[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gait-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gait-disorders":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,51,83,113,140,161,202,236,263,295,321,346,378,407],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100641553","cognitive-based-balance-rehabilitation-in-parkinsons-disease-virtual-reality-vs-dual-task-100641553",false,"NCT07660978","Cognitive-Based Balance Rehabilitation in Parkinson's Disease: Virtual Reality vs. Dual Task","Effects of Cognitive-Based Balance Rehabilitation on Balance, Gait and Cognitive Functions in Parkinson's Disease Patients: Comparison of Virtual Reality and Dual Task","Inclusion Criteria:\n\n* Diagnosed with Parkinson's Disease by a neurologist.\n* Hoehn \\& Yahr Stage I-III.\n* Aged between 40-80 years.\n* Literate and capable of performing basic mathematical calculations.\n* Montreal Cognitive Assessment≥21\n* Stable pharmacological treatment.\n* Physician's approval for exercise participation.\n\nExclusion Criteria:\n\n* Currently participating in another exercise or drug trial.\n* Presence of any additional neurological disorders.\n* Significant musculoskeletal disorders, arthritis, or cardiovascular disease.\n* Uncontrolled epilepsy or severe orthostatic hypotension.\n* Engaged in regular moderate-intensity exercise more than once a week in the last 6 months.","ALL","40 Years","80 Years",{"count":20,"type":21},34,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective, randomized, single-blind, controlled clinical trial aims to evaluate and compare the efficacy of cognitive-based balance rehabilitation delivered via immersive Virtual Reality (VR) versus traditional Dual-Task Training (DTT) on balance, gait, cognitive functions, and quality of life in patients with Parkinson's Disease (PD). Postural instability and cognitive decline are hallmark features of progressive PD that significantly elevate fall risks and compromise daily independence, yet conventional pharmacological therapies offer limited effectiveness in restoring complex postural control. Given that motor and cognitive processes are intrinsically linked, this study addresses a critical gap in neurorehabilitation by investigating two contemporary modalities designed to challenge these systems simultaneously. A total of 34 participants diagnosed with PD (aged 40-80 years, Hoehn and Yahr stages I-III) will be randomly allocated to either the Dual-Task Group (DTG), receiving structured therapeutic exercises integrated with sequential cognitive tasks, or the Virtual Reality Group (VRG), engaging in an immersive balance program utilizing the Oculus Quest 2® headset with the FIT-XR application. Both groups will undergo an identical intervention protocol consisting of 45-minute supervised sessions, conducted twice weekly for 8 consecutive weeks during their pharmacological \"on\" phase. Standardized assessments will be performed by a blinded clinician at baseline and post-intervention (Week 8). The primary outcome measures will be dynamic balance and gait assessed through the Mini-Balance Evaluations Systems Test (Mini-BESTest) alongside global cognitive performance measured via the Montreal Cognitive Assessment (MoCA). Secondary outcomes will encompass objective posturographic indices using the Biodex Balance System, motor severity via the Unified Parkinson's Disease Rating Scale (UPDRS-III), freezing of gait, health-related quality of life, global perceived improvement, and potential cyber-sickness symptoms monitored through the Virtual Reality Sickness Questionnaire (VRSQ) to comprehensively determine the safety and comparative therapeutic value of these interventions.",[27,28,29,30,31,32,33],"PARKINSON DISEASE (Disorder)","Parkinson Disease (PD)","Parkinson s Disease","Postural Instability","Postural Instability Gait Disorders","Gait Disorders","Cognitive Dysfunction, Cognitive Disorder",[35,30,32,36,37,38],"Parkinson Disease","Cognitive Dysfunction","Dual Task","Virtual Reality","NOT_YET_RECRUITING","2026-06-23",{"date":42,"type":43},"2026-06-25","ACTUAL",{"date":45,"type":21},"2026-06-20",{"date":47,"type":21},"2027-12-30",{"name":49,"class":50},"Bezmialem Vakif University","OTHER",{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":82},"100589812","balance4mobility-effects-of-walkasins-use-in-individuals-with-peripheral-neuropathy-and-balance-problems-100589812","NCT06959277","Balance4Mobility: Effects of Walkasins Use in Individuals With Peripheral Neuropathy and Balance Problems","Balance4Mobility: Effects of Walkasins Use on Clinical Outcomes of Gait and Balance Function in Individuals With Peripheral Neuropathy and Balance Problems - A Randomized Control Trial","Inclusion Criteria:\n\n* Able to understand and provide informed consent for him or herself\n* Age 55 and older, male or female\n* Able to complete all functional outcome measures without the use of an assistive device\n* Clinical diagnosis of peripheral neuropathy prior to participating in the study as documented in the participant's medical record or by physician's note. Individuals with chemo-induced peripheral neuropathy must be at least one-year post-chemotherapy, indicating that their PN has become a chronic condition.\n* Self-reported gait and balance problems\n* Foot size that allows the Walkasins to function appropriately\n* Willing to use the Walkasins device as recommended\n\nExclusion Criteria:\n\n* Ability to stand on one leg for at least 30 seconds (If the person can stand for at least 30 seconds, he\u002Fshe is excluded because his\u002Fher balance is likely not impaired enough to benefit from Walkasins.)