[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fragility\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fragility":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,47,78,104,132,158,185,211,238],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100538135","frailty-physical-capacity-and-lung-function-in-postoperative-pulmonary-endarterectomy-patients-100538135",false,"NCT06286891","Frailty, Physical Capacity and Lung Function in Postoperative Pulmonary Endarterectomy Patients","Evaluation of Frailty, Physical Capacity and Lung Function in Postoperative Pulmonary Endarterectomy Patients: an Observational and Prospective Clinical Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Both genders\n* Elective pulmonary endarterectomy surgery\n* Absence of cognitive or peripheral motor impairment that prevents the performance of functional tests in the preoperative period.\n\nExclusion Criteria:\n\n* Reoperation for any reason\n* Presence of cognitive or peripheral motor impairment that prevents the performance of functional tests in the postoperative period.","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","OBSERVATIONAL","The goal of this observational and prospective study is to investigate changes in physical performance, lung function, respiratory and peripheral muscle strength in patients during the postoperative period following pulmonary endarterectomy (PET).",[24,25,26],"Chronic Thromboembolic Pulmonary Hypertension","Physical Disability","Fragility",[28,29,30,31,32,33],"Pulmonary Endarterectomy Surgery","Six-minute walk test","Short Physical Performance Battery","One-minute sit-to-stand test","Muscular strength","Spirometry","RECRUITING","2026-06-18",{"date":37,"type":38},"2026-06-22","ACTUAL",{"date":40,"type":38},"2024-02-29",{"date":42,"type":20},"2026-11-30",{"name":44,"class":45},"University of Sao Paulo General Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":76,"locationsCount":46},"100643432","sedation-methods-in-percutaneous-transhepatic-biliary-drainage-procedure-quality-and-recovery-100643432","NCT07640243","Sedation Methods in Percutaneous Transhepatic Biliary Drainage: Procedure Quality and Recovery","Evaluation of Sedation Methods Used in Percutaneous Transhepatic Biliary Drainage Procedures in Terms of Procedure Quality, Recovery Time, and Side Effects","Inclusion Criteria:\n\n* Scheduled for elective percutaneous transhepatic biliary drainage (PTBD) and\u002For biliary stenting\n* ASA physical status II-IV\n* Fasting time of at least 6 hours prior to the procedure\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Inability to provide informed consent or to complete study assessments (e.g., Ramsay Sedation Scale, FRAIL scale, Numeric Rating Scale)\n* Clinical diagnosis of Alzheimer's Disease\n* Clinical diagnosis of demantia\n* Known allergy or hypersensitivity to propofol, remifentanil, ketamine, ondansetron, or deksketoprofen\n* Grade 3-4 aortic, mitral, or tricuspid valve disease\n* Advanced or decompensated heart failure (ejection fraction \\\u003C25%)\n* Emergency procedures\n* Refusal to participate in the study",{"count":55,"type":20},98,"INTERVENTIONAL",[58],"NA","This prospective, randomized, single-center study aims to evaluate and compare two different sedation and analgesia regimens used during percutaneous transhepatic biliary drainage (PTBD) procedures. A total of 96 adult patients undergoing elective PTBD or biliary stenting will be randomized to receive either propofol-remifentanil or propofol-ketamine sedation. The primary outcome is recovery time assessed using the Modified Aldrete Score. Secondary outcomes include procedure quality, pain scores, patient and operator satisfaction, hemodynamic stability, and the incidence of sedation-related adverse events. The study is designed to determine the optimal sedation strategy for PTBD, particularly in fragile and elderly patient populations.",[26,61,62,63],"Biliary Obstruction","Cholangitis","Malignancy",[65,66,67,68,69],"FRAGILITY","Percutaneous Transhepatic Biliary Drainage","SEDATION","KETAMINE","REMİFENTANIL","2026-06-08",{"date":72,"type":38},"2026-06-10",{"date":74,"type":38},"2026-02-01",{"date":72,"type":20},{"name":77,"class":45},"Ankara City Hospital Bilkent",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":56,"phases":87,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":46},"100643220","impact-of-a-multicomponent-physical-exercise-program-on-the-functional-capacity-of-patients-admitted-to-an-intermediate-care-hospital-vivifrail-for-a-better-vig-frail-100643220","NCT07637383","IMPACT OF A MULTICOMPONENT PHYSICAL EXERCISE PROGRAM ON THE FUNCTIONAL CAPACITY OF PATIENTS ADMITTED TO AN INTERMEDIATE CARE HOSPITAL. VIVIFRAIL FOR A BETTER VIG-FRAIL.","* baseline Barthel Index ≥60\n* ability to communicate, ambulate, and complete the exercise program","65 Years",{"count":86,"type":20},120,[58],"INTRODUCTION Physical exercise in frail individuals has demonstrated benefits in variables such as reduced mortality risk and improved frailty and quality of life. Specifically, the most beneficial type appears to be multicomponent exercise, which includes strength, endurance, balance, and gait training. Within this field, the VIVIFRAIL project is an internationally recognized physical exercise promotion program.