","Appetitive Behavior",[85,86],"resistance exercise","energy expenditure","2024-08-08",{"date":89,"type":57},"2024-08-12",{"date":91,"type":23},"2024-09-01",{"date":93,"type":23},"2025-12-30",{"name":95,"class":64},"National Taiwan Normal University"]