[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"frontotemporal-degeneration-ftd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:frontotemporal-degeneration-ftd":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100567470","a-multifocal-tdcs-eeg-protocol-for-improving-symptoms-of-mild-cognitive-impairment-and-early-dementia-100567470",false,"NCT06668610","A Multifocal tDCS-EEG Protocol for Improving Symptoms of Mild Cognitive Impairment and Early Dementia","An Integrated Multifocal tDCS-EEG Protocol for Improving Cognitive and Affective Symptoms in Mild Cognitive Impairment and Early Stages of Dementia: a Crossover Double-blind Randomised Controlled Trial","MuSt-MID","Inclusion Criteria:\n\n* age between 55 and 85 years;\n* diagnosis of minor neurocognitive disorder, or major neurocognitive disorder with mild severity, according to Diagnostic and Statistical Manual of Mental Disorders (DSM-5; APA 2013) with a Clinical Dementia Rating Scale (CDR) of .05 or 1 (Morris, 1993);\n* right handedness.\n\nExclusion Criteria:\n\n* brain events with an acute aetiology (stroke, traumatic brain injury, neoplastic ablation);\n* psychiatric disorders (schizophrenia, psychosis, bipolar disorder) and assumption of psychotropic drugs;\n* diagnosis of moderate or severe major neurocognitive disorders (DSM-5; APA 2013) with CDR scores equal or above 2 (Morris, 1993);\n* any condition with may also hypothetically interfere with electrophysiological recording and neurostimulation (metallic implants in the brain, cochlear implant, pacemakers, or suffering from epilepsy) (Antal et al., 2017; Bikson et al., 2016).","ALL","55 Years","85 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn if an integrated protocol using multifocal non invasive brain stimulation and brain recording combined with cognitive training is effective in treating cognitive and affective symptomatology in patients with mild cognitive impairment and early stages of dementia. The main questions it aims to answer are:\n\n* Does multifocal non-invasive brain stimulation reduce cognitive and affective symptoms in patients with mild cognitive impairment and early stages of dementia?\n* Do some specific factors, such as education and cognitive reserve, affect the extent of the possible outcomes achievable from the intervention?\n* Do electrophysiological measures contribute identifying responders and non-responders to the treatment? Researchers will compare real non-invasive brain stimulation to a placebo stimulation (reproducing the same feeling of stimulation without actually stimulating the brain) combined with cognitive rehabilitation on general cognition measures and depression symptoms.\n\nParticipants will\n\n* Undergo two treatment cycles (real stimulation or placebo over frontal and temporal ares of the left hemisphere) combined with cognitive training twice a week for two months.\n* Complete neuropsychological evaluations before the first rehabilitation cycle and at the end of each rehabilitation cycle.\n\nCaregivers will provide information on functional daily living activities for their relatives.",[28,29,30,31,32,33],"Mild Cognitive Impairment (MCI)","Dementia","Alzheimer Disease, Early Onset","Alzheimer Disease","Frontotemporal Degeneration (FTD)","Neurocognitive Decline",[35,36,37,38,39,40,41,42],"non invasive brain stimulation (NIBS)","transcranial direct current stimulation (tDCS)","electroencephalography (EEG)","crossover","randomised controlled trial","mild cognitive impairment","early stage dementia","multifocal brain stimulation","RECRUITING","2026-04-21",{"date":46,"type":47},"2026-04-22","ACTUAL",{"date":49,"type":47},"2024-10-01",{"date":51,"type":22},"2026-10-01",{"name":53,"class":54},"University of Campania Luigi Vanvitelli","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":17,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":4,"studyType":23,"phases":69,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":55},"100482183","social-cognitive-functioning-validation-of-a-new-neuropsychological-test-100482183","NCT05558709","Social-cognitive Functioning: Validation of a New Neuropsychological Test","Social-cognitive Functioning: Validation of a New Neuropsychological Test and Prediction of Social Behavioural Disorders in Daily Life","REALSOCOG","Inclusion Criteria:\n\nFor patients:\n\n* Patient aged between 18 and 90 years\n* Mini Mental State Examination (MMSE) score greater than or equal to 20\n* Patient able to express his or her non-opposition to participate in the study in an informed and autonomous manner\n* Patient with a neurodegenerative pathology: FTD, AD or LBD.\n\nFor caregivers:\n\n* Over 18 years of age\n* Regular contact with the patient (≥ 2 times per month)\n\nExclusion Criteria:\n\nFor patients:\n\n* Neurological or psychiatric comorbidity\n* Notable sensory disorders (e.g., profound or total deafness, age-related macular degeneration, blindness, etc.) that may interfere with experimental completion.\n* Opposition to participation in the study",true,"18 Years","90 Years",{"count":68,"type":22},120,[25],"It is now established that disturbances in social cognition are frequent in neurology and that they contribute to the development of social conduct disorders. Their assessment is therefore essential, particularly in order to propose early and adapted care. However, this assessment remains limited today. A new serious game-type test, REALSoCog, has been developed to address the shortcomings of current tools and to highlight disturbances in social behaviors. The latter are not always observed in consultation although they are often reported by caregivers. The objective of this research is therefore to validate the REALSoCog task in a pathological population (currently being standardized in the general population: CER-U, IRB N°: 00012020-115). The clinical interest of this task will be tested with a group of patients suffering from a neurodegenerative disease (Alzheimer's disease (AD), dementia with Lewy bodies (DCL), fronto-temporal lobar degeneration (FTD)) in order to assess its sensitivity and specificity in the detection of social-cognitive disturbances, and in particular in terms of social behaviors (detection of social behavioral disorders reported in daily life). The objective is also to document the socio-cognitive profiles in the mentioned diseases thanks to a more ecological test, and to better understand the links between socio-cognitive processes on the one hand, and individual characteristics on the other hand (e.g. mood and social participation).",[72,73,32],"Alzheimer's Disease (AD)","Lewy Body Dementia (LBD)",[75,76,77,78],"Neurodegenerative diseases","Social behavior","Social cognition","Neuropsychological assessment","2026-03-11",{"date":81,"type":47},"2026-03-13",{"date":83,"type":47},"2026-02-04",{"date":85,"type":22},"2030-02-04",{"name":87,"class":54},"Assistance Publique - Hôpitaux de Paris"]