\n* Self-reported acute thrombophlebitis, including deep vein thrombosis\n* Self-reported severe peripheral vascular disease\n* Untreated lymphedema\n* Untreated lesion of any kind, swelling, infection, inflamed area of skin or eruptions on the lower leg near product use\n* Self-reported, untreated fractures in the foot and ankle\n* Other neurological or musculoskeletal conditions that moderately or severely impact walking\n* Use of ankle-foot orthosis for ambulation that prevents donning of Walkasins\n* Weight of more than 300 pounds\n* Inability to perceive vibration from Walkasins Haptic Module","55 Years",{"count":60,"type":21},200,[24],"The goal of this clinical trial is to is to test whether Walkasins can help people with peripheral neuropathy maintain their balance better. The main question it aims to answer is whether participants who use Walkasins on an everyday basis over a six-month period will report better awareness of their foot placement on the ground.\n\nResearchers will compare Walkasins users to a control group of participants who are not using Walkasins to see if the device improves the users' performance on some standing and walking tests. Control group participants will get Walkasins after six months of being in the study.\n\nDuring the study participants will be asked to do the following:\n\n* Answer questions about their medical history and balance.\n* Do some standing and walking tests. Some of the tests will be timed.\n* Attend study visits and participate in study phone calls.\n* Keep track of any falls and notify study staff if they fall.\n* Wear the Walkasins device on a regular basis.",[64,65,66,67,32],"Peripheral Neuropathies","Peripheral Neuropathy Due to Chemotherapy","Peripheral Neuropathy With Type 2 Diabetes","Balance Control in Elderly",[69,70,71],"Walkasins","Peripheral Neuropathy","Balance Problems","RECRUITING",{"date":74,"type":43},"2026-06-24",{"date":76,"type":43},"2025-06-17",{"date":78,"type":21},"2027-12-31",{"name":80,"class":81},"RxFunction Inc.","INDUSTRY",6,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":91,"targetDuration":93,"studyType":94,"phases":4,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":108,"leadSponsor":110,"locationsCount":112},"100634487","effects-of-cognitive-dual-task-on-gait-in-parkinsons-disease-100634487","NCT07540325","Effects of Cognitive Dual-Task on Gait in Parkinson's Disease","Investigating the Effects of Cognitive Dual-Task on Gait in Individuals With Parkinson's Disease","Inclusion Criteria for Individuals with Parkinson's Disease:\n\n* A clinical diagnosis of Parkinson's Disease confirmed by a neurologist according to the United Kingdom Parkinson's Disease Society Brain Bank diagnostic criteria\n* Classified between stages 1 and 3 according to the Modified Hoehn and Yahr Staging Scale\n* Aged between 40 and 80 years\n* A score of at least 21 on the Montreal Cognitive Assessment (MoCA)\n* Ability to walk continuously for at least 10 minutes without interruption and without the use of any assistive walking device\n* Having received at least 5 years of formal education\n\nExclusion Criteria for Individuals with Parkinson's Disease:\n\n* Presence of any neurological disorder other than Parkinson's Disease\n* Presence of any cardiopulmonary or musculoskeletal condition that may impair safe ambulation\n* A score of ≥10 for anxiety and ≥7 for depression on the Hospital Anxiety and Depression Scale (HADS)\n* Presence of visual or auditory impairments that cannot be corrected with assistive devices\n\nInclusion Criteria for Healthy Individuals:\n\n* Aged between 40 and 80 years\n* A score of at least 21 on the Montreal Cognitive Assessment (MoCA)\n\nExclusion Criteria for Healthy Individuals:\n\n* Presence of any neurological disorder\n* Presence of any cardiopulmonary or musculoskeletal condition that may affect safe ambulation\n* A score of ≥10 for anxiety and ≥7 for depression on the Hospital Anxiety and Depression Scale (HADS)\n* Presence of visual or auditory impairments that cannot be corrected with assistive devices",true,{"count":92,"type":21},30,"2 Days","OBSERVATIONAL","The aim of this study is to evaluate gait in individuals diagnosed with PD under tasks involving different cognitive domains, to compare the results with those of age and sex-matched healthy individuals, and to determine which cognitive function has the greatest impact on gait in PD.",[97,98,32],"Parkinson's Disease (PD)","Cognition",[100,101,102,103],"Gait","Cognitive Function","Dual-Task","Parkinson's Disease","2026-04-17",{"date":106,"type":43},"2026-04-20",{"date":106,"type":21},{"date":109,"type":21},"2026-12-31",{"name":111,"class":50},"Gazi University",1,{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":126,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":112},"100630465","effects-of-the-stimulation-site-of-tsms-with-tms-on-functional-mobility-in-individuals-with-parkinsons-disease-100630465","NCT07488026","Effects of the Stimulation Site of tsMS With TMS on Functional Mobility in Individuals With Parkinson's Disease","Effects of the Stimulation Site of Trans-spinal Magnetic Stimulation Combined With Transcranial Magnetic Stimulation on Functional Mobility in Individuals With Parkinson's Disease","Inclusion Criteria: (i) a clinical diagnosis of Parkinson's disease confirmed by a neurologist; (ii) stable dopaminergic pharmacological treatment for at least three months; (iii) age 40 years or older; (iv) disease stage between 2.5 and 3 on the modified Hoehn and Yahr scale; (v) (v) gait impairment, defined as the occurrence of at least one freezing of gait episode per week.