[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fractures-bone\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fractures-bone":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,22,0,[8,40,92,116,143,199,231,265,294,337,354,380,404,436,465,487,513,545,571,593,618,641],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100392419","continuous-passive-motion-following-fixation-of-pelvic-and-knee-fractures-100392419",false,"NCT04389749","Continuous Passive Motion Following Fixation of Pelvic and Knee Fractures","The Role of Continuous Passive Motion in Pain Control of Patients Undergoing Operative Management of Isolated Acetabular Fractures, Supracondylar Femur Fractures, or Tibial Plateau Fracture: A Comparative Study","Inclusion Criteria:\n\n* Age 18 or greater\n* Isolated acetabular fractures, supracondylar femur fractures, or tibial plateau fracture\n* Have undergone operative intervention for fracture\n\nExclusion Criteria:\n\n* Injury to either lower extremity that affects the patient's ability to weight bear\n* Under the age of 18\n* Pregnant\n* A prisoner","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"NA","The investigators will directly compare the visual analog scale scores and narcotic pain medication requirements in the patients who have continuous passive motion (CPM) versus those who do not during the course of the hospital admission following an open reduction internal fixation surgery for acetabular fracture, supracondylar femur fracture, or a tibial plateau fracture.",[26],"Fractures, Bone","RECRUITING","2026-04-28",{"date":30,"type":31},"2026-05-04","ACTUAL",{"date":33,"type":31},"2020-10-06",{"date":35,"type":20},"2027-06",{"name":37,"class":38},"University of Cincinnati","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":67,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":39},"100634199","time-to-healing-in-displaced-pediatric-diaphyseal-forearm-fractures-treated-with-bioabsorbable-compared-to-titanium-intramedullary-nails-100634199","NCT07536581","Time to Healing in Displaced Pediatric Diaphyseal Forearm Fractures Treated With Bioabsorbable Compared to Titanium Intramedullary Nails","Time to Healing in Displaced Pediatric Diaphyseal Forearm Fractures Treated With Bioabsorbable Compared to Titanium Intramedullary Nails: A Single-Center, Multi-Blinded, Randomized Parallel-Group, Non-Inferiority Study","FOREST","Inclusion Criteria:\n\n* Diagnosis of a traumatic diaphyseal forearm fracture of the radius, ulna, or both\n* Operative fixation required\n* Fractures must be complete (not unicortical or greenstick) AND displaced \\>50% of bone width (after attempted closed reduction) AND\u002FOR angulated \\>10° in any plane (after attempted closed reduction)\n* Informed consent obtained\n\nExclusion Criteria:\n\n* Conditions where internal fixation is contraindicated (e.g. active or potential infection)\n* Grossly open fractures (Gustilo Anderson grade \\> 2)\n* Fracture occurred more than 2 weeks prior\n* Fractures that are well managed conservatively (undisplaced or minimally displaced)\n* Previous ipsilateral forearm fracture (risk of closed medullary canal)\n* Fractures unsuited for intramedullary nailing (e.g. multifragmentary, metaphyseal or epiphyseal)\n* Concurrent ipsilateral wrist or elbow involvement (e.g. Monteggia or Galeazzi variants)\n* Unable to participate in follow-up\n* Existing bone pathology (e.g. tumor, osteogenesis imperfecta, degenerative disease)\n* Participation in any other medical device or medicinal product study within the previous month that could influence in opinion of the PI the results of the present study\n\nIntraoperative exclusion criteria:\n\n* Fractures suitable for closed reduction and casting (see 6.3.9)\n* Indication for treatment 1 (BIN) only\n* Indication for treatment 2 (ESIN) only\n* Intraoperative decision to use implants other than the devices under investigation","3 Years","13 Years",{"count":51,"type":20},60,[23],"This study looks at children with forearm fractures that need surgery. The standard treatment uses titanium nails, which usually need to be removed in a second operation later. This study compares titanium nails with bioabsorbable nails, which gradually dissolve in the body and may help some children avoid another operation.\n\nThe study will compare how quickly the fractures heal on X-ray, and also look at complications, recovery, function, and the family's experience. Children who need surgery will be randomly assigned to one of the two treatments so the comparison is fair.\n\nHypothesis: The researchers expect that fractures treated with bioabsorbable nails will heal almost as quickly as fractures treated with titanium nails, while reducing the need for later implant removal surgery.",[55,56,57,26,58,59,60,61,62,63,64,65,66],"Forearm Injuries","Radius Fractures","Ulna Fractures","Child","Adolescent","Fracture Fixation, Intramedullary","Internal Fixation","Orthopedic Operations","Polymers","Fracture Healing","Radiography","Randomized Controlled Trial (RCT)",[66,68,69,70,71,72,73,74,75,76,77,78,79,80,81],"pediatric forearm fracture","forearm shaft fracture in children","elastic stable intramedullary nailingelastic stable intramedullary nailing","ESIN","titanium elastic nail","bioabsorbable intramedullary nail","TEN","BIN","radiographic healing","radiographic union","modified Radiographic Union Score","mRUS","non-inferiority trial","randomized trial","NOT_YET_RECRUITING","2026-04-17",{"date":85,"type":31},"2026-04-22",{"date":87,"type":20},"2026-04",{"date":89,"type":20},"2031-12",{"name":91,"class":38},"Children's Fractures Interest Group, Denmark",{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":21,"phases":101,"briefSummary":103,"conditions":104,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":39},"100524782","phase-4-nonopioid-pain-control-regimen-after-open-reduction-and-internal-fixation-of-traumatic-fractures-100524782","NCT06113211","Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures","Inclusion Criteria:\n\n* All adult patients over age eighteen and scheduled for primary open reduction internal fixation following a traumatic fracture at Henry Ford Hospital (Detroit, Michigan, United States), and Henry Ford West Bloomfield Hospital (West Bloomfield, Michigan, United States) will be eligible for inclusion in this study. All patients will be met in our abulatory orthopedic clinics. All surgeries will be performed by a fellowship trained truama surgeons.\n\nExclusion Criteria:\n\n* patients with a medical history of known allergies or intolerance to allergies or intolerance to Motrin, Lyrica, Tylenol, tramadol, Zanaflex\n* substantial alcohol or drug abuse\n* pregnancy\n* history of narcotics within 6 months of surgery\n* renal impairment, peptic ulcer disease, GI bleeding.","80 Years",{"count":100,"type":20},75,[102],"PHASE4","An open reduction and internal fixation is a painful procedure requiring intensive postoperative pain management. Traditionally, opioid analgesia has been the gold standard for postoperative pain control. However, given the harmful side effect profile and opioid epidemic in the United States, it is advantageous to use alternate forms of analgesia. Multimodal pain control captures the effectiveness of different analgesic modalities and maximizes analgesia while minimizing side effects. The theory behind their use is that agents with different mechanisms of action work synergistically in preventing acute pain.