[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gait-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gait-disorder":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100631607","deep-phenotyping-gait-deficits-in-orthopedic-manifestations-of-pediatric-cancer-patients-100631607",false,"NCT07502885","Deep Phenotyping Gait Deficits in Orthopedic Manifestations of Pediatric Cancer Patients","Inclusion Criteria\n\nCases:\n\n* Participant requiring orthopedic surgery due to a diagnosis of lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis (Appendix III) and will receive further additional treatment and\u002For follow-up care at St. Jude.\n* Participant is between the ages of ≥5 and ≤20 years old at the time of enrollment.\n\nControls:\n\n* Participant is between the ages of ≥5 and ≤20 years old at the time of enrollment.\n* Participant (or their parent\u002Flegal guardian) considers themself healthy for their age.\n* Participant (or their parent\u002Flegal guardian) reports being able to participate in normal daily activities of life with respect to their age.\n\nExclusion Criteria\n\nCases:\n\n* Individuals with pre-existing genetic\u002Fcongenital disorders affecting gait will be excluded e.g., cerebral palsy.\n* Individuals who are unable to follow age-appropriate instructions during the gait assessment.\n* Inability or unwillingness of research participant or legal guardian\u002Frepresentative to give written informed consent.\n* Individuals diagnosed with radiation-induced avascular necrosis.\n\nControls:\n\n* Individuals who are unable to follow age-appropriate instructions during the gait assessment.\n* Individuals who self-report health conditions affecting gait and mobility.\n* Individuals who have the following conditions: diabetes mellitus due to impaired circulation, sensation and strength, malignant cancers, demyelinating inflammatory and degenerative neurological conditions, pregnancy, obesity (BMI \\>40 kg\u002Fm2), severe cardiac or pulmonary disease affecting performance of daily activities, history of major surgery affecting gait and mobility, infections or inflammatory arthropathies, severe mobility impairment necessitating dependence on mobility aids for all ambulation.\n* Individual or legal guardian\u002Frepresentative is unable or unwilling to give written informed consent.",true,"ALL","5 Years","20 Years",{"count":20,"type":21},300,"ESTIMATED","OBSERVATIONAL","The goal of DEEPGAIT study is to determine how serious walking problems are for pediatric cancer patients who have had orthopedic surgery, how they change over time, and what can be done to help. Healthy participants without cancer will also be included in this study in order to better understand the difference in walking problems between the 2 groups.\n\nDEEPGAIT is a long term study that uses advanced tools-including 3D motion capture, muscle sensors, force plates, and wearable devices-to take a detailed look at how these patients move. Their results are compared to healthy children of the same age and sex.\n\nPRIMARY OBJECTIVES\n\n* Characterize gait deficits in pediatric cancer patients 1 year following orthopedic surgery for lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis.\n* Identify personal, disease, treatment and environment risk factors for gait deficits in pediatric cancer patients 1 year following orthopedic surgery for lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis.\n\nSECONDARY OBJECTIVES\n\n* Build a library of broadly representative normative reference values to generate age- and sex-matched z-scores to quantify frequency, severity and progression of gait deficits among pediatric cancer patients in relation to healthy controls.\n* Characterize the changes of gait parameters in pediatric cancer patients with or without gait deficits 1 year after orthopedic surgery for lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis, up to 5 years after surgery.\n* Identify personal, disease, treatment and environment risk factors for trajectories of gait deficits in pediatric cancer patients with or without gait deficits 1 year after orthopedic surgery for lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis, up to 5 years after surgery.",[25,26,27],"Sarcoma, Bone","Sarcoma, Soft Tissue","Gait Disorder","RECRUITING","2026-06-16",{"date":31,"type":32},"2026-06-18","ACTUAL",{"date":29,"type":32},{"date":35,"type":21},"2032-01",{"name":37,"class":38},"St. Jude Children's Research Hospital","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100618686","anterior-foot-wedge-with-neuromuscular-training-for-balance-in-parkinsons-disease-100618686","NCT07334847","Anterior Foot Wedge With Neuromuscular Training for Balance in Parkinson's Disease","Efficacy of Anterior Foot Wedge Modulation With Neuromuscular Training on Balance During Walking in Parkinsonian Patients","AFW-NT","Inclusion Criteria:\n\n* Diagnosis of Parkinson's disease, confirmed by neurologist. Disease severity classified as Stage III on the Hoehn \\& Yahr scale. Age between 45 and 75 years. Medically stable (normal vital signs). Conscious, cooperative, and able to follow instructions. No severe cognitive or psychological impairment. Able to provide informed consent.