\n\n\\-\n\nExclusion Criteria:\n\n(i) other neurological disorders, orthostatic hypotension, vestibular, musculoskeletal, or visual impairments that could compromise performance on the proposed assessments; (ii) other osteomuscular conditions affecting the lower limbs that interfere with mobility and functional performance; (iii) a Montreal Cognitive Assessment (MoCA) score lower than 21 points; (iv) prior surgical procedures for Parkinson's disease; or (v) contraindications to magnetic stimulation techniques, including a history of seizures or the presence of metallic implants in the neck or spinal region.",{"count":92,"type":21},[24],"This randomized clinical trial aims to compare the effects of two different trans-spinal magnetic stimulation (tsMS) application sites, cervical versus thoracic, when combined with repetitive transcranial magnetic stimulation (rTMS), on functional mobility in individuals with Parkinson's disease (PD). Participants diagnosed with PD will be randomized into two intervention groups (rTMS + cervical tsMS or rTMS + thoracic tsMS) and will undergo 10 treatment sessions. Outcomes will include functional mobility, gait speed, motor function, freeing of gait, balance, quality of life, global perceived improvement and adverse events. The study is expected to identify the most effective tsMS application site to enhance mobility and motor outcomes in PD, contributing to the optimization and standardization of tsMS protocols as an adjunct therapy.",[97,32,124,125],"Transcranial Magnetic Stimulation","Spinal Cord Stimulation",[127,128,129,130],"gait disorders","spinal cord stimulation","transcranial magnetic stimulation","parkinson's disease","2026-03-18",{"date":133,"type":43},"2026-03-23",{"date":135,"type":43},"2026-01-05",{"date":137,"type":21},"2026-12",{"name":139,"class":50},"Universidade Federal de Pernambuco",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":90,"sex":16,"minAge":147,"maxAge":18,"enrollmentInfo":148,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":112},"100629320","quantifying-gait-disorders-with-wearable-sensors-100629320","NCT07473141","Quantifying Gait Disorders With Wearable Sensors","Quantification of Gait Differences Between Healthy Volunteers and Patients Suffering From Gait Disorders Through Wearable Sensors","Inclusion Criteria:\n\n* Hospitalized at the Department of Rehabilitation and Functional Recovery of IRCCS Ospedale San Raffaele - Milan (during the hospitalization period)\n* Ability to understand and sign informed consent\n* ≥ 18 years ≤80 years\n* Male and female\n* Presence of clinically diagnosed gait impairments\n* No skin conditions or allergies preventing sensor application\n\nExclusion Criteria:\n\n* Cognitive impairment interfering with task comprehension\n* Cardiorespiratory instability or other contraindications to walking assessment","18 Years",{"count":149,"type":21},100,"This is a single-centre, cross-sectional observational study with adjunctive procedure for the healthy voluteers at IRCCS Ospedale San Raffaele's Rehabilitation Department.\n\nPatients (n=50): use of inertial measurement units (IMU) and electromyographic (EMG) data routinely acquired during their standard clinical gait-rehabilitation sessions (no protocol changes; purely observational, data extracted from treatments).\n\nHealthy volunteers (n=50): age- and sex-matched volunteers who complete three 18 meters gait sessions with IMUs on trunk, thighs, shanks and feet and surface EMG on gluteus, quadriceps, hamstrings, tibialis anterior, and gastrocnemius. Healthy volunteers will be enrolled from hospital personnel, family members of the patients in visit at San Raffaele Hospital.\n\nData \\& Analysis: Kinematic (range of motion - ROM, step timing, walking speed) and EMG (activation amplitude\u002Ftiming) parameters will be extracted. Between-group comparisons will employ t-tests\u002Fanalysis of variance - ANOVA - (or non-parametric equivalents).",[32],"2026-03-10",{"date":154,"type":43},"2026-03-16",{"date":156,"type":21},"2026-03-02",{"date":158,"type":21},"2028-01-08",{"name":160,"class":50},"IRCCS San Raffaele",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":16,"minAge":169,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":22,"phases":172,"briefSummary":173,"conditions":174,"keywords":179,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":112},"100621832","spinal-stimulation-with-gait-training-to-improve-lower-limbs-motor-recovery-in-spinal-cord-injury-100621832","NCT07375745","Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury","Combined Gait Training and Transcutaneous Spinal Cord Stimulation to Enhance Lower Limbs Motor Recovery After Subacute SCI","CIMELocomotion","Inclusion Criteria:\n\n* paraplegic or quadriplegic participants with a subacute spinal cord injury (sSCI), defined as the stage of spinal cord damage occuring between 1 week and 6 months post-injury\n* above 16 years old\n* have a lesion between C1 - L2\n* be considered as AIS A to D\n* be able to stay at least 10 minutes standing with or without assistance\n* can provide informed consent (no cognitive deficits by MoCA)\n* be able to follow instructions in French or English\n\nExclusion Criteria:\n\n* pacemaker\n* active cancer on stimulation site or metastatic cancer\n* unhealed wound, scar or pain which makes positioning of the electrodes impossible\n* participants with specific contraindications to TMS (epilepsy, non-union cranial fracture and increased intracranial pressure) will be able to participate in the study, but will not receive TMS\n* chronic and severe neuropathic pain\n* pharmacology or implants that may impede with rehabilitation or spinal stimulation\n* pregnancy","16 Years",{"count":171,"type":21},40,[24],"Spinal cord injury (SCI) often results in partial or complete loss of movement. In the subacute phase (\\\u003C 6 months), the central nervous system shows increased potential for neuroplasticity, making it more responsive to rehabilitation and external stimulation. Standard care in rehabilitation centers relies on activity-based therapy (ABT), which uses intensive, task-specific training to promote recovery. Although ABT can improve mobility, its effects are often limited due to the nature of SCI and the indirect activation of neural circuits.\n\nRecent findings suggest that adding transcutaneous spinal cord stimulation (tSCS) to ABT in chronic SCI (\\> 12 months) can enhance lower-limb motor recovery. This study will evaluate whether combining tSCS with gait training is safe and feasible in individuals with subacute SCI and whether it improves lower-limb motor outcomes compared with gait training alone.