\n\nObjective: To measure postoperative pain control in patients in two treatment arms of ORIF of the clavicle: a treatment group given a nonopioid pain control regimen, and a standard of care control group given standard opioid pain control regimen.\n\nStudy Design: A randomized single blinded standard of care controlled clinical trial comparing pain management interventions. All adult patients scheduled for an ORIF following a traumatic fracture by fellowship trained Trauma surgeons will be eligible for inclusion. Patients will be excluded if their medical history presents known allergies or intolerance to Motrin, Lyrica, Tylenol, Zanaflex, substantial alcohol or drug abuse, and pregnancy, history of narcotics within 6 months of surgery, renal impairment, peptic ulcer disease, GI bleeding.\n\nOn the day of surgery, patients will be randomized to receive a nonopioid pain control regimen or an opioid regimen using a computer-generated sequence.\n\nIf pain is uncontrolled, patients will also be sent home with a prescription with 10 pills of 5 mg of Oxycodone for breakthrough pain. The amount of oxycodone taken will be recorded. Patients can call the resident on call, available 24-hours per day, if additional pain control is needed.\n\nTreatment: All patients will undergo previously scheduled ORIF of the clavicle in standard fashion and be randomized to the non-narcotic pain regimen vs the narcotic pain regimen.",[105,26,106],"Opioid Use","Trauma","2026-04-07",{"date":109,"type":31},"2026-04-13",{"date":111,"type":31},"2024-10-01",{"date":113,"type":20},"2026-09-15",{"name":115,"class":38},"Henry Ford Health System",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":39},"100577080","study-of-icg-fluorescence-imaging-in-open-fracture-and-infection-patients-100577080","NCT06793644","Study of ICG Fluorescence Imaging in Open Fracture and Infection Patients","Prospective Observational Study of ICG Fluorescence Imaging in Open Fracture and Infection Patients: Early Comparison With a Novel Imaging Device","cBPI","Inclusion Criteria:\n\n* Patients 18 years of age or older.\n* Open extremity fracture, planning for management with external fixation, internal fixation or joint fusion.\n* Fracture Related Infection, planning for management with debridement and possible removal of hardware.\n* Will have all planned fracture care surgeries performed by a participating surgeon or delegate.\n* Provision of informed consent.\n\nExclusion Criteria:\n\n* Inability of patient to provide informed consent\n* Fracture of the hand.\n* Iodine allergy.\n* Burns at the fracture site.",{"count":125,"type":20},10,"OBSERVATIONAL","The purpose of this study is to determine whether an indocyanine green (ICG) fluorescence imaging system (cBPI) can be used to provide surgeons with information about bone health or bone blood flow. This will help surgeons better understand the healing potential of bone and relative risk of complication. This is important to help surgeons select the most appropriate treatment for severe traumatic injuries and infections.",[26,129],"Trauma Injury",[131,132,133],"Immunofluorescence","Orthopaedic Trauma","Infection","2026-03-17",{"date":136,"type":31},"2026-03-19",{"date":138,"type":31},"2025-06-10",{"date":140,"type":20},"2027-10",{"name":142,"class":38},"Dartmouth-Hitchcock Medical Center",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":21,"phases":152,"briefSummary":153,"conditions":154,"keywords":173,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":39},"100481933","performance-and-safety-evaluation-of-inion-compresson-screw-in-foot-and-ankle-surgeries-pmcf-investigation-100481933","NCT05555459","Performance and Safety Evaluation of Inion CompressOn Screw in Foot and Ankle Surgeries. PMCF Investigation","The Performance and Safety Evaluation of Bioabsorbable Headless Inion CompressOn Screws in Selected Fracture, Osteotomy and Artrodesis Surgeries of the Foot and Ankle","Inclusion Criteria:\n\n1. Read the patient information bulletin on the study and signed the patient consent form\n2. Adult patient (over 18-year-old)\n3. Suitable and in need for surgical lower limb operation listed in the indications of this study that requires fastening of bone structures with screws (or an alternative attachment method) in the ankle or foot area, according to a statement of the investigator surgeon\n4. Ability to fill in questionnaires.\n5. Willingness to comply with rehabilitation instructions.\n6. Availability for follow-up visits.\n\nExclusion Criteria:\n\n1. Active infection\n2. Patient conditions including limited blood supply (e.g. patients with severe circulatory disorder of the lower limb\n3. Patient conditions including insufficient quality or quantity of bone (diagnosed osteoporosis, conditions causing secondary osteoporosis e.g. diabetes, rheumatism, eating disorder)\n4. Patient conditions where patient cooperation cannot be guaranteed (alcohol use, drug abuse etc.)\n5. High-load bearing indications (e.g., diaphyseal fractures of long bones) unless used in conjunction with traditional rigid fixation\n6. Patients with significant neuropathy\n7. Pregnancy\n8. Patients who refuse to participate\n9. Lower limb tumor or metastasis\n10. Complex Regional Pain Syndrome (CRPS) in operated foot",{"count":151,"type":20},125,[23],"The study in question is a post market clinical follow up (PMCF) study to evaluate the safety and performance of bioabsorbable headless compression screw Inion CompressOn in selected fracture, osteotomy and arthrodeses operations of the foot and ankle. The study recruits 125 adult patients who meet the acceptance criteria. The follow-up time for each study patient is 4 years. The study is a single center single group study which is conducted in Tampere University Hospital (TAYS) in Finland. The main focus of the study in terms of performance is to evaluate the bone healing\u002Fossification of operated areas. The main focus of the study in terms of safety is to evaluate the occurrence of adverse events and required revision surgeries that are or might be related to the study device.",[155,156,157,158,159,160,161,162,163,26,164,165,166,167,168,169,170,171,172],"Medial Malleolus Fracture","Lisfranc Injury","Lisfranc Fracture","Talus Fracture","Calcaneus Fracture","Navicular Fracture","Deformity, Foot","Ankle Fractures","Foot Fracture","Fracture of Foot","Foot Deformities","Foot Injury","Feet Deformity Tarsus","Metatarsalgia","Hallux Rigidus","Hallux Valgus","Deformity of Toe","Deformity of Foot",[174,175,176,177,178,179,180,181,182,183,184,185,186,187,188],"bioabsorbable