[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"frailty-at-older-adults\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:frailty-at-older-adults":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,56,86,112,138,168,194,219,247,268,299,326,353,384,416,443,472],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100639065","evaluation-of-the-impact-of-virtual-park-on-training-motivation-in-adult-patients-100639065",false,"NCT07616050","Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients","Evaluation of the Impact of a Rehabilitation Intervention Based on Cycling With Virtual Park on Training Motivation in Adult Patients","VP_Adults","Inclusion Criteria:\n\n* Informed consent to the study\n* subjects \\> 18 years and \\\u003C85 years\n* diagnosis of MCI according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders VTh Edition (DSM V TR American Psychological Association 2013)\n* detection of ischemic stroke within 6 months preceding the study, frail elderly subjects (Gobbens RJ et al. 2010)\n* subjects affected by idiopathic Parkinson's disease according to the MDS-PD criteria (Postuma et al., 2015)\n* subjects affected by possible, probable and definite ALS according to the revised El Escorial criteria (Brooks Br, et al. 2000)\n* subjects affected by MS according to the McDonald criteria (2017) with disability measured with the EDSS (Expanded Disability Status Scale) \\\u003C= 8\n* patients with spinal cord injury of different etiology with incomplete spinal cord injury, AIS (ASIA impairment scale) grade C and D, MMSE \\>18\n* subjects naïve to the use of the RV\n* no therapeutic changes or rehabilitation interventions in the month prior to inclusion in the study\n* no ongoing behavioral disorders.\n\nExclusion Criteria:\n\n* Other concomitant neurological pathologies in addition to the one under study\n* presence of visual disturbances that do not allow access to the experimental virtual reality protocol\n* presence of impaired cardiorespiratory function or other organic instabilities that contraindicate ergometer training\n* severe osteoporosis","ALL","18 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this clinical study is to evaluate the feasibility, usability, and motivational impact of VirtualPark, a virtual reality-based dual-task rehabilitation system, in adults with neurological and age-related conditions.\n\nVirtualPark is a virtual reality application designed to deliver cognitive exercises during cycling training using a commercially available ergometer (THERA-Trainer Tigo). The system integrates physical and cognitive tasks in simulated real-life environments.\n\nThe intervention integrates motor and cognitive training tasks targeting domains such as attention, inhibition, working memory, and navigation.\n\nThis is a prospective, multicenter, randomized, cross-over pilot study. It will compare cycling training performed with and without virtual reality. Participants will complete both intervention conditions over a 4-week period separated by a wash-out phase with standard rehabilitation activities. The order of conditions will be randomized.\n\nThe study will assess motivation during rehabilitation training, usability and user experience of the system, as well as exploratory effects on cognitive and motor performance, functional abilities, perceived exertion, and safety.\n\nThe study will enroll adult participants (≥18 years) with conditions such as stroke, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, mild cognitive impairment, spinal cord injury, and frail older adults.",[27,28,29,30,31,32],"Post-stroke","Parkinson Disease","Amyotrophic Lateral Sclerosis","Mild Cognitive Impairment (MCI)","Multiple Sclerosis","Frailty at Older Adults",[34,35,29,36,31,37,38,39,40,41,42],"post-stroke","parkinson disease","Mild Cognitive Impairment","spinal cord injury","rehabilitation","dual-task","virtual reality","intrinsic motivation","frail elderly patients with multiple comorbidities","NOT_YET_RECRUITING","2026-05-25",{"date":46,"type":47},"2026-05-29","ACTUAL",{"date":49,"type":21},"2026-06",{"date":51,"type":21},"2027-01",{"name":53,"class":54},"Marta Mondellini","OTHER",7,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":63,"minAge":64,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100638695","frailty-in-older-adults-with-prostate-cancer-a-prospective-cohort-study-100638695","NCT07605936","Frailty in Older Adults With Prostate Cancer: a Prospective Cohort Study","A Prospective Cohort Study to Assess Frailty, Healthcare Needs and Health Related Quality of Life in Patients With a Diagnosis of Prostate Cancer","Inclusion Criteria:\n\n* adults aged ≥65 years with a diagnosis of prostate cancer\n\nExclusion Criteria:\n\n* Neither the patient nor the carer has sufficient proficiency in English sufficiently to complete consent or baseline assessment\n* Patients will be excluded if they present outside of research nurse (RN) operational hours( 8am and 5pm Monday - Friday).\n* Patients who are acutely unwell and unable to answer the questionnaire will also be excluded.","MALE","65 Years",{"count":66,"type":21},80,"OBSERVATIONAL","Prostate cancer is the most common solid tumour cancer amongst men in Ireland, with almost 4,000 new cases diagnosed annually and a median age at diagnosis of 67 years. The incidence of frailty amongst cancer patients is high. Among patients undergoing systemic anti-cancer therapy, frailty increases the risk of treatment related toxicity, hospitalisation, and death and is associated with a poorer quality of life.\n\nThis study aims to describe the demographic, clinical and frailty characteristics of men living with prostate cancer in the Mid-West of Ireland. In addition, we will assess the predictive accuracy of three frailty screening tools currently used in Irish clinical practice,G8, CFS and PRISMA 7, for predicting poorer outcomes at baseline, 6 and 12 months.",[32,70],"Prostate Cancer",[72,73,74],"frailty","older adults","prostate cancer","RECRUITING","2026-05-18",{"date":78,"type":47},"2026-05-26",{"date":80,"type":47},"2026-04-23",{"date":82,"type":21},"2027-11",{"name":84,"class":54},"University of Limerick",1,{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":94,"sex":17,"minAge":64,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":97,"conditions":98,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":85},"100636818","implementation-of-a-clinical-decision-support-system-in-primary-care-for-the-screening-and-assessment-of-frailty-in-patients-aged-65-and-over-100636818","NCT07570628","Implementation of a