[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"frail-elderly-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:frail-elderly-syndrome":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,47,83,102,126,153,182,209,241,266,289,316,341,374],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100552157","the-impact-of-geriatric-assessment-on-the-treatment-plan-of-elderly-patients-with-t2dm-100552157",false,"NCT06469437","The Impact of Geriatric Assessment on the Treatment Plan of Elderly Patients With T2DM","The Impact of Geriatric Assessment on the Treatment Plan of Elderly Patients With Type 2 Diabetes Mellitus: a Randomized Clinical Trial.","Inclusion Criteria:\n\n* Age 60 years or older\n* Diagnostic of type 2 diabetes mellitus according to American Diabetes Association criteria\n* Patients under follow-up in a specialized endocrinology outpatient clinic\n* Patients who have a glycated hemoglobin measurement of up to three months\n\nExclusion Criteria:\n\n* Lack of consent for research participation from the patient or the physician\n* Patients classified as Clinical Frailty Scale 9.","ALL","60 Years",{"count":19,"type":20},220,"ESTIMATED","INTERVENTIONAL",[23],"NA","Introduction: With the aging of the world population and the increasing incidence of type 2 diabetes mellitus (T2DM) with age, the number of elderly individuals living with diabetes has been considerably rising. It is known that uncontrolled T2DM negatively impacts various health outcomes, including geriatric outcomes such as sarcopenia, frailty, immobility, incontinence, and infections. Current medical literature fails to establish appropriate glycemic targets for different elderly profiles. Although guidelines emphasize the need to individualize targets, there is no concise tool to identify which individuals benefit from each therapeutic approach. Data suggest that frailty is the best predictor of negative outcomes in elderly patients living with T2DM. The Clinical Frailty Scale (CFS) and the 10-minute Targeted Geriatric Assessment (TaGA-10) are validated tools for prognosis in elderly patients and for identifying frail elderly individuals.\n\nMethods: Randomized controlled trial. Elderly individuals diagnosed with T2DM at a tertiary care outpatient clinic will be included. All enrolled patients will undergo geriatric assessment using CFS, TaGA-10, and Charlson Comorbidity Index. Patients will be randomized into usual care and intervention groups, and the intervention involves providing the geriatric assessment to the care team to support their decisions. The adequacy of the therapeutic approach will be measured in one week by reviewing the consult record or interviewing the physician. The clinical impact on the frequency of hypoglycemia, falls, infections, hospitalizations, and mortality will be evaluated at 3 and 6 months by telephone interviews.\n\nDiscussion: Current guidelines recommend using age, comorbidities, cognitive, and functional status to individualize therapeutic targets in elderly patients with T2DM; however, it is possible that these variables alone may not be sufficient to classify all elderly individuals in their complexity adequately. A tool with such power and easy to use in clinical practice is necessary.",[26,27,28,29],"Type2diabetes","Frail Elderly Syndrome","Frailty","Geriatric Assessment",[31,28,32,33],"Type 2 diabetes","Geriatric assessement","Glycated hemoglobin","RECRUITING","2026-05-27",{"date":37,"type":38},"2026-05-29","ACTUAL",{"date":40,"type":38},"2024-07-05",{"date":42,"type":20},"2028-12-31",{"name":44,"class":45},"Hospital de Clinicas de Porto Alegre","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":4},"100636079","high-technology-telerehabilitation-for-the-treatment-of-the-fragile-patient-100636079","NCT07561021","High-technology TeleRehabilitation for the Treatment of the FRAgile Patient","TeleRiab4Fra","Inclusion Criteria:\n\n* Age 65 years or older.\n* Diagnosis of chronic heart failure for at least 6 months, on stable optimal medical therapy for at least 1 month, regardless of systolic function classification (HFrEF, HFmrEF, or HFpEF), and in NYHA class I-III.\n* Pre-frailty or frailty documented by validated instruments, defined by at least one of the following: Fried phenotype: pre-frailty (1-2 criteria) or frailty (3 or more criteria); Italian Frailty Index (IFI): score ≥1;\n\nShort Physical Performance Battery (SPPB):\n\ntotal score 5-9\u002F12, consistent with functional frailty; or total score 10\u002F12, consistent with pre-frailty if the reduction is attributable to the sit-to-stand test, as documented in the case report form.\n\n* Ability to provide written informed consent, or availability of a legally authorized representative when applicable.\n* Availability of a caregiver, when required for participation in the rehabilitation program.\n\nExclusion Criteria:\n\n* Age younger than 65 years.\n* NYHA class IV and\u002For high likelihood of heart transplantation or ventricular assist device (VAD) implantation within 6 months after screening.\n* Absence of pre-frailty\u002Ffrailty, defined as:\n\nFried phenotype = 0 criteria, and IFI = 0, and SPPB ≥ 11\u002F12 (or 10\u002F12 without evidence of impairment in the sit-to-stand component according to the predefined criterion).\n\n* Severe renal impairment (estimated glomerular filtration rate eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m²) or dialysis.\n* Inability to walk independently, even with assistive devices. SPPB total score \\\u003C5\u002F12, indicating severe functional impairment not compatible with safe execution of the study protocol, regardless of IFI or Fried criteria.