screw","compression screw","headless screw","orthopaedic screw","bone fixation","bioabsorbable screw study","resorbable","biodegradable","bioabsorbable","fracture fixation with resorbable implants","inion","post-market follow-up study","orthopedic bone fixation","arthrodesis","osteotomy","2026-03-11",{"date":191,"type":31},"2026-03-13",{"date":193,"type":31},"2023-03-07",{"date":195,"type":20},"2032-04-30",{"name":197,"class":198},"Inion Oy","INDUSTRY",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":16,"minAge":207,"maxAge":208,"enrollmentInfo":209,"targetDuration":4,"studyType":21,"phases":211,"briefSummary":213,"conditions":214,"keywords":4,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":39},"100590525","phase-2-sufentanil-versus-ketamine-intranasally-in-the-management-of-severe-acute-trauma-related-pain-in-children-100590525","NCT06968546","Sufentanil Versus Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children.","Randomized Controlled Study Comparing Sufentanil and Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children.","SUF-KET-PED","Inclusion Criteria:\n\n* Children aged 6 to 17 years inclusive, under 18 years old, weighing more than 10kg, and requiring analgesia for the management of acute pain\n* Presenting with pain assessed as severe using a validated pain scale (VAS \\> 6\u002F10)\n* Acute traumatic lime injury\n* Pain caused by trauma, excluding thoracic trauma with dyspnea and abdominal pain\n* Obtaining written and signe informed consent from one of the two parents or legal guardians\n* Affiliation with a social security system\n* Hemodynamically stable\n* For post-menarche girls: negative urine pregnancy test and effective contraception, in accordance with national regulations\n\nExclusion Criteria:\n\n* Patient in a state of immediate life-threatening distress\n* Parents who don't understand and\u002For don't speak French\n* Known hypersensitivity to opiods\n* Allergy to one of the study treatments\n* History of epilepsy or known psychiatric illness\n* History of respiratory, cardiac or renal insufficiency\n* Use of serotonergic antidepressants\n* Any child with an ongoing respiratory condition (asthma, laryngitis)\n* Thoracic trauma\n* Use of opioids within the 4 hours prior to arrival in the ermergency department\n* Any child with an ongoing respiratory condition (asthma, laryngitis)\n* Thoracic trauma\n* Use of opioids within the 4 hours prior to arrival in the ermergency department\n* History of head, abdominal, or spinal trauma\n* Confirmed pregnancy\n* History of toxic substance use\n* Facial or nasal trauma\n* Whithdrawal of informed consent from the parents or legal guardian","6 Years","17 Years",{"count":210,"type":20},116,[212],"PHASE2","Pain is one of the most common reasons for children to attend emergency departments, particularly following traumatic injuries such as fractures, sprains, or contusions. Despite advances in medical care, severe acute pain in children is still sometimes inadequately treated. One important reason is that intravenous pain medication can be technically difficult, stressful, or delayed in paediatric patients.\n\nIntranasal drug administration, which involves spraying medication into the nose, offers a rapid and needle-free way to relieve pain and is increasingly used in paediatric emergency care. Two medications can be administered through this route: ketamine and sufentanil. Intranasal ketamine is already widely used in children for pain management. Sufentanil is a potent opioid analgesic commonly used in adults and in anaesthesia but has been much less studied in children when administered intranasally.\n\nThe aim of this study is to compare the effectiveness and safety of intranasal sufentanil and intranasal ketamine in children aged 6 to 17 years who present to the emergency department with severe traumatic limb pain. Both medications will be given in addition to standard care, including the routine use of an oxygen-nitrous oxide gas mixture (MEOPA), which is commonly used to reduce pain and anxiety in children.\n\nChildren who take part in the study will be randomly assigned to receive either intranasal sufentanil or intranasal ketamine. Pain levels will be assessed at regular time points after medication administration using age-appropriate pain scales. Sedation level and possible side effects will also be closely monitored for a short period following treatment.\n\nThe hypothesis of this study is that intranasal sufentanil will provide greater pain relief than intranasal ketamine 30 minutes after administration, without increasing the risk of adverse effects, when both are used alongside standard emergency care.\n\nThe results of this study are expected to improve knowledge about fast, effective, and non-invasive pain relief strategies for children in emergency settings and may help optimise future pain management protocols in paediatric emergency care.",[215,216,217,218,219,220,221],"Traumatology","Wounds and Injury","Fractures Bone","Analgesia","Pain","Pain Management","Acute Pain","2026-01-26",{"date":224,"type":31},"2026-01-28",{"date":226,"type":20},"2026-02-05",{"date":228,"type":20},"2028-03-31",{"name":230,"class":38},"Fondation Lenval",{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":238,"targetDuration":4,"studyType":21,"phases":240,"briefSummary":241,"conditions":242,"keywords":246,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":264},"100574042","assessing-ai-supported-fracture-detection-in-emergency-care-units-100574042","NCT06754137","Assessing AI-Supported Fracture Detection in Emergency Care Units","Evaluating the Cost-Efficiency and Workflow Impact of AI-Supported Fracture Detection in an Orthopedic Emergency Care Unit","Inclusion Criteria:\n\n* Presenting to the emergency department with an isolated injury or joint complaint\n* Patients able and willing to provide informed consent.\n\nExclusion Criteria:\n\n* Patients with injuries or complaints involving multiple body regions\n* Patients with prior imaging of the affected extremity or region within the past 6 months\n* Contraindications to X-ray imaging (e.g., pregnancy or severe instability)\n* Patients with other ongoing studies that may interfere with this study\n* Patients unable to provide consent due to cognitive impairment or language barriers without an available representative.",{"count":239,"type":20},4800,[23],"Brief Summary The purpose of this study is to determine if artificial intelligence (AI) can assist doctors in detecting broken bones, effusions, dislocations and bone lesions more quickly and accurately in an emergency room setting. The study will also evaluate whether AI can save time and reduce costs in healthcare.\n\nThe main questions to be addressed are:\n\n* Does AI improve the accuracy of detecting broken bones\u002Fdislocations\u002Feffusions\u002Fbone lesions?\n* Can AI expedite the process of diagnosing broken bones\u002Fdislocations\u002Feffusions\u002Fbone lesions?\n* Does AI reduce healthcare costs by enhancing efficiency?