Clinical Decision Support System in Primary Care for the Screening and Assessment of Frailty in Patients Aged 65 and Over","Implementation of a Clinical Decision Support System in Primary Care for the Screening and Assessment of Frailty in Patients Aged 65 and Over: A Real-World Prospective Cohort Study","FRAGICLIC","Inclusion Criteria:\n\n* Patients aged 65 years or older\n* Patient or trusted person who provided oral non-opposition after receiving full information about the protocol\n* Managed by the general practitioner if the patient or nurse during the study period. If patients are assessed by a nurse : Patients whose general practitioner is a participating physician in the study\n\nExclusion Criteria:\n\n* Patients unable to express non-opposition or without a trusted person available to express non-opposition\n* Patients whose general practitioner (GP) is not a participating GP in the study\n* Patients or trusted persons who do not speak French",true,{"count":96,"type":21},726,"This observational study aims to evaluate the real-life use of a digital tool (Fragiclic) by general practitioners (GPs) and nurses to screen and assess frailty in adults aged 65 and over. Frailty is a syndrome that increases the risk of loss of autonomy, falls, hospitalizations, or death. The tool includes simple screening questionnaires (such as SEGAm) and a comprehensive assessment (CGA - Comprehensive Geriatric Assessment) to better manage patients' health.\n\nThe main question it aims to answer is:\n\n* What proportion of patients aged 65 and over will benefit from frailty screening or assessment using Fragiclic over 12 months?\n\nA secondary question is\n\n\\- Does the use of Fragiclic reduce the risk of unplanned hospitalizations or death in these patients?\n\nFor the secondary question, researchers will compare patients who received screening or assessment (with or without a Personalized Care Plan (PCP)) to those who did not, to determine if Fragiclic improves their health outcomes.\n\nParticipants will not have additional tasks: Their GP or nurse will use Fragiclic during routine consultations. Some patients may be asked to provide information about their health or quality of life (via their healthcare provider).\n\nAll data will be collected anonymously and securely",[32,99,100,101,102],"Primary Care","Geriatric Assessment","Implementation Research","Interprofessional Collaboration","2026-05-11",{"date":105,"type":47},"2026-05-13",{"date":107,"type":21},"2027-01-02",{"date":109,"type":21},"2029-01-02",{"name":111,"class":54},"CNGE Conseil",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":119,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":124,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":85},"100577745","preventing-frailty-in-hospital-through-mobilizing-100577745","NCT06802289","Preventing Frailty in Hospital Through Mobilizing","Preventing Frailty in Hospital Through Mobilizing Patients: A Pilot RCT","Inclusion Criteria:\n\nEligible patients are:\n\n1. 50 years or older,\n2. projected to be in-hospital for at least 3-days,\n3. not in a shared room with another study participant, and\n4. can independently provide consent or have a caregiver to provide consent.\n\nExclusion Criteria:\n\n* Patients enrolled in other clinical trials or interventions that might confound the results of the study.","50 Years",{"count":66,"type":21},[24],"Frailty describes the variability in aging and explains why two people of the same chronological age may look very different. Higher frailty leads to poor quality of life, disability, and death. Hospitalized patients living with frailty have a higher risk for functional decline, new impairments in activities of daily living, a longer hospital stay, hospital readmission, and death. A previous study from our team has reported that 60% of inpatients have more difficulty with 1+ basic activity of daily living (i.e., eating, getting out of bed, using the toilet, etc.) after hospitalization compared to pre-admission, with 1-in-4 patients having difficulty with 3+ basic tasks. Patients with few health deficits can recover to their pre-admission level, but those with higher frailty levels cannot, priming them for readmissions. Physical activity and reducing time spent sitting or lying postures prevent and improve frailty. Older patients who walk at least once\u002Fday outside their room during hospitalization have \\~1.7 days shorter length of hospital stay compared with those who stayed in their room. Although multiple barriers exist to promoting upright time in a hospital, strategies that help address patients' excessive time spent in bed are often not implemented but could attenuate the development of frailty in the hospital. Few exercise interventions in hospital studies have considered frailty. The investigators have conducted a clinical trial within the Halifax Infirmary (Nova Scotia Health) that focused on mobilizing patients (average age: \\~75 years) via regular visits by a Kinesiologist and observed that the intervention groups reduced their frailty level from preadmission and admission versus discharge. While preliminary findings from this model were promising, its reach was limited to acute geriatric care and dependent upon researchers to conduct the intervention. At the Georges-L. Dumont hospital, a patient mobilization program has been introduced in General and Internal Medicine (floor 4C) that embedded Kinesiologists within care to visit patients daily. Preliminary findings indicate that patients and staff are enjoying the program via self-report questionnaire. However, evaluations of the program's effectiveness in changing objectively measured activity and frailty levels and whether multiple patient visits would be more effective (e.g., refining the program) are unclear. The investigators propose to evaluate the effectiveness of the existing patient mobilization program and if more patient contact improves outcomes. Our study integrates activity monitoring technology and frailty assessments to help patients leave the hospital healthier and decrease the risk of readmission. Study Objectives: The proposed study will test the hypothesis that, compared to usual care (Kinesiology visit once\u002Fday), patients who receive multiple check-ins will, 1) increase their step counts and upright time, 2) decrease their frailty level, and 3) have a less length of stay and less readmission rates.",[32],[125,126,127,128],"Frailty management","Mobilization","Sex differences","Physical activity","2026-04-28",{"date":131,"type":47},"2026-04-29",{"date":133,"type":47},"2025-01-13",{"date":135,"type":21},"2026-08-30",{"name":137,"class":54},"Université