\n\nThe investigators hypothesize that pairing gait training with tSCS early after injury will be safe and feasible and that tSCS delivered during gait training will augment leg muscle activation and lead to greater functional improvements. The study will also assess the feasibility, safety and tolerability of implementing this combined intervention in a intensive functional rehabilitation setting.",[175,176,177,178,32],"Spinal Cord Injury","Spinal Cord Injury Subacute","Locomotion","Gait Disorder, Sensorimotor",[175,180,177,181,182,183,100,124,184,185,186,187,188,189,190,191,192],"Neuromodulation","tSCS","Non-invasive","Transcutaneous","Subacute","Artificial Intelligence","AI","Lower Limb","Gait training","Walking","Transcutaneous spinal stimulation","Tonic stimulation","Combined gait training and neuromodulation","2026-03-04",{"date":195,"type":43},"2026-03-06",{"date":197,"type":21},"2026-07-01",{"date":199,"type":21},"2029-07",{"name":201,"class":50},"Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":16,"minAge":209,"maxAge":210,"enrollmentInfo":211,"targetDuration":212,"studyType":94,"phases":4,"briefSummary":213,"conditions":214,"keywords":220,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":4},"100626161","walking-function-outcomes-following-surgical-correction-with-rehabilitation-versus-physical-therapy-alone-in-charcot-marie-tooth-disease-a-bidirectional-cohort-study-100626161","NCT07432035","Walking Function Outcomes Following Surgical Correction With Rehabilitation Versus Physical Therapy Alone in Charcot-Marie-Tooth Disease: A Bidirectional Cohort Study","CMT-WALK","Inclusion Criteria:\n\n* Participants aged 12 years or older at the time of enrollment\n* Genetically or clinically confirmed CMT, based on established diagnostic criteria\n* Presence of foot deformity and\u002For gait impairment attributable to CMT, as determined by a treating clinician\n* Ability to ambulate at least 10 meters, with or without assistive devices\n* Medically eligible for either functional surgical intervention or structured physical therapy, as determined by the treating team\n* Willingness and ability to participate in longitudinal follow-up assessments\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Previous major foot or ankle surgery that substantially altered lower-limb biomechanics\n* Presence of non-CMT-related neurological disorders affecting gait (eg, stroke, Parkinson disease, multiple sclerosis)\n* Severe musculoskeletal conditions unrelated to CMT that limit walking ability (eg, advanced hip or knee osteoarthritis)\n* Active lower-limb infection, ulceration, or acute injury at the time of enrollment\n* Severe cognitive impairment or psychiatric condition precluding reliable participation\n* Medical contraindications to surgery or exercise-based rehabilitation, when relevant\n* Inability to complete baseline functional assessments or anticipated inability to complete follow-up","12 Years","60 Years",{"count":60,"type":21},"5 Years","The goal of this study is to compare changes in walking ability in people with Charcot-Marie-Tooth disease (CMT) who receive two different treatment approaches for foot deformities that affect walking.\n\nCMT is an inherited nerve condition that can cause muscle weakness, loss of sensation, and foot deformities. These changes often make walking difficult and can reduce independence and quality of life. Treatment options commonly include physical therapy alone or surgery to correct foot alignment followed by rehabilitation. However, it is not clear whether one approach leads to better long-term walking outcomes.\n\nThe main question this study aims to answer is whether individuals who undergo functional foot surgery followed by rehabilitation experience different changes in walking ability over time compared with those who receive structured physical therapy alone.\n\nResearchers will compare walking performance between these two treatment groups over a period of up to two years. Walking ability will be evaluated using standardized walking tests and patient questionnaires.\n\nParticipants included in this study are individuals with CMT-related foot deformities that affect walking and who received either surgery followed by rehabilitation or physical therapy alone. Researchers will analyze changes in walking ability over time and determine how many participants achieve meaningful improvement.\n\nThe findings from this study may help clinicians and individuals with CMT better understand how different treatment strategies influence walking function over time.",[215,216,217,218,219,32],"Charcot Marie Tooth Disease (CMT)","Pes Cavovarus","Surgery","Exercise Training","Neuromuscular Diseases (NMD)",[221,222,223,224,225,226],"Charcot Marie Tooth disease","Walking performance","Functional surgery","Physical therapy","Gait impairment","Propensity score matching","2026-02-24",{"date":229,"type":43},"2026-02-25",{"date":231,"type":21},"2026-02-11",{"date":233,"type":21},"2028-02-10",{"name":235,"class":50},"Peking University Third Hospital",{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":16,"minAge":210,"maxAge":18,"enrollmentInfo":244,"targetDuration":4,"studyType":22,"phases":246,"briefSummary":247,"conditions":248,"keywords":253,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":259,"leadSponsor":261,"locationsCount":4},"100618145","effect-of-mental-arithmetic-priming-on-gait-and-balance-in-stroke-100618145","NCT07327814","Effect of Mental Arithmetic Priming on Gait and Balance in Stroke","Mental Calculus Can Enhance Gait Performance in Post-Stroke Patients: A Randomized Controlled Trial","MA-Stroke","Inclusion Criteria:\n\n* Diagnosis of stroke.\n* Mini-Mental State Examination (MMSE) score ≥ 23.