[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"frailtysarcopenia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:frailtysarcopenia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100457700","enhancing-voluntary-motion-in-broad-patient-populations-with-modular-powered-orthoses-100457700",false,"NCT05240014","Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses","Inclusion criteria for able-bodied, young participants will be:\n\n* Aged between 18 to 65 years\n* Weigh less than 250 lbs due to limitations in the design of the orthoses\n* Ability to lift and lower a 10 kg weight using the neutral-spine squat technique for 10 repetitions\n\nExclusion criteria for able-bodied, young adult participants will be:\n\n* Pregnant (self-report)\n* Any significant neuromuscular or musculoskeletal disorder that would interfere with the study\n* Prior history of chronic lower-back pain\n* Unable to walk for 20 minutes\n* History of any cardiovascular, vestibular, or visual diseases and\u002For impairments that may interfere with the study\n* Cognitive deficits that would impair their ability to give informed consent or impair their ability to follow simple instructions during the experiments. Cognitive deficits will be determined by a Mini-Mental State Examination (MMSE) score of \\\u003C22.\n* Adults with a known allergy to medical grade tape\n\nInclusion criteria for elderly participants will be:\n\n* Aged between 65 to 85 years\n* Weigh less than 250 lbs due to limitations in the design of the orthoses\n* Ability to walk 6 minutes without assistance from a person (may use walking aid)\n\nExclusion criteria for elderly participants will be:\n\n* Pregnant (self-report)\n* Significant pain due to arthritis or other joint problems that would limit their ability to walk\n* Any recent lower-extremity fracture (within 3 months)\n* Significant neurological (e.g., stroke), orthopedic, or cardiovascular disorder that may affect the ability to walk\n* Advised by a physician not to walk or exercise\n* Uncontrolled hypertension or diabetes\n* Cognitive deficits or visual impairment that would impair their ability to give informed consent or impair their ability to follow simple instructions during the experiments. Cognitive deficits will be determined by a Mini-Mental State Examination (MMSE) score of \\\u003C22.\n* Adults with a known allergy to medical grade tape",true,"ALL","18 Years","85 Years",{"count":20,"type":21},33,"ESTIMATED","INTERVENTIONAL",[24],"NA","The overall goal of this project is to develop modular, lower-limb, powered orthoses that fit to user-specific weakened joints and control force\u002Ftorque in a manner that enhances voluntary motion in broad patient populations. This project aims to establish feasibility of assisting different populations with these modular powered orthoses. The investigators hypothesize that assisting lower-limb musculature with modular powered orthoses will improve 1) lifting\u002Flowering posture in able-bodied subjects and 2) functional outcomes in elderly subjects.",[27,28,29],"Lower-limb Orthoses","Frailty\u002FSarcopenia","Chronic Overuse Musculoskeletal Injuries","RECRUITING","2025-07-15",{"date":33,"type":34},"2025-07-18","ACTUAL",{"date":36,"type":34},"2022-07-29",{"date":38,"type":21},"2026-09-21",{"name":40,"class":41},"University of Michigan","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":18,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":60,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100588498","phase-2-safety-and-efficacy-of-isomyosamine-in-reducing-inflammation-and-treating-muscle-loss-in-older-adults-after-hip-or-thigh-bone-fractures-100588498","NCT06942182","Safety and Efficacy of Isomyosamine in Reducing Inflammation and Treating Muscle Loss in Older Adults After Hip or Thigh Bone Fractures","Double Blind Placebo-Controlled Parallel Group Study Of Safety And Efficacy Of Isomyosamine In Treating Sarcopenia After Hip Or Femoral Fracture In Gerontological Population","Inclusion Criteria:\n\n1. Age 60 to 85 years of age\n2. Non-complex, non-comminuted fracture of the femoral head, femoral neck, or acetabulum due to an accidental (non-neurologic or cardiovascular) fall\n3. Concomitant medication limited to treatment for chronic conditions\n4. The ability to give informed consent and comply with study procedures\n5. Body weight ≥35 kg\n6. Adequate dietary intake\n7. Potential subjects' intention to avoid reproductive activity will be confirmed\n\n   And one or more of the following criteria:\n8. Previous history frailty or sarcopenia diagnosis using standardized tests;\n9. Positive assessment for frailty or sarcopenia using standardized