[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"functional-cognitive-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:functional-cognitive-disorder":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100628092","lombard-cohort-of-brain-health-services-100628092",false,"NCT07457138","Lombard Cohort of Brain Health Services","LoBHeS","Inclusion Criteria:\n\n* Adults (≥18 years)\n* Diagnosis of SCD, FCD, or \"well worried\" individuals without objective cognitive impairment\n* Evaluation at one of the Lombardy BHS\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Diagnosis of mild cognitive impairment or dementia at baseline visit\n* Enrollment in another interventional study with an expected effect on cognition\n* Pregnancy or breastfeeding","ALL","18 Years",{"count":19,"type":20},1000,"ESTIMATED","OBSERVATIONAL","The goal of this multicenter prospective observational cohort study is to better understand the clinical, neuropsychological, and biological characteristics of individuals attending Brain Health Services (BHS) in the Lombardy region. The study focuses on adults with subjective cognitive decline (SCD), functional cognitive disorder (FCD), or \"well worried\" individuals without objective cognitive impairment.\n\nThe main questions it aims to answer are:\n\n* What clinical, cognitive, and biological differences exist between individuals who are positive versus negative for Alzheimer's disease (AD) plasma biomarkers (p-tau217) at baseline?\n* What factors predict positivity to AD biomarkers at baseline?\n* How does communication of biomarker results (risk disclosure) affect psychological well-being shortly after receiving results?\n* What factors predict longitudinal changes in AD biomarkers over 5 years?\n* Do baseline biomarkers predict the development of mild cognitive impairment (MCI) or dementia during follow-up?\n\nParticipants will:\n\n* Undergo standard clinical evaluation at their local BHS\n* Provide blood samples for plasma biomarker analysis (e.g., p-tau217, GFAP, NfL, ApoE)\n* Undergo neuropsychological testing and cognitive screening\n* Complete questionnaires assessing psychological impact and risk perception (before and after biomarker disclosure)\n* Undergo additional center-specific procedures when clinically indicated (e.g., MRI, lumbar puncture, polysomnography)\n* Be followed annually for 5 years\n\nThe study plans to enroll approximately 1000 participants across multiple BHS in Lombardy and will follow them for a total duration of 7 years. The results will help clarify the role of biomarkers in early cognitive complaints and support the development of preventive strategies within BHS.",[24,25,26,27],"Subjective Cognitive Decline (SCD)","Functional Cognitive Disorder","Alzheimer's Disease","Brain Health",[29,30,26,25,31,32,33],"Brain Health Services","Subjective Cognitive Decline","pTau-217","GFAP","NfL","RECRUITING","2026-03-13",{"date":37,"type":38},"2026-03-17","ACTUAL",{"date":40,"type":38},"2026-02-01",{"date":42,"type":20},"2033-02-01",{"name":44,"class":45},"University of Milano Bicocca","OTHER",5,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100622138","brief-intervention-for-fcd-a-feasibility-study-100622138","NCT07379723","Brief Intervention for FCD: A Feasibility Study","Feasibility Pilot Study of a Brief Intervention in Functional Cognitive Disorder","Inclusion Criteria:\n\n* Adults aged 65 or below\n* Meet criteria for diagnosis of FCD (criteria include normal MRI results with no neurological diagnosis, and symptoms that are not explained by any other medical condition, performance at routine pre-baseline neuropsychological assessment within the service)\n* Not taking part in any other intervention study or trial\n\nExclusion Criteria:\n\n* Aged above 65 years\n* Lack capacity to consent\n* MRI results not in normal range\n* Neurological diagnosis\n* Indication of severe low mood or depression (from clinical interview, routine measures)\n* Taking part in any other intervention study or trial","65 Years",{"count":56,"type":20},30,"INTERVENTIONAL",[59],"NA","The goal of this study is to learn if a single session intervention for people with Functional Cognitive Disorder (FCD) is feasible and acceptable. The main questions it aims to answer are:\n\nWhat is the impact of a single session intervention on FCD symptoms, functional impairment, and quality of life in people with FCD?\n\nWhat is the feasibility and acceptability of piloting a single session intervention for people with FCD.\n\nParticipants will:\n\n* Complete questionnaires about cognitive concerns, anxiety, depression, functional impairment and quality of life\n* Visit the clinic for a single session intervention including practicing the Attention Training Technique (ATT)\n* Complete 2 telephone calls with a researcher to discuss their use of the intervention and to complete the same questionnaires from their clinic visit, and a questionnaire about their experience of the study and intervention.",[25],[25,63,64,65,66],"Brief Interventions","Feasibility","Pilot","Attention Training","2026-01-23",{"date":69,"type":38},"2026-01-30",{"date":71,"type":38},"2025-11-11",{"date":73,"type":20},"2026-05-01",{"name":75,"class":45},"King's College Hospital NHS Trust",1]