[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"free-flap-reconstruction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:free-flap-reconstruction":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100576415","phase-4-sufentanil-infusion-vs-intravenous-methadone-for-postoperative-analgesia-following-head-and-neck-dissection-with-free-flap-or-rotational-reconstruction-100576415",false,"NCT06784999","Sufentanil Infusion vs Intravenous Methadone for Postoperative Analgesia Following Head and Neck Dissection With Free Flap or Rotational Reconstruction","Randomized Prospective Study Comparing Sufentanil Infusion vs Intravenous Methadone for Postoperative Analgesia Following Head and Neck Dissection With Free Flap or Rotational Reconstruction","Inclusion Criteria:\n\n* • Patients undergoing head and neck dissection with free flap or rotational reconstruction at Indiana University Health Adult Academic Health Center\n\n  * ASA class 1, 2, or 3 (See Appendix)\n  * Age 18 to 80\n  * male or female\n  * Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Any contraindication to opiates, (i.e. allergy to opioids, substance use disorder) as determined by PI review and any contraindications reported by the patient\n* Patient on home methadone at any dose\n* Any physical, mental or medical conditions which, in the opinion of the investigators, may confound quantifying postoperative pain resulting from surgery\n* Known true allergy to the study medications (sufentanil, methadone)\n* Any history of substance abuse in the past 6 months which would include heroin or any other illegal street drugs\n* End stage liver disease, end stage renal disease\n* Patient staying intubated or on mechanical ventilation after surgery\n* Patient (home dose) taking more than 30mg PO morphine equivalent (OME) per day\n* Any additional and concurrent surgical procedures to the patient","ALL","18 Years","80 Years",{"count":20,"type":21},128,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The main purpose of this study is to determine which type of medication, sufentanil or methadone, is better at controlling pain during and, more importantly, after surgery in patients undergoing a head and neck dissection with free flap or rotational tissue reconstruction. Prior to their operation, subjects will be randomized to receive either Sufentanil or Methadone. After surgery, research staff will obtain information about recovery and pain levels.",[27],"Free Flap Reconstruction",[29,30,31,32],"head and neck dissection","free flap","sufentanil","methadone","RECRUITING","2026-04-27",{"date":36,"type":37},"2026-05-01","ACTUAL",{"date":39,"type":37},"2025-01-10",{"date":41,"type":21},"2027-11-04",{"name":43,"class":44},"Indiana University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100616510","effectiveness-of-hydrogen-water-intervention-on-acute-oral-inflammation-oral-microbiota-and-pain-following-free-flap-reconstruction-in-patients-with-oral-cancer-100616510","NCT07306546","Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral Cancer","Inclusion Criteria:\n\n* Diagnosed with oral cancer and receiving microsurgical free flap reconstruction.\n* Age 18 years or older.\n* Conscious and able to follow study instructions.\n* Able to communicate without difficulty in Mandarin, Taiwanese, or through written communication.\n\nExclusion Criteria:\n\n* Abnormal salivary gland function or severe xerostomia.\n* Recent use of antibacterial mouthwash or antibiotic therapy that may affect oral microbiota.\n* Presence of severe bacterial or viral oral infections, or significant periodontal disease.",{"count":53,"type":21},36,[55],"NA","This study employs a Randomized Controlled Trial (RCT) design. Patients diagnosed with oral cancer by the attending physician and who meet the inclusion criteria will be admitted to the study after receiving a full explanation of the study objectives, intervention methods, potential risks, and participant rights from the research team upon their stable transfer to the plastic surgery ward post-operation. Written consent will be obtained from the patient and\u002For their legally authorized representative after adequate informed consent has been provided, before they are enrolled in the study.",[58,59,60,27,61],"Oral Squamous Cell Carcinoma (OSCC)","Postoperative Pain","Postoperative Oral Mucositis","Oral Cancer",[63,64,65,66,67],"Hydrogen water","Oral cancer","Free flap reconstruction","Pain assessment","Salivary Biomarkers","NOT_YET_RECRUITING","2025-12-25",{"date":71,"type":37},"2025-12-29",{"date":73,"type":21},"2026-01",{"date":75,"type":21},"2027-10-31",{"name":77,"class":44},"Kaohsiung Medical University Chung-Ho Memorial Hospital"]