\n\nTo investigate these questions, two groups of patients will be compared. One group will follow the traditional diagnostic approach, while the other group will utilize AI to assist in diagnosing X-rays.\n\nParticipants in the study will:\n\nUndergo standard X-ray imaging of injured arms or legs, as part of routine care.\n\nHave X-rays reviewed by doctors with or without AI support, depending on the assigned group.\n\nThe study will include patients of all ages presenting to the emergency room with an isolated injury or joint complaints. No additional tests or treatments beyond standard care will be involved.",[26,243,244,245],"Effusion Joint","Bone Lesion","Dislocation",[247,248,249,250,251,252,253,254,245,244],"Artificial Intelligence","Fracture Detection","Emergency Care","Cost-Efficiency","AI-Assisted Diagnosis","Diagnostic Accuracy","Orthopedic Diagnostics","Effusion","2026-01-20",{"date":257,"type":31},"2026-01-22",{"date":259,"type":31},"2025-03-31",{"date":261,"type":20},"2026-04-30",{"name":263,"class":38},"Salzburger Landeskliniken",3,{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":271,"eligibilityCriteria":272,"healthyVolunteers":273,"sex":16,"minAge":274,"maxAge":17,"enrollmentInfo":275,"targetDuration":4,"studyType":21,"phases":277,"briefSummary":278,"conditions":279,"keywords":280,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":284,"lastUpdatePostDateStruct":285,"startDateStruct":287,"completionDateStruct":289,"leadSponsor":291,"locationsCount":39},"100592217","cast-art-for-kids-with-extremity-fractures-100592217","NCT06990555","Cast Art for Kids With Extremity Fractures","Cast Art for Kids With Extremity Fractures on Satisfaction and Perception of Pain (CAKEPOP)","CAKE POP","Inclusion Criteria:\n\n* Age 5 years old and greater, and less than 18 years old\n* Sustained an upper or lower extremity fracture\n* Scheduled for orthopedic clinic visit for injury evaluation\n* Have radiographic and clinical data available for review\n\nExclusion Criteria:\n\n* Age 18 years old or greater at the time of screening\n* Patient\u002Fparents do not consent to being included in the study\n* Underwent surgery",true,"5 Years",{"count":276,"type":20},96,[23],"The goal of this clinical trial is to compare casts with cast art versus those without art in children who sustain a fracture of the extremity. The main goals are:\n\n* Determine the difference in satisfaction as measured by the visual analog scale for satisfaction between patients treated in a cast with cast customization versus those in a cast with no cast art\n* Determine the difference in perceived pain scores between patients treated in a cast with cast customization versus those in a case with no cast art\n\nParticipants will be randomized to one of three groups: one with plain white cast, one with cast of color wrap of choice, and one with custom cast art.\n\nResearchers will compare to see the differences in satisfaction and perception of pain based on what cast the study participant receives.",[26],[281,282,283],"Cast","Art","Fractures","2025-10-07",{"date":286,"type":31},"2025-10-09",{"date":288,"type":31},"2023-05-08",{"date":290,"type":20},"2025-12-30",{"name":292,"class":293},"United States Naval Medical Center, Portsmouth","FED",{"id":295,"slug":296,"hasResults":11,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":300,"eligibilityCriteria":301,"healthyVolunteers":273,"sex":302,"minAge":17,"maxAge":303,"enrollmentInfo":304,"targetDuration":4,"studyType":21,"phases":306,"briefSummary":308,"conditions":309,"keywords":320,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":39},"100559957","phase-3-vitamin-d-in-pregnancy-for-prevention-of-early-childhood-asthma-100559957","NCT06570889","VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma","VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma (VICTORY)","VICTORY","* Pregnant Danish women before week 26 with blood levels of EPA+DHA above 4.7% of total fatty acids\n* No current vitamin D intake above the recommended 400 IU\u002Fday\n* No endocrine-, heart-, kidney- or auto-immune disorders\n* No disorders requiring treatment with blood thinning medication","FEMALE","45 Years",{"count":305,"type":20},2000,[307],"PHASE3","The overall aim of the study is to develop a nutritional preventive vitamin D supplementation strategy in pregnancy for early childhood asthma\u002Fpersistent wheeze during the first three years of life as we hypothesize that supplementation in higher doses than recommended could reduce the risk of disease development.",[310,311,312,313,314,315,316,26,317,318,319],"Asthma","Respiratory Tract Infections","Gastrointestinal Infection","Croup","Eczema","Allergy","Wheezing","Development, Child","Cognition Disorders in Children","Psychiatric Diagnosis",[321,310,322,314,315,323,324,325,326,327],"Childhood","Infections","Development","Psychiatry","Bone development","Cognition","Growth","2025-09-24",{"date":330,"type":31},"2025-09-30",{"date":332,"type":31},"2024-12-20",{"date":334,"type":20},"2033-03",{"name":336,"class":38},"Professor Klaus Bønnelykke",{"id":338,"slug":339,"hasResults":11,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":343,"eligibilityCriteria":344,"healthyVolunteers":273,"sex":302,"minAge":17,"maxAge":303,"enrollmentInfo":345,"targetDuration":4,"studyType":21,"phases":346,"briefSummary":347,"conditions":348,"keywords":349,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":350,"startDateStruct":351,"completionDateStruct":352,"leadSponsor":353,"locationsCount":39},"100559140","phase-3-fish-oil-in-pregnancy-for-personalized-prevention-of-early-childhood-asthma-100559140","NCT06560255","Fish Oil in pREgnancY for Personalized Prevention of Early Childhood Asthma","Fish Oil in pREgnancY for Personalized Prevention of Early Childhood Asthma (FREYA)","FREYA","* Pregnant Danish women before week 26 with blood levels of EPA+DHA below 4.7% of total fatty acids\n* No planned use of fish oil supplementations\n* No endocrine-, heart-, kidney- or auto-immune disorders\n* No disorders requiring treatment with blood thinning medication",{"count":305,"type":20},[307],"The overall aim of the study is to develop a nutritional preventive fish oil supplementation strategy in pregnancy for early childhood asthma\u002Fpersistent wheeze during the first three years of life as we hypothesize that both supplementations in higher doses than recommended could reduce the risk of disease development.",[310,311,312,313,314,315,316,26,317,318,319],[321,310,322,314,315,323,324,325,326,327],{"date":330,"type":31},{"date":332,"type":31},{"date":334,"type":20},{"name":336,"class":38},{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":361,"targetDuration":362,"studyType":126,"phases":4,"briefSummary":363,"conditions":364,"keywords":367,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":39},"100578529","anticholinergic-burden-and-osteoporosis-in-rheumatoid-arthritis-100578529","NCT06812481","Anticholinergic Burden and Osteoporosis in Rheumatoid Arthritis","Anticholinergic Drug Use in