[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"functional-impairment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:functional-impairment":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,48,80,112,140,169],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100547207","a-partnered-evaluation-to-improve-the-identification-and-management-of-functional-impairment-and-frailty-among-older-veterans-in-primary-care-settings-100547207",false,"NCT06404970","A Partnered Evaluation to Improve the Identification and Management of Functional Impairment and Frailty Among Older Veterans in Primary Care Settings","A Partnered Evaluation to Improve Identification and Management of Functional Impairment and Frailty for Older Veterans in VA Primary Care","Inclusion Criteria:\n\n* Veteran\n* \\>60 years old\n* Seen in Veterans Health Administration primary care after implementation begins\n\nExclusion Criteria:\n\n* Non-Veteran\n* \\\u003C60 years old\n* Not seen in Veterans Health Administration primary care","ALL","60 Years",{"count":19,"type":20},10000,"ESTIMATED","INTERVENTIONAL",[23],"NA","Maintaining functional status, or the ability to perform daily activities, is central to older adults' quality of life, health, and ability to remain independent. Identifying functional impairments is essential for clinicians to provide optimal care to older adults, and on a population level, understanding function can help anticipate service needs. Yet uptake of standardized measurement of functional status into patient care has been slow and inconsistent due to the burden posed by current tools. The purpose of the proposed QUERI Partnered Evaluation Initiative is to implement and evaluate a patient-centered, low-burden intervention to improve measurement of functional status in VA primary care settings nationally. The investigators hypothesize that implementing this intervention will increase identification and improve management of functional impairment among older Veterans while providing key data to inform VHA strategic planning related to long-term services and supports.",[26,27],"Functional Impairment","Frailty",[29,30,31,32,33,34],"adult, aged","adult, middle aged","primary health care","functional status","frailty","patient reported outcome measures","RECRUITING","2026-06-16",{"date":38,"type":39},"2026-06-18","ACTUAL",{"date":41,"type":39},"2025-03-03",{"date":43,"type":20},"2026-12-31",{"name":45,"class":46},"VA Office of Research and Development","FED",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":47},"100633673","multicomponent-exercise-and-virtual-reality-for-older-adults-100633673","NCT07529743","Multicomponent Exercise and Virtual Reality for Older Adults","Effects of a Combined Multicomponent Exercise and Non-Immersive Virtual Reality Program on Functionality, Balance, Cognition, and Occupational Participation in Older Adults: A Mixed-Methods Pilot Study With a Control Group","MOVE ON","Inclusion Criteria:\n\n* Participants must be aged 65 years or older.\n* A score of ≥23 points on the Montreal Cognitive Assessment (MoCA) score\n* Functional independence or minimal dependence in activities of daily living (A score of \\>90 on the Barthel Index).\n* Participants must be able to understand instructions and provide written informed consent.\n\nExclusion Criteria:\n\n* Conditions that prevent walking or safe participation in a group intervention.",true,"65 Years",{"count":59,"type":20},60,[23],"Population aging is associated with an increased risk of frailty, falls, and loss of autonomy. This pilot study aims to evaluate the effects of a program that combines multicomponent exercise and non-immersive virtual reality (MCE+VR-NI), compared with virtual reality alone (VR-NI) and usual treatment. The primary objective is to determine the program's impact on physical function, balance, cognition, and occupational participation in community-dwelling adults aged over 65 years.",[27,63,26],"Aging",[65,66,67,68],"Non-immersive virtual reality","Balance","Cognition","Occupational participation","NOT_YET_RECRUITING","2026-04-13",{"date":72,"type":39},"2026-04-14",{"date":74,"type":20},"2026-04-07",{"date":76,"type":20},"2026-07-31",{"name":78,"class":79},"European University Miguel de Cervantes","OTHER",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":21,"phases":90,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":47},"100603163","development-and-feasibility-of-ctrac-fit-100603163","NCT07132944","Development and Feasibility of