de Sherbrooke",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":17,"minAge":146,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":22,"phases":150,"briefSummary":151,"conditions":152,"keywords":153,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":85},"100632439","enhancing-physical-reserve-to-promote-resilience-in-physically-frail-older-adults-100632439","NCT07513701","Enhancing Physical Reserve to Promote Resilience in Physically Frail Older Adults","Enhancing Physical Reserve to Promote Cognitive and Physical Resilience in Physically Frail Older Adults: A 3-Month Randomized Controlled Trial","MRI exercise","Inclusion Criteria:\n\n1. are community-dwelling (i.e., not residing in a nursing home or extended care unit) ;\n2. scored \\\u003C 9\u002F12 on the SPPB;\n3. scored \\>18\u002F30 on the MoCA;\n4. are able to walk independently; use of walking aid is acceptable;\n5. are able to safely engage in exercise as indicated by the Physical Activity Readiness Questionnaire Plus33 and confirmed by their physician;\n6. have internet at home; and\n7. are able to provide written informed consent.\n\nExclusion Criteria:\n\n1. diagnosed with dementia or stroke;\n2. self-report engaging in strength and balance training exercises \\> two-times-per-week in the 3 months prior to screening;\n3. unable to understand, speak, and read Cantonese\u002FChinese\u002FEnglish proficiently; and\n4. contraindications for MRI such as MRI-incompatible implants.","60 Years","90 Years",{"count":149,"type":21},224,[24],"The goal of this clinical trial is to assess the efficacy of combined aerobic and resistance training in enhancing physical reserve in older adults with physical frailty. Investigator contend that enhanced physical reserve will enable preservation of cognitive and physical function. The main questions aims to answer are: (1) Compared with usual care (i.e., CON), will 3-month aerobic and resistance training (ATRT) improve physical reserve in older adults with physical frailty? (2) Compared with CON, will ATRT lead to changes in the neural network organization? (3) Will improved physical reserve lead to better maintenance of cognitive and physical functioning in spite of presence of white matter hyperintensities (WMH)?",[32],[154,155,156,157,158],"physical frailty","aerobic exercise","resistance training","magnetic resonance imaging","physical reserve","2026-03-30",{"date":161,"type":47},"2026-04-07",{"date":163,"type":47},"2026-01-19",{"date":165,"type":21},"2029-03-31",{"name":167,"class":54},"The Hong Kong Polytechnic University",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":17,"minAge":64,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":178,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":85},"100587245","effect-of-micronized-creatine-monohydrate-on-muscle-mass-strength-and-performance-in-older-adults-submitted-to-total-knee-arthroplasty-100587245","NCT06925880","Effect of Micronized Creatine Monohydrate on Muscle Mass, Strength and Performance in Older Adults Submitted to Total Knee Arthroplasty","Efficacy of Supplementation With Micronized Creatine Monohydrate in the Recovery of Muscle Mass, Muscle Strength and Functional Capacity in Older Adults Operated on for Total Knee Arthroplasty: Randomized Clinical Trial","CREAR","Inclusion Criteria:\n\n* Persons 65 years of age or older who have been operated on for the first time for total knee arthroplasty,\n* who are undergoing an outpatient rehabilitation program according to standard clinical practice,\n* who sign the informed consent form.\n\nExclusion Criteria:\n\n* Chronic renal disease at stage G3b or higher or glomerular filtration rate \\\u003C30 ml\u002Fmin\u002F1.73m2.\n* Hepatic insufficiency, cirrhosis.\n* Neuromuscular and neurodegenerative diseases (amyotrophic lateral sclerosis, multiple sclerosis, muscular dystrophy, myasthenia gravis, Parkinson's disease, etc.).\n* Severe or very severe chronic obstructive pulmonary disease (COPD) (GOLD III-IV).\n* Moderate or severe chronic heart failure (NYHA 3-4).\n* Central sensitivity syndrome (fibromyalgia and chronic fatigue syndrome).\n* Moderate or severe cognitive impairment (GDS≥4).\n* Moderate-severe dependence for basic activities of daily living (preintervention Barthel index \\\u003C60 points).\n* Hemiparesis, amputation or malformation of any limb.\n* Consumption of creatine monohydrate supplements in the last 6 months.",{"count":177,"type":21},262,[24],"Double-blind randomized placebo-controlled clinical trial with two parallel arms. The main objective is to evaluate the efficacy and safety of creatine supplementation in older adults who have been operated on for total knee arthroplasty and undergoing a usual rehabilitation program. The intervention will consist of daily creatine monohydrate supplementation for 12 weeks. The intervention will start after surgery with a loading dose of 20g\u002Fday for 1 week and then continue with a maintenance dose of 5g\u002Fday for 11 weeks.\n\nMain outcome mesures included muscle mass, muscle strenght, sarcopenia, frailty, functional capacity and physical performance and will be assessed at baseline, 3 and 6 months follow-up.",[181,32,182,183,184,185],"Sarcopenia in Elderly","Functional Capacity","Creatine Supplementation","Arthroplasties, Knee Replacement","Physical Performance","2026-03-25",{"date":159,"type":47},{"date":189,"type":47},"2025-06-10",{"date":191,"type":21},"2027-10-31",{"name":193,"class":54},"Consorci Sanitari del Maresme",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":17,"minAge":146,"maxAge":147,"enrollmentInfo":201,"targetDuration":4,"studyType":22,"phases":203,"briefSummary":204,"conditions":205,"keywords":206,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":85},"100631181","a-novel-multi-modal-approach-to-promote-functional-outcomes-in-cognitively-frail-older-adults-100631181","NCT07497334","A Novel Multi-Modal Approach to Promote Functional Outcomes in Cognitively Frail Older Adults","TMS MRI TBS","Inclusion Criteria:\n\n1. be between 60 and 90 years old;\n2. scored \\\u003C 9\u002F12 on the SPPB;\n3. scored \\>18\u002F30 on the MoCA;\n4. scored \\>9\u002F42 on the PFFS;\n5. lived in the community;\n6. be able to ambulate up to four meters with or without assistive devices;\n7. be able to provide written informed consent on their own behalf;\n8. can understand verbal and written Cantonese and\u002For English.