Patients With Rheumatoid Arthritis and Its Effects on Fracture Risk","Inclusion Criteria:\n\n* Patients diagnosed with rheumatoid arthritis\n\nExclusion Criteria:\n\n* Kemik metabolizmasını etkileyen sistemik hastalıkları veya ilaçları kullanan hastalar,\n* Kemik mineral yoğunluk ölçümünü etkileyen kalça veya lomber vertebralarda metalik materyalleri olan hastalar",{"count":19,"type":20},"3 Months","Background: Rheumatoid arthritis (RA) is a chronic, progressive, inflammatory rheumatological disease. Use of corticosteroids for more than 3 months in RA treatment is considered an important risk factor in terms of developing secondary osteoporosis and increasing the risk of fracture. The cumulative effect of taking one or more drugs with anticholinergic properties is called anticholinergic load. It is stated that anticholinergic load also increases the risk of fracture in individuals. The aim of this study is to investigate the effects of drugs used by patients with Rheumatoid Arthritis (RA) on anticholinergic load and fracture risk. The Fracture Risk Assessment Tool (FRAX) will be used to assess fracture risk in patients.\n\nMaterials and methods: The study was planned as a prospective cohort study. The study will included 100 patients who were followed up as outpatients with rheumatoid arthritis diagnosis in the physical medicine and rehabilitation clinic between 2024-2025. Patients of both genders and over 18 years of age diagnosed with rheumatoid arthritis will be included in the study. Patients with systemic diseases or medications affecting bone metabolism and those with metallic materials in the hip or lumbar vertebrae affecting bone mineral density measurement will be excluded from the study. Demographic characteristics, systemic diseases, medications used, bone density measurement and blood test values of the patients will be recorded.\n\nPatients taking multiple medications with anticholinergic effects create an anticholinergic burden. The Anticholinergic Drug Scale, Anticholinergic Cognitive Burden Scale and Anticholinergic Risk Scale will be used to measure anticholinergic burden in the study.",[365,366,26],"Rheumatoid Arthritis (RA)","Anticholinergic Adverse Reaction",[368,369,370],"Rheumatoid arthritis","anticholinergic load","risk of fracture","2025-09-16",{"date":373,"type":31},"2025-09-18",{"date":375,"type":31},"2025-09-15",{"date":377,"type":20},"2025-12-31",{"name":379,"class":38},"Balikesir University",{"id":381,"slug":382,"hasResults":11,"nctId":383,"briefTitle":384,"officialTitle":384,"acronym":385,"eligibilityCriteria":386,"healthyVolunteers":11,"sex":16,"minAge":387,"maxAge":4,"enrollmentInfo":388,"targetDuration":4,"studyType":21,"phases":390,"briefSummary":391,"conditions":392,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":395,"lastUpdatePostDateStruct":396,"startDateStruct":398,"completionDateStruct":400,"leadSponsor":402,"locationsCount":39},"100476756","pained-project-addressing-inequities-in-the-emergency-department-100476756","NCT05488080","PAINED: Project Addressing INequities in the Emergency Department","PAINED","Inclusion Criteria:\n\n* All Children's National Hospital Emergency Department clinicians\n* Patients 0-21 years with symptoms suggestive of appendicitis or long bone fracture\n\nExclusion Criteria:\n\n* Emergency Severity Index (ESI 1)","0 Years",{"count":389,"type":20},22032,[23],"Racial and ethnic inequities in health care quality have been described across a broad range of clinical settings, patient populations, and outcomes. Our overarching goal is to eradicate health care inequities through evidence-based interventions. The objectives of this proposal are to develop and test the impact of two interventions on overcoming clinician implicit bias and mitigating inequities in the management of pain among children seeking care in the emergency department for the treatment of appendicitis or long bone fractures.",[219,393,394,26],"Appendicitis","Bias, Racial","2025-07-14",{"date":397,"type":31},"2025-07-17",{"date":399,"type":31},"2023-02-27",{"date":401,"type":20},"2026-08-23",{"name":403,"class":38},"Children's National Research Institute",{"id":405,"slug":406,"hasResults":11,"nctId":407,"briefTitle":408,"officialTitle":409,"acronym":4,"eligibilityCriteria":410,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":411,"targetDuration":413,"studyType":126,"phases":4,"briefSummary":414,"conditions":415,"keywords":422,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":429,"completionDateStruct":431,"leadSponsor":433,"locationsCount":435},"100385462","safety-efficacy--use-of-vivigen-cellular-bone-matrix-allograft-in-orthopaedic-fracture-care-100385462","NCT04299022","Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care","Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care: A Multi-Center Prospective Registry and Retrospective Data Collection Study","Prospective Cohort Inclusion Criteria:\n\n* Any skeletally mature patient treated with Vivigen bone graft in the setting of an acute fracture, delayed, non-union or fusion setting will be eligible for inclusion.\n\nRetrospective Cohort Inclusion Criteria:\n\n\\- Any skeletally mature patient treated with adjunct bone graft in the setting of an acute fracture, delayed, non-union or fusion setting will eligible for inclusion.\n\nProspective Cohort Exclusion Criteria:\n\n1. Patients unable to understand either an English or Spanish consent will be excluded.\n2. Patients unable to consent secondary to dementia and\u002For other mental\u002Fpsychiatric diagnoses will be excluded.",{"count":412,"type":20},250,"24 Months","Prospective registry and retrospective data collection study to assess the efficacy and safety of Vivigen Cellular Bone Matrix (Vivigen) in orthopaedic trauma patients who require bone grafting in the acute, delayed, non-union fracture as well as use in fusion procedure settings.",[26,416,417,418,419,420,421],"Nonunion of Fracture","Fractures, Open","Fractures, Ununited","Fracture, Tibial","Fracture of Femur","Fracture Arm",[423,424,425],"fracture","nonunion","allograft","2025-03-28",{"date":428,"type":31},"2025-04-02",{"date":430,"type":31},"2021-06-01",{"date":432,"type":20},"2026-07-31",{"name":434,"class":198},"LifeNet Health",4,{"id":437,"slug":438,"hasResults":11,"nctId":439,"briefTitle":440,"officialTitle":441,"acronym":4,"eligibilityCriteria":442,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":443,"enrollmentInfo":444,"targetDuration":446,"studyType":126,"phases":4,"briefSummary":447,"conditions":448,"keywords":451,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":456,"lastUpdatePostDateStruct":457,"startDateStruct":459,"completionDateStruct":461,"leadSponsor":463,"locationsCount":39},"100495212","point-of-care-gastric-ultrasound-for-fracture-surgery-100495212","NCT05728242","Point-of-care Gastric Ultrasound for Fracture Surgery","Perioperative Point-of-care Gastric Ultrasound for Surgical Fracture Repair: Effect of Stress on Gastric Emptying","Inclusion Criteria:\n\n* • American Society