[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"functionality\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:functionality":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,77,107,136],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100643220","impact-of-a-multicomponent-physical-exercise-program-on-the-functional-capacity-of-patients-admitted-to-an-intermediate-care-hospital-vivifrail-for-a-better-vig-frail-100643220",false,"NCT07637383","IMPACT OF A MULTICOMPONENT PHYSICAL EXERCISE PROGRAM ON THE FUNCTIONAL CAPACITY OF PATIENTS ADMITTED TO AN INTERMEDIATE CARE HOSPITAL. VIVIFRAIL FOR A BETTER VIG-FRAIL.","* baseline Barthel Index ≥60\n* ability to communicate, ambulate, and complete the exercise program","ALL","65 Years",{"count":18,"type":19},120,"ESTIMATED","INTERVENTIONAL",[22],"NA","INTRODUCTION Physical exercise in frail individuals has demonstrated benefits in variables such as reduced mortality risk and improved frailty and quality of life. Specifically, the most beneficial type appears to be multicomponent exercise, which includes strength, endurance, balance, and gait training. Within this field, the VIVIFRAIL project is an internationally recognized physical exercise promotion program.\n\nOBJECTIVES To analyze the effects of an individualized multicomponent physical exercise program as an effective method for preventing\u002Fimproving functional status and frailty in individuals admitted to an intermediate care hospital (ICH).\n\nTo assess whether improvements in functionality\u002Ffrailty are maintained 3-4 months after discharge and to evaluate the impact of the program on quality of life variables and health indicators at 6 months.\n\nMETHODOLOGY Design: randomized clinical trial with two groups (control and intervention) and 6 months of follow-up.\n\nStudy population: adults older than 65 years admitted to an intermediate care hospital (ICH).\n\nInclusion criteria: baseline Barthel Index ≥60, ability to communicate, ambulate, and complete the exercise program.\n\nPrimary variables: functionality (Short Physical Performance Battery - SPPB) and frailty (Frail-VIG Index).\n\nSecondary variables: grip strength, depressive symptoms, fear of falling, mortality, institutionalization, hospital admissions\u002Femergency room and primary care visits, level of physical activity, medications (number, analgesics, opioid use, antidepressants, anxiolytics), and quality of life.\n\nSample size: assuming a 15% loss to follow-up, the final required sample size is 120 patients. Linear mixed-effects models will be used with a significance level of 0.05.",[25,26],"Functionality","Fragility",[28,29,30],"Frailty","physical exercise","Quality of life","RECRUITING","2026-06-04",{"date":34,"type":35},"2026-06-09","ACTUAL",{"date":37,"type":35},"2026-02-18",{"date":39,"type":19},"2027-02",{"name":41,"class":42},"Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":15,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":54,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":43},"100607016","patients-diagnosed-with-scleroderma-physical-performance-and-functionality-100607016","NCT07183072","Patients Diagnosed With Scleroderma: Physical Performance and Functionality","Investigating the Relationship Between the Biopsychosocial Status of Individuals Diagnosed With Scleroderma and Their Physical Performance and Functionality","\\*For a child diagnosed with scleroderma\\*\n\nInclusion Criteria:\n\n* Cases diagnosed with scleroderma,\n* Cases aged 7-18 years will be included.\n\nExclusion Criteria:\n\n* Advanced heart\u002Flung\u002Fliver\u002Fkidney disease, neurological disease, and malignancies\n* Cases that are not willing to participate in the study will be excluded.\n* Having participated in a regular exercise program for the past 3 months\n* Individuals who are not willing to participate in the study\n\n\\*For adults diagnosed with scleroderma\\*\n\nInclusion Criteria:\n\n* Individuals diagnosed with scleroderma,\n* Individuals over the age of 18 will be included.\n\nExclusion Criteria:\n\n* Advanced heart\u002Flung\u002Fliver\u002Fkidney disease, neurological disease, and malignancies\n* Individuals who are not willing to participate in the study will be excluded.\n* Having participated in a regular exercise program for the past 3 months\n* Individuals who are not willing to participate in the study","7 Years",{"count":53,"type":19},50,"2 Weeks","OBSERVATIONAL","Physical functionality and performance are important for individuals diagnosed with scleroderma. There is a need to address children and adults diagnosed with scleroderma comprehensively and to evaluate them on a biopsychosocial basis to support their disease management. In light of all this literature, the aim was to evaluate the biopsychosocial characteristics of both pediatric and adult scleroderma patients and to examine their physical performance and functionality.