[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fracture-fixation-internal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fracture-fixation-internal":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100636119","phase-4-extended-oral-antibiotic-prophylaxis-in-diabetic-fracture-patients-100636119",false,"NCT07561541","Extended Oral Antibiotic Prophylaxis in Diabetic Fracture Patients","Extended Oral Antibiotic Prophylaxis in Diabetic Patients With Lower Extremity Fracture: A Multicenter Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Low extremity fracture requiring surgical treatment\n* Uncontrolled diabetes (Hemoglobin A1c \\> 7.0 or random glucose \\> 200 mg\u002FdL)\n* Age 18 years or older\n* Able to provide informed consent\n* English or Spanish speaker\n\nExclusion Criteria:\n\n* Known allergy to prescribed antibiotic and pre-determined alternatives\n* Open fractures\n* Current infection requiring antibiotic treatment\n* Immunocompromised status (chemotherapy, immunosuppressant medications)\n* End-stage renal disease that medication dosing cannot be adjusted for\n* Pregnant or breast-feeding\n* Unable to comply with follow-up","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The goal of this clinical trial is to learn if taking an antibiotic pill for 7 days after surgery reduces the risk of wound infection in adults with poorly controlled diabetes who have surgery to fix a broken bone in the leg, ankle, or foot. It will also learn about the safety of the extended antibiotic course. The main questions it aims to answer are:\n\nDoes a 7-day antibiotic course after surgery lower the rate of wound infection within 90 days? What medical problems do participants have when taking the extended antibiotic course?\n\nResearchers will compare a 7-day course of an oral antibiotic (cefadroxil) to standard care (no additional antibiotics after surgery) to see if the extended course reduces infections.\n\nParticipants will:\n\nTake an antibiotic pill or receive standard care for 7 days after surgery Receive a phone call from the study team about 1 week after surgery Visit the clinic at 3 weeks, 6 weeks, and 3 months after surgery for checkups",[26,27,28],"Fracture Lower Leg","Diabetes","Fracture Fixation, Internal",[27,30,31],"Lower extremity fracture","Extended oral antibiotic prophylaxis","RECRUITING","2026-05-06",{"date":35,"type":36},"2026-05-08","ACTUAL",{"date":38,"type":36},"2026-04-01",{"date":40,"type":20},"2027-12-31",{"name":42,"class":43},"Texas Tech University Health Sciences Center, El Paso","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":17,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100635444","phase-4-a-clinical-trial-on-the-use-of-lidocaine-infusion-during-surgery-for-pediatric-upper-extremity-fractures-and-its-impact-on-total-perioperative-opioid-requirements-100635444","NCT07552766","A Clinical Trial on the Use of Lidocaine Infusion During Surgery for Pediatric Upper Extremity Fractures and Its Impact on Total Perioperative Opioid Requirements","A Prospective, Randomized, Double-blind Trial of the Impact of Intraoperative Intravenous Lidocaine Infusion on Total Opioid Requirements in Children Undergoing Surgical Fixation of Upper Extremity Long Bone Fractures Under General Anesthesia","Inclusion Criteria:\n\n* Patients aged 3-18 years\n* Patients \\> 10 kg\n* Patients who present to Nemours Children's Hospital - Delaware Valley (NCH-DE) for surgical fixation of upper extremity fractures from distal humerus to distal radius\n\nExclusion Criteria:\n\n* Children \\\u003C 3 years or \\> 18 years\n* Patients with allergy to local anesthetics\n* Patients who are eligible for an receive a peripheral nerve block\n* Patients with multi-trauma or open fractures\n* Patients with previous history of seizure disorder\n* Patients with conduction abnormalities or cardiac arrhythmia requiring chronic treatment\n* Patients on strong CYP450 inhibitors (fluvoxamine, erythromycin, ciprofloxacin, rifampin, allopurinol, ketoconazole, itraconazole)\n* Patients