[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:function":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100633077","impact-of-exercise-training-on-serum-glial-fibrillary-acidic-protein-gfap-brain-volumetry-and-functional-outcomes-in-multiple-sclerosis-100633077",false,"NCT07521995","Impact of Exercise Training on Serum Glial Fibrillary Acidic Protein (GFAP), Brain Volumetry, and Functional Outcomes in Multiple Sclerosis","The Effect of an Exercise Intervention on Serum Glial Fibrillary Acidic Protein (GFAP), Brain Volumetry and and Functional Outcomes in Patients With Multiple Sclerosis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Clinically confirmed relapsing-remitting multiple sclerosis (RRMS) diagnosis according to revised McDonald criteria (2017)\n* Mild-to-moderate disability (EDSS score 1.0-5.5)\n* No corticosteroid treatment within the previous 3 months\n\nExclusion Criteria:\n\n* Acute MS relapse within 90 days before enrollment\n* Regular participation in structured exercise programs (\\>3 hours\u002Fweek)\n* Comorbid conditions that may limit exercise participation, including significant orthopedic impairments, unstable cardiopulmonary conditions, and other systemic disorders affecting physical activity\n* Standard MRI contraindications (metallic implants, claustrophobia, etc.)\n* Concurrent neurological disorders (other than MS)\n* Initiation or modification of disease-modifying therapy within 6 months\n* Severe spasticity (Modified Ashworth Scale ≥3 in any major muscle group)","ALL","18 Years","65 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This single-blind, randomized controlled trial will employ a two-arm parallel design (exercise group vs. control group) with a 12-week intervention period. Randomization will be implemented using SPSS 25.0 (IBM Corporation, Armonk, NY, USA) to ensure balanced group allocation. All outcome measures will be assessed at baseline and post-intervention.",[27,28,29],"Multiple Sclerosis","Exercise","Function",[28,31,32],"Glial Fibrillary Acidic Protein","Brain Volume","NOT_YET_RECRUITING","2026-04-03",{"date":36,"type":37},"2026-04-13","ACTUAL",{"date":39,"type":21},"2026-05-01",{"date":41,"type":21},"2026-09-01",{"name":43,"class":44},"Firat University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":45},"100599833","investigation-of-the-relationship-between-core-stability-and-reaction-time-hand-eye-coordination-pain-and-functional-status-in-individuals-with-rotator-cuff-lesions-100599833","NCT07089628","Investigation of the Relationship Between Core Stability and Reaction Time, Hand-Eye Coordination, Pain, and Functional Status in Individuals With Rotator Cuff Lesions","Inclusion Criteria:\n\n* Having a diagnosis of a rotator cuff lesion confirmed by a physician\n* Having no history of any surgical procedure related to the shoulder\n* Experiencing activity-related pain scored as 3 or higher on the Visual Analog Scale\n\nExclusion Criteria:\n\n* Presence of systemic inflammatory diseases\n* Pregnancy\n* Presence of mental health disorders\n* Individuals with communication difficulties\n* Presence of other significant shoulder pathologies such as dislocation, fracture, arthritis, or frozen shoulder\n\n  * All of these criteria apply to the group with rotator cuff lesions. The other group consists of healthy, asymptomatic individuals.",true,{"count":54,"type":21},52,"OBSERVATIONAL","Rotator cuff lesions are among the most common problems within musculoskeletal disorders. The prevalence of these lesions increases with age, and they encompass a wide spectrum of various injuries and pathological conditions. The literature frequently reports that such lesions often lead to pain, decreased functional capacity, and a reduction in quality of life. Although some of these lesions are traumatic in origin, the majority of rotator cuff problems are degenerative due to age-related changes in tendon structure.\n\nRecent scientific studies have indicated that core stability may be a significant factor in such musculoskeletal problems. Adequate core stabilization not only minimizes the load on the vertebral column but also enhances the strength and endurance of peripheral joints and facilitates the transfer of energy to distal segments. Given that rotator cuff lesions can adversely affect upper extremity functions and potentially result in reduced core stability, we hypothesize that they may negatively influence reaction time and hand-eye coordination, which are essential for the effective execution of motor tasks.\n\nTo date, no studies have been identified in the literature investigating the relationship between core stability and reaction time or hand-eye coordination in individuals with rotator cuff lesions. In light of this information, the aim of our planned study is to examine the relationship between core stability and reaction time, hand-eye coordination, pain, and functional status in individuals with rotator cuff lesions and to compare these findings with asymptomatic individuals.",[58,59,60,61,29],"Core Stability","Core Stabilization","Reaction Time","Pain",[58,59,63,64,61,29],"Reaction time","Hand- Eye Coordination","RECRUITING","2025-09-15",{"date":68,"type":37},"2025-09-18",{"date":70,"type":37},"2025-08-01",{"date":72,"type":21},"2025-12-31",{"name":74,"class":44},"Bandırma Onyedi Eylül University",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":81,"maxAge":18,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":94,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":45},"100567889","additional-effects-of-kinesio-taping-along-with-conservative-physical-therapy-on-upper-limb-function-range-of-motion-and-spasticity-in-the-patients-with-subacute-stroke-100567889","NCT06674057","Additional Effects of Kinesio-Taping Along with Conservative Physical Therapy on Upper Limb Function, Range of Motion and Spasticity in the Patients with Subacute Stroke","Inclusion Criteria:\n\n* Age group: 40-65 years onwards\n* Both males and females\n* Patients with history of diagnosed stroke and lie within subacute stage of stroke\n* MAS scale score of 1\\_2\n\nExclusion Criteria:\n\n* Any congenital deformities\n* cognitive deficits\n* Fractures\n* Upper limb surgery","40 Years",{"count":83,"type":21},40,[24],"A randomized control trial will be done on diagnosed stroke patients of subacute stage in Fauji Foundation Hospital Rawalpindi and leading edge physical therapy and rehabilitation clinic.The purpose of the study is to determine Additional Effects of Kinesio-Taping along with conservative Physical Therapy on upper limb function, Range of motion and Spasticity in the patients with Subacute Stroke. The conservational physical therapy includes Passive and active ROMs 25 repetitions each, 3 times per week. PNF stretching (hold relax) for spastic muscles for 20 repetitions with a 10 second hold and 10 second relaxation of the muscle group 3 times per week.\n\nD1 flexion and extension for 20 repetitions 3 times per week. Kinesio tape 3 times per week. (Anchor opposed to effected compartment to provide facilitation and sustained stretch). with srtrngth training included in week 3-6 with a resistance band of medium resistance.\n\ntreatment time will be 30 minutes on alternate days for six weeks.",[87,88,89,90,91,92,93,29],"Subacute Stroke","Upper Limb","Range of Motion","Spasticity","CVA (Cerebrovascular Accident)","KINESIOTAPING","Stroke",[95,96,97,98,99,100],"Stroke.","subacute stroke","kinesio taping","proprioceptive neuromuscular facilitation","Upper limb function.","range of motion","2024-11-04",{"date":103,"type":37},"2024-11-05",{"date":105,"type":37},"2024-06-20",{"date":107,"type":21},"2025-01-20",{"name":109,"class":44},"Foundation University Islamabad"]