[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"frail-elderly\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:frail-elderly":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,48,77,102,132,163,190,219,249,273,303,332,359,380,403,434],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100628162","comparson-of-the-effcacy-of-conventonal-exercse-and-plates-n-pre-fral-and-fral-older-adults-100628162",false,"NCT07458048","Comparıson of the Effıcacy of Conventıonal Exercıse and Pılates ın Pre-fraıl and Fraıl Older Adults","Inclusion Criteria:\n\n* Age 60 years and older Classified as prefrail or frail according to the FRAIL Scale A score of 24 or higher on the Mini-Mental State Examination (MMSE) Provided written informed consent after being informed about the study\n\nExclusion Criteria:\n\nPresence of unstable cardiovascular disease Having received physical therapy and rehabilitation within the past 6 months History of severe neurological disorders History of major surgery affecting mobility within the past 6-12 months Severe musculoskeletal or orthopedic conditions that limit or preventt independent mobility.\n\n\\-","ALL","60 Years",{"count":18,"type":19},40,"ESTIMATED","INTERVENTIONAL",[22],"NA","Brief Summary\n\nThis clinical study aims to compare the effects of a conventional exercise program and a Pilates exercise program in prefrail and frail older adults. A total of 40 participants aged 60 years and older who are classified as prefrail or frail according to the FRAIL Scale will be included in the study.\n\nParticipants will be randomly assigned to either the conventional exercise group or the Pilates group. Both exercise programs will be conducted twice weekly for 6 weeks. The interventions will focus on stretching exercises, balance and perturbation training, and strength exercises targeting major muscle groups.\n\nPrimary outcomes will include changes in frailty status assessed before and after the intervention. Secondary outcomes will include functional mobility and balance assessed by the Timed Up and Go Test, dynamic balance assessed by the Functional Reach Test, lower extremity strength assessed by the 30-Second Sit-to-Stand Test, gait speed assessed by the 10-Meter Walk Test, depressive symptoms and psychological well-being assessed by the Yesavage Geriatric Depression Scale, independence in daily activities assessed by the Lawton Instrumental Activities of Daily Living Scale, cognitive status assessed by the Mini-Mental State Examination, and fatigue assessed by the Modified Borg Scale. Frailty status will be evaluated using the FRAIL Scale.\n\nThroughout the study, participant safety will be monitored, and any adverse events, such as injuries or discomfort occurring during exercise sessions, will be recorded and managed appropriately.\n\nThis study is expected to provide valuable clinical evidence regarding the effectiveness of conventional exercise and Pilates programs in improving physical health and reducing frailty in prefrail and frail older adults, thereby contributing to the identification of best practice approaches for the management of this vulnerable population.",[25,26,27,28],"Frailty Syndrome","Prefrail Elderly","Frail Elderly","Geriatric",[30,31,32,33,34,35],"Pilates","geriatric","conventional","frailty","exercises","prefrail","NOT_YET_RECRUITING","2026-06-20",{"date":39,"type":40},"2026-06-25","ACTUAL",{"date":42,"type":19},"2026-06-22",{"date":44,"type":19},"2027-02",{"name":46,"class":47},"Istanbul University - Cerrahpasa","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":15,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":20,"phases":58,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100642961","clinical-efficacy-of-a-multicomponent-exercise-and-comprehensive-geriatric-assessment-program-frailap-in-frail-older-adults-within-primary-care-a-randomized-controlled-trial-100642961","NCT07643064","Clinical Efficacy of a Multicomponent Exercise and Comprehensive Geriatric Assessment Program (FRAIL+AP) in Frail Older Adults Within Primary Care: A Randomized Controlled Trial","FRAIL+AP","Inclusion Criteria:\n\n* Community-dwelling adults aged 70 years or older.\n* Ability and willingness to provide written informed consent.\n* Medical clearance to participate in low-to-moderate intensity physical exercise.\n* Presence of frailty or pre-frailty defined by meeting at least two of the following criteria:\n* Functional independence sufficient to participate in the intervention (Barthel Index \\>80.\n* FRAIL Scale score ≥ 1.\n* Short Physical Performance Battery (SPPB) score \\\u003C 10.\n* Gait speed \\\u003C 0.8 m\u002Fs.\n* Timed Up and Go (TUG) test \\> 12 seconds.\n* Registered at one of the participating primary care centers.\n\nExclusion Criteria:\n\n* Absolute contraindications to physical exercise, including recent acute myocardial infarction, unstable angina, severe uncontrolled cardiovascular disease, or severe uncorrected aortic stenosis.\n* Severe cognitive impairment preventing comprehension of study procedures or exercise instructions.\n* Severe psychiatric disorders interfering with participation.\n* Absence of a legally authorized representative when required.\n* Severe uncontrolled behavioral disturbances.\n* Any acute or chronic medical condition considered by the investigators to make participation unsafe.\n\nDiscontinuation Criteria:\n\n* Failure to attend the initial mandatory health education workshop.\n* Attendance at fewer than 6 of the 12 scheduled supervised exercise sessions.\n* Development of an acute medical condition that results in a temporary or permanent contraindication to physical activity.\n* Participant withdrawal of informed consent.","70 Years",{"count":57,"type":19},200,[22],"Frailty is a multidimensional clinical syndrome associated with increased vulnerability to adverse health outcomes in older adults. Despite strong evidence supporting multicomponent exercise interventions, their implementation in primary care settings remains limited.\n\nThis randomized controlled trial aims to evaluate the efficacy of the FRAIL+AP program, which integrates Comprehensive Geriatric Assessment (CGA) with a 12-week multicomponent exercise intervention, including visual-spatial gait retraining using the Tapiz Fisior system.