with chronic kidney or liver dysfunction\n* Patients with planned use of continuous infusion pain medications (opioids, ketamine, alpha-2- agonists)\n* Patients with positive pregnancy test prior to surgery or nursing mothers\n* Patients who parents decline enrollment","3 Years",{"count":53,"type":20},90,[23],"This study is a prospective, randomized, double-blind clinical trial evaluating whether intraoperative intravenous lidocaine infusion (IVLI) reduces opioid requirements and improves postoperative pain control in children undergoing surgical fixation of upper extremity long bone fractures under general anesthesia. Ninety pediatric patients, ages 3-18 will be enrolled and randomized 1:1 to receive either IV lidocaine or placebo (normal saline) during surgery.\n\nAll participants will receive standardized anesthesia care and postoperative pain management. Opioid consumption and pain scores will be measured intraoperatively and throughout the postoperative recovery, with the primary outcome focused on total opioid use 60 minutes after arrival to the post-anesthesia care unit (PACU). Secondary outcomes include opioid use at additional time points, postoperative pain scores, PACU length of stay, rescue antiemetic use and the relationship between infusion duration and outcomes.\n\nPatients will be closely monitored for signs of local anesthetic systemic toxicity and other adverse events. The goal of this study is to determine whether IV lidocaine is an effective opioid-sparing adjunct in pediatric orthopedic surgery and to support safer, multimodal analgesia strategies.",[57,58,59,60,28,61,62],"Fracture Arm","Fracture Closed of Lower End of Forearm, Unspecified","Fracture Elbow","Fracture Fixation","Fracture Forearm","Fracture Distal Radius","NOT_YET_RECRUITING","2026-04-22",{"date":66,"type":36},"2026-04-27",{"date":68,"type":20},"2026-05",{"date":70,"type":20},"2029-07",{"name":72,"class":43},"Nemours Children's Clinic",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100595137","remeos-drillpin-for-fixation-of-distal-radius-fractures-in-children-100595137","NCT07028541","RemeOs™ DrillPin for Fixation of Distal Radius Fractures in Children","To Evaluate the Feasibility of the Clinical Application of Mg-based RemeOs™ DrillPin for Fixation of Fractures of the Distal Radius in Children From the Age of Over 5 and Under 14.","Inclusion Criteria:\n\n* Distal Radius Fractures\n* Written informed consent of the parent, oral agreement of the patient documented as informant consent of the child\n* Subject and parents have been informed of the nature of the study, agrees to participate and parent signs the approved consent form. • Female patients in childbearing age (female patients who have begun menstruation) perform a pregnancy test prior inclusion\n\nExclusion Criteria:\n\n* Pathological bone lesions (e.g. bone cyst or osteomyelitis)\n* Underlying diseases (kidney diseases, uncontrolled diabetes mellitus)\n* Polytraumatized patients\n* Suspicion of child abuse\n* Inability or unwillingness to give informed consent\n* Multiple fracture (excluding associated ulna fracture)\n* Open Fracture\n* Pregnancy (tested in all female patients who have begun menstruation)","5 Years","13 Years",{"count":84,"type":20},20,[86],"NA","This is a pre-market, single-arm, open-label, monocenter clinical investigation evaluating the safety and performance of the magnesium (Mg)-based bioresorbable RemeOs™ DrillPin for surgical fixation of distal radius fractures in pediatric patients. The study will enroll 20 children aged over 5 and under 14 years to assess implantation success, early safety outcomes, and long-term effects on growth and bone healing.",[28,89],"Distal Radius Fracture",[91,92,93,94,95],"Distal radius","fracture","RemeOs","DrillPin","Biodegradable Implant","2025-06-11",{"date":98,"type":36},"2025-06-19",{"date":100,"type":20},"2025-09",{"date":102,"type":20},"2027-12",{"name":104,"class":105},"Bioretec Ltd.","INDUSTRY"]