[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fusion-of-spine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fusion-of-spine":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,73,103,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100608648","lumbar--sacroiliac-fusion-study-involving-previously-implanted-devices-100608648",false,"NCT07204288","Lumbar & Sacroiliac Fusion Study Involving Previously Implanted Devices","Lumbar & Sacroiliac Fusion Study: Multi-Center Prospective Radiographic Study on Subjects Previously Implanted With Spinal Simplicity Lumbar and\u002For Sacroiliac Fusion Device(s)","FUSION","Inclusion Criteria:\n\n1. Be 18 years of age or older at the time of enrollment\n2. Be willing and able to provide informed consent and comply with study visit requirements\n3. Subjects who received a Spinal Simplicity fusion implant(s) (Minuteman G5, Liberty, and\u002For Patriot) between April 1, 2022 and March 31, 2025\n\nExclusion Criteria:\n\n1. Unable to provide consent and complete prospective data collection\n2. Women who are pregnant, or may become pregnant, during the course of the study\n3. Contraindication to CT scanning, in the opinion of the investigator","ALL","18 Years",{"count":20,"type":21},500,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is a multi-center, observational, prospective and retrospective data collection study",[27,28],"Fusion of Spine","Sacroiliac; Fusion","RECRUITING","2026-03-16",{"date":32,"type":33},"2026-03-18","ACTUAL",{"date":35,"type":33},"2025-09-11",{"date":37,"type":21},"2026-12",{"name":39,"class":40},"Spinal Simplicity LLC","INDUSTRY",3,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":72},"100544359","phase-4-efficacy-and-safety-of-preemptive-intravenous-dexamethasone-in-mis-tlif-100544359","NCT06367855","Efficacy and Safety of Preemptive Intravenous Dexamethasone in MIS-TLIF","MIS-TLIF","Inclusion Criteria:\n\n* Age range: 50-80 years old.\n* Undergoing MIS TLIF surgery at 1-2 spinal levels.\n\nExclusion Criteria:\n\n* Previously undergone spine surgery.\n* HbA1C greater than or equal to 7.5 mg%\n* Allergic to all types of experimental medication.\n* History of using systemic steroids.",true,"50 Years","80 Years",{"count":53,"type":21},60,[55],"PHASE4","Researchers are considering Dexamethasone as preemptive medication before minimally invasive spine fusion surgery to minimize postoperative back pain with minimal side effects, aiming to enhance the effectiveness of surgery and improve patient outcomes.",[58,59,60,27,61],"Spinal Stenosis Lumbar","Disc Degeneration","Disc Disease","Surgery","2025-08-31",{"date":64,"type":33},"2025-09-08",{"date":66,"type":33},"2024-05-01",{"date":68,"type":21},"2025-12-31",{"name":70,"class":71},"Potsawat Surabotsopon","OTHER",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":72},"100517995","vertebropexy---randomized-controlled-trial-100517995","NCT06024785","Vertebropexy - Randomized-controlled Trial","Comparison of Ligamentous Fixation Technique (Vertebropexy) Versus Conventional Decompression or Fusion Surgery for Degenerative Lumbar Spinal Disease: A Randomized Controlled Trial","VPRCT","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Single-level or two-level lumbar surgery needed\n* Indication for decompression surgery in patients with spinal canal stenosis and additional stable degenerative listhesis (without facet joint effusion ≥ 2mm)\n* Indication for fusion surgery in patients with spinal canal stenosis and additional unstable degenerative listhesis (facet joint effusion ≥ 2mm), in patients with foraminal stenosis and additional degenerative listhesis, and in patients with segment degeneration of the disc\n* Understanding in German language\n\nExclusion criteria:\n\n* Indication for decompression and\u002For fusion surgery in patients with solely disc herniation, fractures, lytic listhesis, tumor\n* Patients undergoing revision surgery for infection\n* Patients undergoing revision surgery on the same level if bony structures have been removed (e.g. prior laminectomy or midline decompression)\n* Patients undergoing revision surgery in case of prior fusion surgery\n* Inability to understand the study for linguistic or cognitive reasons\n* Anticipated clinical follow-up of less than 6 weeks after inclusion\n* Participation in other clinical trials",{"count":82,"type":21},164,[24],"To assess the need for additional fusion surgery versus the risk of a revision surgery in patients with degenerative lumbar spinal disease and to assess efficacy and risk of the ligamentous fixation technique (vertebropexy)",[86,87,27],"Degeneration","Spinal Stenosis",[89,90,91,92,93],"degenerative lumbar spinal disease","decompression","fusion","vertebropexy","ligamentous fixation","2025-02-11",{"date":96,"type":33},"2025-02-13",{"date":98,"type":33},"2025-01-16",{"date":100,"type":21},"2028-12",{"name":102,"class":71},"Balgrist University Hospital",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":72},"100319474","to-brace-or-not-to-brace-for-single-level-lumbar-fusion-pilot-100319474","NCT03439228","To Brace or Not to Brace for Single Level Lumbar Fusion Pilot","To Brace or Not to Brace for Single Level Lumbar Fusion: a Pilot Prospective Randomized Controlled Trial","BRACE Pilot","Inclusion Criteria:\n\n* Single-level lumbar instrumented postero-lateral fusion from L2-L5\n* Life expectancy greater than 2 years\n\nExclusion Criteria:\n\n* Previous lumbar