CTraC-FIT","Development and Feasibility of a Function-focused Transitional Care Intervention to Support Functional Recovery in Older Veterans","CTraC-FIT","Inclusion Criteria:\n\n* .Age \\> or = 65 years\n* Score of \\> 3 on Vulnerable Elders Survey, (VES-13)\n* Score of 4-9 on Short Physical Performance Battery (SPPB)\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Admitted to VA Boston for acute psychiatric are or substance abuse detoxification\n* Plan to discharge anywhere except home (e.g., assisted living, group home, or skilled nursing facility)",{"count":89,"type":20},40,[23],"Functional decline after hospitalization is a serious concern for older Veterans, often leading to loss of independence and disability. VA's nurse-led Coordinated Transitional Care (CTraC) program has demonstrated success in improving care transitions, but currently lacks targeted assessment and intervention to support Veterans' functional recovery. This project aims to develop and test a function-focused CTraC protocol (CTraC-FIT) to address this critical gap and optimize functional outcomes for Veterans transitioning from hospital to home. By integrating evidence-based functional assessment and intervention strategies into the CTraC protocol, this project aims to empower Veterans to regain and maintain their independence and improve their quality of life.",[26,93],"Functional Performance",[95,96,97,98,99,100,101,102,103],"Physical function","Transitional care","Function-focused care","Function","Care Transition","Physical performance","Functional performance","Health care transition","Transition of care","2026-01-22",{"date":106,"type":39},"2026-01-26",{"date":108,"type":20},"2026-07-01",{"date":110,"type":20},"2030-12-31",{"name":45,"class":46},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":56,"sex":16,"minAge":119,"maxAge":57,"enrollmentInfo":120,"targetDuration":4,"studyType":122,"phases":4,"briefSummary":123,"conditions":124,"keywords":127,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":47},"100619769","the-relationship-between-functional-independence-and-family-well-being-in-children-with-rare-genetic-disorders-100619769","NCT07348926","The Relationship Between Functional Independence and Family Well-being in Children With Rare Genetic Disorders","Examination of Families' Psychological Status and Quality of Life According to the Functional Independence Status of Children With Rare Genetic Diseases in Early Childhood","Inclusion Criteria:\n\n* Caregivers of children aged 0-4 years diagnosed with a rare genetic disorder.\n* The child must have been receiving physiotherapy for at least 6 months.\n* Caregivers who voluntarily agree to participate and provide informed consent.\n* Caregivers who are able to read and understand Turkish to complete the questionnaires.\n\nExclusion Criteria:\n\n* Caregivers who have cognitive or language limitations that prevent them from completing the questionnaires.\n* Caregivers who decline participation or submit incomplete questionnaire forms.\n* Children or caregivers with an additional medical or neurological condition that prevents participation in the study.","18 Years",{"count":121,"type":20},45,"OBSERVATIONAL","This study aims to examine the psychological status and quality of life of families with children who have rare genetic disorders. The focus of the study is to understand how the child's level of functional independence relates to the well-being of the family. Functional independence will be assessed using standardized tools, and parental psychological status and quality of life will be evaluated with validated questionnaires.\n\nThe information gathered from this study may help improve the understanding of how rare genetic disorders affect family dynamics and daily functioning. The results may guide health care professionals in planning family-centered physiotherapy, psychological support, and care programs.",[125,126,26],"Rare Genetic Disorders","Quality of Life",[125,128,129,126,130],"physical therapy","Depression","Family","2026-01-10",{"date":133,"type":39},"2026-01-16",{"date":135,"type":39},"2025-10-25",{"date":137,"type":20},"2026-03-15",{"name":139,"class":79},"Bahçeşehir University",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":56,"sex":147,"minAge":148,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":21,"phases":151,"briefSummary":152,"conditions":153,"keywords":154,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":168},"100505070","the-health-and-social-consequences-of-depression-among-the-elderly-100505070","NCT05856552","The