\n* Ability to walk 10 meters independently (with or without assistive device).\n\nExclusion Criteria:\n\n* Hemianopia.\n* Wernicke's aphasia or Global aphasia.\n* Orthopedic injuries or recent surgeries affecting the lower limbs.",{"count":245,"type":21},17,[24],"This study investigates the effect of cognitive priming through mental arithmetic on functional mobility in post-stroke patients. It hypothesizes that performing mental calculations (addition, subtraction, multiplication) prior to movement stimulates frontoparietal networks, thereby improving gait speed and dynamic balance compared to a passive control condition.",[249,250,32,251,252],"Stroke","Hemiparesis","Posture","Disorders",[249,250,251,254,32],"Balance","2026-02-10",{"date":257,"type":43},"2026-02-12",{"date":231,"type":21},{"date":260,"type":21},"2026-06-01",{"name":262,"class":50},"Lebanese University",{"id":264,"slug":265,"hasResults":11,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":269,"eligibilityCriteria":270,"healthyVolunteers":11,"sex":16,"minAge":271,"maxAge":272,"enrollmentInfo":273,"targetDuration":4,"studyType":22,"phases":274,"briefSummary":275,"conditions":276,"keywords":278,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":112},"100622306","effects-of-transcranial-direct-current-stimulation-combined-with-nordic-walking-on-gait-and-balance-in-parkinsons-disease-100622306","NCT07381907","Effects of Transcranial Direct Current Stimulation Combined With Nordic Walking on Gait and Balance in Parkinson's Disease","Effects of Transcranial Direct Current Stimulation Over the Supplementary Motor Area Combined With Nordic Walking on Gait and Balance in Parkinson's Disease","tDCS+NW-PD","Inclusion Criteria:\n\n* Idiopathic Parkinson's disease (e.g., UK Brain Bank criteria)\n* Hoehn \\& Yahr stage II-IV (on medication)\n* Stable antiparkinsonian medication for ≥4 weeks before enrollment\n* Slowed gait phenotype (e.g., ≥6 seconds on 10-Meter Walk at preferred speed)\n* Able to ambulate at least 10 meters with or without a cane\u002Fpoles (no hands-on assistance from a therapist)\n* Able to follow simple commands; provides written informed consent (MMSE ≥24 or equivalent cognitive screening)\n* Willing to maintain stable PD medication and usual care during the 4-week intervention, unless medically required\n\nExclusion Criteria:\n\n* Contraindications to tDCS: implanted cranial\u002Fbrain devices (e.g., DBS), metal in the skull (excluding dental), active skin disease\u002Flesions at electrode sites, uncontrolled epilepsy or history of seizure in the past 12 months\n* Unstable medical or psychiatric conditions that preclude safe participation (e.g., uncontrolled hypertension, recent cardiovascular events, severe orthostatic hypotension with syncope)\n* Severe freezing of gait or fall risk that prevents safe participation in supervised Nordic Walking, as judged by the clinical team\n* Severe musculoskeletal or vestibular disorders that limit walking with poles; severe uncorrected visual impairment\n* Cognitive impairment incompatible with consent or testing (e.g., MMSE \\\u003C24)\n* Current participation in other interventional trials targeting gait\u002Fbalance or brain stimulation; recent initiation or dose change of antiparkinsonian medication within 4 weeks.","50 Years","75 Years",{"count":171,"type":21},[24],"Parkinson's disease can cause slow or unsteady walking and balance problems that raise the risk of falls. This study will test whether adding a gentle, non-invasive brain stimulation called transcranial direct current stimulation (tDCS) during a supervised Nordic Walking program improves mobility in people with Parkinson's disease. Participants will be randomly assigned to receive either active tDCS or an inactive (sham) procedure that feels the same but does not deliver current, while both groups complete the same supervised walking program. Sessions occur three times per week for four weeks. We will measure walking speed with a 10-Meter Walk Test as the main outcome, and also evaluate balance, motor symptoms, quality of life, and any side effects. We expect that tDCS given during the walking sessions will help people walk faster and feel steadier compared with the walking program alone.",[28,32,277],"Postural Balance",[279,280,281,282,283,284,285],"transcranial direct current stimulation","nordic walking","parkinson disease","gait","postural balance","motor cortex","rehabilitation","2026-01-27",{"date":288,"type":43},"2026-02-02",{"date":290,"type":43},"2025-06-09",{"date":292,"type":21},"2026-03",{"name":294,"class":50},"Universidade Metodista de Piracicaba",{"id":296,"slug":297,"hasResults":11,"nctId":298,"briefTitle":299,"officialTitle":299,"acronym":4,"eligibilityCriteria":300,"healthyVolunteers":11,"sex":16,"minAge":147,"maxAge":4,"enrollmentInfo":301,"targetDuration":4,"studyType":22,"phases":303,"briefSummary":304,"conditions":305,"keywords":307,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":112},"100613212","the-effect-of-balance-focused-exercise-programme-in-enhancing-the-solus-muscle-activation-during-gait-initiation-for-people-with-parkinson-disease-100613212","NCT07263646","The Effect of Balance-focused Exercise Programme in Enhancing the Solus-muscle Activation During Gait Initiation for People With Parkinson Disease","Inclusion Criteria:\n\n* participants diagnosed by their neurologist with Parkinson's disease (moderate to severe stage)\n* stable on anti-Parkinson's drugs\n* able to walk independently without a frame or walking stick.