\n\nExclusion Criteria:\n\n1. have magnetic resonance imaging (MRI) contraindications;\n2. have aerobic exercise contraindications;\n3. have transcranial magnetic stimulation contraindications;\n4. be diagnosed with neurodegenerative conditions (i.e., dementia, Parkinson's, Alzheimer's disease, Amyotrophic lateral sclerosis, and stroke);\n5. live in a nursing home or other care facilities\u002Finstitutions;\n6. bed taking fixed dose of medication or had been taking medications known to potentially affect cognitive and physical function (e.g., psychotropic medications), as identified through a review of their medication lists recorded in the health software. Medications were categorized by properties (e.g., antipsychotics, antidepressants, etc.) to inform eligibility decisions.\n7. have a history indicative of carotid sinus sensitivity (i.e., falls due to loss of consciousness);\n8. cancer and undergo radiation therapy.",{"count":202,"type":21},45,[24],"The goal of this clinical trial is to explore the effects of intermittent theta burst stimulation (iTBS) primed with theta burst stimulation (cTBS), on top of aerobic exercise, on cognitive function, mobility, and brain activity in older adults with cognitive frailty. Understanding these effects will help us develop intervention models that benefit cognitively frail older adults. The main questions it aims to answer are:\n\n1. Does the combination of iTBS primed with cTBS and aerobic exercise lead to greater improvements in cognition and mobility in older adults with cognitive frailty compared to non-priming iTBS and sham stimulation?\n2. What are the neural mechanisms responsible for the improvements in cognition and mobility associated with the combination of iTBS primed with cTBS and aerobic exercise in older adults with cognitive frailty?",[32,36],[207,208,209,155,210],"cognitive frailty","cTBS","iTBS","fMRI","2026-03-23",{"date":213,"type":47},"2026-03-27",{"date":215,"type":47},"2025-01-05",{"date":217,"type":21},"2027-06-30",{"name":167,"class":54},{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":225,"eligibilityCriteria":226,"healthyVolunteers":94,"sex":17,"minAge":227,"maxAge":4,"enrollmentInfo":228,"targetDuration":4,"studyType":22,"phases":230,"briefSummary":231,"conditions":232,"keywords":233,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":246},"100627347","motivational-support-for-an-autonomous-exercise-program-for-healthy-aging-100627347","NCT07447453","Motivational Support for an Autonomous Exercise Program for Healthy Aging","Computational Ecosystem With Motivational Support and Functional Assessment for an Autonomous Exercise Program Promoting Healthy Aging (MOTIVA)","MOTIVA","Inclusion Criteria:\n\n* 70 years of age or older.\n* Obtain a score of 4 or higher on the SPPB.\n* Be able to ambulate, with or without assistance.\n\nExclusion Criteria:\n\n* Be unable to give consent or refuse to do so.\n* Be unable to understand the instructions.\n* Have a diagnosis of a disease or clinical condition that, in the researcher's judgment, contraindicates physical exercise.","70 Years",{"count":229,"type":21},190,[24],"An effective implementation of an exercise programme such as VIVIFRAIL, in an unsupervised mode, requires a careful consideration of the patient's motivational traits and state, and the adaptation of the interventions to the current stage in the behaviour change process, as critical countermeasures to fight against abandonment and lack of compliance. A computational ecosystem with motivational support, and functional and performance assessment for an autonomous exercise programme will improve the robust and prefrail community-dwelling older adults' independence and their physical and cognitive health, while reducing healthcare utilisation.",[32],[234,235,236],"Frailty","Clinical trial","Motivational profile","2026-02-26",{"date":239,"type":47},"2026-03-03",{"date":241,"type":47},"2025-04-08",{"date":243,"type":21},"2026-07-31",{"name":245,"class":54},"Hospital Universitario Getafe",2,{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":253,"eligibilityCriteria":254,"healthyVolunteers":11,"sex":17,"minAge":146,"maxAge":4,"enrollmentInfo":255,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":257,"conditions":258,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":85},"100622090","implementation-of-the-personalized-care-plan-pcp-proposed-at-the-end-of-step-2-of-the-icope-program-100622090","NCT07379099","Implementation of the Personalized Care Plan (PCP) Proposed at the End of Step 2 of the ICOPE Program","Implementation of the Personalized Care Plan (PCP) Proposed at the End of Step 2 of the ICOPE Program : Description of the Procedures for Negotiating the PCP With the Patient, the Procedures for Implementing the PCP in a Multi-professional Setting, and Implementation of the PCP at 1 Year","INEPPS","Inclusion Criteria:\n\n* Age ≥ 60 years\n* ADL ≥ 5.5\n* Affiliated or beneficiary of a social security scheme or equivalent.\n* having completed a STEP 2 ICOPE\n* not opposed to the collection of their data",{"count":256,"type":21},600,"The ICOPE (Integrated Care for the Elderly) program is based on an integrated approach including a personalized care plan (PCP). Negotiation methods with the patient and interprofessional cooperation could be key elements in the success of this program. The main objective is to evaluate the feasibility of the implementation of the ICOPE program on the number and content of the PCP carried out at 1 year",[234,32],"2026-01-23",{"date":261,"type":47},"2026-01-30",{"date":263,"type":47},"2024-12-01",{"date":265,"type":21},"2028-04-01",{"name":267,"class":54},"MSPU de Pins-Justaret",{"id":269,"slug":270,"hasResults":11,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":4,"eligibilityCriteria":274,"healthyVolunteers":11,"sex":275,"minAge":276,"maxAge":4,"enrollmentInfo":277,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":279,"conditions":280,"keywords":285,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":85},"100609894","the-better-harder-faster-stronger-study-100609894","NCT07220512","The Better, Harder, Faster, Stronger Study","The BHFS Study (Better, Harder, Faster, Stronger): Does Neoadjuvant Chemotherapy Improve Fitness for Surgery?","Inclusion Criteria:\n\n* Ability to understand and willingness to sign an IRB-approved informed consent.\n* Age \\> 55 years at the time of enrollment.\n* Newly diagnosed suspected ovarian\u002Fprimary peritoneal\u002Ffallopian tube carcinoma of any histological subtype, FIGO Stage II-IV, per enrolling investigator, or newly diagnosed suspected endometrial carcinoma of any histologic subtype, FIGO Stage II-IV, per enrolling investigator.