\n* Other serious diseases substantially limiting life expectancy (for example, end-stage cancer or end-stage lung disease).\n* Severe visual impairment preventing completion of study procedures even with caregiver support and reasonable accommodations.\n* Current or suspected pregnancy.","65 Years",{"count":56,"type":20},70,[23],"The aim of this randomized controlled clinical trial is to evaluate the efficacy of an 8-week sensorimotor and cognitive telerehabilitation program in frail and pre-frail older adults with stable chronic heart failure. The study will compare a synchronous telerehabilitation intervention with a caregiver-supervised home exercise program. The primary question is whether telerehabilitation improves functional capacity, measured by change in peak oxygen uptake (VO₂peak) on cardiopulmonary exercise testing, more than the control intervention. A key secondary question is whether telerehabilitation improves frailty status, measured by the Italian Frailty Index (IFI), compared with the control group. Secondary outcomes include quality of life, physical performance, cognitive function, treatment adherence, caregiver burden and stress, and selected biomarkers related to heart failure and frailty. Participants will undergo baseline and follow-up clinical, functional, cognitive, and laboratory assessments and will be followed for up to 24 weeks.",[60,61,27],"Heart Failure","Prefrail Elderly",[63,64,65,66,67,68,69,70,71,72],"Chronic Heart Failure","Cardiac Rehabilitation","Tele-rehabilitation","Telemedicine","Exercise Training","Remote Monitoring","mHealth","Wearable Sensors","Home-based Rehabilitation","Digital Health","NOT_YET_RECRUITING","2026-05-01",{"date":76,"type":38},"2026-05-07",{"date":78,"type":20},"2026-05-15",{"date":80,"type":20},"2027-03-15",{"name":82,"class":45},"University of Salerno",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":46},"100390627","assessing-a-new-tool-to-assess-frailty-in-frail-hospitalized-elderly-100390627","NCT04366388","Assessing a New Tool to Assess Frailty in Frail Hospitalized Elderly","Inclusion Criteria:\n\n* be 65 years of age or older\n* be admitted in ACE Unit\n\nExclusion Criteria:\n\n* be less than 65 years of age\n* be nonambulatory\n* be diagnosed with end-stage organ failure (end-stage COPD, renal failure requiring dialysis, end-stage heart failure)",{"count":90,"type":20},120,"OBSERVATIONAL","The major purpose of this study is to establish the use of daily step counts as inexpensive, easy to measure marker for frailty and sarcopenia in an inpatient population of older adults.",[27],"2026-04-27",{"date":74,"type":38},{"date":97,"type":38},"2022-06-01",{"date":99,"type":20},"2026-12",{"name":101,"class":45},"University of British Columbia",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":111,"conditions":112,"keywords":113,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":4},"100607685","the-importance-of-anesthesia-method-in-fragile-patients-100607685","NCT07191769","The Importance of Anesthesia Method in Fragile Patients","The Effect of the Selected Anaesthesia Method on Morbidity and Mortality in Frail Patients Scheduled for Transurethral Surgery","Inclusion Criteria:\n\n* Elderly patients aged 65 and over\n* ASA (American Society of Anaesthesiologists) physical condition classification I-III patients\n* meeting the criteria for frailty\n\nExclusion Criteria:\n\n* Non-elective emergency surgeries\n* Patients under 65 years of age\n* Patients classified as ASA Class IV\n* Patients unable to provide informed consent due to cognitive impairment\n* Patients who have previously undergone major neurological or cardiac surgery",{"count":110,"type":20},180,"The aim of this study is to comparatively evaluate the effects of different anaesthesia methods (spinal anaesthesia and general anaesthesia) administered to frail elderly patients scheduled for transurethral surgery (e.g. TUR-Prostate or TUR-Bladder) on postoperative morbidity and mortality rates.",[27],[114,115,116],"frail patient","general anaesthesia","regional anaesthesia","2025-09-23",{"date":119,"type":38},"2025-09-25",{"date":121,"type":20},"2025-10-01",{"date":123,"type":20},"2026-02",{"name":125,"class":45},"Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":16,"minAge":134,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":21,"phases":137,"briefSummary":138,"conditions":139,"keywords":141,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":149,"leadSponsor":151,"locationsCount":4},"100606956","effect-of-a-combined-exercise-and-anti-inflammatory-nutritional-intervention-in-frail-older-adults-100606956","NCT07182292","Effect of a Combined Exercise and Anti-Inflammatory Nutritional Intervention in Frail Older Adults","Effectiveness of Combined Therapeutic Exercise and Anti-Inflammatory Nutritional Supplementation in Frail, Malnourished Older Adults","AliFrail","Inclusion Criteria:\n\n* Patient aged ≥ 75 years.\n* Diagnosis of frailty according to Linda Fried's criteria.\n* Diagnosis of malnutrition according to GLIM (Global Leadership Initiative on Malnutrition) criteria.\n* Barthel Index score ≥ 60 points.\n* Absence of advanced chronic kidney disease (defined as glomerular filtration rate \\\u003C 25 mL\u002Fmin\u002F1.73m²).\n* Absence of terminal illness as defined by SECPAL (Spanish Society for Palliative Care) criteria.\n\nExclusion Criteria:\n\n* Presence of type 1 or type 2 diabetes mellitus with poor metabolic control (HbA1c \\> 8% or insulin-dependent).\n* Oropharyngeal dysphagia to liquids that prevents safe intake of oral supplementation.