\n* Able to walk for more than 10 mins unaided\n* without cognitive disability (Able to follow simple instructions and communicate, orally),\n* have good vision (with or without corrective aids)\n\nExclusion Criteria:\n\n* are pregnant\n* cardiac problems exacerbated by exercise\n* currently complaining of joint or muscle problems that affect walking ability\n* known to have neurological conditions (other than Parkinson) that affect walking ability\n* uncorrected hearing or vision problems\n* history of severe motion sickness\n* history of vestibular or balance problems\n* an active skin condition that could be irritated by contact with sticky tape.",{"count":302,"type":21},80,[24],"Gait initiation (GI) is a crucial component of walking that requires a balanced muscle activity and postural stability. GI could be challenging for people with neurological condition such as people with Parkinson (PWP), where GI is usually impaired. The purpose of this study is determining effectiveness of comprehensive, balanced-focused exercise programme in controlling the activation of Solus-muscle in people with Parkinson disease. We hypothesise that balance-focus exercise programe could improve Solus-muscle activation during GI.\n\nstudy type: this is a parallel group prospective (10 weeks) randomised single-blinded controlled trial conduct in Kuwait.\n\nParticipant: People with Parkinson, who met the inclusion criteria.",[35,32,306],"Gait Balance",[308,309,285,310],"gait initiation","Parkinson disease","balance-focus exercise","2025-12-03",{"date":313,"type":43},"2025-12-10",{"date":315,"type":21},"2026-01-22",{"date":317,"type":21},"2028-12-22",{"name":319,"class":320},"Ministry of Health, Kuwait","OTHER_GOV",{"id":322,"slug":323,"hasResults":11,"nctId":324,"briefTitle":325,"officialTitle":326,"acronym":4,"eligibilityCriteria":327,"healthyVolunteers":11,"sex":16,"minAge":328,"maxAge":4,"enrollmentInfo":329,"targetDuration":4,"studyType":22,"phases":330,"briefSummary":332,"conditions":333,"keywords":334,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":112},"100604286","phase-4-effectiveness-and-safety-of-electrically-powered-orthopedic-exercise-device-for-gait-disorders-100604286","NCT07147543","Effectiveness and Safety of Electrically Powered Orthopedic Exercise Device for Gait Disorders","Study to Verify the Effectiveness and Safety of the Electrically Powered Orthopedic Exercise Device on Gait Ability in Patients With Gait Disorders : Investigator-Initiated, Single-Center, Single-Group Clinical Trial","Inclusion Criteria:\n\n1. Adults aged 19 years or older\n2. Patients experiencing subjective gait or balance disorders\n3. Individuals who visited Yongin Severance Hospital, understood the study, voluntarily agreed to participate, and signed the consent form\n4. Patients with a Functional Ambulatory Category (FAC) score of less than 4\n5. Individuals who can sit on the edge of a bed without assistance and stand for 10 seconds with or without support\n6. Individuals with sufficient cognitive ability to follow and understand simple instructions (Mini-Mental State Examination score ≥ 20)\n\nExclusion Criteria:\n\n1. Individuals with contraindications to weight-bearing in the lower extremities, such as severe lower extremity joint contractures, osteoporosis, or untreated fractures\n2. Individuals who cannot wear the device due to skin diseases or open wounds\n3. Individuals with a significant discrepancy in lower extremity length\n4. Individuals with severe lower extremity deformities or joint contractures\n5. Individuals unable to maintain a sitting or standing posture independently\n6. Individuals with severe cognitive impairment (Mini-Mental State Examination score \\\u003C 20), delirium, or severe speech impairment preventing cooperation in wearing the device\n7. Individuals unable to stand or walk for extended periods due to underlying conditions such as orthostatic hypotension or reduced cardiopulmonary function\n8. Pregnant or potentially pregnant individuals\n9. Individuals with other clinically significant conditions deemed inappropriate for this study by the principal investigator or research team based on medical judgment","19 Years",{"count":92,"type":21},[331],"PHASE4","Aging is a global trend, and consequently, the prevalence of age-related diseases is increasing. Gait disorders are common among the elderly and can result not only from various underlying conditions affecting gait but also from the decline in physiological and neurological functions associated with the normal aging process.\n\nGait is a fundamental daily activity that requires the coordinated integration of the central and peripheral nervous systems, as well as the musculoskeletal system. Therefore, impairments in any of these systems-including the nervous, cardiovascular, respiratory, or musculoskeletal systems-can lead to gait dysfunction. Gait disorders negatively impact quality of life by increasing the risk of falls, reducing the ability to perform activities of daily living (ADLs), and limiting physical activity. Accordingly, various approaches to maintaining and improving gait function in older adults are being actively explored.\n\nCurrently, gait aids such as canes and walkers are commonly used to support individuals with gait impairments. These devices help redistribute body weight by providing a broader base of support, thereby assisting with balance and stability. However, they do not directly facilitate the movement of the lower limbs. To enhance gait function, numerous studies have investigated repetitive lower-limb movement training using bicycles or robotic devices. However, the extent of functional improvement resulting from such training remains unclear, and the long-term efficacy is still uncertain.