\n* Planned for 3 or 4 cycles of NACT, with interval cytoreductive surgery planned thereafter.\n* Ability to read, understand, and write the English language.\n* As determined by the enrolling investigator, ability of the participant to understand and comply with study procedures for the entire length of the study.\n\nExclusion Criteria:\n\n* History of brain metastases.\n* History of poorly controlled psychiatric conditions, defined as hospitalization within the prior 3 months for psychiatric disorders, traumatic brain injury, cerebrovascular event, or dementia, per the enrolling investigator.\n* Use of anti-amyloid agents, cholinesterase inhibitors, or glutamate regulators at the time of enrollment.\n* Vision impairment that would impede completion of study assessments, per enrolling investigator.","FEMALE","55 Years",{"count":278,"type":21},35,"The purpose of this study is to evaluate changes in the electronic Frailty Index (eFI) score following 3-4 cycles of neoadjuvant chemotherapy (NACT) in participants with advanced ovarian and endometrial cancer.",[32,281,282,283,284],"Ovarian Cancer","Endometrial Cancer","Cognitive Dysfunction","Neoadjuvant Chemotherapy",[234,286,287,288,289],"ovarian cancer","endometrial cancer","cognitive dysfunction","neoadjuvant chemotherapy","2025-10-22",{"date":292,"type":47},"2025-10-24",{"date":294,"type":47},"2025-07-28",{"date":296,"type":21},"2027-05",{"name":298,"class":54},"Wake Forest University Health Sciences",{"id":300,"slug":301,"hasResults":11,"nctId":302,"briefTitle":303,"officialTitle":304,"acronym":4,"eligibilityCriteria":305,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":306,"targetDuration":4,"studyType":22,"phases":308,"briefSummary":309,"conditions":310,"keywords":311,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":324,"locationsCount":85},"100607113","interprofessional-education-programme-for-nursing-and-physiotherapy-students-providing-home-based-care-to-older-adults-100607113","NCT07184333","Interprofessional Education Programme for Nursing and Physiotherapy Students Providing Home-Based Care to Older Adults","Interprofessional Education and Connected Care: A Home-Based Digital-Integrated Frailty Management Programme for Older Adults With Mild Impairments","Students\n\nInclusion criteria:\n\n* Aged 18 years or above.\n* Nursing students: Year 3 Higher Diploma in Nursing students at HKMU enrolled in NURS N222C Clinical Practicum. OR Physiotherapy students: Year 3 and Year 4 Bachelor of Science (Hons) in Physiotherapy students at HKMU enrolled in PHSI N212F Clinical Practicum II.\n* Able to read Chinese and English, and speak Cantonese.\n* Willing to participate in the training workshop and conduct home-based intervention.\n\nOlder Adults\n\nInclusion criteria:\n\n* Aged 60 years or above.\n* Service users of AKA.\n* Mild impairments (non-bedbound, physically capable of participating in simple exercises).\n* Able to read Chinese and\u002Fcommunicate in Cantonese.\n* Willing to participate in health surveys, home visits, and follow-ups, and to receive and respond to text messages.\n* Must own a smartphone and know how to use it.\n\nStudents\n\nExclusion criteria:\n\n* Unwilling to provide consent.\n* Cannot read Chinese or speak Cantonese.\n\nOlder adults\n\nExclusion criteria:\n\n* Not a registered service user from AKA.\n* Unwilling to provide consent.\n* Cannot read Chinese or speak Cantonese.\n* Unwilling to participate in the interventions conducted by students.\n* Severe communication impairments.\n* Do not own a smartphone.",{"count":307,"type":21},150,[24],"The goal of this mixed-methods research is to investigate the impact of interprofessional education on the professional development and clinical skills of nursing and physiotherapy students who provide home-based care to older adults in Hong Kong. The main questions it aims to answer are:\n\n1. Is an interprofessional home-based digital frailty management program feasible for training nursing and physiotherapy students ?\n2. Can the training enhance students' skills in providing holistic, home-based care, interprofessional teamwork and communication?\n3. Can the training improve elderly health awareness, behavior, and outcomes?\n\nThe study will involve 50 students from Hong Kong Metropolitan University, including nursing and physiotherapy students in clinical placement courses. Approximately 100 older adults with mild health conditions, living in home-based community settings, will take part as care recipients.\n\nStudents will:\n\n1. Attend a training programme delivered by healthcare professionals, including nurses, physiotherapists, and social workers.\n2. Carry out supervised home visits in pairs, working directly with older adults to assess their needs, provide health education, and support healthy lifestyle changes.\n3. Use a tablet-based digital platform to record care plans, share information, and follow up with participants.",[32],[312,313,72,314,73,315,316,317],"Interprofessional education","home-based care","interprofessional collaboration","nursing","physiotherapy","student","2025-09-14",{"date":320,"type":47},"2025-09-19",{"date":322,"type":47},"2025-09-01",{"date":243,"type":21},{"name":325,"class":54},"Hong Kong Metropolitan University",{"id":327,"slug":328,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":4,"eligibilityCriteria":332,"healthyVolunteers":94,"sex":17,"minAge":146,"maxAge":333,"enrollmentInfo":334,"targetDuration":4,"studyType":22,"phases":336,"briefSummary":337,"conditions":338,"keywords":342,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":85},"100599184","dose-response-effect-of-community-dance-programme-100599184","NCT07081191","Dose-response Effect of Community Dance Programme","Dose-response Effect of Community Dance Programme on the Physical, Cognitive, Psychosocial Health of Pre-frail and Mildly Frail Older Adults: A Cluster Randomised Trial With Co-design Approach and Process Evaluation","Inclusion Criteria:\n\n* Aged 60 to 85.\n* Able to understand and communicate in either English or Mandarin.\n* Able to give consent to participate.\n* Able to commit for three months and able to achieve at least an attendance rate of 75% for the dance program.\n* Lives within the community setting.\n* Abbreviated Mental Test (AMT) score\\>= 8\n* Obtain a score of less than or equal to 7 in Edmonton Frail Scale - Acute Care or less than or equal to 5 in Clinical Frailty Scale\n* Able to ambulate with minimal assistance\n* Willing to avoid other physical exercise during the interventional period.