[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fracture-lower-leg\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fracture-lower-leg":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100636119","phase-4-extended-oral-antibiotic-prophylaxis-in-diabetic-fracture-patients-100636119",false,"NCT07561541","Extended Oral Antibiotic Prophylaxis in Diabetic Fracture Patients","Extended Oral Antibiotic Prophylaxis in Diabetic Patients With Lower Extremity Fracture: A Multicenter Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Low extremity fracture requiring surgical treatment\n* Uncontrolled diabetes (Hemoglobin A1c \\> 7.0 or random glucose \\> 200 mg\u002FdL)\n* Age 18 years or older\n* Able to provide informed consent\n* English or Spanish speaker\n\nExclusion Criteria:\n\n* Known allergy to prescribed antibiotic and pre-determined alternatives\n* Open fractures\n* Current infection requiring antibiotic treatment\n* Immunocompromised status (chemotherapy, immunosuppressant medications)\n* End-stage renal disease that medication dosing cannot be adjusted for\n* Pregnant or breast-feeding\n* Unable to comply with follow-up","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The goal of this clinical trial is to learn if taking an antibiotic pill for 7 days after surgery reduces the risk of wound infection in adults with poorly controlled diabetes who have surgery to fix a broken bone in the leg, ankle, or foot. It will also learn about the safety of the extended antibiotic course. The main questions it aims to answer are:\n\nDoes a 7-day antibiotic course after surgery lower the rate of wound infection within 90 days? What medical problems do participants have when taking the extended antibiotic course?\n\nResearchers will compare a 7-day course of an oral antibiotic (cefadroxil) to standard care (no additional antibiotics after surgery) to see if the extended course reduces infections.\n\nParticipants will:\n\nTake an antibiotic pill or receive standard care for 7 days after surgery Receive a phone call from the study team about 1 week after surgery Visit the clinic at 3 weeks, 6 weeks, and 3 months after surgery for checkups",[26,27,28],"Fracture Lower Leg","Diabetes","Fracture Fixation, Internal",[27,30,31],"Lower extremity fracture","Extended oral antibiotic prophylaxis","RECRUITING","2026-05-06",{"date":35,"type":36},"2026-05-08","ACTUAL",{"date":38,"type":36},"2026-04-01",{"date":40,"type":20},"2027-12-31",{"name":42,"class":43},"Texas Tech University Health Sciences Center, El Paso","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100609933","phase-4-single-shot-exparel-vs-catheters-in-lower-extremity-trauma-100609933","NCT07221019","Single Shot Exparel vs Catheters in Lower Extremity Trauma","Single-Shot Exparel Versus Catheters for Lower Extremity Orthopedic Trauma Patients","Inclusion Criteria:\n\n* Closed lower extremity orthopedic injury\n* Opioid naive patients\n* No other significant surgical injuries on admission as determined by study physician\n\nExclusion Criteria:\n\n* Allergy to local anesthetics\n* Multiple traumatic injuries\n* Weight less than 60 kg\n* Prior opioid use or risk of increased pain control needs as determined by PI\n* Chronic opioid use\n* Open fractures\n* Plastic surgery needed for complete closure\n* Patient has intraoperative cardiac arrest",{"count":52,"type":20},90,[23],"This study will compare the use of single-shot Exparel, a long-acting local anesthestic, with the use of catheters that deliver a continuous flow of the short-acting local anesthetic ropivacaine. The comparison will be done in patients who receive preoperative adductor and sciatic nerve blocks prior to orthopedic surgery for traumatic lower extremity injury. The patients' pain will then be monitored for up to 72 hours after injection, measuring every 12 hours after injection until the 72-hour mark. Opioid consumption (measured in morphine milligram equivalents) will also be tracked over this time period.",[56,57,58,26,59],"Fracture Dislocation of Ankle Joint","Fracture Leg","Fracture Femur","Fracture","2025-10-24",{"date":62,"type":36},"2025-10-28",{"date":64,"type":36},"2025-09-12",{"date":66,"type":20},"2029-08-11",{"name":68,"class":43},"George Washington