\n\nThe study will assess whether this intervention improves frailty status, physical performance, and functional independence, while reducing falls among community-dwelling older adults compared to standard care.",[27],[62,33,63,64,65],"exercise","elderly","physiotherapy","primary care","RECRUITING","2026-06-07",{"date":69,"type":40},"2026-06-11",{"date":71,"type":40},"2026-05-28",{"date":73,"type":19},"2026-12-31",{"name":75,"class":47},"Universidad Europea de Madrid",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":15,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":20,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100503106","up-2-study-cognitively-engaging-walking-exercise-and-neuromodulation-to-enhance-brain-function-in-older-adults-100503106","NCT05830942","Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults","Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults","Inclusion Criteria:\n\n* Age 65+\n* Objective executive function decline, based on standardized cognitive assessments.\n* Subjective cognitive decline, based on the question: \"During the past 12 months, have you experienced confusion or memory loss that is happening more often or getting worse?\"\n* Ability to walking independently for 6 minutes (use of cane permitted)\n\nExclusion Criteria:\n\n* Major cognitive disorder that interferes with independence\n* Percentile score less than 10th percentile on standardized cognitive assessments\n* Medications that are thought to influence tDCS neuroplasticity.\n* Contraindications to tDCS or MRI.","65 Years",{"count":86,"type":19},120,[22],"Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.",[90,91,27],"Cognitive Dysfunction","Mobility Limitation","2026-06-02",{"date":94,"type":40},"2026-06-03",{"date":96,"type":40},"2024-04-15",{"date":98,"type":19},"2027-04-30",{"name":100,"class":47},"University of Florida",2,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":15,"minAge":55,"maxAge":4,"enrollmentInfo":110,"targetDuration":112,"studyType":113,"phases":4,"briefSummary":114,"conditions":115,"keywords":116,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":76},"100609190","high-intensity-interval-training-versus-moderate-intensity-continuous-training-in-frail-elderly-100609190","NCT07211334","High Intensity Interval Training Versus Moderate Intensity Continuous Training in Frail Elderly","Comparison of the Effects of Different Exercise Modalities in Frail Elderly People Care Setting","EPAF","Inclusion Criteria:\n\n* Adults aged 70 or older;\n* Patients meeting at least 1 of 5 frailty criteria (Fried criteria; 2001);\n* Patient does not object to the analysis of anonymized data;\n* Person affiliated with social security;\n* Patient's ability to use an ergocycle safely;\n* Patients medically stable patients with no acute illness or recent decompensation that could be aggravated by exercise (at the physician's discretion).\n\nExclusion Criteria:\n\n* Unstable medical conditions that may be aggravated by physical activity (as determined by a physician)\n* Musculoskeletal disorders and severe neurocognitive conditions that make it impossible to safely use the ergocycle or participate in the exercise program\n* individuals participating in other interventional studies or who have recently participated in an interventional study that could influence the results of this study\n* Persons referred to in Articles L1121-5 to L1121-8 of the public health code (corresponds to all protected persons: pregnant women, women in labor, breastfeeding mothers, persons deprived of their liberty by judicial or administrative decision, persons subject to legal protection measures)",{"count":111,"type":19},92,"6 Months","OBSERVATIONAL","The assessment and systematic integration of physical activity into the care pathway of frail elderly people is essential to prevent loss of independence and improve the quality of life of this population. This project, which is part of routine care, aims to evaluate the practices and, in particular, the effects of different types of physical exercise currently in use at the Health and Sport Center of the Grenoble Alpes University Hospital. It therefore aims to optimize professional practices without changing the standard care provided to patients. Recommendations regarding intensity during cardiorespiratory endurance training sessions (moderate to high, taking into account emotional factors) are broad and vary greatly in their application depending on the facilities that work with older adults. This project aims to compare the exercise methods used on ergocycle at Health and Sport Center of Grenoble Alpes University Hospital: high-intensity interval training (HIIT) vs. moderate-intensity continuous training (MICT) to reverse the functional decline that occurs in frail older adults.",[27],[117,118,119,120,121,122],"Frailty","Elderly","High Intensity Interval Training","Moderate Intensity Continuous Training","Motivation for Physical Activity","Support for Changing Behavior Regarding Physical Activity","2026-04-28",{"date":125,"type":40},"2026-05-05",{"date":127,"type":40},"2025-12-11",{"date":129,"type":19},"2028-02",{"name":131,"class":47},"University Hospital, Grenoble",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":15,"minAge":140,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":20,"phases":143,"briefSummary":144,"conditions":145,"keywords":150,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":162},"100623395","pre-operative-risk-assessment-combined-with-targeted-intervention-in-the-chinese-elderly-with-spine-surgery-ii-100623395","NCT07396077","Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery II","Multimodal Physiological Reserve Optimizing Prehabilitation Program (PHYSIO-Prehab) in the Chinese Elderly With Spine Surgery","PRACTICE-2","Inclusion Criteria:\n\n1. Aged ≥75 years at the time of screening\n2. Voluntarily sign the informed consent form\n3. Clinically diagnosed with degenerative lumbar spinal disorders with duration of symptoms \\>6 months\n4. Requiring elective lumbar fusion surgery (single-level or multi-level, open or minimally invasive approach)\n5. No severe cognitive impairment (Mini-Mental State Examination score \\> 9)\n6. Scheduled to undergo surgery within 6-8 weeks after screening (allowing completion of the 6-week prehabilitation program)\n\nExclusion Criteria:\n\n1. Scheduled to undergo other emergency surgery or day surgery\n2. Urgent medical conditions requiring priority management before spinal surgery\n3. With spinal disorders other than degenerative diseases (spinal fracture, tumor, metastasis, infection, ankylosing spondylitis, scoliosis with Cobb angle \\>40°)\n4. With contraindications to prehabilitation exercise (New York Heart Association Class IV heart failure, unstable angina, uncontrolled hypertension \\[systolic BP ≥180 mmHg or diastolic BP ≥110 mmHg despite medication\\])\n5. With severe functional disability for other disorders or long-term bedridden status unable to perform basic physical activities\n6. With allergy or intolerance to nutritional supplements used in the prehabilitation program\n7. Participating in another clinical trial involving prehabilitation, perioperative intervention, or spinal surgery within 3 months before screening","75 Years",{"count":142,"type":19},248,[22],"This multicenter, parallel-group, assessor-blinded randomized controlled trial will enroll 248 adults aged ≥75 years with degenerative lumbar spinal diseases scheduled for elective lumbar fusion surgery, and they will be randomized 1:1 into the intervention and usual care groups. The intervention group will receive a 6-week PHYSIO-Prehab multimodal prehabilitation program, including multicomponent exercise, nutritional intervention, comorbidity optimization, and cognitive prehabilitation with brain protection strategies. The control group will receive standard health education provided via a manual, and both groups will receive consistent perioperative Enhanced Recovery After Surgery care. The primary outcome will be the change in Barthel Index (a tool for assessing independence in activities of daily living) from baseline to 30 days postoperatively; secondary outcomes will include pain scores, disability, patient satisfaction, and the 30-day postoperative Comprehensive Complication Index. The trial will initiate recruitment in April 2026 and conclude in December 2027, aiming to evaluate the feasibility and efficacy of PHYSIO-Prehab and provide high-quality evidence for patient-centered perioperative care pathways in this population.",[146,147,27,148,149],"Spine Degeneration","Lumbar Degenerative Disease","Enhanced Recovery After Surgery (ERAS) Protocol","Prehabilitation",[149,151,152,153],"ERAS","lumbar fusion","ADL","2026-04-26",{"date":123,"type":40},{"date":157,"type":40},"2026-04-15",{"date":159,"type":19},"2027-12-30",{"name":161,"class":47},"Xuanwu Hospital, Beijing",4,{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":15,"minAge":84,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":20,"phases":172,"briefSummary":173,"conditions":174,"keywords":177,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":4},"100635028","effect-of-animation-based-digital-education-on-risk-knowledge-and-frailty-in-older-adults-100635028","NCT07547358","EFFECT OF ANIMATION-BASED DIGITAL EDUCATION ON RISK KNOWLEDGE AND FRAILTY IN OLDER ADULTS","THE IMPACT OF A DIGITAL TRAINING MODEL DEVELOPED USING ANIMATION TECHNIQUE ON RISK KNOWLEDGE LEVEL AND FRAILTY AMONG OLDER ADULTS","Inclusion Criteria:\n\n* Aged 65 years or older\n* Ability to speak and understand Turkish\n* Minimum literacy level (able to read and write)\n* Mini-Mental State Examination (MMSE) score ≥ 24\n* No visual or auditory impairment, or ability to compensate for such impairments with assistive devices\n* Ability to interact with digital devices such as smartphones or tablets at a basic level\n\nExclusion Criteria:\n\n* Diagnosis of cognitive impairment or dementia\n\nWITHDRAWAL CRITERIA:\n\n* Participants will be withdrawn from the study if:\n* Serious health problems occur during any phase of the study or death occurs\n* Perception or compliance problems are identified during sessions\n* The participant fails to attend at least one educational session",{"count":171,"type":19},66,[22],"With the global aging trend, the management of geriatric risks faced by older adults and the effectiveness of health education for this population are gaining increasing importance. Literature indicates that health education for older adults, when delivered through methods that support individual engagement and the use of digital tools, yields more effective results in terms of learning and behavior change. This doctoral study aims to evaluate the effect of a digital education model, structured based on the Health Belief Model and developed using branching scenario animation technique, on geriatric risk knowledge level and frailty status among older adults residing in nursing homes.\n\nThe study will be conducted as a randomized controlled trial in three nursing homes in Istanbul, with measurements at baseline (T0), immediately post-intervention (T1), 1-month follow-up (T2), and 3-month follow-up (T3). Based on power analysis, 66 participants will be randomly assigned to intervention and control groups (33 per group) using block randomization. The intervention group will receive scenario-based digital animation education developed on the Vyond platform and structured according to the theoretical components of the Health Belief Model. The control group will receive standard care during the study period and will be offered the same digital animation education after completion of all assessments (post 3-month follow-up).\n\nThe primary outcome is geriatric risk knowledge level, assessed using an interactive digital game called \"Knowledge Wheel.\" Secondary outcomes include frailty status, measured by the Edmonton Frail Scale, and technology acceptance. Changes in knowledge and frailty levels measured through assessment tools will reveal the short- and medium-term effects of the education. Thus, the model's impact on health-related behavior change in older adults will be comprehensively evaluated.