\n\nRecent advancements in sensing technology for joint motion and actuator efficiency have led to the development of wearable assistive devices that are significantly more compact and lightweight compared to conventional robotic systems. This study aims to evaluate the effectiveness of a newly developed electrically powered orthopedic exercise device in patients with gait disorders by assessing changes in gait parameters upon wearing the device, thereby exploring its clinical feasibility.",[32],[335,100,336,32],"Rehabilitation","Wearable robot","2025-08-21",{"date":339,"type":43},"2025-08-29",{"date":341,"type":43},"2025-04-07",{"date":343,"type":21},"2026-04-06",{"name":345,"class":50},"Yonsei University",{"id":347,"slug":348,"hasResults":11,"nctId":349,"briefTitle":350,"officialTitle":351,"acronym":4,"eligibilityCriteria":352,"healthyVolunteers":11,"sex":16,"minAge":147,"maxAge":272,"enrollmentInfo":353,"targetDuration":4,"studyType":22,"phases":355,"briefSummary":356,"conditions":357,"keywords":359,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":376,"locationsCount":112},"100595853","the-effects-of-the-control-strategies-of-wearable-lower-limb-rehabilitation-robots-100595853","NCT07037849","The Effects of the Control Strategies of Wearable Lower Limb Rehabilitation Robots","Effects of Control Strategies in Wearable Lower Limb Rehabilitation Robots","Inclusion Criteria:\n\nStroke patients aged between 18 and 75 years. Patients who are medically stable and able to stand and walk independently for at least 10 meters during rehabilitation.\n\nStroke event occurred at least 3 months ago Patients with impaired lower limb motor function but with some degree of muscle activity in the lower extremities.\n\nPatients without severe cognitive impairment and capable of understanding and following the treatment protocol.\n\nPatients without severe balance or coordination disorders, able to maintain balance and perform gait training with assistive devices.\n\nPatients without lower limb fractures or other serious skeletal issues affecting the lower limbs.\n\nPatients without severe cardiovascular or other serious illnesses and able to tolerate the intensity and duration of rehabilitation therapy.\n\nPatients willing to participate in the study and able to provide written informed consent.\n\nExclusion Criteria:\n\nSevere cognitive impairment that prevents the patient from understanding or complying with the treatment protocol.\n\nSevere balance or coordination disorders that prevent the patient from maintaining balance and participating in gait training, even with assistive devices.\n\nOther serious motor disorders, such as abnormal muscle tone or ataxia, which may interfere with the effectiveness of rehabilitation therapy.\n\nActive cardiovascular disease or other serious systemic illnesses that may affect the patient's safety or treatment outcomes.\n\nLower limb fractures or other serious skeletal issues that may impact the suitability and safety of robot-assisted rehabilitation therapy.\n\nPatients currently receiving other rehabilitation or experimental treatments. Patients with skin ulcers, infections, or other severe skin conditions that may interfere with the use and application of robotic devices.\n\nUnexplained discomfort or pain symptoms that may limit the patient's ability to participate in rehabilitation therapy.\n\nFailure to meet other specific inclusion criteria outlined in the study protocol.",{"count":354,"type":21},10,[24],"Post-stroke patients were required to complete a session of robot-assisted training, which involved nine repetitions of 5-meter overground walking (three trials for each of the three controllers) in a rectangular hospital corridor.",[249,358,32],"Gait Training",[360,361,362,363,364,365,366,367,368,369],"Robots","Assistive robots","Trajectory","Torque","Force","Robot kinematics","Knee","Limb","Muscles","Hip",{"date":371,"type":43},"2025-06-26",{"date":373,"type":43},"2024-10-23",{"date":375,"type":21},"2027-04-22",{"name":377,"class":50},"Eighth Affiliated Hospital, Sun Yat-sen University",{"id":379,"slug":380,"hasResults":11,"nctId":381,"briefTitle":382,"officialTitle":382,"acronym":383,"eligibilityCriteria":384,"healthyVolunteers":11,"sex":16,"minAge":147,"maxAge":4,"enrollmentInfo":385,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":387,"conditions":388,"keywords":393,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":399,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":405,"locationsCount":112},"100570901","study-of-the-link-between-freezing-of-gait-and-oropharyngeal-freezing-in-parkinsons-patients-100570901","NCT06713265","Study of the Link Between Freezing of Gait and Oropharyngeal Freezing in Parkinson's Patients","Freez in park","Inclusion Criteria:\n\n* Diagnosis of idiopathic Parkinson's disease established by a neurologist;\n* Patient affiliated with the social security system;\n* Patient aged over 18 years.\n\nExclusion Criteria:\n\n* Patients under legal protection measures;\n* Neurological history that could be the cause of a swallowing disorder (e.g., stroke) or a history of ENT cancer;\n* Patient with a gastrostomy without oral intake;\n* Pregnant women or those suspected of being pregnant;\n* Minor patients",{"count":386,"type":21},66,"Parkinson's Disease: Study of the Link Between Gait Freezing and Oropharyngeal Freezing Parkinson's disease is the second most common neurodegenerative disorder worldwide. Parkinsonian dysphagia is a frequently encountered disorder in this condition, affecting all phases of swallowing: oral, pharyngeal, and esophageal. This dysphagia can occur at any stage of the disease. While most swallowing difficulties develop in the advanced stages of Parkinson's disease, they can also appear early on and are often underdiagnosed. The prevalence of swallowing disorders in Parkinson's disease is estimated to range from 40% to 80%, with this variability explained by the significant differences in the precision of swallowing evaluations conducted and the fact that dysphagia is still too frequently underdiagnosed. Yet, dysphagia is the leading cause of mortality in Parkinson's patients.\n\nDysphagia can negatively affect patients' quality of life. It leads to difficulties during oral intake (food, liquids, and medications), weight loss, dehydration, malnutrition, and limitations in social activities. Depression is frequently associated with reduced quality of life in Parkinson's patients with swallowing disorders. Moreover, aspiration pneumonia due to mis-swallowing is one of the primary reasons for hospitalization in Parkinson's patients, potentially leading to severe complications and, at times, death.