University",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":77,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100604283","relationship-between-mortality-rates-of-fractures-in-different-sites-and-several-factors-in-elderly-patients-100604283","NCT07147504","Relationship Between Mortality Rates of Fractures in Different Sites and Several Factors in Elderly Patients","A Retrospective Study on the Relationship Between Mortality Rates of Fractures in Different Sites and Factors Such as Age, Metabolism, and Nutritional Status in Elderly Patients: A Single-center Retrospective Study","Inclusion Criteria:\n\n* Patients admitted to the National Orthopedic Center of Shanghai Sixth People's Hospital between January 1, 2010, and December 31, 2019;\n* Age ≥ 60 years;\n* Shanghai resident registration;\n* Diagnosed with limb or spinal fractures and receiving surgical treatment at Shanghai Sixth People's Hospital.\n\nExclusion Criteria:\n\n* Multiple fractures;\n* Conservative treatment selected;\n* Incomplete medical records.","60 Years",{"count":79,"type":20},3000,"OBSERVATIONAL","Background and Purpose:\n\nAs people age, bones become weaker and break more easily. Older adults (people 60 years and older) who break bones may face serious health problems and have a higher chance of dying compared to younger people. The location of the broken bone, a person's age, and overall health may affect the chances of survival.\n\nThis study will conduct a retrospective analysis of medical records from geriatric patients who underwent surgical intervention for bone fractures at Shanghai Sixth People's Hospital between 2010 and 2019. The primary objective is to identify the key prognostic factors associated with post-operative mortality in this patient cohort.\n\nThe study will retrospectively analyze the medical records of patients who meet all of the following criteria:\n\nAged 60 years or older at the time of fracture diagnosis. Residents of Shanghai. Diagnosed with a fracture of the extremities (upper or lower limbs) or the spine.\n\nUnderwent surgical intervention for the diagnosed fracture.\n\nThe investigators will assess the following variables as potential prognostic factors for post-operative mortality:\n\nFracture Characteristics: The anatomical location of the fracture (e.g., hip, spine, upper extremity, lower extremity).\n\nPatient Demographics: The patient's age at the time of injury. Physiological Status: Indicators of the patient's nutritional and metabolic health.\n\nComorbidities: The presence and severity of pre-existing medical conditions.\n\nHow investigators will do this study:\n\nThis study is designed as a retrospective cohort analysis. Data will be systematically extracted from existing patient medical records. As an observational study, it involves no new interventions or modifications to patient care. The primary endpoint is all-cause mortality, which will be assessed at 1, 3, and 5 years post-operatively to determine long-term survival rates.\n\nInvestigators will group participants by:\n\nThe location of fracture (20 different bone locations); Age (60-65, 66-70, 71-75, 76-80, and over 80 years old); Nutrition and health status.\n\nWhy This Study Matters:\n\nThe results of this study will help doctors better understand which older patients are at higher risk after breaking a bone. This information could help healthcare teams provide better care and potentially save lives by identifying patients who need extra attention and treatment.\n\nStudy Details:\n\nThis study will examine records from approximately 2000 participants; All participants already received their treatment between 2010-2019; No new treatments or procedures will be performed; Participant's privacy will be completely protected; The study will take about 14 months to complete;\n\nThis research will help improve care for older adults who experience bone fractures and may guide treatment decisions for future patients.",[26,83,84],"Fracture Dislocation of Upper Limb Joint","Spinal Fractures",[86,87,88,89,90,91],"fracture","Limb fractures","Spinal fractures","Elderly people","the old","Survival rate","NOT_YET_RECRUITING","2025-08-29",{"date":95,"type":36},"2025-09-08",{"date":97,"type":20},"2025-09-01",{"date":99,"type":20},"2026-02-28",{"name":101,"class":43},"Shanghai 6th People's Hospital"]