surgery\n* Spine tumour\u002Fcancer\n* Documented osteoporosis\n* High grade (3 or 4) spondylolisthesis",{"count":112,"type":21},50,[24],"The use of a lumbar brace following single-level lumbar fusion for degenerative spondylosis (non-traumatic) is variable between surgeons. Some surgeons prefer to prescribe a brace and others do not. There is a lack of guidelines and evidence to support either treatment option. The purpose of this study is to assess feasibility and collect preliminary data to conduct a larger, definitive trial to provide evidence as to whether prescribing a brace or not results in better or equal outcomes. Imaging by CT scan, one year after surgery, will be used to analyze bone fusion (healing), and functional and pain scores from patients during their recovery will be compared to identify differences between patients who wore a brace and those who did not.",[116,27],"Lumbar Spondylosis","2024-10-21",{"date":119,"type":33},"2024-10-23",{"date":121,"type":33},"2018-07-16",{"date":123,"type":21},"2025-12",{"name":125,"class":71},"Hamilton Health Sciences Corporation",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":22,"phases":136,"briefSummary":137,"conditions":138,"keywords":157,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":72},"100410368","cervical-arthroplasty-cost-effectiveness-study-caces-100410368","NCT04623593","Cervical Arthroplasty Cost Effectiveness Study (CACES)","Economic Evaluation of Anterior Cervical Discectomy With Arthroplasty Versus Anterior Cervical Discectomy With Fusion in the Surgical Treatment of Cervical Degenerative Disc Disease, a Randomized Controlled Trial","CACES","Inclusion Criteria:\n\n* Indication for anterior cervical decompression surgery.\n* Single- or multilevel CDDD between C3 and C7.\n* Symptoms of myelopathy, radiculopathy, or myeloradiculopathy.\n* In case of pure radiculopathy: refractory to at least 6 weeks of conservative therapy.\n* In case of myelopathy: symptomatic myelopathy.\n* Patients ≥ 18 years of age.\n\nExclusion criteria\n\n* Indication for (additional) posterior surgical approach.\n* Indication for additional stabilization of the pathological segment by a plate.\n* Previous ventral surgery of the cervical spine.\n* Traumatic origin of the compression.\n* Previous radiotherapy of the cervical spine.\n* Metabolic bone disease.\n* Inflammatory spinal disease: e.g., Bechterew's disease, Forestier's disease.\n* Infection of the cervical spine.",{"count":135,"type":21},198,[24],"To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD). The most commonly used surgical treatment for patients with single- or multilevel symptomatic CDDD is anterior cervical discectomy with fusion (ACDF). However, new complaints of radiculopathy and\u002For myelopathy commonly develop at adjacent levels, also known as clinical adjacent segment pathology (CASP). It remains unknown to what extent kinematics, surgery-induced fusion and natural history of disease play a role in its development. Anterior cervical discectomy with arthroplasty (ACDA) is thought to reduce the incidence of CASP by preserving motion in the operated segment. ACDA is often discouraged as the implant costs are higher whilst the clinical outcomes are similar to ACDF. However, preventing CASP might be a reason for ACDA to be a more cost-effective technique in the long-term.\n\nIn this randomized controlled trial patients will be randomized to receive ACDF or ACDA in a 1:1 ratio. Adult patients with single- or multi-level CDDD and symptoms of radiculopathy and\u002For myelopathy will be included. The primary outcome is cost-effectiveness and cost-utility of both techniques from a societal perspective. Secondary objectives are the differences in clinical and radiological outcomes between the two techniques, as well as the qualitative process surrounding anterior decompression surgery. All outcomes will be measured at baseline and every 6 months till 4 years postoperatively.\n\nHigh quality evidence regarding the cost-effectiveness of both ACDA and ACDF is lacking, to date no prospective trials from a societal perspective exist. Considering the ageing of the population and the rising healthcare costs, the need for a solid clinical cost-effectiveness trial addressing this question is high.",[139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,27,156],"Radiculopathy, Cervical","Myelopathy Cervical","Myelopathy, Compressive","Radiculopathy, Cervical Region","Radiculopathy; in Spondylosis","Radiculopathy; in Intervertebral Disc Disorder","Myelopathy Neurological","Myelopathy Due to Spondylosis","Cervical Disc Disease","Cervical Disc Herniation","Cervical Disc Degeneration","Cervical Disc Disorder With Myelopathy","Cervical Disc Prolapse With Myelopathy","Cervical Spondylosis","Cervical Fusion","Cervical Disc Disorder With Radiculopathy","Cervical Disc Prolapse With Radiculopathy","Disc Prolapse Cervical",[158,159,160,161,162,163,164,165,166,167,168,169,170,171],"Cost-effectivity","Economic evaluation","Health Utility","Randomised controlled trial","RCT","ACDA","ACDF","Anterior cervical discectomy and fusion","Anterior cervical discectomy with arthroplasty","Degenerative cervical myelopathy","Degenerative cervical radiculopathy","ASD","Adjacent Segment Disease","Adjacent Level Disease","2024-01-24",{"date":174,"type":33},"2024-01-25",{"date":176,"type":33},"2022-01-17",{"date":178,"type":21},"2028-06-01",{"name":180,"class":71},"Valérie Schuermans"]