\n\nThe unique aspect of this study is that it will be one of the first experimental studies to implement an interactive scenario-based digital education model in older adults. The findings are expected to contribute to the development of age-friendly health education models.",[175,27,176],"Aging","Geriatric Syndromes",[33,178,179,180],"Older Adults","Digital Health Education","Branching Scenario Animation","2026-04-17",{"date":183,"type":40},"2026-04-23",{"date":185,"type":19},"2026-09-01",{"date":187,"type":19},"2027-02-01",{"name":189,"class":47},"Saglik Bilimleri Universitesi",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":196,"eligibilityCriteria":197,"healthyVolunteers":198,"sex":15,"minAge":84,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":20,"phases":201,"briefSummary":202,"conditions":203,"keywords":206,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":218},"100565720","targeting-aging-with-a-ketone-ester-for-function-in-frailty-100565720","NCT06645847","Targeting Aging With a Ketone Ester for Function in Frailty","A Randomized, Double-blind, Placebo-controlled, Parallel Group, Pilot Study to Evaluate the Effect of a Ketone Ester on Muscle and Immune Function in Older Men and Women Who Are at Risk for Strength and Mobility Decline","TAKEOFF","Inclusion Criteria:\n\n1. Subject is greater than or equal to 65 years of age, inclusive at Screening.\n2. Passes the gait speed criteria at Screening.\n3. Minimum body weight of 50 kgs at Screening.\n4. Subject is willing and able to comply with all study procedures including randomization into any of the experimental groups, maintenance of habitual dietary intake, exercise and medication and supplement use, blood draws and the following prior to test visits: fasting (≥10 h; water only), no alcohol (≥ 10 h), no cannabis products (≥10 h) and no exercise (≥ 10 h).\n5. Subject understands the study procedures and can provide informed consent to participate in the study.\n\nExclusion Criteria:\n\n1. Subject is non ambulatory.\n2. Subject has a CSHA clinical frailty score \\> 5.\n3. Subject requires assistance with any activity of daily living, excluding continence.\n4. Subject lives in an institutional setting (skilled nursing facility or residential care facility for the elderly).\n5. Subject is a female who has not passed menopause.\n6. Subject is unable to converse in English (or Spanish, if available at the study site).\n7. Subject has been hospitalized within 30 days of Screening.\n8. Subject has any physical limitation that would prevent them from performing 1RM leg press based on Medical Officer judgement.\n9. Subject has an abnormal laboratory test result(s) of clinical importance at Screening, indicating unstable chronic disease of major organ dysfunction that requires urgent evaluation, at the discretion of the Medical Officer. One re-test will be allowed on a separate day prior to Visit 1, for subjects with abnormal laboratory test results. Additional clinical information may be gathered from the participant if needed to interpret the urgency of laboratory abnormalities (e.g. recent laboratory trends if an electrolyte is abnormal).\n10. Subject has uncontrolled hypercholesterolemia on screening labs.\n11. Subject has a history or presence of acute or uncontrolled and\u002For clinically active pulmonary (chronic obstructive pulmonary disease \\>= Gold 3), cardiac (e.g. \\>= New York Heart Association class III), hepatic (cirrhosis), renal (chronic kidney disease stage \\>= IIIb), endocrine (including type 1 diabetes), hematologic, immunologic, neurologic (e.g., Alzheimer's or Parkinson's diseases), psychiatric (including unstable depression and\u002For anxiety disorders) or biliary disorders. \"Uncontrolled\" and \"clinically active\" are per the judgement of the Medical Officer. Stable chronic disease is not an exclusion criterion unless specified. Chronic disease that is managed with the patient's physician per shared decision-making, even if sub optimally by typically recommended care, is not an exclusion criterion unless uncontrolled or clinically active.\n12. Subject has a clinically important gastrointestinal condition that would potentially interfere with the evaluation of the study beverage \\[e.g., inflammatory bowel disease, irritable bowel syndrome, chronic constipation, severe constipation (in the opinion of the Medical Officer), history of frequent diarrhea, history of surgery for weight loss, gastroparesis, systemic disease that might affect gut motility according to the Investigator, history of gastrointestinal ulcers or bleeding, history of pancreatitis, history of hiatal hernia, history of Barrett's esophagus, or history of esophageal cancer\\].\n13. Heavy drinking (For women, 8 or more drinks per week. For men, 15 or more drinks per week).\n14. Subject has a history of alcohol or substance abuse.\n15. Subject has been instructed not to consume alcohol for medical reasons.\n16. Subject has a known, clinically important allergy, intolerance, or sensitivity to any of the ingredients in the study beverages, including soy and milk protein.\n17. Subject has uncontrolled hypertension as defined by the blood pressure measured at Screening. For subjects with elevated blood pressure at Screening, they are allowed for the purpose of this criteria to submit home readings from three separate days, or to have a repeat reading taken at the study site on a separate day before Visit 1.\n18. Subject is undergoing treatment or active surveillance for cancer or has been diagnosed with cancer in the prior two years, except for non-melanoma skin cancer. Active surveillance is defined as regular imaging or laboratory tests at a frequency greater than annually. Cancer under long-term monitoring such as stable chronic lymphocytic leukemia need not be an exclusion, on the discretion of the Medical Officer.\n19. Immunosuppressive disorders, taking immunosuppressive medications (including oral prednisone \\>10mg\u002Fday and biological immunosuppressants), or receiving chemotherapy.\n20. Chronic antibiotic use (e.g. expected to be ongoing, regardless of frequency, throughout the study period).\n21. Subject has extreme dietary habits (e.g., intermittent fasting or time restricted eating, Atkins diet, vegan, very high protein\u002Flow carbohydrate or has used weight-loss medications (including over-the-counter medications and\u002For supplements) or programs within 30 days of Screening.\n22. Subject has followed a ketogenic diet or used ketone supplements (ketone salts or esters, and medium chain triglycerides) within 30 days of Screening.