[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fracture-of-tibia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fracture-of-tibia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100542009","phase-3-incisional-negative-pressure-wound-therapy-to-reduce-infection-and-complications-in-high-risk-fractures-100542009",false,"NCT06337292","Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures","Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures: A Multicenter Randomized Controlled Trial","iVAC","Inclusion Criteria:\n\n1. All open or closed tibial plateau or pilon fractures treated operatively with internal fixation at high risk for complication. Any open Gustilo Type I, II or IIIA tibial shaft fracture treated definitively with internal or external fixation with or without ipsilateral leg compartment syndrome if at least one wound is primarily closed.\n2. We define high-risk fractures as those that are either:\n\n   * Closed fracture initially treated with an external fixator (with or without limited internal fixation) and treated definitive more than 3 days later after swelling has resolved;\n   * Any open type I, II or IIIA fracture, regardless of timing of definitive treatment;\n   * Any tibial plateau fracture associated with ipsilateral leg compartment syndrome fasciotomy wounds that has at least one wound primarily closed\n3. Requiring incision for fixation or debridement of 3 cm or greater.\n4. Patients 18 years of age or older\n\nExclusion Criteria:\n\n1. The study injury is already infected at time of study enrollment.\n2. Patient is unable to receive incisional NPWT for any reason.\n3. Patients who have already had definitive fixation prior to enrollment in the study.\n4. Severe problems with maintaining follow-up (e.g., patients who are homeless at the time of injury or those who are intellectually challenged without adequate family support or who are prisoners).\n5. The study injury is a Gustilo Type IIIB or IIIC open fracture.","ALL","18 Years",{"count":20,"type":21},352,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","This is a multi-center, pragmatic, parallel arm randomized controlled trial (RCT) of 352 patients with high-risk open or closed tibial plateau fracture, high-risk open or closed tibial pilon fracture, or open tibial shaft fracture with incision \\>3cm. Eligible participants will be randomized to receive either incisional negative pressure wound therapy (NPWT) or a non-suction standard-of-care wound dressing for their definitive wound management. The primary outcome will be a composite outcome to evaluate clinical status 3 months after randomization.",[27,28,29,30,31],"Fracture of Tibia","Wound Heal","Infected Wound","Wound Complication","Wound Dehiscence","RECRUITING","2026-05-07",{"date":35,"type":36},"2026-05-12","ACTUAL",{"date":38,"type":36},"2025-01-01",{"date":40,"type":21},"2028-12-31",{"name":42,"class":43},"Major Extremity Trauma Research Consortium","OTHER",6,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":5},"100477786","conservative-versus-intramedullary-nailing-for-pediatric-tibial-shaft-fractures-100477786","NCT05501496","Conservative Versus Intramedullary Nailing for Pediatric Tibial Shaft Fractures","Internal Fixation Versus Casting of Displaced Tibial Shaft Fractures in Children and Dolescents: a Study Protocol of a Randomized Controlled Trial","CINPED","Inclusion Criteria:\n\n\\- 6 to 15-year old children with displaced tibial shaft fracture\n\nExclusion Criteria:\n\n* Open fracture\n* Compartment syndrome\n* Neurovascular deficit\n* Pathological fracture\n* Systemic disease affecting bone structure and quality\n* Associated injuries preventing either casting or intramedullary nailing.","6 Years","15 Years",{"count":56,"type":21},66,[58],"NA","Tibial shaft fracture is a common fracture in the pediatric and adolescent population. The outcomes of both conservative and operative treatment are not clear and to date there is no randomized prospective trial comparing different methods of treatment.\n\nThe investigators will conduct a multicenter, randomized non-inferiority trial comparing closed reduction and cast immobilization to intramedullary nailing in 6-15 year old children and adolescents with displaced tibial shaft fractures and open proximal tibial physis.",[27],[62,63,64],"conservative treatment","intramedullary nailing","pediatric tibial shaft fracture","NOT_YET_RECRUITING","2022-08-17",{"date":68,"type":36},"2022-08-22",{"date":70,"type":21},"2022-10-01",{"date":72,"type":21},"2035-12-31",{"name":74,"class":75},"Turku University Hospital","OTHER_GOV"]