tests or as per clinician's judgement;\n10. Previous positive assessment for elevated biomarkers of inflammation (serum IL-6 level\\> LOQ, TNFR1 level \\> LOQ, and\u002For TNF-alpha level \\> LOQ)\n\nExclusion Criteria:\n\n1. Receiving immunotherapy for cancer or solid organ transplantation\n2. Complex or comminuted fracture or fracture of multiple long bones\n3. Regular treatment for chronic disease including chronic renal failure, chronic heart failure (CHF) cerebrovascular disease including stroke, rheumatoid arthritis, or polymyalgia rheumatica\n4. Chronic kidney disease (estimated glomerular filtration rate \\[eGFR\\] \\\u003C60 mL\u002Fmin)\n5. Newly (\\\u003C 2 weeks) diagnosed COVID-19\n6. Inability or unwillingness to give written informed consent\n7. History of upper\u002Flower respiratory tract infection, requiring systemic steroids, antibiotics, and or emergency room (ER) visit or urgent care within 6 weeks of screening visit\n8. History of adverse reaction or allergy to TNF inhibitor\n9. History of neurological, hepatic, renal, diabetic mellitus, thyroid disorder, psychiatric, addiction or other medical conditions that may interfere with the interpretation of data or the patient's participation in the study or may increase safety concerns per investigator discretion\n10. Currently under treatment by an anti-TNFα drug, such as adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, and biosimilars\n11. Currently under treatment by an anti-diabetic medication, including glucagon-like peptide-1 (GLP-1) drugs such as semaglutide, or any of metformin, jenuvia, or insulin\n12. Unwillingness or inability to comply with study procedures, including smoking cessation\n13. History of epilepsy or seizure propensity, ataxia, abnormal EEG findings, abnormal brain magnetic resonance image, or other co-morbid neurological conditions\n14. Positive TB test\n15. Patients who are pregnant or breastfeeding","60 Years",{"count":52,"type":21},60,[54],"PHASE2","This Phase II clinical study investigates the safety and effectiveness of a new drug, Isomyosamine, in patients with sarcopenia or frailty, conditions associated with aging and muscle weakness. Isomyosamine is a promising oral medication that reduces inflammation by targeting cytokines like TNF-α and IL-6, which are linked to these conditions. Previous studies have shown it is well-tolerated and may help improve muscle strength, mobility, and healing after hip fractures. This trial aims to determine its potential benefits in reducing inflammation and improving recovery in elderly patients.",[57,58,28,59],"Sarcopenia in Elderly","Frailty","Frailty in Older Adults",[61,58,62,63,64,65,66],"sarcopenia","Hip Fracture","Older population","Gerontological","Femur fracture","Sarcopenia and Frailty","NOT_YET_RECRUITING","2025-04-16",{"date":70,"type":34},"2025-04-24",{"date":72,"type":21},"2025-05-01",{"date":74,"type":21},"2026-03-01",{"name":76,"class":77},"TNF Pharmaceuticals, Inc.","INDUSTRY",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":42},"100584454","comparison-of-preoperative-frailty-assessment-tools-100584454","NCT06889545","Comparison of Preoperative Frailty Assessment Tools","Evaluation of a Feasible Frailty Assessment Tool for Preoperative Risk Evaluation of Older Patients","PREFAS","Inclusion Criteria:\n\n* 70 years and older\n* scheduled surgery\n* estimated time of surgery 120 Minutes or more\n\nExclusion Criteria:\n\n* insufficient German language skills (for cognitive testing)\n* mental retardation\n* relevant psychiatric disorder (not allowing for cognitive testing)","70 Years",{"count":88,"type":21},584,"OBSERVATIONAL","Frailty is a significant risk factor for postoperative complications and functional decline. Preoperative assessment of frailty is therefore recommended in all older adults. However, despite the availability of many frailty tools, few have been tested in the preoperative setting and there is little comparison of their predictive value in identifying patients at risk. The aim of this study is to investigate which of the following instruments for determining frailty has the highest predictive power with regard to the occurrence of postoperative complications: Risk Analysis Index, Clinical Frailty Scale, the Groningen Frailty Indicator, the Edmonton Frail Scale and the LUCAS-FI. The aim of this research project is to identify a suitable frailty instrument for preoperative risk stratification of older patients during the premedication visit.",[58,59,28],"2025-03-30",{"date":94,"type":34},"2025-04-03",{"date":96,"type":21},"2025-04-15",{"date":98,"type":21},"2027-10-01",{"name":100,"class":41},"Universitätsklinikum Hamburg-Eppendorf"]