\n23. Subject has a condition the Medical Officer believes would interfere with their ability to provide informed consent, comply with the study protocol, which might confound the interpretation of the study results, or put the subject at undue risk.\n24. Subject works nights or shifts that means it is not possible to maintain a consistent meal schedule during the study.",true,{"count":200,"type":19},180,[22],"This study aims to find out if a food supplement that contains a naturally occurring substance, ketones, can help to improve strength and general wellness in adults at, or over the age of 65 years who are experiencing a slight decline in their physical function.\n\nParticipation will involve a screening visit and 4 additional study visits over the course of 20 weeks. After being assessed for eligibility, study participants will be sorted into two groups at random and consume either a ketone or placebo supplement at home every day for 20 weeks. Both study products can cause gastro-intestinal side effects in some individuals. At all study visits, subjects will provide blood samples. At three study visits, subjects will be asked to complete physical performance tests, provide blood, stool and urine samples. They will also complete questionnaires during three study visits to assess physical function, markers of inflammation, and other aspects of general well-being.\n\nThe study enrolls at three sites across the United States, in California (Buck Institute), Ohio (Ohio State University), and Connecticut (University of Connecticut). The study is coordinated by the San Francisco Coordinating Center (California Pacific Medical Center).",[27,175,204,205],"Immune Function","Muscle Function",[207,208],"ketone ester","exogenous ketone","2026-03-12",{"date":211,"type":40},"2026-03-13",{"date":213,"type":40},"2025-02-05",{"date":215,"type":19},"2028-04-01",{"name":217,"class":47},"Buck Institute for Research on Aging",3,{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":11,"sex":15,"minAge":226,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":20,"phases":229,"briefSummary":230,"conditions":231,"keywords":233,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":76},"100626247","comparison-of-smartphone-and-community-based-delivery-of-the-otago-exercise-program-for-fall-risk-in-older-adults-100626247","NCT07433153","Comparison of Smartphone and Community-Based Delivery of the Otago Exercise Program for Fall Risk in Older Adults","Effectiveness of Smartphone-Based Versus Community-Based Otago Exercise Programs for Fall Risk Reduction in Community-Dwelling Older Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Community-dwelling older adults 55 years of age or older\n* Communicate in English\n* Able to ambulate at least 10 meters with or without an assistive device.\n* Cognitively intact based on scoring 18\u002F22 or greater on the Montreal Cognitive Assessment (MoCA)-Blind during a phone screening process\n* Have access to an Android or iOS smartphone\n* Intermediate or high risk of falling, based on World Guidelines for Falls Prevention (Montero-Odasso et al, 2022)\n\nExclusion Criteria:\n\n* Lower limb amputation\n* Visual impairment uncorrectable with lenses\n* Uncontrolled hypertension, diabetes, neurological or musculoskeletal impairment\n* Persistent symptoms of dizziness or lightheadedness\n* Spine or lower-extremity surgery in the past 12 months\n* Self-reported pain of \\>7 on a scale of 0-10","55 Years",{"count":228,"type":19},30,[22],"The long-term goal of this project is to effectively bridge the research-clinic-community gap and to foster partnerships that support the implementation, utilization, and advocacy of evidence-based fall prevention programs in the older adult community. The Otago Exercise Program (OEP) is an evidence-based fall prevention program that has been shown to reduce falls and fall-related injuries among older adults. Traditionally, OEP is delivered in the home by a physical therapist and focuses on muscle strengthening and balance training. Despite its proven effectiveness, adherence and compliance rates have been low. The personnel and resource demands of program delivery, along with challenges in monitoring participant adherence, represent significant barriers to broader implementation. Alternative delivery systems using remote and community-based platforms may help address these limitations.\n\nSpecific Aim 1: To compare the effectiveness of two delivery modes of the Otago Exercise Program: a remotely delivered, home-based smartphone program and an in-person, community-based program.\n\nSpecific Aim 2: To examine the feasibility, acceptability, and usability of the Otago Exercise Program delivered through both smartphone-based and in-person formats.",[27,232],"Fall",[234,235,236,237,238,239],"Otago","Falls","Smartphone","Group Exercise","Balance","Stepping","2026-02-24",{"date":242,"type":40},"2026-02-25",{"date":244,"type":40},"2026-02-16",{"date":246,"type":19},"2026-12-01",{"name":248,"class":47},"Binghamton University",{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":255,"eligibilityCriteria":256,"healthyVolunteers":11,"sex":15,"minAge":84,"maxAge":140,"enrollmentInfo":257,"targetDuration":4,"studyType":20,"phases":259,"briefSummary":260,"conditions":261,"keywords":262,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":76},"100625140","community-based-program-integrating-nurse-led-mind-body-exercise-and-nutrition-for-frailty-100625140","NCT07418762","Community-Based Program Integrating Nurse-Led Mind-Body Exercise and Nutrition for Frailty","Community-Based Rehabilitation Integrating Nurse-Led Mind-Body Exercise and Nutritional Supplementation for Frailty: A Three-Arm Randomized Controlled Trial","N-CARE Frailty","Inclusion Criteria:\n\n* Eligibility criteria included age ≥65 years, a Frail Scale score of 1-3 (pre-frail) or 4-5 (frail), ability to stand and walk independently without permanent assistive devices, willingness to participate for eight weeks (three sessions per week), and provision of written informed consent.