[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fracture-femur\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fracture-femur":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,73,100],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100623121","cognitive-and-physical-recovery-after-hip-fracture-in-frail-patients-using-digital-rehabilitation-technology-100623121",false,"NCT07392515","Cognitive and Physical Recovery After Hip Fracture in Frail Patients Using Digital Rehabilitation Technology","Cognitive and Motor Recovery in Frail Patients With Hip Fracture: Effectiveness of Digital Technology-Assisted Rehabilitation and Analysis of Biomolecular Mechanisms","FEWF","Inclusion Criteria:\n\n* Age between 65 and 89 years\n* Patients who have undergone one of the following surgical treatments specifically for proximal femur fracture including Total hip arthroplasty (total hip replacement), Partial hip arthroplasty (hemiarthroplasty), Intramedullary nailing\n* Time since surgery not exceeding 15 days\n* Clinical stability\n* Patients admitted to the rehabilitation wards of the centers involved in the study and therefore eligible for rehabilitative therapy.\n\nExclusion Criteria:\n\n* Age \\> 90 years\n* Age \\\u003C 65 years\n* Refusal to sign the informed consent form\n* Behavioral or cognitive disorders limiting compliance with the rehabilitative treatment\n* Presence of mechanical instability of the implanted surgical device\n* Clinical instability (e.g., sepsis, severe anemia, cardiorespiratory failure) or pre-existing comorbidities affecting ambulation (neurological diseases or chronic pre-existing disabilities)\n* Concomitant presence of other fractures that prevent the possibility of carrying out a rehabilitative treatment\n* Severe visual impairments not correctable with lenses that prevent the patient from performing the treatment using digital tools\n* Pre-existing motor disability prior to the femur fracture due to other systemic diseases (e.g., advanced-stage neurodegenerative diseases, severe heart failure)\n* Conditions contraindicating the use of sensors (pacemaker, epilepsy, skin lesions, open wounds, and severe allergies in areas of contact with the devices).","ALL","65 Years","89 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of this study is to evaluate whether integrating a technology-based rehabilitation approach with conventional therapies in the rehabilitation of patients with proximal femoral fracture may be advantageous compared with conventional therapy alone. Specifically, the objective is to assess whether the addition of technology-assisted rehabilitation can improve cognitive function, in addition to motor function and overall abilities, compared with conventional rehabilitation alone. Furthermore, the study intends to explore the feasibility of implementing technology-assisted rehabilitation as a stable and routine component of everyday clinical practice, also considering the perspective of healthcare professionals.",[28,29,30],"Fracture Femur","Hip Arthroplasty Replacement","Total Hip Arthroplasty (THA)","RECRUITING","2026-03-11",{"date":34,"type":35},"2026-03-13","ACTUAL",{"date":37,"type":35},"2026-02-09",{"date":39,"type":22},"2026-07-31",{"name":41,"class":42},"C.O.T. Cure Ortopediche Traumatologiche S.p.A.","OTHER",2,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100616773","feasibility-of-integrating-local-vibration-into-rehabilitation-of-elderly-patients-after-hip-fracture-100616773","NCT07309965","Feasibility of Integrating Local Vibration Into Rehabilitation of Elderly Patients After Hip Fracture","Feasibility Study on the Implementation of Local Muscle Vibration as Part of a Rehabilitation Program for Elderly Patients Following Fracture of the Upper End of the Femur","ORTHOBOOSTER-P","Inclusion Criteria:\n\n* Patients aged 75 or over who have undergone surgery for a fracture of the upper end of the femur\n* Hospitalised in the SMR department no later than D14 of their operation\n* Resource Iso Group greater than or equal to 3 on the Aggir scale\n* Patient capable of consenting who has signed a consent form or patient unable to express consent at the discretion of the principal investigator, informed and not opposed to the study, for whom a trusted person, or if not available, the family, or if not available, a close relative has signed an informed consent within a maximum of 2 days. For patients under guardianship, the guardian's consent will be requested, and for patients under curatorship, the patient will sign the consent in the presence of the curator within a maximum of 2 days as well.