\n\nOBJECTIVES To analyze the effects of an individualized multicomponent physical exercise program as an effective method for preventing\u002Fimproving functional status and frailty in individuals admitted to an intermediate care hospital (ICH).\n\nTo assess whether improvements in functionality\u002Ffrailty are maintained 3-4 months after discharge and to evaluate the impact of the program on quality of life variables and health indicators at 6 months.\n\nMETHODOLOGY Design: randomized clinical trial with two groups (control and intervention) and 6 months of follow-up.\n\nStudy population: adults older than 65 years admitted to an intermediate care hospital (ICH).\n\nInclusion criteria: baseline Barthel Index ≥60, ability to communicate, ambulate, and complete the exercise program.\n\nPrimary variables: functionality (Short Physical Performance Battery - SPPB) and frailty (Frail-VIG Index).\n\nSecondary variables: grip strength, depressive symptoms, fear of falling, mortality, institutionalization, hospital admissions\u002Femergency room and primary care visits, level of physical activity, medications (number, analgesics, opioid use, antidepressants, anxiolytics), and quality of life.\n\nSample size: assuming a 15% loss to follow-up, the final required sample size is 120 patients. Linear mixed-effects models will be used with a significance level of 0.05.",[90,26],"Functionality",[92,93,94],"Frailty","physical exercise","Quality of life","2026-06-04",{"date":97,"type":38},"2026-06-09",{"date":99,"type":38},"2026-02-18",{"date":101,"type":20},"2027-02",{"name":103,"class":45},"Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":112,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":56,"phases":115,"briefSummary":116,"conditions":117,"keywords":118,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":46},"100626521","effects-of-vivifrail-program-on-functional-capacity-and-geriatric-syndromes-in-the-elderly-100626521","NCT07436715","Effects of VIVIFRAIL Program on Functional Capacity and Geriatric Syndromes in the Elderly.","Effects of the VIVIFRAIL Multicomponent Physical Exercise Program on Functional Capacity and Geriatric Syndromes in Frail and Pre-frail Older Adults Over 70 Years in Primary Care in Almeria: A Quasi-Experimental Study.","VIVIAL","INCLUSION CRITERIA:\n\nParticipants aged 70 years or older.\n\nClassified as pre-frail or frail according to the FRAIL scale (score ≥ 1).\n\nBarthel Index score ≥ 60 points.\n\nAbility to communicate effectively.\n\nAbility to ambulate, with or without assistive devices.\n\nEXCLUSION CRITERIA:\n\nRecent acute myocardial infarction or unstable angina.\n\nUncontrolled atrial or ventricular arrhythmias.\n\nDissecting aortic aneurysm.\n\nSevere aortic stenosis.\n\nAcute endocarditis or pericarditis.\n\nUncontrolled arterial hypertension.\n\nAcute thromboembolic disease.\n\nSevere acute heart failure.\n\nSevere acute respiratory failure.\n\nUncontrolled orthostatic hypotension.\n\nDiabetes mellitus with acute decompensation or uncontrolled hypoglycemia.\n\nRecent bone fracture within the last month.\n\nInstitutionalization (e.g., nursing home residents).","70 Years",{"count":114,"type":20},86,[58],"The aim of this quasi-experimental, pretest-posttest study is to evaluate the effectiveness of the Vivifrail multicomponent physical exercise program in improving the functional capacity of pre-frail and frail older adults (aged 70 and older) attending the Virgen del Mar Health Center in Almería.\n\nThe main questions it aims to answer are:\n\n* Does functional capacity, as measured by the Short Physical Performance Battery (SPPB), significantly improve after participating in the Vivifrail program?\n* What is the effect of the Vivifrail program on various geriatric syndromes and associated health conditions (e.g., fall risk, sarcopenia, chronic pain, mild cognitive impairment, depression), and what patient profile is most likely to benefit from the intervention?\n* As a single-arm interventional study, there is no parallel comparison group. Researchers will compare each participant's outcomes against their own baseline at three time points (baseline, week 6, and week 12) to assess for significant improvements following the intervention.\n\nParticipants will:\n\n* Complete a 12-week home-based, multicomponent physical exercise program (five sessions per week including strength, balance, flexibility, and aerobic endurance training), tailored to their baseline functional level.\n* Attend three in-person visits at the health center (baseline, a 6-week follow-up, and a final visit at 12 weeks) for the research staff to assess their clinical, functional, and sociodemographic variables.\n* Complete an Activity Diary to record their home-based sessions and perceived rate of exertion in order to monitor adherence.