\n\nExclusion Criteria:\n\n* Exclusion criteria included severe cardiac or respiratory conditions (contraindications to exercise), moderate to severe cognitive impairment (MoCA-Ina), recent stroke or severe musculoskeletal disorders, and known allergies or intolerance to protein supplements.",{"count":258,"type":19},48,[22],"This study aims to develop and evaluate a community-based rehabilitation program integrating nurse-led mind-body exercises and nutritional supplementation for frail older adults in Indonesia. This study uses a Randomized Controlled Trial (RCT) with three parallel groups and assessor blinding. The intervention was conducted for 8 weeks in community-dwelling older adults aged ≥ 65 years who live within the working area of a Community Health Center in Surabaya City. The sample size is 48 elderly. Participants will be divided into 3 groups: the control group, the Nurse-Led Mind-Body Exercise group, and the MBE + Nutritional Supplementation (MBE + Nutrition) group. The procedure is carried out after respondents provide voluntary consent. Confidentiality and anonymity of data will be strictly maintained throughout the research process. Data analysis between groups and within groups will be conducted using repeated-measures ANOVA and Intention-to-treat (ITT) analysis.",[27],[117,118,263],"Nurse Led Mind-Body","2026-02-11",{"date":266,"type":40},"2026-02-18",{"date":268,"type":19},"2026-03-30",{"date":270,"type":19},"2026-05-25",{"name":272,"class":47},"Universitas Airlangga",{"id":274,"slug":275,"hasResults":11,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":11,"sex":15,"minAge":84,"maxAge":4,"enrollmentInfo":280,"targetDuration":4,"studyType":20,"phases":282,"briefSummary":283,"conditions":284,"keywords":287,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":4},"100608704","freefrail-project-a-multicomponent-intervention-for-the-management-of-frailty-in-primary-care-a-randomized-controlled-trial-100608704","NCT07205016","FreeFrail Project: A Multicomponent Intervention for the Management of Frailty in Primary Care: A Randomized Controlled Trial","FreeFrail Project: Effectiveness of a Multicomponent Intervention Including Dual-task Exercise to Increase Functionality and Cognitive Performance in Frail and Pre-frail Individuals Over 65 Years Aged in Primary Care Compared to Usual Care: Protocol for a Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 65 or older\n* Frailty according to Fragil-VIG index (\\>0,20)\n* Barthel index \\> 60\n* Able to perform physical exercise\n* Able to understand and communicate in Catalan or Spanish\n\nExclusion Criteria:\n\n* Decompensated \u002F Unstable cardiovascular disease or recent diagnosed\n* Upper or lower injury with functional impairment\n* Institutionalized patient.\n* Terminal or tumoral processes\n* People who participated in another clinical trial or exercise programme during last year\n* Diagnosis of severe dementia",{"count":281,"type":19},220,[22],"The primary aim is to assess the effectiveness of a multicomponent intervention including dual-task exercise in improving functionality and cognitive performance and in reducing frailty among community-dwelling adults aged ≥65 years compared to usual care. Secondary objectives include evaluating its impact on pain, anxiety or depression, sleep quality, quality of life, physical activity, handgrip strength, and polypharmacy.\n\nA double-blind, randomized, parallel-group controlled trial will be conducted in primary care centers in Lleida. Frail older adults (≥65 years) will be recruited and randomly allocated to either the intervention group, receiving a structured cognitive-motor dual-task based multicomponent program, or the control group, receiving usual care. Outcomes will be assessed using validated tools at baseline and follow-up.",[27,285,286,117],"Dual Task Exercises in Elderly People","Exercise Training",[288,289,290,291,292,293],"primary care Health [MeSH]","multicomponent intervention","exercise therapy [MeSH]","cognitive-motor dual-task","frail elderly [MeSH]","frailty [MeSH]","2025-09-24",{"date":296,"type":40},"2025-10-03",{"date":298,"type":19},"2026-01",{"date":300,"type":19},"2026-10",{"name":302,"class":47},"Universitat de Lleida",{"id":304,"slug":305,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":308,"acronym":309,"eligibilityCriteria":310,"healthyVolunteers":11,"sex":15,"minAge":311,"maxAge":4,"enrollmentInfo":312,"targetDuration":4,"studyType":113,"phases":4,"briefSummary":314,"conditions":315,"keywords":318,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":76},"100599609","frailty-in-hip-or-knee-arthroplasty-patients-100599609","NCT07086716","Frailty in Hip or Knee Arthroplasty Patients.","The Role of Frailty in the Rehabilitation Pathway Following Hip or Knee Arthroplasty Surgery.","FRAKH","Inclusion Criteria:\n\n* Received elective hip or knee arthroplasty;\n* Ability to understand written and oral instructions;\n* Gave consent to study participation.\n\nExclusion Criteria:\n\n* Arthroplasty revision or not elective intervention;\n* Participation in other studies;\n* Hospitalized in the rehabilitation ward more then 10 days after surgery.","18 Years",{"count":313,"type":19},124,"The study aims to understand the existing differences between frail and non-frail subjects who underwent a rehabilitation path after receiving hip or knee arthroplasty surgery.",[27,316,317],"Arthroplasties Hip Replacement","Arthroplasty Knee",[117,319,320,321,322],"Hip","Knee","Arthroplasty","rehabilitation","2025-07-18",{"date":325,"type":40},"2025-07-25",{"date":327,"type":40},"2025-06-03",{"date":329,"type":19},"2027-12",{"name":331,"class":47},"Joel Pollet",{"id":333,"slug":334,"hasResults":11,"nctId":335,"briefTitle":336,"officialTitle":337,"acronym":338,"eligibilityCriteria":339,"healthyVolunteers":11,"sex":15,"minAge":84,"maxAge":4,"enrollmentInfo":340,"targetDuration":4,"studyType":20,"phases":342,"briefSummary":343,"conditions":344,"keywords":346,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":357,"locationsCount":76},"100594105","applying-a-multidisciplinary-intervention-for-drug-adequacy-in-an-intermediate-care-hospital-amida-ich-100594105","NCT07015112","Applying a Multidisciplinary Intervention for Drug Adequacy in an Intermediate Care Hospital (AMIDA-ICH)","Applying a Multidisciplinary Intervention for Drug Adequacy in a Intermediate Care Hospital (AMIDA-ICH)","AMIDA-ICH","Inclusion Criteria:\n\n* older adults (65+ years)\n* ≥ 3 or more chronic conditions requiring medical therapy\n* able to speak Spanish\n* capacity to provide informed consent or have a surrogate able to consent on their behalf\n\nExclusion Criteria:\n\n* unable to provide informed consent\n* anticipated length of hospital stay \\\u003C 72h\n* estimated life expectancy \\\u003C 3 months\n* homeless\n* already enrolled in a drug trial",{"count":341,"type":19},300,[22],"The goal of this clinical trial is to learn if a multi-professional (conducted by geriatricians, clinical pharmacists, nurses) medication revision, centered on patients' goals and characteristics, can improve treatment adequacy in older adults admitted to an intermediate care hospital.