\n* Moderate-to-severe cognitive impairment, defined as a score ≥ 5 on the Global Deterioration Scale (GDS) of Reisberg.\n* Refusal to sign the informed consent by the patient, primary caregiver, or legal representative, or inability to obtain it.\n* Known allergy or intolerance to any component of the study supplements.\n* Institutionalized in a long-term care or residential facility.","75 Years",{"count":136,"type":20},158,[23],"The goal of this clinical trial is to evaluate whether a combined intervention of therapeutic exercise and anti-inflammatory nutritional supplementation improves physical performance and reduces systemic inflammation in frail, malnourished older adults. The main questions it aims to answer are:\n\nDoes the addition of an anti-inflammatory nutritional supplement (Alisenoc™) to a multicomponent exercise program (Vivifrail) lead to greater improvements in physical performance compared to standard exercise and conventional nutritional support?\n\nDoes the combined intervention reduce levels of inflammatory biomarkers (e.g., IL-6, TNF-α, IL-8, GDF-15) in this population?\n\nAre there measurable changes in body composition (e.g., muscle mass, fat mass, bone health) following the intervention?\n\nDoes the intervention impact clinical outcomes such as hospital readmissions, functional independence, or mortality over the following 12 months?\n\nResearchers will compare two groups:\n\nOne group receiving the Vivifrail exercise program plus a daily dose of the anti-inflammatory nutritional supplement Alisenoc™.\n\nAnother group receiving the same Vivifrail program plus an isocaloric, protein-equivalent conventional supplement.\n\nParticipants will:\n\nBe aged 75 years or older and identified as frail and malnourished according to Fried and GLIM criteria.\n\nUndergo baseline evaluation including functional performance (SPPB), body composition via bioimpedance analysis, and blood sample collection for inflammatory biomarkers.\n\nBe randomly assigned to one of the two intervention groups.\n\nFollow a 12-week home-based multicomponent exercise program guided by educational materials and supervised remotely.\n\nConsume the assigned oral nutritional supplement daily for the same 12-week period.\n\nReturn for outcome assessments at 12 weeks, and again at 6 and 12 months for long-term follow-up.\n\nAll study procedures will take place at the Hospital Universitario de Navarra (HUN), Spain. Participants will be recruited from outpatient geriatrics and nutrition clinics and assessed at a dedicated research unit with nursing support. The intervention is designed to be feasible, scalable, and representative of real-world multidisciplinary care in older populations with high vulnerability.\n\nThe study aims to provide evidence for an integrative, personalized approach to reversing frailty through combined physical and nutritional strategies targeting the biological basis of inflammaging.",[27,140],"Malnutrition Elderly",[142,143,144],"inflammaging","malnutrition","frailty","2025-09-11",{"date":147,"type":38},"2025-09-19",{"date":121,"type":20},{"date":150,"type":20},"2027-10-01",{"name":152,"class":45},"Fundacion Miguel Servet",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":16,"minAge":159,"maxAge":4,"enrollmentInfo":160,"targetDuration":161,"studyType":91,"phases":4,"briefSummary":162,"conditions":163,"keywords":168,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":181},"100582028","patients-database-prepare-for-your-surgery-program-100582028","NCT06857981","Patient's Database: Prepare for Your Surgery Program","Inclusion Criteria:\n\n* Patients referred to the Prepare for Your Surgery program\n* Patients characterized as frail according to the Clinical Frailty Scale (score ≥ 4), FRAIL scale or FRIED frailty phenotype or the clinical judgment of the referring surgeon, with at least 4 weeks to receive surgery\n* Elective surgery to be performed at Hospital Clinico Red de Salud UC-Christus\n\nExclusion Criteria:\n\n* Patients who will not undergo elective surgery at Hospital Clínico Red de Salud UC-Christus.\n* Patients who require emergency surgery\n* Patients who for various reasons cannot comply with the interventions proposed for this preparation.","18 Years",{"count":90,"type":20},"3 Months","Frailty is a multidimensional syndrome that predominantly affects older people and people with long-term treatments such as cancer and chronic pain. This results in an increased risk of disability, reduced resistance and greater vulnerability to stressors.\n\nThese factors culminate in worse postoperative outcomes, including higher rates of complications and mortality. With the current demographic shift towards an aging population in Latin America and Chile, the prevalence of frailty among surgical patients is increasing.\n\nDespite the clear association between frailty and adverse postoperative effects, in Chile there are few centers that routinely perform objective preoperative frailty assessment before to surgery. This is due to logistical challenges, the need for specialized training, and assessment tools. As a result, frailty remains an underestimated syndrome in the perioperative setting.\n\nVarious interventions have been proposed to improve the care of fragile surgical patients. Prehabilitation, a multidisciplinary program designed to prepare patients for surgery and improve their resilience to surgical stress, has emerged as a promising intervention. Recent studies indicate that prehabilitation may lead to shorter hospital length of stay (LOS) and fewer complications.