\n* Affiliated to a social security scheme\n\nExclusion Criteria:\n\n* Persons deprived of their liberty by a judicial or administrative decision\n* Individuals with severe psycho-behavioral disorders (major psychiatric or neurocognitive disorders)\n* Persons admitted to a health or social establishment for purposes other than research\n* Contraindications to electrical stimulation:\n\n  * Patient with active devices such as pacemakers, defibrillators, insulin pumps, neurostimulators, etc\n  * Patient with phlebitis or risk of thrombosis\n  * Epileptic patient\n  * Patient with fragile skin or open wounds on the lower limbs\n* Subject participating in another interventional study with an exclusion period still in progress at pre-inclusion.","75 Years",{"count":54,"type":22},25,[25],"Fractures of the upper end of the femur in elderly patients are the 2nd most common fracture.\n\nA fracture leads to a syndrome of psychomotor maladjustment, encouraged by pain and aggravated by hospitalisation. In 2014, 50,000 women and 16,000 men suffered this type of fracture every year. The consequences are serious, with a one-year mortality rate of 20 to 24% and an institutionalisation rate of 25%. In 2015, the direct cost of hip fracture in France was estimated at around €1 billion.\n\nIn line with the recommendations of the National Institute for Health and Care Excellence (NICE) and the results of meta-analyses, it is recommended that, in the absence of surgical or medical contraindications, patients should be assessed within 24 hours of hip fracture surgery, with a view to initiating early mobilisation and multidisciplinary rehabilitation.\n\nIt has been shown in healthy subjects that prolonged application of localised vibrations optimises nerve capacity, leading to an increase in maximum voluntary force.\n\nFor population of frail elderly post-operative patients, this localised vibration technique could accelerate and improve functional recovery, particularly in terms of muscle strength, joint mobility and pain. A reduction in muscle loss is hoped for, with benefits in terms of tolerance compared with neurostimulation.\n\nAs part of the implementation of the above-mentioned recommendations, the investigators wish to assess the quality of the integration of this technique, already in use in the department on an ad hoc basis, into the organisation of the department and of the patient's care pathway as a complement to the rehabilitation protocols, by identifying the obstacles and facilitating factors. The study will also provide the first estimates of the effect on muscle recovery.\n\nThe investigator hypothesise that this local vibration protocol can be integrated into the rehabilitation department's work schedule and into the patient's care pathway, and that it will be acceptable to both the patient and the nursing staff.",[28,58],"Elderly",[60,61,62,63],"Rehabilitation","Fracture of the upper end of the femur","Local muscle vibration","Geriatrics","2026-02-05",{"date":37,"type":35},{"date":67,"type":35},"2025-11-19",{"date":69,"type":22},"2026-12-19",{"name":71,"class":42},"Hospices Civils de Lyon",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":99},"100615995","oral-supplementation-with-a-formulation-based-on-cetylated-fatty-acids-for-post-fracture-long-bone-healing-100615995","NCT07299851","Oral Supplementation With a Formulation Based on Cetylated Fatty Acids for Post-fracture Long Bone Healing","Randomized, Double-blind, Placebo-controlled Study With 12 Weeks Oral Supplementation With a Formulation Based on Cetylated Fatty Acids to Support the Early Stage of Long Lower Limb Bone Healing After Fracture Stabilization","CETIULTRA-BONE","Inclusion Criteria:\n\n* Between 18 and 85 years old\n* Presence of simple closed unifocal fracture (transverse, oblique, spiral, butterfly-shaped) in a long bone which need a standard of care surgical stabilization\n* Presence of diaphyseal fracture of lower limb (femur or tibia, Subtrochanteric