\n\nAdditionally, this study aims to identify effective tests that can be used in future research to assess physical performance and functionality in individuals diagnosed with scleroderma.",[58,59,60,61,25],"Systemic Sclerosis (SSc)","Scleroderma","Scleroderma (Limited and Diffuse)","Scleroderma, Localized",[63,64,65,66,67],"Juvenile scleroderma","scleroderma","systemic sclerosis","physical performance","functionality","2025-09-13",{"date":70,"type":35},"2025-09-19",{"date":72,"type":35},"2025-08-04",{"date":74,"type":19},"2027-08-04",{"name":76,"class":42},"Hacettepe University",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":15,"minAge":85,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":20,"phases":87,"briefSummary":88,"conditions":89,"keywords":95,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100603350","postoperative-rotator-cuff-rehabilitation-functional-pain-and-sleep-quality-100603350","NCT07135375","Postoperative Rotator Cuff Rehabilitation: Functional, Pain and Sleep Quality","Postoperative Rotator Cuff: Functional, Pain and Sleep Quality","REHAB-PSF","Inclusion Criteria:\n\n* People over 50 years of age\n* People have undergone arthroscopic rotator cuff of one or more tendons.\n* Patients must sign informed consent and undergo physical therapy center (up to week 12 postoperatively).\n\nExclusion Criteria:\n\n* Patients who develop postoperative stiffness or adhesive capsulitis during the rehabilitation process.\n* Patients with symptoms of cervical radiculopathy or previously diagnosed sleep disorders.\n* Patients with neurological or cognitive disorders who have difficulty following instructions","50 Years",{"count":53,"type":19},[22],"Rotator cuff injuries are the third leasing cause of pain and disability, accounting for 16% of all musculoskeletal injuries. Following surgical intervention, patients typically undergo a 4 to 6 week immobilization period before starting physical therapy. This rehabilitation phase can last between 4 to 6 months. Despite this, there is currently a lack of clear guidelines regarding specific physical therapy protocols or the expected post surgical recovery for patients who have undergone rotator cuff repair.",[90,25,91,92,93,94],"Rotator Cuff Injuries","Pain","Sleep","Rehabilitation","Rotator Cuff",[93,96],"Rotator cuff","2025-09-03",{"date":99,"type":35},"2025-09-10",{"date":101,"type":35},"2025-08-26",{"date":103,"type":19},"2026-03-30",{"name":105,"class":42},"LAURA CASTILLO VEJAR",2,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":114,"sex":15,"minAge":115,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":20,"phases":117,"briefSummary":118,"conditions":119,"keywords":122,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":43},"100568141","impact-of-creatine-monohydrate-micronized-supplementation-with-or-without-multicomponent-training-in-older-adults-100568141","NCT06677359","Impact of Creatine Monohydrate Micronized Supplementation With or Without Multicomponent Training in Older Adults.","CREAGED","Inclusion Criteria:\n\n* Age: 75 years or older.\n* Able to ambulate with or without personal\u002Ftechnical assistance.\n* Life expectancy ≥ 6 months.\n* Barthel Index \\> 60.\n* Informed consent by patients, or legal representatives.\n\nExclusion Criteria:\n\n* Global Deterioration Scale (GDS 6-7).\n* Intolerance or allergy foods or drugs.\n* Deglutition problems (Dx: dysphagia)\n* Any pathological or metabolic condition incompatible with physical exercise.\n* Creatine supplementation for less than 6 weeks.\n* Consumption of more than 200 mg of caffeine daily.\n* Supervised physical training.",true,"75 Years",{"count":18,"type":19},[22],"The goal of this clinical trial is to study and evaluate whether a protocol of creatine supplementation, with or without multicomponent training, improves functional and cognitive capacity in individuals over 75 years old. The results of this study will further our understanding of creatine supplementation effects in the context of older patients and in combination with multicomponent training, thereby enhancing patient care strategies. Additionally, the goal is to improve the quality of life for the elderly and the efficiency of the healthcare system.\n\nThe main questions it aims to answer are:\n\n1. Does creatine supplementation alone provide physical, functional and cognitive benefits to people over 75 years of age?\n2. Is creatine supplementation safe for people over 75 years old?\n\nResearchers will compare creatine monohydrate supplementation with or without multicomponent training intervention to placebo supplementation with or without multicomponent training intervention to see if the creatine supplementation protocol leads to significant improvements in functional and cognitive outcomes. This comparison will help determine the effectiveness of the supplementation intervention in enhancing the overall well-being of elderly patients.\n\nParticipants will:\n\n* Engage in a structured multicomponent exercise program designed specifically for elderly patients. This program will include activities focused on strength training, balance exercises, and walking to improve mobility and reduce the risk of falls.