\n\nRecognizing the vital role that frailty plays in surgical outcomes and the paucity of research on prehabilitation, a prehabilitation or timely presurgical conditioning program (Prepare for Your Surgery Program) has been implemented at our center. This proposal seeks to optimize the patient before a surgical intervention in order to reduce frailty and complications, thus improving recovery and medium-term results.\n\nThe program consists of interventions 4 to 6 weeks before surgery focused on: nursing assessment, screening and follow-up, geriatric and\u002For internal medicine assessment and intervention, physiotherapy assessment and intervention, nutrition assessment and intervention, psychological assessment and intervention, and preoperative anesthesiology intervention.\n\nFor this purpose, it has been proposed to create a prospective database of patients from the Prepare for Your Surgery Program, who undergo elective surgery at Hospital Clinico Red Salud UC-Christus.",[164,27,165,166,167],"Frailty in Adult Surgery","Database","Perioperative Care","Prehabilitation",[165,169,170,28,171,167],"Perioperative care","Prospective Studies","Follow-Up Studies","2025-06-05",{"date":174,"type":38},"2025-06-10",{"date":176,"type":38},"2025-05-21",{"date":178,"type":20},"2026-06-30",{"name":180,"class":45},"Pontificia Universidad Catolica de Chile",2,{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":190,"targetDuration":4,"studyType":21,"phases":192,"briefSummary":193,"conditions":194,"keywords":197,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":203,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":46},"100515611","non-pharmacological-prevention-of-pod-in-frailty-elderly-undergoing-elective-surgery-applied-by-nursing-teams-100515611","NCT05993754","Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams","Impact of Non-pharmacological Measures Applied by the Nursing Team in Reducing the Incidence of Postoperative Delirium During the Postoperative and 24hr After Surgery in Frail Elderly Undergoing Elective Non-cardiac Surgeries.","NPPOD","Inclusion Criteria:\n\n* Patients older than 65 years\n* Elective non-cardiac surgery\n* General anesthesia with Bilateral BIS electroencephalographic monitoring or SedLine\n* ASA I, II or III.\n\nExclusion Criteria:\n\n* Neurosurgical patients\n* History of alcohol and\u002For drug abuse\n* History of recreational psychoactive drug use\n* Allergy to anesthetic drugs.",{"count":191,"type":20},400,[23],"The increase in the population over 60 years of age who could receive surgery due to changes in life expectancy and advances in surgical and anesthetic techniques.\n\nLikewise, elderly people (EP) may have a higher risk of postoperative morbidity and mortality compared to young people, with frailty being one of the risk factors that increases adverse outcomes in this period and increases the probability of developing syndromes such as postoperative delirium (POD).\n\nAssessment of frailty in EP prior to surgery is not routine, so it is unknown how many frail and\u002For pre-frail EP undergo surgery in health care systems. There is an association between being frail and developing greater delirium and\u002For postoperative cognitive deficit, which in summary translates into an increase in perioperative morbidity and mortality.\n\nFor the prevention of POD, there are pharmacological and non-pharmacological measures that seek to promote orientation with respect to their environment and make it as familiar as possible, stimulate early aspects of memory and thinking skills, as well as promote sleep using environmental hygiene measures.\n\nIn Chile, protocols of non-pharmacological measures have been proposed by occupational therapy teams, which have had positive results in reducing POD in frail elderly patients. These measures are temporal-spatial reorientation, physical mobilization, correction of sensory deficits, environmental management, sleep protocol, and reduction of anticholinergic drugs with statistically significant results in the reduction of POD.\n\nIn accordance with the above, the objective of this study is to evaluate the impact of non-pharmacological measures applied by the nursing team in reducing the incidence of POD during the post-surgical period in fragile and pre-fragile EP undergoing elective non-cardiac surgeries.\n\nIt is expected that in the end, frail and pre-frail EP who receive non-pharmacological interventions by the nursing team will present a lower incidence of POD at 24 hours compared to those who receive traditional care.",[27,195,196,28],"Primary Prevention","Postoperative Delirium",[198,199,200,28,201,202],"Delirium","Non-pharmacological","Elderly","Nursing","Postoperative",{"date":174,"type":38},{"date":205,"type":38},"2024-04-01",{"date":207,"type":20},"2026-12-31",{"name":180,"class":45},{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":16,"minAge":134,"maxAge":4,"enrollmentInfo":217,"targetDuration":4,"studyType":21,"phases":219,"briefSummary":221,"conditions":222,"keywords":225,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":181},"100532109","phase-2-the-nadage-study-nicotinamide-riboside-replenishment-therapy-against-functional-decline-in-aging-100532109","NCT06208527","The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging","The NADage Study: a Randomized Double-blind Trial of NAD Replenishment Therapy on Aging","NADage","Inclusion Criteria:\n\n* Participant must understand the nature of the study and be able to provide written, informed consent.\n* Male or female aged ≥ 75 years at baseline.\n* Fried Frailty Phenotype score ≥ 3 to identify frail individuals.