\n\nThe main question it aims to answer is: does this approach reduce the average number of medications taken per patient?\n\nResearchers will compare this multi-professional patient-centered revision to the usual standard of care (treatment revision conducted by a clinical pharmacist) to see if the patient-centered revision works in improving treatment adequacy.\n\nParticipants admitted to an intermediate care hospital will undergo a comprehensive assessment by a geriatrician, and a medication revision (conducted by a multidisciplinary team or a clinical-pharmacist alone). They will also be asked to fulfill some questionnaires on their health status and attitudes. Any possible adverse events to the medications will be recorded at discharge. Participants will be contacted again three months after discharge to check for any readmission or death.",[345,27],"Poly Pharmacy",[347,33,348,349],"polypharmacy","adverse drug event","deprescribing","2025-06-10",{"date":352,"type":40},"2025-06-11",{"date":354,"type":40},"2024-01-04",{"date":356,"type":19},"2026-06",{"name":358,"class":47},"Parc Sanitari Pere Virgili",{"id":360,"slug":361,"hasResults":11,"nctId":362,"briefTitle":363,"officialTitle":364,"acronym":4,"eligibilityCriteria":365,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":366,"targetDuration":4,"studyType":20,"phases":368,"briefSummary":369,"conditions":370,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":76},"100564416","effect-of-modified-poco-poco-exercise-to-frailty-stages-expression-of-global-dna-methylation-gdf15-and-lamin-a-cop-100564416","NCT06628895","Effect of Modified Poco-Poco Exercise to Frailty Stages, Expression of Global DNA Methylation, GDF15 and Lamin A COP","Effect of Modified Poco-Poco Exercise to Frailty Stages, Expression of Global DNA Methylation, GDF15 and Lamin A COP on Elderly Living On Community in Bandung","Inclusion Criteria:\n\n1. Frailty level is in pre-frailty\n2. MoCA INA score above 18\n3. Domicile in Bandung City\n4. Willing to participate in the study after informed consent\n\nExclusion Criteria:\n\n1. There is a hearing impairment that may prevent the subject from receiving verbal instructions\n2. There is uncorrected visual impairment\n3. There are musculoskeletal disorders so that they cannot perform exercise procedures or procedures for measuring research variables\n4. Subjects received other rehabilitation programs\n5. Post-stroke with average limb muscle strength below three\n6. There are diseases that cause impaired cognition such as Alzheimer\\'s disease, traumatic head injury, Parkinson\\'s disease.\n7. There are severe joint diseases such as osteoarthritis and rheumatoid arthritis that may worsen during exercise or may cause difficulty in carrying out the exercise program.\n8. Severe cardiovascular disease as assessed by a heart and vascular specialist\n9. Unable to attend Exercises regularly",{"count":367,"type":19},17,[22],"The goal of this clinical trial is to know the effect of multicomponent exercise in frail elderly in community to aging hallmarks. The main question\\[s\\] it aims to answer are:\n\n1. Do global DNA methylation levels change in elderly people in Bandung after receiving modified poco-poco exercise?\n2. Do GDF15 levels change in elderly people in Bandung after they are given modified poco-poco exercise?\n3. Do lamin A COP levels change in elderly people in Bandung after they are given modified poco-poco exercise?\n4. Does the level of frailty in elderly people in Bandung change after they are given modified poco-poco exercise?\n\nParticipants will be asked to do flexibility, balance, aerobic and strengthening exercise included in poco-poco modified exercise three times a week for 12 weeks",[27],"2025-02-27",{"date":373,"type":40},"2025-03-04",{"date":375,"type":40},"2024-09-15",{"date":377,"type":19},"2025-04-30",{"name":379,"class":47},"Universitas Padjadjaran",{"id":381,"slug":382,"hasResults":11,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":4,"eligibilityCriteria":386,"healthyVolunteers":11,"sex":15,"minAge":84,"maxAge":4,"enrollmentInfo":387,"targetDuration":4,"studyType":20,"phases":389,"briefSummary":390,"conditions":391,"keywords":392,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":395,"lastUpdatePostDateStruct":396,"startDateStruct":398,"completionDateStruct":399,"leadSponsor":401,"locationsCount":76},"100567681","video-decision-support-for-advance-care-planning-in-geriatric-patients-with-frailty-100567681","NCT06671353","Video Decision Support for Advance Care Planning in Geriatric Patients With Frailty","Randomized, Controlled Trial of a Video Decision Support for Advance Care Planning in Geriatric Patients With Frailty","Inclusion Criteria:\n\n* age \\> or = 65 y\u002Fo can communicate and sign informed consent diagnosed to be frailty with clinical frailty scale 4-7\n\nExclusion Criteria:\n\n* impaired visual acuity or hearing that can't watch video had signed advance decision before",{"count":388,"type":19},96,[22],"As the proportion of the aging population continues to rise, age-related frailty syndrome, characterized by a decline in the function of multiple physiological systems and accompanied by vulnerability to stress, has become a significant issue. It has been associated with higher mortality rates, hospitalization rates, risk of falls, occurrence of fractures, decreased mobility, depression, cognitive decline, dementia, loneliness, and admission to long-term care facilities. Advance care planning is a thoughtful and communicative process that helps individuals, while still cognitively capable, to pre-determine and express their preferences for medical