\n* Attend supervised exercise sessions several times a week, allowing for individualized attention and adjustments based on each participants abilities and health status.\n* Be monitored for changes in functional capacity using standardized assessments, which will measure improvements in mobility, strength, and overall physical functioning.\n* Undergo cognitive assessments to evaluate any changes in cognitive status throughout the intervention and during follow-up periods after discharge.\n* Participate in surveys and interviews to assess their quality of life, including physical, emotional, and social well-being, before and after the intervention.\n* Attend follow-up assessments at designated intervals to track their progress and outcomes, ensuring that any long-term benefits of the exercise program are recognized and documented.\n\nInclusion criteria will focus on individuals aged over 75 years. Participants must be capable of communication and ambulation, either independently or with assistance.\n\n* Life expectancy ≥ 6 months.\n* Barthel Index \\> 60.\n\nExclusion criteria will ensure the safety and appropriateness of the intervention. Individuals who explicitly refuse to participate or cannot provide informed consent will be excluded. Additionally, those with a life expectancy of less than three months, terminal illnesses, or significant medical contraindications for exercise will not be eligible. Participants with moderate to severe neurocognitive disorders or disabilities that severely limit mobility will also be excluded to maintain the integrity of the intervention.\n\nThis clinical trial aims to recruit a total of 120 participants from the Geriatric Department or Primary Care, providing a comprehensive dataset to analyze the effectiveness and safety of the multicomponent exercise program. By examining the outcomes related to functional capacity, cognitive status, and quality of life, the study seeks to provide valuable insights into the benefits of physical activity for elderly patients during hospitalization.",[25,120,121],"Cognition","Strength Training Effects",[123,124,125,126],"creatine","supplementation","multicomponent training","older people","2025-06-09",{"date":129,"type":35},"2025-06-12",{"date":131,"type":35},"2024-11-30",{"date":133,"type":19},"2026-12-01",{"name":135,"class":42},"Fundacion Miguel Servet",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":15,"minAge":143,"maxAge":4,"enrollmentInfo":144,"targetDuration":146,"studyType":55,"phases":4,"briefSummary":147,"conditions":148,"keywords":156,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":43},"100532846","update-on-the-detection-of-frailty-in-older-adults-100532846","NCT06218121","Update on the Detection of Frailty in Older Adults","Update on the Detection of Frailty in Older Adults: A Multicenter Cohort Machine Learning-Based Study","Inclusion Criteria:\n\nA diagnosis of signs and symptoms of frailty by a geriatric physician in the research group will be used as the primary inclusion criterion. Frailty will be assessed and diagnosed using the frailty phenotype and the Clinical Frailty Scale.\n\nExclusion Criteria:\n\n* Acute myocardial infarction in the last 3 months and\u002For unstable angina pectoris\n* Uncontrolled arrhythmia, recent thromboembolism and terminal illness.\n* Patients undergoing MMII unloading or MMSS\u002FMMII fractures in the last three months.\n* Patients with a functional gait index of 1 (Inability to walk)\n* Severe pain (7\u002F10 VAS)\n* Previous neuromuscular pathology presenting with weakness\n* Medication that does not allow the patient's actual muscle reaction to be assessed\n* Severe cognitive impairment that would prevent collaboration and understanding of the tests to be performed.\n* Cardiovascularly unstable patients and uncontrolled arterial hypertension.","62 Years",{"count":145,"type":19},500,"2 Years","The main objective is to update the diagnostic assessment of frailty by correlating several variables with the ultrasound image of the frail elderly patient.\n\nSecondarily, the investigators intend to collect and analyze data on functional capacity and quality of life variables on the evolution of musculoskeletal symptoms, as well as on pain and psychological variables. Similarly, it is intended to make a record of different profiles and subtypes of frail older adult patients to be stored in Machine Learning in order to establish therapeutic intervention plans that allow both the evaluation and treatment of patients.",[149,150,151,25,91,152,153,154,155],"Strength","Quality of Life","Functional Independence","Sarcopenia","Anxiety","Kinesiophobia","Depression",[28,30,152,157],"Ultrasound","2024-07-08",{"date":160,"type":35},"2024-07-09",{"date":162,"type":35},"2024-04-20",{"date":164,"type":19},"2025-06-15",{"name":166,"class":42},"Universidad Europea de Madrid"]