\n* Consent to video and photography of the dance sessions and audio recording of the FGDs.\n\nExclusion Criteria:\n\n* Abbreviated Mental Test (AMT) score of less than 8.\n* A score of more than 7 on the Edmonton Frail Scale - Acute Care or a score of more than 5 on Clinical Frailty Scale\n* Diagnosed with severe cognitive or psychiatric disorders.\n* Have severe hearing or vision impairments\n* Have medical conditions which results in limitation of dancing (e.g. walking aids, wheelchair etc.)\n* Older adults with serious chronic diseases (e.g. postural hypotension etc.)\n* Registered in any other dance group during the intervention period","85 Years",{"count":335,"type":21},284,[24],"The goal of this interventional study is to examine the dose-response effect of Community Dance Programme (CDP) on the physical, cognitive and psychological health of pre-frail and mildly frail community-dwelling older adults. The main questions it aims to answer are:\n\nHypothesis 1: Two sessions of CDP per week (75 minutes each) significantly increase the physical outcomes (i.e. CFS, EFS, SPPB, grip strength) of community-dwelling older adults as compared to one session of CDP per week.\n\nHypothesis 2: Two sessions of CDP per week significantly improve the cognitive outcomes (i.e. MoCA, SDMT) of community-dwelling older adults as compared to one session of CDP per week.\n\nHypothesis 3: Two sessions of CDP per week significantly improve the psychosocial outcomes (i.e. WHOQOL-OLD, De Jong Giervald Loneliness Scale, GPIC scale, SHS, SSQ) of community-dwelling older adults as compared to one session of CDP per week.\n\nIntervention: The participants will be asked to attend two sessions of CDP per week for 12 weeks at their respective Active Ageing Centres (AACs).\n\nActive control: The participants will be asked to attend one session of CDP per week for 12 weeks AACs.\n\n* The participants will be asked to go to the AACs at baseline and after 12 weeks of CDP intervention for the collection of data.\n* The participants will be asked to wear fitness trackers to track their heart rates during the CDP sessions to ensure that the dance curriculum is kept within the moderate intensity.",[339,340,32,341],"Dance","Older Adults","Active Ageing",[343,344,234],"dance","Older adults","2025-07-23",{"date":294,"type":47},{"date":348,"type":47},"2025-05-07",{"date":350,"type":21},"2027-08",{"name":352,"class":54},"National University of Singapore",{"id":354,"slug":355,"hasResults":11,"nctId":356,"briefTitle":357,"officialTitle":357,"acronym":358,"eligibilityCriteria":359,"healthyVolunteers":94,"sex":17,"minAge":64,"maxAge":4,"enrollmentInfo":360,"targetDuration":4,"studyType":22,"phases":362,"briefSummary":363,"conditions":364,"keywords":369,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":85},"100589558","the-effect-of-pectin-supplementation-on-geriatric-with-frailty-a-randomised-placebo-controlled-dietary-intervention-study-100589558","NCT06955975","The Effect of Pectin Supplementation on Geriatric With Frailty: A Randomised Placebo-Controlled Dietary Intervention Study","GEOFF","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the study.\n* Participant eligibility includes those aged \\>65 years who have a body mass index (BMI) between 18.5 and 39.9 kg\u002Fm2.\n* Participants who are considered as pre-frail or frail based on FRAIL (Simple Frailty Questionnaire).\n\nExclusion Criteria:\n\n* Have gastrointestinal conditions e.g. malabsorptive conditions such as IBS\u002FIBD, coeliac or functional conditions such as gastroparesis or food intolerances etc.\n* History of major surgery which potentially limit participation or completion of the study.\n* History of gastrointestinal resection surgery, including bariatric surgery.\n* Used of antibiotics, antifungal medications, probiotics or prebiotics 90 days before the start of the study.\n* Are taking the following medications: immunosuppressants, amiodarone and\u002For perhexiline.\n* Are currently following or anticipated to commence a specialised commercially available weight loss diet and\u002For program.\n* History of side effects towards probiotics or prebiotics.\n* History or current psychiatric illness.\n* History or current neurological condition (e.g. epilepsy).\n* Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance.",{"count":361,"type":21},30,[24],"The study involves the intake of Low-methoxy (LM) pectin (polysaccharides extracted from citrus peels), which are commonly found in the UK diet (not pharmacological agents), to test their effects on systematic inflammation in the body and gut microbiome composition. Study subjects will be healthy elderly with early signs of frailty or pre-frailty from the local population and will be asked to attend the laboratory on 2 occasions; before and after 4-week' supplementing the diet daily with either 10g of pectin with 10g of whey protein and 10g of cocoa powder added as flavour (active arm) or 10g of whey protein with 10g of cocoa powder added as flavour (placebo). Participants will be given the blinded products portioned in individual sachets, with instructions to add the contents of one sachet a day to 150ml of milk and to consume immediately.\n\nAt each study visit (\\~90 minutes), participants will be asked to provide a stool and blood sample, will have blood pressure, heart rate, weight, height, and waist\u002Fhip ratio measured, research team will perform physical functioning test (Time up and go test, 30-second sit to stand test) as well as participants will complete the quality-of-life questionnaire (SF-36), the Depression and Anxiety (HADS) and the Gastrointestinal Symptom Rating Scale (GSRS).",[32,365,234,366,367,368],"Pre-Frailty","Diet","Dietary Fiber","Systemic Inflammatory Response",[370,371,234,365,372,373,374],"Pectin","LM Pectin","Systemic inflammation","Dietary intervention","Gut microbiome","2025-06-17",{"date":377,"type":47},"2025-06-22",{"date":379,"type":47},"2025-02-10",{"date":381,"type":21},"2026-03-31",{"name":383,"class":54},"University of Nottingham",{"id":385,"slug":386,"hasResults":11,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":11,"sex":17,"minAge":64,"maxAge":4,"enrollmentInfo":391,"targetDuration":4,"studyType":22,"phases":393,"briefSummary":394,"conditions":395,"keywords":401,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":410,"completionDateStruct":412,"leadSponsor":414,"locationsCount":85},"100595037","frailty-intervention-in-postoperative-hip-fracture-inpatients-100595037","NCT07027241","Frailty Intervention in Postoperative Hip Fracture Inpatients","Multicomponent Exercise and Nutrition Based Frailty