\n* Montreal Cognitive Assessment (MoCA) at screening adjusted to age, gender, and educational level, with a threshold set at the 10th percentile (z-score ≤ -1.28).\n\nExclusion Criteria:\n\n* Inability to provide informed consent.\n* Does not reside in a facility or institution.\n* Advanced disability, end-stage disease, presence of severe chronic illness and\u002For life expectancy of less than a year.\n* Inability to complete a 6-minute walk test (6MWT) and\u002For contraindications to the procedure (history of unstable angina or myocardial infarction within 30 days prior to the test).\n* Diagnosis of active malignancy in the last 2 years at baseline (exceptions include non-metastatic skin conditions and non-metastatic and\u002For treated prostate cancer with stable prostate-specific antigen (PSA) levels in six months prior to baseline). Specific considerations may apply depending on the type of cancer.\n* Significant neurological or psychiatric disorders, including but not limited to psychotic disorders, severe bipolar or unipolar depression, multiple sclerosis, uncontrolled seizure conditions, and neurodegenerative disorder.\n* A history of cerebrovascular events, excluding transient ischemic attack (TIA) that occurs more than 3 months prior to baseline.\n* Hospitalization or major surgery within 3 months prior to baseline.\n* Significant changes in medications or treatment plans made less than one month prior to baseline, judged by the site investigator to interfere with the subject's participation in the study.\n* Consumption of NAD precursor supplements (e.g., Nicotinamide riboside, nicotinamide mononucleotide or Vitamin B3), or related supplements within 6 months prior to baseline.\n* Elective surgeries scheduled during the study duration.\n* Concurrent participation in other clinical trials with interventions that could affect frailty measures.\n* Any medical history, at the discretion of the investigator, might hinder compliance with study procedures or increase risk to the participant.",{"count":218,"type":20},100,[220],"PHASE2","This clinical study, designed as a double-blind, randomized, placebo-controlled trial, aims to investigate the potential of nicotinamide riboside (NR) to decelerate functional decline in the elderly frail population. In animal studies, NR, which is converted to nicotinamide adenine dinucleotide (NAD), has shown potential as a neuroprotective agent, with indications of protection against amyotrophic lateral sclerosis (ALS), Alzheimer's dementia, and Parkinson's disease. Furthermore, aging is commonly associated with decreased tissue NAD levels, a phenomenon linked to premature aging and a spectrum of age-related disorders, including cardiovascular diseases and cancers. Existing preclinical and clinical research highlights the promise of NAD replenishment through enhanced DNA repair, sirtuin activity, and improved mitochondrial function. The research center has conducted two phase II clinical trials on NR for Parkinson's disease (NAD-PARK and NR-SAFE), administering up to 3000 mg of NR daily. These trials have shown promising results, indicating NR's potential as a treatment that may alter the course of the disease and possibly as neuroprotective treatment in Parkinson's disease.\n\nThe NAD age trial primarily aims to determine:\n\n* The efficacy of NAD therapy in improving clinical symptoms of frailty, evaluated through standardized physical and cognitive function tests.\n* The safety of administering 2000 mg NR daily in an elderly frail population.\n\nThe study will include 100 individuals, classified as frail based on the Fried Frailty Phenotype. Participants will be randomly assigned to receive either 2000 mg of NR daily or a placebo. Over a 52-week period, participants will undergo:\n\n* Clinical evaluations, including actigraphy and questionnaires.\n* Cognitive assessments.\n* Bio sampling.\n* Magnetic resonance imaging (MRI).\n* Positron emission tomography (FDG-PET) scanning.\n\nThe outcomes of this study could potentially demonstrate that NR effectively reduces signs of frailty, offering considerable advantages to the individuals affected, their families, and society as a whole.",[28,27,223,224],"Frailty Syndrome","Aging",[28,226,227,228,229,230,224,231],"Nicotinamide Riboside","NR","Nicotinamide adenine dinucleotide","NAD","Frail","Functional decline","2025-01-17",{"date":234,"type":38},"2025-01-20",{"date":236,"type":20},"2025-01",{"date":238,"type":20},"2030-12",{"name":240,"class":45},"Haukeland University Hospital",{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":21,"phases":251,"briefSummary":252,"conditions":253,"keywords":255,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":46},"100397913","multimodal-prehabilitation-for-surgery-in-the-elderly-a-randomised-prospective-multicenter-multidisciplinary-trial-100397913","NCT04461301","Multimodal Prehabilitation for Surgery in the Elderly: a Randomised, Prospective, Multicenter, Multidisciplinary Trial","Multimodal Prehabilitation for Major Surgery in Elderly Patients to Lower Complications and to Increase Cost Effectiveness: a Randomised, Prospective, Multicenter, Multidisciplinary Trial (PREHABIL Trial).","PREHABIL","Inclusion Criteria:\n\n* Written informed consent\n* comorbid (≥ASA 3)\n* pre-existing fitness deficit: AT\\\u003C11ml\u002Fkg\u002Fmin respectively VO2peak\\\u003C14ml\u002Fkg\u002Fmin if AT unavailable or VE\u002FVCO2 slope \\> 33\n* scheduled for major urologic, thoracic, visceral, orthopaedic or cardiovascular surgery\n* screening at least 2 weeks prior to surgery\n\nExclusion Criteria:\n\n* Paralysis or patients with mobility problems (who are unable to exercise),\n* Premorbid conditions