care in the event of future incapacity. With the ongoing development in the field of frailty and the rapid aging of the population, the increasing age may be accompanied by severe illnesses, symptom burden, functional dependence, caregiver burden, and extensive medical utilization. The importance of advance care planning is increasingly emphasized, but its implementation and promotion remain challenging. In addition to systematic promotion from a policy perspective, tools to assist patients in decision-making have been proposed. Video decision aids can encourage people to engage in advance care planning by sparking conversations about informed consent and helping individuals contemplate the choices they may face. Video decision aids can also assist individuals in envisioning future scenarios and reflecting on their decisions. Previous randomized controlled trials have explored the benefits of such video tools for specific patient populations, such as cancer patients, heart failure patients, and elderly individuals hospitalized. However, there is a need for innovative approaches to enhance the knowledge, willingness, and actual signing rates of advance care planning for frail elderly individuals. This study aims to develop a video decision aid specifically tailored for the elderly frail population undergoing advance care planning.\n\nThrough a randomized controlled trial, the study aims to validate its actual benefits, expecting to assist the elderly frail population in understanding and expressing their willingness for advance care planning, increasing the actual willingness to sign advance directives, and helping clinical healthcare teams achieve person-centered, high-quality care for this population.",[27],[33,393,394],"advance care planning","shared decision making","2024-11-19",{"date":397,"type":40},"2024-11-21",{"date":395,"type":40},{"date":400,"type":19},"2027-12-01",{"name":402,"class":47},"National Taiwan University Hospital",{"id":404,"slug":405,"hasResults":11,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":409,"eligibilityCriteria":410,"healthyVolunteers":11,"sex":15,"minAge":411,"maxAge":4,"enrollmentInfo":412,"targetDuration":4,"studyType":20,"phases":414,"briefSummary":415,"conditions":416,"keywords":420,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":432,"locationsCount":76},"100563564","advanced-practice-nurses-for-fall-incidence-prevention-in-very-old-robust-adults-100563564","NCT06617806","Advanced Practice Nurses for Fall Incidence PrevenTion in Very Old Robust Adults","Advanced Practice Nurses for Fall Incidence PrevenTion in Robust Very Old Adults: Protocol for the APN-FIT Hybrid Randomized Controlled Trial","APN-FIT","Inclusion criteria:\n\n* Aged 80 or over;\n* Vigorous according to the \" Clinical Frailty Scale \" (scores 1, 2, 3) ;\n* Having a referring primary care physician working in pairs with the local Advanced Practice Nurse;\n* affiliated to a Health Care Plan\n* Informed and having signed consent to participate in the research.\n\nExclusion criteria:\n\n* Under guardianship or trusteeship;\n* Unable to travel to the primary care office or unable to follow the adapted physical activity program;\n* Poor understanding of French.","80 Years",{"count":413,"type":19},386,[22],"APN-FIT is a hybrid type 1 clinical trial comparing the effect of an APN delivered fall prevention programme with standard care in non-frail patients. All participants will receive a full geriatric assessment at enrolment and, on a voluntary basis, physical activity programmes during the 12-month period. Falls occurring during the study will be recorded at 2, 4, 6, 8, 10 and 12 months after enrolment. An ancillary study will specifically examine implementation outcomes of the tested intervention.",[417,418,27,419],"Fall Prevention","Autonomy of Older People","Advanced Practice Nursing",[421,175,422,423,424],"Fall prevention","Frailty - robustness","Advanced practice nurses","Very old adults","2024-11-13",{"date":427,"type":40},"2024-11-15",{"date":429,"type":40},"2024-10-15",{"date":431,"type":19},"2027-10-31",{"name":433,"class":47},"Nantes University Hospital",{"id":435,"slug":436,"hasResults":11,"nctId":437,"briefTitle":438,"officialTitle":439,"acronym":4,"eligibilityCriteria":440,"healthyVolunteers":11,"sex":15,"minAge":84,"maxAge":4,"enrollmentInfo":441,"targetDuration":4,"studyType":20,"phases":443,"briefSummary":444,"conditions":445,"keywords":448,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":451,"lastUpdatePostDateStruct":452,"startDateStruct":454,"completionDateStruct":456,"leadSponsor":457,"locationsCount":101},"100369184","innovative-models-in-the-rehabilitation-of-the-elderly-with-parkinsons-disease-through-technological-innovation-100369184","NCT04087031","Innovative Models in the Rehabilitation of the Elderly With Parkinson's Disease Through Technological Innovation","Assistive Robotic in the Elderly: Innovative Models in the Rehabilitation of the Elderly With Parkinson's Disease Through Technological Innovation","Inclusion Criteria:\n\n* Hoen and Yahr scale: 1-3 stage\n* FAC ≤ 2\n* Ranking scale score ≤ 3\n* Stability of drug treatment for at least 1 month\n* Geriatric Depression Scale 5-items: negative\n\nExclusion Criteria:\n\n* Concomitant participation in other studies\n* Lack of written informed consent\n* Clinical dementia rating (CDR) score ≥ 3\n* History of syncopal episodes, epilepsy and vertigo not controlled pharmacologically\n* Serious dysfunction of the autonomic system\n* Severe behavioral syndromes not compensated by drugs\n* Concurrent neurological diseases\n* Severe systemic diseases with life expectancy \\\u003C 1 year\n* Patients unable to follow up.",{"count":442,"type":19},195,[22],"The final goal of the present study is to propose a new approach in the Parkinson's Disease rehabilitation, focused on the use of robotic devices and to check the results not only at the end of the treatment but also in the long term, foreseeing 3 follow-up.",[446,27,447],"Parkinson Disease","Robotic Devices in Rehabilitation",[449,450,63,322],"Parkinson disease","robotics","2023-10-20",{"date":453,"type":40},"2023-10-23",{"date":455,"type":40},"2019-12-03",{"date":73,"type":19},{"name":458,"class":47},"Istituto Nazionale di Ricovero e Cura per Anziani"]