Intervention in Postoperative Hip Fracture Inpatients","Inclusion Criteria:\n\n* Older adults \\>\u002F= 65\n* Clinical Frailty Score 4-6 (This includes patients with very mild, mild and moderate frailty. This would be in keeping with literature quoting frailty interventions where patients who are 'pre-frail' and frail are included)\n* Post fragility hip fracture (including subtrochanteric fracture)\n* Post hip fracture surgery (all types including total hip replacement, hemiarthroplasty, IM nailing)\n* Medically stable postoperatively\n* No weightbearing restriction\n* Mobile pre-admission (including aids and max assist of 1 person)\n\nExclusion Criteria:\n\n* Medically unstable (NEWS \\>3, unless a higher cutoff is stipulated by the primary medical researcher)\n* Non fragility hip fracture (fracture from non osteoporotic aetiology, pathologic fracture)\n* Hip surgery for other aetiology (prosthetic joint infection, arthritis, implant loosening, avascular necrosis, periprosthetic fracture)\n* Polytrauma\n* Delirium or severe cognitive impairment (as defined by inability to follow instructions and unable to provide informed consent)\n* Pre-existing neurologic or cardiovascular disorders that would affect participation\u002F compliance with exercise intervention\n* Open hip fracture\n* Other lower limb orthopaedic disorders that affect participation\u002F compliance with exercise intervention\n* Terminal illness with \\\u003C\u002F= 6 months to live\n* Active treatment for cancer (systemic chemotherapy or radiotherapy, patients on oral chemotherapeutic agents\u002F checkpoint inhibitors will be eligible for inclusion)\n* Nursing Home Resident\n* Severe lower limb pain post-op\n* Severe skin issues\u002F ulcers in non-operated lower limb that would preclude utilisation of ankle weights\n* Swallowing disorders\u002F difficulty\n* Renal impairment with eGFR \\\u003C30\n* Hepatic failure\n* Patients with a dairy\u002F soy allergy",{"count":392,"type":21},50,[24],"Hip fracture is a big health concern in older adults, and can lead to increased risk of death, reduced level of independence \\& mobility, reduced quality of life, and higher likelihood of admission to nursing homes. Frailty is a medical condition associated with ageing that results in a reduced ability to do daily tasks. A frail older adult is also less able to recover well from conditions that may affect their wellbeing (for example, infections, falls resulting in injuries or hospital admissions). Frailty is common in older adults with hip fractures.\n\nThere has been increasing research showing that frailty can be slowed down and improved by a combination of nutritional supplementation and exercise. However, most of the research in this area has been in frail older adults living at home or in nursing homes. The exercise or nutritional programs in these studies tend to be carried out over weeks or months. There are very few studies looking at older adults in hospital and how exercise and nutrition help with frailty over shorter periods of time, even more so in patients who have sustained an injury.\n\nThere is, however, very little research in hospital based frailty programs in older patients who have suffered major trauma. It is well known that standing up and starting to walk soon after a hip fracture improves time to recovery, reduces hospital length of stay and death. Hence, physiotherapy on the first day after hip fracture surgery is now recommended. However, there needs to be more research to aid in developing physiotherapy and exercise programs that are safe and doable in the care of hip fracture patients despite limited resources in our healthcare system.\n\nSimilarly, although malnutrition is common in frail older adults with hip fractures, the benefits of nutritional supplementation in these patients is not fully understood. It is known that having a hip fracture puts a person at risk of muscle breakdown and increasing protein intake is recommended to help reduce this risk. Research on exercise and nutrition based frailty programs specific to hip fracture patients is strongly needed, specifically the development of that are doable and safe in the hospital setting that can help improve outcomes in hip fracture patients after surgery.\n\nThe investigators believe that a multicomponent exercise and nutrition based frailty program will be safe, doable and acceptable in frail older adults after hip fracture surgery.",[396,32,397,398,399,400],"Hip Fractures (ICD-10 72.01-72.2)","Strength Training","Resistance Training","Exercise Training","Protein Supplementation",[402,403,404,405,406,234],"Hip fracture","Exercise","Nutrition","Protein supplementation","Strength and resistance training","2025-06-16",{"date":409,"type":47},"2025-06-18",{"date":411,"type":21},"2025-08-01",{"date":413,"type":21},"2026-02",{"name":415,"class":54},"Royal College of Surgeons, Ireland",{"id":417,"slug":418,"hasResults":11,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":422,"eligibilityCriteria":423,"healthyVolunteers":94,"sex":17,"minAge":64,"maxAge":4,"enrollmentInfo":424,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":426,"conditions":427,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":4},"100586133","palliative-assessment-cohort-in-the-geriatric-emergency-setting-100586133","NCT06911411","PALLIATIVE ASSESSMENT COHORT IN THE GERIATRIC EMERGENCY SETTING","PALLIATIVE ASSESSMENT AND MANAGEMENT IN THE GERIATRIC EMERGENCY SETTING (PALMA)","PALMA cohort","Inclusion Criteria: Older patient \\>64 years acutely admitted to the geriatric emergency department -\n\nExclusion Criteria: Severe cognitive impairment. Not able to provide informed consent. Not reading Danish\n\n\\-",{"count":425,"type":21},300,"The PALMA project is part of a larger palliative research program COPAL in Capital Region of Denmark led by Professor Tom Møller. PALMA aims to improve palliative care for geriatric patients transitioning from emergency-hospital to primary care. The project addresses the lack of a systematic approach for assessing and managing palliative symptoms in geriatric patients to enhance communication between hospitals and municipal health care services.