\n* Receive biweekly follow-up phone calls from the research team to reinforce motivation, track adherence, and monitor for any potential adverse events (e.g., falls, pain).",[26],[26,119,120],"Exercise","Primary Care","NOT_YET_RECRUITING","2026-02-22",{"date":124,"type":38},"2026-02-27",{"date":126,"type":20},"2026-03-16",{"date":128,"type":20},"2026-06-15",{"name":130,"class":131},"Elena Pérez Expósito, MD","OTHER_GOV",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":46},"100577330","symptoms-respiratory-dysfunction-and-frailty-level-in-allergic-and-eosonophilic-asthmatics-100577330","NCT06796894","Symptoms, Respiratory Dysfunction and Frailty Level in Allergic and Eosonophilic Asthmatics","Comparison of Symptoms, Respiratory Dysfunction and Frailty Level in Allergic and Eosonophilic Asthmatics","Inclusion Criteria:\n\n* Age between 35-75 years,\n* Diagnosed with allergic or eosonophilic asthma according to the Global Strategy for the Prevention and Treatment of Asthma (GINA).\n\nExclusion Criteria:\n\n* Known cognitive impairment,\n* Having had an acute asthma attack in the last 6 weeks,\n* Having changed medication in the last 4 weeks.","35 Years","75 Years",{"count":142,"type":20},60,"The aim of this study is to determine the level of respiratory dysfunction, symptoms and frailty in patients with asthma according to different endophenotypes (allergic and eosonophilic asthma). In the light of the data obtained, it is thought that rehabilitation approaches that can be determined according to different endophenotypes in line with the evaluated parameters will guide health professionals working in this field.\n\nHypotheses H0: There is no difference between allergic and eosonophilic asthmatics in terms of pulmonary function, respiratory dysfunction, symptoms, dyspnoea, fatigue, rhinitis, perception of breathlessness in activities of daily living, asthma control, level of frailty or quality of life.\n\nH1: There is a difference between individuals with allergic and eosonophilic asthma in terms of pulmonary function, respiratory dysfunction, symptoms, dyspnoea, fatigue, rhinitis, perception of breathlessness in activities of daily living, asthma control, level of frailty or quality of life.",[145,146,26],"Asthma","Respiratory Disease",[145,148,26],"Respiratory Dysfunction","2025-12-25",{"date":151,"type":38},"2025-12-29",{"date":153,"type":38},"2024-08-01",{"date":155,"type":20},"2026-12-01",{"name":157,"class":45},"Hacettepe University",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":164,"sex":16,"minAge":84,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":56,"phases":167,"briefSummary":169,"conditions":170,"keywords":173,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":46},"100501394","phase-2-ischemic-conditioning-to-promote-microvascular-resiliency-in-frail-individuals-100501394","NCT05808686","Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals","Inclusion Criteria:\n\n* Women and men ages 65-85 years of age\n\nExclusion Criteria:\n\n* Myocardial infarction in last 6 months\n* morbid obesity (BMI \\>40)\n* heart failure\n* uncontrolled hypertension\n* other condition that precludes high intensity exercise (ex, neurological disorder, acute systemic infection)\n* history of blood clots in the extremities\n* any condition in which compression of the arm or transient ischemia is contraindicated (e.g., wounds in the arm).",true,"85 Years",{"count":142,"type":20},[168],"PHASE2","The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of exercise.\n\nParticipants will come in for 3 study visits and get home-based ischemic conditioning. At Study Visit 1, participants will be assessed for their frailty and physical function. Afterwards, they will perform an exercise test. At Study Visit 2, patients will undergo 2 microvascular assessments, perform a high-intensity exercise, then undergo the same 2 microvascular assessments again. Participants will be given a handheld sphygmomanometer and a blood pressure cuff to take home. Depending on which group the participants get randomized into, participants will place the blood pressure cuff around their non-dominant upper arm and inflate to either a low or high pressure for 2 weeks at home. Participants will repeat the same steps in Study Visit 2 for Study Visit 3. In addition, participants will also be assessed for their frailty and physical function.",[171,26,172],"Aging","Endothelial Dysfunction",[174,119,175],"Vasodilation","Fitness","2025-09-22",{"date":178,"type":38},"2025-09-23",{"date":180,"type":38},"2023-05-02",{"date":182,"type":20},"2029-12",{"name":184,"class":45},"Medical College of Wisconsin",{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":56,"phases":194,"briefSummary":195,"conditions":196,"keywords":200,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":46},"100586149","impact-of-nutritional-management-on-the-frailty-of-patients-waiting-for-liver-transplantation-via-the-lfi-tool-100586149","NCT06911619","Impact of Nutritional Management on the Frailty of Patients Waiting for Liver Transplantation (Via the LFI Tool)","LFI-PATH","Inclusion Criteria:\n\n* Patient aged ≥ 18 years\n* Patient registered on the waiting list for Hepatic Transplantation in the Transplantation center of the Croix Rousse Hospital (GHN), Hospices Civils de Lyon\n* Dated and signed an informed consent\n* Affiliated to a social security scheme or beneficiary of a similar scheme\n\nExclusion Criteria:\n\n* Patient hospitalized in intensive care\n* Patient with initial LFI test result \\\u003C to 3.2, that is considered as \"robust\".