or orthopaedic impairments that contraindicate exercise,\n* Cognitive disabilities,\n* Chronic renal failure (need for dialysis)\n* Emergency procedures.",{"count":250,"type":20},466,[23],"This multicentric, randomised controlled trial is to the investigators knowledge the first implementation of a multimodal, multidisciplinary prehabilitation approach using knowledge from different specialties to lower complications and to increase cost effectiveness after major surgery in elderly, frail patients.",[27,254],"Major Surgery",[256],"Comprehensive Complication Index","2024-10-29",{"date":259,"type":38},"2024-11-01",{"date":261,"type":38},"2022-02-01",{"date":263,"type":20},"2026-12-30",{"name":265,"class":45},"Insel Gruppe AG, University Hospital Bern",{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":4,"eligibilityCriteria":272,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":273,"targetDuration":4,"studyType":21,"phases":275,"briefSummary":276,"conditions":277,"keywords":278,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":4},"100567051","effectiveness-of-a-socio-community-health-intervention-on-pre-frailty-in-older-adults-100567051","NCT06663150","Effectiveness of a Socio-Community Health Intervention on Pre-Frailty in Older Adults","Effectiveness of a Health Intervention With a Socio-community Approach on Frailty in Older Adults With Pre-frailty","Inclusion Criteria:\n\n* Individuals ≥ 60 years old classified as pre-frail in the last 3 months and documented in their medical history.\n* Individuals who meet the requirements and provide voluntary informed consent for their participation.\n* Individuals available to remain in Bogotá D.C. during the study period.\n\nExclusion Criteria:\n\n* Individuals receiving care at community-focused medical centers.\n* Individuals attending community dining programs, physical activity programs, community groups, care blocks, volunteering, or other related activities.\n* Individuals who have experienced falls in the last 6 months with clinical consequences (hospitalization, fractures, traumatic brain injury).\n* Individuals with a clinical history of moderate cognitive impairment, neurodegenerative diseases (e.g., Parkinson's disease), and\u002For neuro-musculoskeletal disorders, active cancer, end-stage renal disease, unstable ischemic heart disease, uncontrolled arrhythmias, severe aortic stenosis, uncontrolled hypertension (\\>180\u002F100 mmHg), or advanced heart failure, exacerbation of chronic diseases (COPD, heart failure), unrehabilitated severe hearing loss, deafness, or blindness with communication limitations.\n* Acute conditions requiring hospitalization, such as acute myocardial infarction or urinary tract infections.\n* Bone fractures in the last 3 months.\n* Individuals unable to follow instructions or with behavioral changes that hinder their participation in the study.\n* Individuals with severe psychiatric illness that, in the physician's judgment, prevents proper adherence to the study intervention.\n* Institutionalized individuals in long-term care facilities.",{"count":274,"type":20},160,[23],"The objective of this study is: To evaluate the effectiveness of a health intervention with a socio-community approach on frailty in older adults with pre-frailty.\n\nSpecific Objectives:\n\nTo characterize the study population according to sociodemographic and clinical variables.\n\nTo evaluate the effect of the intervention on the functionality domain at 3 and 6 months.\n\nTo evaluate the effect of the intervention on the cognitive-emotional domain at 3 and 6 months.\n\nTo evaluate the effect of the intervention on the socio-community domain at 3 and 6 months.\n\nTo evaluate the effect of the intervention on frailty in older adults. To determine the proportion of participants hospitalized during the study period.\n\nTo determine the proportion of participants who visited the emergency room during the study period.\n\nTo determine the proportion of participants in long-term care facilities. To determine the proportion of adverse events associated with the intervention.\n\nStudy Hypothesis\n\nThe mean frailty score pre-intervention is equal to the mean frailty score post-intervention.\n\nThe mean frailty score pre-intervention is different from the mean frailty score post-intervention.",[27],[279,28,280],"Prefrailty","Older Adults","2024-10-28",{"date":257,"type":38},{"date":284,"type":20},"2024-11-15",{"date":286,"type":20},"2026-11-30",{"name":288,"class":45},"Keralty SAS. Colombia",{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":293,"acronym":294,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":16,"minAge":134,"maxAge":4,"enrollmentInfo":296,"targetDuration":297,"studyType":91,"phases":4,"briefSummary":298,"conditions":299,"keywords":302,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":314,"locationsCount":46},"100396045","antibiotic-dosing-in-geriatric-patients-at-the-emergency-department-100396045","NCT04436991","Antibiotic Dosing in Geriatric Patients At the Emergency Department","AGED","Inclusion Criteria:\n\n* Patients presenting at the emergency department and later on admitted to the geriatric department\n* Patient age 75 years or older\n* Patients with geriatric profile according to KATZ scale, G8 screening test or CIRS score.\n* Patient receiving antibiotic treatment (amoxicillin-clavulanate, piperacillin-tazobactam)\n* Intravenous access available for blood sampling. For measurement of the peak concentration an intravenous access other than the drug infusion line is required.\n\nExclusion Criteria:\n\n* Admission to other units than the geriatric department incl. the ICU.