\n\nExclusion Criteria:\n\n* Severe disability or advanced Parkinsonism (Stage IV or V). Presence of other neurological or orthopedic conditions affecting gait or balance (e.g., stroke, spinal cord injury, severe arthritis).\n\nHistory of diabetes in second-degree relatives (as specified in your protocol). Unstable medical conditions (e.g., uncontrolled hypertension, cardiac disease). Inability to stand or walk with minimal assistance. Non-cooperative or unable to tolerate assessment procedures (EMG, Biodex, motion analysis).","45 Years","75 Years",{"count":51,"type":21},30,"INTERVENTIONAL",[54],"NA","This study will test whether combining an anterior foot wedge with neuromuscular training can improve balance, gait, and muscle activity in people with Parkinson's disease. Thirty patients (ages 45-75) with moderate Parkinson's (Hoehn \\& Yahr Stage III) will be randomly assigned to one of two groups:\n\nGroup 1 (Control): Receives a standard physical therapy program including stretching, strengthening, PNF, weight-shifting, and gait training.\n\nGroup 2 (Experimental): Receives the same physical therapy plus neuromuscular training using the Biodex Multi-Joint System and a custom anterior foot wedge.\n\nAll participants will train for 60 minutes, three times per week, for 8 weeks. Before and after the program, researchers will measure: balance (using the Biodex Balance System), gait (via Unified Parkinson's Disease Rating Scale and motion analysis), and muscle activity in the trunk (using electromyography). The goal is to find a more effective rehabilitation approach to reduce fall risk and improve walking in Parkinson's patients.",[57,58,27],"Parkinson's Disease","Postural Instability",[60,61,62,63,64,65,66],"Anterior foot wedge","Neuromuscular training","Balance","Gait","Biodex","Electromyography","Postural stability","NOT_YET_RECRUITING","2025-12-31",{"date":70,"type":32},"2026-01-12",{"date":72,"type":21},"2026-01-02",{"date":74,"type":21},"2026-03-14",{"name":76,"class":38},"MTI University",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":85,"maxAge":49,"enrollmentInfo":86,"targetDuration":4,"studyType":52,"phases":88,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":39},"100507442","isokinetic-strength-training-in-hemiparetic-patient-with-knee-extension-thrust-100507442","NCT05887440","Isokinetic Strength Training in Hemiparetic Patient With Knee Extension Thrust","Effects of Isokinetic Strength Training of Knee Flexor and Extensor Muscles on Walking in Hemiparetic Patients With Knee Extension Thrust","ISOWALK","Inclusion Criteria:\n\n* Hemiparetic patient (hemorragic or ischemic stroke)\n* Subacute stage (\\\u003C 6 Months) ou chronic stage of stroke (\\> 6 months) (6 patients in each group)\n* Age between 18 and 75 years\n* Able to walk 10 meters independently without any assistive devices\n* Knee extension thrust during stance phase of gait cycle (rapid posterior movement of the knee toward extension)\n* Scheduled rehabilitation program with isokinetic strength training\n* affiliation to a social security\n* Patients who received and signed informed consent\n\nExclusion Criteria:\n\n* Major comprehension deficit that not allow to give informed consent and participate to isokinetic strength training (assessed with comprehension subscore of Langague screening Test)\n* non stable (unstable cardiovascular condition)\n* musculoskeletal disorders with knee pain that not allowed isokinetic strength training\n* Botulinum toxin injection less than 3 months or repeated injection in lower limb,\n* Proprioception trouble assessed with proprioception section of the Fugl-Meyer Assessment \\[FMA-P\\] 0\u002F2\n* spasticity of triceps surae ≥2 (Modified Ashworth scale)\n* ankle dorsiflexion angle less than 90°\n* pregnant women or breastfeeding\n* persons with safety measure","18 Years",{"count":87,"type":21},12,[54],"The purpose of this study is to assess the impact of an isokinetic strength training of knee flexor and extensor muscles on walking performance in hemiparetic patients with knee extension thrust.",[91,27],"Hemiparesis\u002FHemiplegia (One Sided Weakness\u002FParalysis)",[93,94,95,96,97,98],"Stroke","Extensor thrust","resistance training","Isokinetic","walking speed","rehabilitation","2023-09-01",{"date":101,"type":32},"2023-09-05",{"date":103,"type":32},"2023-08-21",{"date":105,"type":21},"2026-12-01",{"name":107,"class":38},"Rennes University Hospital"]