fracture are also allowed)\n* Presence intramedullary nail\n* Weight bearing as tolerated after surgery\n* Having signed an informed consent, understand study procedures and ability to follow them\n* Agreed to stop vitamin D intake for participants who take prophylactic Vitamin D\n\nExclusion Criteria:\n\n* Treatment with vitamin D for medical purpose (Non-union, osteoporosis…)\n* BMI \\> 30\n* Open fracture\n* Intra articular fracture\n* Metaphyseal fracture\n* Polytrauma patient (injury severity score: ISS \\>= 16)\n* More than one lower limb long bone fracture\n* Bridging plate\n* Fracture treated conservatively with plaster\n* Presence of active infection (body temperature ≥ 38°C or other symptoms)\n* Any sign of severe vascular compromise across the fracture site (such as compartment syndrome, presence of serious vascular damage, etc.)\n* Pathological fracture or diseases with a risk of recurrent falling (e.g. Parkinson's disease\u002Fsyndrome, Hemiplegia after stroke, symptomatic stenosis of the spinal canal, polyneuropathy, epilepsy, recurring vertigo, recurring syncope)\n* Participants with known bone disease which would negatively impact on the bone healing process\n* Participants currently being treated with radiation, chemotherapy, immunosuppression, or steroid therapy\n* Diabetic participants\n* Daily smoker participants (cigarette or vaping containing nicotine)\n* Participants under cortisone intake\n* Participants under rheumatic medications intake\n* Allergy or adverse effect of food supplement composition\n* Unwilling or unable to take study medication\n* Chronic drug or alcohol abuse\n* Pregnant or breastfeeding at the time of enrolment\n* Any other investigational treatment or food supplement within 3 months.","18 Years","85 Years",{"count":84,"type":22},100,[25],"This clinical study aims to evaluate the potential benefits of a formulation based on Cetylated Fatty Acids in improving fracture healing of long bones in the lower limbs. The investigational product is administered orally over a 12-week period. Study procedures are limited to standard imaging techniques (radiography and echography), blood sampling, and completion of validated quality of life questionnaires.",[28,88],"Fracture Tibia","2025-12-17",{"date":91,"type":35},"2025-12-23",{"date":93,"type":35},"2025-10-01",{"date":95,"type":22},"2026-06",{"name":97,"class":98},"Pharmanutra S.p.a.","INDUSTRY",6,{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":17,"minAge":81,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":23,"phases":109,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":72},"100609933","phase-4-single-shot-exparel-vs-catheters-in-lower-extremity-trauma-100609933","NCT07221019","Single Shot Exparel vs Catheters in Lower Extremity Trauma","Single-Shot Exparel Versus Catheters for Lower Extremity Orthopedic Trauma Patients","Inclusion Criteria:\n\n* Closed lower extremity orthopedic injury\n* Opioid naive patients\n* No other significant surgical injuries on admission as determined by study physician\n\nExclusion Criteria:\n\n* Allergy to local anesthetics\n* Multiple traumatic injuries\n* Weight less than 60 kg\n* Prior opioid use or risk of increased pain control needs as determined by PI\n* Chronic opioid use\n* Open fractures\n* Plastic surgery needed for complete closure\n* Patient has intraoperative cardiac arrest",{"count":108,"type":22},90,[110],"PHASE4","This study will compare the use of single-shot Exparel, a long-acting local anesthestic, with the use of catheters that deliver a continuous flow of the short-acting local anesthetic ropivacaine. The comparison will be done in patients who receive preoperative adductor and sciatic nerve blocks prior to orthopedic surgery for traumatic lower extremity injury. The patients' pain will then be monitored for up to 72 hours after injection, measuring every 12 hours after injection until the 72-hour mark. Opioid consumption (measured in morphine milligram equivalents) will also be tracked over this time period.",[113,114,28,115,116],"Fracture Dislocation of Ankle Joint","Fracture Leg","Fracture Lower Leg","Fracture","2025-10-24",{"date":119,"type":35},"2025-10-28",{"date":121,"type":35},"2025-09-12",{"date":123,"type":22},"2029-08-11",{"name":125,"class":42},"George Washington University"]