\n* Absence of informed consent\n* Known hypersensitivity to beta-lactam antibiotics\n* Patients who received oral amoxicillin-clavulanate prior to admission will not be included in the iv. amoxicillin-clavulanate group.",{"count":110,"type":20},"2 Weeks","In this pilot study, we will investigate whether - with the current dosing regimens, used in the Ghent University Hospital - pharmacodynamic targets regarding beta-lactam antibiotics (more specific Amoxicilline-Clavulanate, Piperacillin-Tazobactam and Temocillin) are attained in frail patients admitted to the geriatric department.",[300,28,27,301],"Elderly Infection","Infection, Bacterial",[303,304,305,306,307],"amoxicillin","piperacillin-tazobactam","temocillin","pharmacokinetics","pharmacodynamics","2024-09-05",{"date":310,"type":38},"2024-09-19",{"date":312,"type":38},"2018-01-03",{"date":236,"type":20},{"name":315,"class":45},"University Hospital, Ghent",{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":322,"eligibilityCriteria":323,"healthyVolunteers":11,"sex":16,"minAge":159,"maxAge":4,"enrollmentInfo":324,"targetDuration":4,"studyType":21,"phases":326,"briefSummary":327,"conditions":328,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":46},"100550226","integrated-health-care-for-patients-with-frailty-and-heart-failure-100550226","NCT06444321","INTEgRated Health CARE for Patients With Frailty and Heart Failure","INTEgRated Health CARE for Patients With Frailty and Heart Failure (INTERCARE-HF): Evaluation of an Innovation Project","INTERCARE-HF","Inclusion Criteria:\n\n* Age \\>18 years old\n* Admitted to hospital with heart failure with symptoms of decompensation including dyspnoea in NYHA class ≥ II, pulmonary congestion on chest x-ray and\u002For other signs like oedema or positive rales on auscultation and elevated NT-proBNP concentrations at screening\n* Clinical Frailty Score ≥5\n* Signed informed consent by patient and closest relatives\\* and expected cooperation according to the protocol, ICH\u002FGCP and national\u002Flocal regulations\n\n  * Although we preferably will recruit both patients and their relatives, participation from the next-of-kin will not be an exclusion criterium.\n\nExclusion Criteria:\n\n* Inability to comply with all study requirements, due to major co-morbidities or psychosocial issues, or a history of noncompliance, that might compromise the patient's ability to understand and\u002For comply with the protocol instructions or follow-up procedures.\n* Not being able to understand Norwegian.\n* Permanent nursing home and estimated to stay alive for less than 6 months",{"count":325,"type":20},60,[23],"Frailty, an aging-related syndrome of physiological decline characterized by marked vulnerability to adverse health outcomes, has attracted increasing attention in cardiology due to the growing elderly population with heart failure. Frail patients are mainly excluded from large cardiovascular intervention studies, and clinical trials addressing frailty and showing an impact on treatment on symptom burden, quality of life and \u002For outcome has been requested in recent guidelines and consensus documents. The INTEgrRated health CARE for patients with severe frailty and Heart Failure (INTERCARE-HF) is a proof-of-concept study that aims to evaluate the effect of integrated healthcare services for heart failure patients with a severe level of frailty by establishing interdisciplinary and coordinated follow-up teams across the healthcare boundaries. These teams will assess the patient's needs, goals, and risk areas, conduct advance care planning, and develop individualized treatment and follow-up plans. An open-label, non-randomized intervention study aims to recruit 20 patients and heart failure and a clinical Frailty Score (CSF) \\>=5. A control-group (N=40) matched on age an clinical frailty scale score will be included. The overall hypothesis is that the intervention is feasible in routine clinical practice with favorable effects on quality of life, symptoms, caregiver distress, and healthcare service utilization.",[60,28,27,329,330,331],"Symptom, Behavioral","Utilization, Health Care","Quality of Life","2024-06-12",{"date":334,"type":38},"2024-06-13",{"date":336,"type":38},"2024-06-06",{"date":338,"type":20},"2028-12-20",{"name":340,"class":45},"Vestre Viken Hospital Trust",{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":345,"acronym":346,"eligibilityCriteria":347,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":348,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":350,"conditions":351,"keywords":356,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":46},"100301846","frailty-syndrome-in-daily-practice-of-interventional-cardiology-ward-100301846","NCT03209414","Frailty Syndrome in Daily Practice of Interventional Cardiology Ward","FRAPICA","Inclusion Criteria:\n\n* aged ≥ 65\n* symptomatic coronary artery disease A) stable B) unstable C) NSTEMI D) STEMI\n* written, informed consent\n\nExclusion Criteria:\n\n* lack of consent",{"count":349,"type":20},1000,"The impact of frailty on immediate and long term outcomes of invasive treatment of coronary artery disease is not fully characterized. The assessment of frailty may help physicians in the selection of best treatment option and in the timing and modality of the follow-up. The FRAilty syndrome in daily Practice of Interventional CArdiology ward (FRAPICA) study is designed with the aim to validate the use of the Fried frailty scale and instrumental activities of daily living scale (IADL) as prognostic tools in patients admitted to hospital for symptomatic coronary artery disease, either stable, unstable, or acute coronary syndrome (ACS).