of Anesthesiologists (ASA) Physical Status classification I to III\n\n  * Patients necessitating surgery after traumatic fracture\n\nExclusion Criteria:\n\n* • Patients with a body mass index over 35\n\n  * Diseases that may lead to gastroparesis (\n  * Known gastroesophageal reflux disease\n  * Known autonomic neuropathy\n  * Known diabetes mellitus\n  * Known or operated esophageal abnormalities\n  * History of gastric surgery\n  * Acute gastric or peptic ulcus\n  * Pregnancy\n  * Preoperative narcotic analgesic usage\n  * Known connective tissue disorders like scleroderma or amyloidosis\n  * Known hiatal hernia\n  * Known gallbladder and choledochal stone","90 Years",{"count":445,"type":20},80,"2 Days","Although there are fasting guidelines offered by the American Society of Anesthesiology (ASA) for managing preoperative patient assessment, some patients may need to be more cautious about the risk of aspiration. Since ultrasound has been a part of perioperative anesthesiology practice, it is simple to assess gastric content preoperatively with bedside ultrasonography (USG). More research is necessary to define elective surgeries with a possible risk of aspiration. Therefore, we aimed to evaluate the adequacy of standard fasting protocols in post-traumatic fracture surgery by measuring and evaluating gastric volume and content with USG in the preoperative operating room.",[449,450,26],"Pneumonia, Aspiration","Gastric Content",[452,453,454,455],"gastric ultrasound","aspiration pneumonia","gastric emptying","fracture surgery","2025-03-16",{"date":458,"type":31},"2025-03-20",{"date":460,"type":31},"2023-02-01",{"date":462,"type":20},"2025-07-30",{"name":464,"class":38},"Haseki Training and Research Hospital",{"id":466,"slug":467,"hasResults":11,"nctId":468,"briefTitle":469,"officialTitle":470,"acronym":471,"eligibilityCriteria":472,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":473,"targetDuration":475,"studyType":126,"phases":4,"briefSummary":476,"conditions":477,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":479,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":485,"locationsCount":39},"100535794","prospective-registry-to-evaluate-outcomes-of-nanobone-bone-graft-in-acute-trauma-100535794","NCT06256458","Prospective Registry to Evaluate Outcomes of NanoBone® Bone Graft in Acute Trauma","Multicenter Prospective Registry to Evaluate Use and Outcomes of NanoBone® Bone Graft Substitute in Acute Trauma Patients","ARTIST","Inclusion Criteria:\n\n1. Subjects at least 18 years old at the time of injury\n2. Acute fractures, resulting from blunt or penetrating trauma\n\n   * In the extremities or pelvis\n   * Requiring surgery\n   * Treated emergently, delayed or staged up to 4 weeks from the date of injury\n   * Where bone grafting is clinically indicated\n\nExclusion Criteria:\n\n1. Certain fracture locations (these apply to non-unions as well)\n\n   * Hand - metacarpals, phalanges\n   * Forefoot - metatarsals, phalanges\n   * Skull\n   * Spine\n2. Fractures requiring definitive fracture stabilization beyond the initial 4 weeks from the date of injury\n3. Pathologic fractures secondary to malignancy\n4. Subjects unable to follow recommended post-operative plan and complete follow ups\n5. Subjects unable to complete patient reported outcome measures",{"count":474,"type":20},200,"6 Months","This multicenter prospective patient registry was developed with the aim of documenting how orthopedic surgeons are utilizing the NanoBone products in acute trauma cases along with relevant patient outcomes. These outcomes include radiographic measures such as fracture healing, instrumentation integrity, and clinical outcomes (symptom and function improvement) based on investigator and patient-based outcome assessments.",[26],"2025-02-11",{"date":480,"type":31},"2025-02-12",{"date":482,"type":31},"2023-12-01",{"date":484,"type":20},"2026-12-01",{"name":486,"class":198},"Artoss Inc.",{"id":488,"slug":489,"hasResults":11,"nctId":490,"briefTitle":491,"officialTitle":491,"acronym":4,"eligibilityCriteria":492,"healthyVolunteers":273,"sex":302,"minAge":493,"maxAge":4,"enrollmentInfo":494,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":495,"conditions":496,"keywords":500,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":504,"lastUpdatePostDateStruct":505,"startDateStruct":507,"completionDateStruct":509,"leadSponsor":511,"locationsCount":39},"100493138","skeletal-effects-of-type-1-diabetes-on-low-trauma-fracture-risk-100493138","NCT05701254","Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk","Inclusion Criteria:\n\nCriteria for enrollment of female diabetics\n\n1. No chronic disease diagnoses that may affect bone, as confirmed by the PI.\n2. Normal clinical history, physical, and clinical laboratory exam (except for usual complications of a 10+-year diabetic, i.e., \\~minimal neuropathy or retinopathy, known, but asymptomatic mild vascular disease, etc.)\n3. Glomelular Filtration Rate (GFR) \\>45 ml\u002Fmin (Renal Association lower limit for \"mild\" kidney failure).\n4. Willingness to sign a consent form.\n5. Willingness to undergo a transilial bone biopsy incision that yields 2 bone specimens.\n6. No abnormalities in clinical blood chemistry measurements (small, age-related decreases in GFR, will be permitted).\n7. Caucasian\n\nCriteria for each non-diabetic subject, compared to their matched diabetic:\n\n1. Dual-energy x-ray absorptiometry (DXA) measures (BMD, gm\u002Fcm) must be within +\u002F- 15% in total hip.\n2. Body mass index (BMI) must be within +\u002F-10%.\n3. Age must be within +\u002F- 5 years.\n4. Caucasian\n\nExclusion Criteria:\n\n1. Women who have had Type 1 diabetes for less than 10 years.\n2. Non-insulin dependent Type 1 diabetic.\n3. Less than 50 years old.\n4. Less than 5 years post menopausal.","50 Years",{"count":445,"type":20},"Patients with Type 1 Diabetes Mellitus (T1DM) have a higher risk of low-trauma (osteoporotic) fracture that is 7-12 times higher than non-diabetics. The bone density of people with Type 1 Diabetes is higher at the time of fracture than in non-diabetics. This suggests the presence of underlying bone tissue mechanical defects. The potential benefits to participants would be knowledge gained about their bone density and the results of laboratory tests. On a wider scale, there may be general benefits to society because the knowledge gained from this study may help better understand the effects of diabetes on bone health",[497,498,499,26],"Type 1 Diabetes","Osteopenia","Bone Loss",[501,502,503],"Bone","Cortical Bone","Mechanical Strength","2024-09-23",{"date":506,"type":31},"2024-09-25",{"date":508,"type":31},"2019-06-18",{"date":510,"type":20},"2025-01",{"name":512,"class":38},"Creighton University",{"id":514,"slug":515,"hasResults":11,"nctId":516,"briefTitle":517,"officialTitle":518,"acronym":519,"eligibilityCriteria":520,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":521,"targetDuration":4,"studyType":21,"phases":523,"briefSummary":524,"conditions":525,"keywords":530,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":537,"startDateStruct":539,"completionDateStruct":541,"leadSponsor":543,"locationsCount":39},"100554892","phase-4-powdered-intrawound-vancomycin-in-open-fractures-trial-100554892","NCT06504992","Powdered Intrawound Vancomycin in Open Fractures Trial","Powdered Intrawound Vancomycin in Open Fractures: a Randomized Controlled Trial","PIVOT","Inclusion Criteria:\n\n* 18 years or older at time of surgery\n* Patients with an open fracture classified as Gustilo Type I to IIIc in the clavicle, humerus, radius, ulna, metacarpals, upper extremity phalanges (fingers), femur, tibia, fibula and metatarsals and lower extremity phalanges (toes).