\n* Patient unable to perform LFI exercises (chronic or acute motor disability in lower or upper limbs)\n* Pregnant, parturient or lactating women\n* Persons deprived of liberty by a judicial or administrative decision\n* Persons under psychiatric care\n* Persons admitted to a health or social institution for purposes other than research\n* Adults subject to a legal protection measure (guardianship, curatorship)\n* Inability to understand protocol information\n* Subject participating in another interventional research including an ongoing exclusion period at inclusion",{"count":193,"type":20},210,[58],"Cirrhosis is a major public health issue responsible for about 15000 deaths each year. Liver transplantation (LT) remains the only curative treatment for decompensated cirrhosis. Decompensated cirrhotic patients awaiting LT are malnourished, sarcopenic and fragile. The evaluation of the nutritional status of these patients is complex because the anthropometric data that define undernutrition (weight variation, BMI) are often compromised by the presence of edema and ascites related to liver disease. It therefore seems appropriate to focus on the fragility and sarcopenia of the cirrhotic patient as a reflection of the nutritional status. In 2017, the American team of Lai et al. validated a Liver fraily index (LFI) score of frailty specific to cirrhotic patients waiting for LT. The LFI is composed of three simple physical tests (Grip test, chair lift test, and balance tests) performed at the patient's bedside, which results in a quantitative and reproducible frailty score. Frailty while waiting for LT is associated with an increase in mortality on the waiting list, independently of the MELD (Model for End stage Liver disease) score, which is a reflection of liver severity. About half of the patients who are candidates for LT will present an aggravation of their frailty while waiting for LT. To date, no study has reported the results of a nutritional intervention on the evolution of fragility in patients awaiting LT. The objective of our study is to evaluate the impact of a nutritional management and follow-up by a dietitian specialized in hepatology on the fragility of patients waiting for LT. This is a monocentric study, randomized in two parallel groups (an intervention group with nutritional follow-ups by a trained dietitian and a control group with follow-up by the reference hepatologist without specific dietary management by a dietician) in open. All patients enrolled on the LT list with an LFI \\> 3.2 (pre-frail and frail state) will be included in the study. It is planned to include 210 patients over a period of 24 months. The LFI will be measured for all patients (control group + intervention group) at 3 and 6 months, as part of their follow-up in the LT center. This study will also make it possible to correlate frailty with other parameters (severity of liver disease, access to LT).",[26,197,198,199],"Cirrhosis","Hepatic Transplantation","Undernutrition",[201,198,197],"nutrition","2025-07-01",{"date":204,"type":38},"2025-07-04",{"date":206,"type":38},"2025-06-30",{"date":208,"type":20},"2027-12-30",{"name":210,"class":45},"Hospices Civils de Lyon",{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":4,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":16,"minAge":84,"maxAge":4,"enrollmentInfo":218,"targetDuration":4,"studyType":56,"phases":220,"briefSummary":221,"conditions":222,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":46},"100369604","optimized-recovery-after-trauma-in-geriatric-patient-100369604","NCT04092504","Optimized Recovery After Trauma in Geriatric Patient","Optimized Recovery After Trauma in Geriatric Patient (Gero - ERAT)","Inclusion Criteria:\n\n* ≥ 65 years old\n* In hospital due to physical trauma\n* Able to speak and understand Swedish\n\nExclusion Criteria:\n\n* Documented palliative care\n* Cognitive impairment",{"count":219,"type":20},540,[58],"Currently, there is evidence that structured care within the healthcare system increases the conditions for good care and better recovery. We want to investigate whether a new care concept (gero-ERAT) that combines two variants of structured care can improve the recovery of elderly patients affected by a physical trauma.