\n\nOropharyngeal freezing, also called oral festination, is an involuntary, repetitive anteroposterior movement of the tongue against the soft palate performed before transferring the food bolus to the pharynx. This movement is also observed during multiple swallows. This phenomenon is more frequent in dysphagic Parkinson's patients, yet its impact on swallowing dynamics remains poorly understood. Oropharyngeal freezing has been observed in approximately 40% to 75% of Parkinson's patients during videofluoroscopic swallow studies, also known as swallowing pharyngography. Oropharyngeal freezing inhibits the initiation of swallowing, keeping the airway open and leading to tracheal aspiration of residues. Some fragments then slide into the valleculae and pyriform sinuses. Thus, oropharyngeal freezing exacerbates pharyngeal phase incoordination, increasing the risk of aspiration pneumonia. Therefore, addressing this swallowing disorder is essential.\n\nOropharyngeal freezing is intrinsically rhythmic. While limited studies have been conducted on the topic, they agree that gait freezing (difficulty initiating walking, stopping in response to obstacles, or circumventing them) and oropharyngeal freezing share common pathophysiological mechanisms. Gait freezing is not limited to deficits in the locomotor network but is part of a broader deficit affecting spatiotemporal coordination in various tasks, similar to oropharyngeal freezing.\n\nIt is, therefore, crucial to detect this oral phase swallowing disorder as early as possible, enabling tailored early intervention that helps patients maintain their swallowing abilities for as long as possible and prevents complications mentioned earlier. Since gait freezing is diagnosed much earlier and more systematically, it would be interesting to investigate whether there is a correlation between the presence of gait freezing and oropharyngeal freezing in these patients. This could guide patients with gait freezing toward early speech-language assessments to evaluate the presence of oropharyngeal freezing.\n\nThe objectives of the study are examine the prevalence of oropharyngeal freezing in Parkinson's patients. Based on the results obtained from the NFOG-Q (New Freezing of Gait Questionnaire), two groups will be formed: The first group will consist of patients exhibiting gait freezing. The second group will consist of patients without gait freezing. The secondary objectives of the study are examine the common characteristics between these two types of freezing (gait and oropharyngeal). To assess the sensitivity and reliability of the NFOG-Q in detecting oropharyngeal freezing.To determine the prevalence of oropharyngeal freezing based on the score obtained on the UPDRS (Unified Parkinson's Disease Rating Scale). To analyze the link between patients' rhythmic abilities and the presence or absence of one or both types of freezing.",[103,389,390,391,392,32],"Dysphagia","Swallowing Disorder","Freezing of Gait","Oropharyngeal Disease",[394,389,395,396,397,100],"Parkinson's Disease","Swallowing disorder","Freezing of gait","oropharyngeal freezing","2024-12-02",{"date":400,"type":43},"2024-12-04",{"date":402,"type":43},"2024-10-04",{"date":404,"type":21},"2025-11-30",{"name":406,"class":50},"Hopital La Musse",{"id":408,"slug":409,"hasResults":11,"nctId":410,"briefTitle":411,"officialTitle":411,"acronym":4,"eligibilityCriteria":412,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":413,"targetDuration":4,"studyType":22,"phases":414,"briefSummary":415,"conditions":416,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":420,"completionDateStruct":422,"leadSponsor":424,"locationsCount":4},"100550959","effects-of-biofeedback-footwear-in-parkinsons-disease-assessment-of-functional-motor-abilities-and-locomotion-100550959","NCT06453863","Effects of Biofeedback Footwear in Parkinson's Disease: Assessment of Functional Motor Abilities and Locomotion","Inclusion Criteria:\n\n* Diagnosis of Parkinson's disease, according to the clinical diagnostic criteria of the Movement Disorders Society (Postuma RB, 2015);\n* Hoehn \\& Yahr between II and IV;\n* Stable medical therapy since at least one month before enrollment\n\nExclusion Criteria:\n\n* Concomitant diagnosis of other neurological or psychiatric disorders that may influence study assessments.;\n* MMSE score \\\u003C24;\n* Patients with DBS implant or on DuoDopa therapy;\n* Presence of relevant musculoskeletal or orthopedic pathologies;\n* Presence of relevant internal or vascular pathologies.",{"count":171,"type":21},[24],"The study aims to verify whether the use of a specific footwear providing increased plantar feedback (plantar feedback shoes) could improve gait parameters, postural control and functional performances in people with Parkinson's disease.\n\nSpecifically, the aims are:\n\n* To evaluate the acute effect of plantar feedback shoes, by comparing gait, functional and postural performances in three conditions: neutral shoes, barefoot, and plantar feedback shoes;\n* To evaluate the effect of four weeks of plantar feedback shoes, on gait, functional and postural performances.\n\nParticipants will undergo a comprehensive neurological examination, with administration of disease-specific scales (UPDRS III part 3, NFOG-q, LEDD, DASS-21). At each assessment the participants will perform an inertial gait analysis, a static posturography, and will undergo functional capacity assessments (TUG, 2MWT, 5-STST, 10- mFW).",[35,32],"2024-06-12",{"date":419,"type":43},"2024-06-13",{"date":421,"type":21},"2024-07-01",{"date":423,"type":21},"2025-12-01",{"name":425,"class":50},"IRCCS National Neurological Institute \"C. Mondino\" Foundation"]