\n\nThe FRAPICA study is a single center prospective study enrolling patients aged ≥65 years. The aims are (1) to describe Fried frailty scale and IADL scale distribution before hospital discharge and (2) to investigate the prognostic role of Fried frailty and IADL scores. The outcomes are: (1) results of invasive treatment, (2) its complications (periinterventional MI, contrast-induced nephropathy, blood loss), (3) three-year all-cause mortality, cardiovascular mortality, stroke, myocardial infarction, reintervention, heart failure, hospital readmission for any cause, and a composite of the above mentioned. Ancillary analyses will be focused on different clinical presentations, different tools to assess frailty and risk stratification.\n\nThe FRAPICA program will fill critical gaps in the understanding of the relation between frailty, cardiovascular disease, interventional procedures and outcome. It will enable more personalized risk assessment and identification of new targets for interventions.",[27,352,353,354,355],"Coronary Heart Disease","Acute Coronary Syndrome","Coronary Artery Bypass Grafting","Percutaneous Transluminal Coronary Angioplasty",[357,358,359,360,361,362,363,364],"Frailty syndrome","Coronary heart disease","Coronary revascularization","Major adverse cardiovascular events","Arterial stiffness","Applanation tonometry","Lean body mass","ST2 biomarker","2023-04-10",{"date":367,"type":38},"2023-04-12",{"date":369,"type":38},"2017-05-17",{"date":371,"type":20},"2027-12-31",{"name":373,"class":45},"Medical University of Silesia",{"id":375,"slug":376,"hasResults":11,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":380,"eligibilityCriteria":381,"healthyVolunteers":382,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":383,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":385,"conditions":386,"keywords":391,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":399,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":404,"locationsCount":46},"100402297","prevalence-determinants-and-natural-history-of-frailty-and-pre-frailty-in-elderly-people-100402297","NCT04518423","Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People","Prevalence, Determinants and Natural History of Frailty and Pre-frailty in People Over the Age of 65 Years in a Prospective 5-year Observation","FRAILPOL","Inclusion Criteria:\n\n* Community dwelling elderly individuals over the age of 65 years who get around by themselves.\n\nExclusion Criteria:\n\n* Institutionalization\n* Inability to move around\n* Terminal diseases with an anticipated survival of less than 1 year.",true,{"count":384,"type":20},1093,"Frailty syndrome (i.e. frailty) is a geriatric syndrome which relies on the reduction of multisystem reserve capacity. Frail people have a lower potential to respond to external stressors and various life incidents as well as they present a weak prognosis particularly in cardiovascular diseases. Yet, frailty is not only a set of physical deficits, but it also concerns psychological and social dimensions of human functioning. Hence, an approach to frailty should be multidimensional because such a concept more adequately reflects a functional degradation in the elderly. Frailty is usually associated with the impaired condition of circulatory system, and therefore, an identification of subclinical cardiovascular abnormalities is paramount in the frailty prevention and treatment. Another potential mechanism which may predispose to frailty is a dysfunction of the autonomic nervous system. This system plays a crucial role in the response to internal or external stressors such as diseases and activities of daily living. An impairment of the autonomic nervous system function may maintain or accelerate the frailty process.\n\nIn this scientific project, a comprehensive echocardiography will investigate cardiac function with a particular attention to features which typically change with age, like flow parameters and chambers sizes. The activity of the autonomic nervous system will be explored with the analysis of heart rate, blood pressure and respiratory signals. The study participants will also undergo routine medical examination and a number of additional tests, including: assessment of cognitive function, psychological condition, nutrition status, activities of daily living, and risk of falls. The study group will comprise community dwelling elderly individuals over the age of 65 years who get around by themselves. After 2 years, the participants will be re-examined for their frailty and independence status, as well as their survival will be checked with the National Health Found electronic system. The aim of this project is to seek for factors determining frailty and to explore the frailty impact on the elderly people survival. Particular attention will be paid to the multidimensional frailty which is a new concept of the functional decline in the elderly. In addition, the prevalence of different modes of frailty in Polish community will be investigated. The results of this research should help to establish preventative and therapeutic strategies against frailty.",[28,223,27,387,224,388,389,390],"Fragility","Aging Problems","Aging Disorder","Aging Well",[28,392,393,394,395,200,224,396,397],"Physical Frailty","Cognitive Frailty","Social Frailty","Multidimensional Frailty","Frail Scale","Tilburg Frailty Indicator","2020-08-14",{"date":400,"type":38},"2020-08-19",{"date":402,"type":38},"2017-09-02",{"date":99,"type":20},{"name":405,"class":45},"The Opole University of Technology"]