\n\nThe PALMA cohort investigates the applicability of systematic palliative assessment (EORTC-C15 PAL) in the geriatric emergency setting combined with measures of frailty, socio-demographic risks, and cross-sectoral healthcare support.",[428,429,430,32,431,432,433],"Geriatric","Palliative Care","Socio-demographic Risk","Loneliness","Collaborative Care","Transition of Care","2025-03-28",{"date":436,"type":47},"2025-04-04",{"date":438,"type":21},"2025-04-01",{"date":440,"type":21},"2026-12-30",{"name":442,"class":54},"University Hospital Bispebjerg and Frederiksberg",{"id":444,"slug":445,"hasResults":11,"nctId":446,"briefTitle":447,"officialTitle":448,"acronym":449,"eligibilityCriteria":450,"healthyVolunteers":11,"sex":17,"minAge":146,"maxAge":4,"enrollmentInfo":451,"targetDuration":4,"studyType":22,"phases":453,"briefSummary":454,"conditions":455,"keywords":457,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":464,"lastUpdatePostDateStruct":465,"startDateStruct":467,"completionDateStruct":468,"leadSponsor":470,"locationsCount":85},"100576357","telerehabilitation-on-physical-fitness-functional-status-and-quality-of-life-in-frail-older-adults-100576357","NCT06784245","Telerehabilitation on Physical Fitness, Functional Status, and Quality of Life in Frail Older Adults","Effectiveness of Synchronous Telerehabilitation Versus Face-To-Face Physical Therapy on Physical Fitness, Functional Status, and Quality of Life in Frail Older Adults","Teleactivate 3","Inclusion Criteria:\n\n(i) both sexes aged ≥60 years, (ii) community-dwelling older adults, (iii) older adults having frailty according to the modified Fried phenotype scale, (iv) ability to stand up and walk ≥10 meters without assistance technique, (v) Abbreviated Mini Mental State (MMSE) \\>13 points, (vi) no medical contraindication for physical exercise. In addition, older adults must have a smartphone or tablet, and Internet connection at home. Computer or Internet literacy is not required as an eligibility criterion.\n\nExclusion Criteria: Those older adults presenting fractures and recent acute myocardial infarction, associated cardiovascular pathology, severe acute respiratory failure, high blood pressure, uncontrolled diabetes mellitus, limitations following instructions, as well as people participating in other exercise program during the project.",{"count":452,"type":21},58,[24],"The goal of this randomized controlled trial (RCT) is to analyze whether the effectiveness of a synchronous telerehabilitation program is better than a face-to-face physical therapy program in improving the physical fitness, functional status, and quality of life in frail male and female volunteers aged 60 years or older living in the community and haven frailty according to the modified Fried phenotype scale. The main research questions are: 1) Is a synchronous telerehabilitation program effective in improving the physical fitness, functional status and quality of life of frail older people?; 2) Is a synchronous telerehabilitation program more effective in improving the physical fitness, functional status and quality of life, compared to face-to-face physical therapy program, in frail older adults? In synchronous telerehabilitation program group, a healthcare professional will supervise up to four or five participants remotely exercising at home during each session, using a real-time videoconferencing app. Participants will be able to see and talk to both the health professional and the other participants. The exercise program will consist of 1-hour sessions carried out twice a week for 12 weeks. In the face-to-face physical therapy group, the exercise sessions will take place in a older person care center, which will also last 1 hour twice a week for 12 weeks. Regardless of the group, exercise sessions will include a mixture of cardiovascular, balance, strength, flexibility, and gait exercises.",[456],"Frailty At Older Adults",[458,459,460,461,462,463],"Older person","Fragility","Telerehabilitation","Physical fitness","Functional status","Quality of life","2025-01-29",{"date":466,"type":47},"2025-02-03",{"date":438,"type":21},{"date":469,"type":21},"2025-08-30",{"name":471,"class":54},"Marina Alvarado",{"id":473,"slug":474,"hasResults":11,"nctId":475,"briefTitle":476,"officialTitle":476,"acronym":477,"eligibilityCriteria":478,"healthyVolunteers":94,"sex":17,"minAge":227,"maxAge":4,"enrollmentInfo":479,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":481,"conditions":482,"keywords":483,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":4},"100577066","assessment-of-frailty-as-a-prognostic-factor-for-mortality-disability-and-quality-of-life-after-icu-admission-100577066","NCT06793462","ASSESSMENT of FRAILTY AS a PROGNOSTIC FACTOR for MORTALITY, DISABILITY, and QUALITY of LIFE AFTER ICU ADMISSION","FG-UCI","Inclusion criteria:\n\n* Elderly patients over 70 years of age requiring admission to ICU-semicritical units.\n* Patients receiving at least one life-support intervention for more than 24 hours, including:\n* Mechanical ventilation (invasive or non-invasive),\n* Vasopressor or inotropic treatment,\n* Requirement for acute renal replacement therapies for more than 24 hours,\n\nExtracorporeal support such as:\n\nVeno-Venous Extracorporeal Membrane Oxygenation (ECMO-VV), Veno-Arterial Extracorporeal Membrane Oxygenation (ECMO-VA).\n\nExclusion Criteria:\n\n* Patients with an ICU stay of less than 72 hours.\n* Patients with treatment limitations upon ICU admission, although an isolated \"Do Not Resuscitate\" (DNR) order is acceptable; life expectancy of less than 6 months.\n* Absence of family members or caregivers available to provide medical history. Language barriers (non-Spanish speakers without access to medical translators).\n* Structural neurological diseases requiring ICU admission, including stroke or spinal cord pathology.\n* Patients for whom 12-month follow-up is anticipated to be unfeasible.\n* Patients without consent authorization.",{"count":480,"type":21},246,"Between 30% and 40% of elderly patients (over 70 years old) who require hospitalization and treatment in Intensive Care Units (ICU) exhibit a state of frailty. This condition is associated with adverse prognostic factors such as increased in-hospital mortality, functional decline, and a deterioration in their long-term quality of life. Some frail elderly patients may require invasive mechanical ventilation (ventilator) as life support during the acute phase, which has also been linked to adverse prognostic outcomes. Additionally, frailty is common in patients with severe infections, with a high mortality rate, subsequent functional decline, and reduced quality of life following ICU admission.",[234,456],[484,485,486,487,488],"FRAILTY AND ICU","PROGNOSTIC","ELDERLY","FUNCTIONAL","QUALITY OF LIFE","2025-01-20",{"date":491,"type":47},"2025-01-27",{"date":493,"type":21},"2025-02-01",{"date":495,"type":21},"2027-01-01",{"name":497,"class":54},"Hospital Universitari Vall d'Hebron Research Institute"]