[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fractional-flow-reserve\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fractional-flow-reserve":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100632255","ffr-guided-revascularization-in-atherosclerotic-renal-artery-stenosis-100632255",false,"NCT07511309","FFR-Guided Revascularization in Atherosclerotic Renal Artery Stenosis","Fractional Flow Reserve-Guided Revascularization in Atherosclerotic Renal Artery Stenosis: A Randomized Controlled Trial","FARS","Inclusion Criteria:\n\n1. Renal artery diameter stenosis ≥60%;\n2. Office systolic blood pressure ≥ 160 mmHg and\u002For office diastolic blood pressure ≥ 100 mmHg on at least two separate days without antihypertensive medication, or office systolic blood pressure ≥ 140 mmHg and\u002For office diastolic blood pressure ≥ 90 mmHg while on three antihypertensive drugs at conventional doses;\n3. Serum creatinine \\\u003C 264 μmol\u002FL (3.0 mg\u002FdL);\n4. Affected kidney length ≥ 7.0 cm, with residual glomerular filtration rate (GFR) ≥ 10 mL\u002Fmin;\n\nExclusion Criteria:\n\n1. Unstable clinical condition rendering the patient intolerant to revascularisation therapy;\n2. Urinary protein ≥2+;\n3. Contrast medium allergy;\n4. Renal artery anatomy unsuitable for revascularisation therapy;\n5. Reference vessel diameter \\\u003C3.5mm or \\>8mm.\n6. Patients with non-atherosclerotic renal artery stenosis (such as fibromuscular dysplasia or Takayasu arteritis);\n7. Reference vessel diameter \\\u003C 3.5 mm or \\> 8 mm.","ALL","40 Years","80 Years",{"count":21,"type":22},300,"ESTIMATED","INTERVENTIONAL",[25],"NA","For patients with atherosclerotic renal artery stenosis, the results of randomized controlled trials published in recent years have failed to demonstrate that renal artery stenting is superior to optimal medical therapy. However, these studies still have limitations.\n\nFractional flow reserve (FFR) has been extensively studied in coronary artery disease, and it has been established that FFR-guided revascularization is superior to both angiography-guided percutaneous coronary intervention and medical therapy alone. Whether FFR can guide interventional treatment in patients with renal artery stenosis and hypertension is currently a hot topic in the field of renal artery stenosis research.\n\nEligible patients meeting the inclusion criteria were enrolled. Pharmacologically induced FFR values were measured as the baseline. Patients with FFR ≥ 0.8 were randomly assigned to either the medical therapy group or the stenting group, while patients with FFR \\\u003C 0.8 underwent stent implantation. Changes in eGFR, 24-hour systolic blood pressure, and 24-hour diastolic blood pressure from baseline to 12 months were compared among the groups.",[28,29,30,31],"Atherosclerotic Renal Artery Stenosis","Fractional Flow Reserve","Optimal Medical Therapy","Stent Implantation",[28,29,30],"NOT_YET_RECRUITING","2026-04-27",{"date":36,"type":37},"2026-04-30","ACTUAL",{"date":39,"type":22},"2026-03-31",{"date":41,"type":22},"2028-03-31",{"name":43,"class":44},"Chinese Academy of Medical Sciences, Fuwai Hospital","OTHER",20,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":56,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100566760","dedinje-ffrqfr-registry-100566760","NCT06659367","Dedinje FFR\u002FQFR Registry","Institute for Cardiovascular Diseases \"Dedinje\" Fractional Flow Reserve (FFR) and Quantitative Flow Ratio (QFR) Registry","Inclusion Criteria:\n\n* \\>18 years old\n* Had a clinically indicated FFR procedure performed (either as a planned procedure or ad hoc)\n\nExclusion Criteria:\n\n* Declines to participate in the registry and provide informed consent","18 Years",{"count":55,"type":22},2500,"5 Years","OBSERVATIONAL","Quantitative Flow Ratio (QFR) has shown good diagnostic performance against Fractional Flow Reserve (FFR) in several meta-analyses, comparable or even superior to nonhyperemic pressure ratios. However, the reproducibility of QFR is modest and there is high inter- and intra-observer variability even when fairly experienced but non-core lab operators (at least 150 QFR procedure experience) are performing the analysis. Although smaller studies have demonstrated that non-core analysis and even paramedical user analysis can have good correlation with FFR, the concern about the diagnostic performance of QFR in real-world clinical practice by inexperienced users remains.\n\nThe primary objective of \"Dedinje FFR\u002FQFR Registry\" is to determine the feasibility and diagnostic performance of QFR analysis by vendor-certified inexperienced medical users in a real-world setting using FFR as the gold standard. All patients \\>18 years old who present to the Institute for Cardiovascular Diseases \"Dedinje\" and undergo a planned or ad hoc FFR procedure will be asked to participate in the registry. FFR procedure is performed according to the standardized institutional protocol. QFR analysis will be subsequently performed offline according to a standard operating procedure.",[60,29],"Coronary Artery Disease (CAD)",[62,63,64,65,66],"coronary artery disease","fractional flow reserve","quantitative flow ratio","FFR","QFR","RECRUITING","2024-10-24",{"date":70,"type":37},"2024-10-26",{"date":72,"type":37},"2024-10-02",{"date":74,"type":22},"2034-10-02",{"name":76,"class":44},"Institute for Cardiovascular Diseases Dedinje",1]