\n* Open fracture treated operatively with plate(s) and screw(s) hardware fixation and intramedullary fixation (IM nail).\n* Able to attend standard of care follow up for six months post-operatively\n\nExclusion Criteria:\n\n* Patients with known vancomycin allergy, drug administration reaction, or other sensitivities to vancomycin.\n* Patients who have already had definitive fracture fixation before enrollment in the study\n* Patients with open fracture already infected at time of enrollment\n* Patients with current positive blood cultures (bacteremia) at time of enrollment (current, meaning they have not received treatment and now have negative most-recent blood cultures).\n* Patients who have other forms of local antibiotics that are left in place at the end of the definitive fixation surgery (e.g., antibiotic loaded cement or polymethyl methacrylate (PMMA) beads)\n* Patients who do not speak English\n* Patients who are currently pregnant\n* Patients who are unable to provide consent and do not have a substitute decision maker able to provide consent\n* Patients who will have severe difficulty with follow up",{"count":522,"type":20},350,[102],"The purpose of this randomized control trial is to compare the rate of post-operative infection in patients with open fractures in upper or lower extremity long bones randomized to receive intra-operative intrawound topical vancomycin powder on their open fractures in addition to the current best practice of intravenous antibiotics with irrigation and debridement compared to intravenous antibiotics with irrigation and debridement alone during definitive operative fixation of the fracture.",[526,106,527,417,528,26,529],"Open Fracture","Infection, Surgical Site","Wound Infection","Post-Operative Wound Infection",[531,532,533,534,535],"open fracture","vancomycin","infection","trauma","intrawound","2024-09-17",{"date":538,"type":31},"2024-09-19",{"date":540,"type":20},"2024-11-01",{"date":542,"type":20},"2029-09-01",{"name":544,"class":38},"University of Manitoba",{"id":546,"slug":547,"hasResults":11,"nctId":548,"briefTitle":549,"officialTitle":550,"acronym":4,"eligibilityCriteria":551,"healthyVolunteers":11,"sex":16,"minAge":552,"maxAge":4,"enrollmentInfo":553,"targetDuration":4,"studyType":21,"phases":555,"briefSummary":556,"conditions":557,"keywords":4,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":563,"lastUpdatePostDateStruct":564,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":569,"locationsCount":4},"100562467","the-effect-of-digital-education-for-osteoporosis-patients-on-fracture-risk-and-related-health-outcomes-100562467","NCT06603545","The Effect of Digital Education for Osteoporosis Patients on Fracture Risk and Related Health Outcomes.","The Effect of Digital Education for Osteoporosis Patients on Fracture Risk and Related Health Outcomes in Older Swedish Men and Women.","Inclusion Criteria:\n\n* Patients visiting an osteoporosis unit, 65 years and older.\n* Ability to understand and follow study instructions.\n* Signed informed consent.\n* Have been recommended pharmacological osteoporosis treatment after a clinical evaluation including a DXA-scan and assessment of fracture risk at an osteoporosis clinic.\n* Have access to www.1177.se.\n\nExclusion Criteria:\n\n* Patients with previous osteoporosis medication the last year.","65 Years",{"count":554,"type":20},2640,[23],"A digital education for osteoporosis patients (DEOP) has been developed and tested on patients in Region Vastra Gotaland, Sweden. Currently, the evidence regarding the efficacy of patient education on fracture risk, medication adherence, injurious falls, levels of physical activity, and diet is insufficient. Most patients with osteoporosis in Sweden are diagnosed and treated in primary care, where the knowledge about osteoporosis is often very limited. Thus, in general, osteoporosis patients are not sufficiently informed before receiving a treatment recommendation. This randomized controlled trial aims to investigate if DEOP vs. standard care can reduce the incidence of fracture in older women and men, and if the intervention leads to better adherence to osteoporosis medication, higher quality of life, increased physical activity, and enhanced diet.\n\nThe primary objective is to investigate if DEOP compared to standard care (without DEOP), can reduce the incidence of clinical fractures in men and women, over the age of 65 years, without previous osteoporosis medication the last year, who have been recommended osteoporosis treatment after a DXA scan and assessment of clinical risk factors at an osteoporosis clinic.\n\nThe secondary objectives are to investigate if DEOP compared to standard care (without DEOP), can reduce the incidence of injurious falls, have positive effects on adherence to osteoporosis medication, positively affect diet (calcium and vitamin D intake), physical activity, and improve quality of life in men and women, over the age of 65 years, without previous osteoporosis medication the last year, who have been recommended osteoporosis treatment after a DXA scan and assessment of clinical risk factors at an osteoporosis clinic.\n\nStudy design: randomized multicentre clinical trial. Patients over the age of 65 visiting an osteoporosis unit for a bone density scan (DXA) will be asked to participate in the study. The participants will be randomized to one of two arms where one arm will be invited to DEOP and the other arm will receive standard care, without DEOP.",[558,559,26,560,561,562],"Osteoporosis","Accidental Falls","Patient Reported Outcome Measures","Drug Adherence","Injury Traumatic","2024-09-16",{"date":538,"type":31},{"date":566,"type":20},"2024-09",{"date":568,"type":20},"2029-12",{"name":570,"class":38},"Sahlgrenska University Hospital",{"id":572,"slug":573,"hasResults":11,"nctId":574,"briefTitle":575,"officialTitle":575,"acronym":576,"eligibilityCriteria":577,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":578,"targetDuration":4,"studyType":21,"phases":580,"briefSummary":581,"conditions":582,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":583,"lastUpdatePostDateStruct":584,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":590,"locationsCount":39},"100517154","boneview-ed---impact-of-artificial-intelligence-detecting-fractures-in-the-emergence-department--a-pragmatic-prospective-study-100517154","NCT06013852","Boneview-ED - Impact of Artificial Intelligence Detecting Fractures in the Emergence Department : a Pragmatic Prospective Study","Boneview-ED","Inclusion Criteria:\n\n* Major patient\n* Admitted to the emergency department after trauma less than 48 hours\n* Patient with an indication on an x-ray of the limbs or\u002Fand pelvis\n* Express patient consent\n* Affiliated patient or social security beneficiary\n\nExclusion Criteria:\n\n* Polytraumatized patient\n* X-ray of the corso-lumbar spine, skull, cervical spine (all parts of the body not affected by the intended use of the software)\n* Pregnant, lactating or parturient patient",{"count":579,"type":20},1600,[23],"Traumatic emergencies are the primary reason for consultation in emergency departments and standard radiography is the primary imaging exam for osteoarticular trauma. However, with the increase in the number of patients admitted to emergency departments and thus the increased workload for emergency room attendants, Interpretation of radiographs in trauma emergencies is made more difficult, resulting in a high risk of misinterpretation.\n\nThe growing presence of artificial intelligence in the medical field, notably through the involvement of diagnostic software on imageries, makes its use more relevant in the aid of the replay of osteoarticular imageries.\n\nA recent meta-analysis of 32 studies evaluating the performance of artificial intelligence in fracture detection found comparable performance between experienced radiologists and AI-based diagnosis. However, these were mainly retrospective studies, and thus more distant from the reality of its use in a care stream such as emergencies.\n\nThe objective of this study is therefore to prospectively validate the use of artificial intelligence software during its implementation in an emergency department for patients admitted for a suspicion of osteoarticular trauma.",[26],"2024-08-22",{"date":585,"type":31},"2024-08-26",{"date":587,"type":31},"2024-07-22",{"date":589,"type":20},"2025-01-21",{"name":591,"class":592},"University Hospital, Angers","OTHER_GOV",{"id":594,"slug":595,"hasResults":11,"nctId":596,"briefTitle":597,"officialTitle":598,"acronym":4,"eligibilityCriteria":599,"healthyVolunteers":11,"sex":16,"minAge":600,"maxAge":601,"enrollmentInfo":602,"targetDuration":4,"studyType":21,"phases":604,"briefSummary":605,"conditions":606,"keywords":607,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":610,"startDateStruct":612,"completionDateStruct":614,"leadSponsor":616,"locationsCount":4},"100551041","treatment-of-displaced-medial-epicondyle-fractures-in-children-100551041","NCT06454929","Treatment of Displaced Medial Epicondyle Fractures In Children","Comparison Between Operative And Non-operative Treatment of Displaced Medial Epicondyle Fractures In Children","Inclusion Criteria:\n\n* Patients Age \\\u003C 16 years presenting with a ≥2 mm displaced non-incarcerated medial epicondyle fracture with or without concomitant elbow dislocation and normal ulnar nerve function.\n* Acute fractures were defined as less than7 days between the date of injury and initiation of treatment\n\nExclusion Criteria:\n\n* systemic bone disease\n* concomitant fracture or injury of the same upper limb requiring operative intervention\n* Open fractures, incarceration of the fragment inside the joint or ulnar nerve dysfunction require surgery","1 Year","16 Years",{"count":603,"type":20},52,[23],"Compare the outcome of the operative and non-operative treatment; for fractures of the medial epicondyle of humerus in children as regards union, alignment and complications.",[26],[608],"medial epicondyle fracture","2024-07-26",{"date":611,"type":31},"2024-07-29",{"date":613,"type":20},"2024-09-01",{"date":615,"type":20},"2026-07-01",{"name":617,"class":38},"Assiut University",{"id":619,"slug":620,"hasResults":11,"nctId":621,"briefTitle":622,"officialTitle":623,"acronym":4,"eligibilityCriteria":624,"healthyVolunteers":11,"sex":16,"minAge":274,"maxAge":625,"enrollmentInfo":626,"targetDuration":4,"studyType":21,"phases":628,"briefSummary":630,"conditions":631,"keywords":4,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":632,"lastUpdatePostDateStruct":633,"startDateStruct":635,"completionDateStruct":637,"leadSponsor":639,"locationsCount":4},"100555323","phase-1-biomechanical-analysis-of-distal-radius-greenstick-fracture-healing-100555323","NCT06510595","Biomechanical Analysis of Distal Radius (Greenstick) Fracture Healing","Biomechanical Analysis of Distal Radius (Greenstick) Fracture Healing by Finite Element Method","Inclusion Criteria:\n\n* Child with green stick fracture in the distal third of radius bone.\n* Child with immobilized brace or splint.\n* Angle of fracture is ≤ 15 degrees.\n\nExclusion criteria:\n\nThe participants will be excluded from this study if they have one of the following:\n\n* Other type of bone fracture.\n* Osteoporotic bone.\n* Neurological diseases.","10 Years",{"count":627,"type":20},2,[629,212],"PHASE1","The study will be conducted to investigate the effects of electrical charges (flexoelectric effect) \\& mechanical brachioradialis muscle bending force on the displacement and strain of fracture gap on children with Distal radius greenstick fracture via finite element method.",[26],"2024-07-23",{"date":634,"type":31},"2024-07-24",{"date":636,"type":20},"2024-07-16",{"date":638,"type":20},"2025-06-30",{"name":640,"class":38},"Cairo University",{"id":642,"slug":643,"hasResults":11,"nctId":644,"briefTitle":645,"officialTitle":646,"acronym":4,"eligibilityCriteria":647,"healthyVolunteers":11,"sex":16,"minAge":648,"maxAge":649,"enrollmentInfo":650,"targetDuration":4,"studyType":21,"phases":652,"briefSummary":653,"conditions":654,"keywords":655,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":659,"lastUpdatePostDateStruct":660,"startDateStruct":662,"completionDateStruct":664,"leadSponsor":666,"locationsCount":39},"100355097","virtual-reality-during-pediatric-cast-removal-100355097","NCT03903510","Virtual Reality During Pediatric Cast Removal","A Randomized Control Trial of Virtual Reality to Reduce Anxiety During Pediatric Cast Removal","Inclusion Criteria:\n\n* Sustained a fracture in their arm\u002Fleg\n* No previous experience with a cast removal\n* Must have at least one wrist free of immobilization (for heart rate monitor)\n* Parents and patient are English speaking\n\nExclusion Criteria:\n\n* Patients with a history of epilepsy, ventricular shunt, motion sickness\n* Patients with any history of cognitive, visual or hearing impairment","4 Years","12 Years",{"count":651,"type":20},184,[23],"This study is a randomized control trial of Virtual Reality during cast removal procedures at a pediatric tertiary care center.",[26],[656,657,658],"Virtual Reality","Cast removal","Fracture","2021-02-10",{"date":661,"type":31},"2021-02-11",{"date":663,"type":31},"2019-05-21",{"date":665,"type":20},"2021-09",{"name":667,"class":38},"Gillette Children's Specialty Healthcare"]