\n\nOur hope is that the project will reduce the complications, short care times, fewer re-admissions and that more patients can return to regular living, which reduces the suffering for the patient and his relatives. In addition to patient benefit, a successful outcome will also result in reduced costs for healthcare and society as a whole. The concept of care is based on an increased patient participation, which is in line with the values of the Västra Götaland region and the Sahlgrenska university hospital\n\nThrough the PhD project, four studies will be published. A qualitative interview study to investigate patients' experiences of care and recovery after trauma.\n\nAfter that, a prospective cohort survey of two groups is carried out; conventional care and gero-ERAT. Data will begin to be collected in the control group and when the control group is full geroRATAT will be implemented in the care department and we then collect data in the intervention group.\n\nBased on collected data, we will publish two additional studies one with a focus on health economics as well as one focusing on care time and recovery based on age and harvest estimation.",[223,224,225,26,226,227,228],"Geriatric Assessment","Quality of Life","Trauma","Injury","Rehabilitation","Recovery","2024-11-21",{"date":231,"type":38},"2024-11-25",{"date":233,"type":38},"2019-05-09",{"date":235,"type":20},"2028-01-01",{"name":237,"class":131},"Vastra Gotaland Region",{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":244,"eligibilityCriteria":245,"healthyVolunteers":164,"sex":16,"minAge":84,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":248,"conditions":249,"keywords":255,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":46},"100402297","prevalence-determinants-and-natural-history-of-frailty-and-pre-frailty-in-elderly-people-100402297","NCT04518423","Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People","Prevalence, Determinants and Natural History of Frailty and Pre-frailty in People Over the Age of 65 Years in a Prospective 5-year Observation","FRAILPOL","Inclusion Criteria:\n\n* Community dwelling elderly individuals over the age of 65 years who get around by themselves.\n\nExclusion Criteria:\n\n* Institutionalization\n* Inability to move around\n* Terminal diseases with an anticipated survival of less than 1 year.",{"count":247,"type":20},1093,"Frailty syndrome (i.e. frailty) is a geriatric syndrome which relies on the reduction of multisystem reserve capacity. Frail people have a lower potential to respond to external stressors and various life incidents as well as they present a weak prognosis particularly in cardiovascular diseases. Yet, frailty is not only a set of physical deficits, but it also concerns psychological and social dimensions of human functioning. Hence, an approach to frailty should be multidimensional because such a concept more adequately reflects a functional degradation in the elderly. Frailty is usually associated with the impaired condition of circulatory system, and therefore, an identification of subclinical cardiovascular abnormalities is paramount in the frailty prevention and treatment. Another potential mechanism which may predispose to frailty is a dysfunction of the autonomic nervous system. This system plays a crucial role in the response to internal or external stressors such as diseases and activities of daily living. An impairment of the autonomic nervous system function may maintain or accelerate the frailty process.\n\nIn this scientific project, a comprehensive echocardiography will investigate cardiac function with a particular attention to features which typically change with age, like flow parameters and chambers sizes. The activity of the autonomic nervous system will be explored with the analysis of heart rate, blood pressure and respiratory signals. The study participants will also undergo routine medical examination and a number of additional tests, including: assessment of cognitive function, psychological condition, nutrition status, activities of daily living, and risk of falls. The study group will comprise community dwelling elderly individuals over the age of 65 years who get around by themselves. After 2 years, the participants will be re-examined for their frailty and independence status, as well as their survival will be checked with the National Health Found electronic system. The aim of this project is to seek for factors determining frailty and to explore the frailty impact on the elderly people survival. Particular attention will be paid to the multidimensional frailty which is a new concept of the functional decline in the elderly. In addition, the prevalence of different modes of frailty in Polish community will be investigated. The results of this research should help to establish preventative and therapeutic strategies against frailty.",[92,250,251,26,171,252,253,254],"Frailty Syndrome","Frail Elderly Syndrome","Aging Problems","Aging Disorder","Aging Well",[92,256,257,258,259,260,171,261,262],"Physical Frailty","Cognitive Frailty","Social Frailty","Multidimensional Frailty","Elderly","Frail Scale","Tilburg Frailty Indicator","2020-08-14",{"date":265,"type":38},"2020-08-19",{"date":267,"type":38},"2017-09-02",{"date":269,"type":20},"2026-12",{"name":271,"class":45},"The Opole University of Technology"]