Health and Social Consequences of Depression Among the Elderly","The Health and Social Consequences of Depression Among the Elderly: Evidence From India","Inclusion Criteria:\n\n* At least 55 years of age\n* Women\n\nExclusion Criteria:\n\n* Those with hearing, speech or mental impairment","FEMALE","55 Years",{"count":150,"type":20},5370,[23],"Mental illnesses often go undiagnosed or untreated in low-income settings. Mental health care may be especially important for the elderly - events in the lives of the elderly, like illnesses or deaths of peers, may put these individuals at high risk of mental illness. The study will constitute a randomized controlled trial aimed at reducing depression among elderly women. Through two interventions, the investigators will aim to improve women elder's outlook on life and relationships through cognitive behavioral therapy (CBT) and facilitated group activities. There will be a total of four treatment arms: one for CBT during home visits, one for facilitated group activities, one for both, and a control group receiving neither the CBT nor facilitated group activities. All activities will be delivered by lay government community volunteers. Randomization for group activities will be at the village level, and randomization for CBT will be at the individual-level within each village. Investigators will track outcomes of the elderly at two points in time: immediately after the main 12-week intervention period and 6 months after the main intervention period.",[129,26],[155,156,157,158,129],"Elderly","India","CBT","Group activities","2025-11-20",{"date":161,"type":39},"2025-11-26",{"date":163,"type":39},"2024-11-20",{"date":165,"type":20},"2028-12",{"name":167,"class":79},"National Bureau of Economic Research, Inc.",2,{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":16,"minAge":176,"maxAge":17,"enrollmentInfo":177,"targetDuration":179,"studyType":122,"phases":4,"briefSummary":180,"conditions":181,"keywords":185,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":47},"100486822","the-evolution-and-prognosis-of-moyamoya-disease-100486822","NCT05619068","The Evolution and Prognosis of Moyamoya Disease","Imaging Investigation on the Evolution and Prognosis of Moyamoya Disease","Inclusion Criteria:\n\n* Patients with MMD: Conventional angiography or MRI examination conforms to the Guidelines for Diagnosis and Treatment of MMD (Neurol Med Chir (Tokyo) 52, 245-266, 2012), It is characterized by stenosis or occlusion of the end of the internal carotid artery, anterior cerebral artery and\u002For the beginning of the middle cerebral artery of unknown cause, accompanied by dilatation of the perforating artery at the base of the brain or of capillaries on the surface of the brain, i.e., the formation of smoke vessels. Sign the informed consent. Older than 10 and younger than 60. The education level of patients reached primary school or above (years of education ≥6).\n\nExclusion Criteria:\n\n* Patients with massive cerebral infarction, multiple paraventricular ischemic foci, or significantly enlarged ventricular hydrocephalus after intracerebral hemorrhage. Patients with vascular diseases caused by immune system disease. Patients can not cooperate to complete the cognitive function test. There are other neuropsychiatric diseases that affect cognitive function (such as Alzheimer's disease, Parkinson's disease, depression, anxiety disorder, cerebral hemorrhage, hydrocephalus, craniocerebral trauma, etc.). Patients with contraindications of magnetic resonance examination (patients with pacemakers, nerve stimulators, artificial metal heart valves and other metal foreign bodies) or unable to complete image collection.","10 Years",{"count":178,"type":20},300,"5 Years","To investigate the evolution of imaging appearances and cognitive function of Moyamoya disease (MMD) and to establish a prognosis evaluation system based on imaging biomarkers in MMD. The study may be helpful to optimize and improve the diagnosis and pretreatment assessment of MMD, and provide an important theoretical supplement to the existing guidelines for the management of MMD.",[182,183,184,26],"Moyamoya Disease","Revascularization","Cognitive Impairment",[186,183,187,188],"Moyamoya disease","Cognitive impairment","Functional impairment","2022-12-19",{"date":191,"type":39},"2022-12-21",{"date":193,"type":39},"2022-09-01",{"date":195,"type":20},"2027-12-31",{"name":197,"class":79},"Chinese PLA General Hospital"]