[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gait-impairment-in-stroke-patients\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gait-impairment-in-stroke-patients":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100641741","stroke-rehabilitation-through-intensive-exercise-100641741",false,"NCT07650500","Stroke Rehabilitation Through Intensive Exercise","S-THRIVE","Inclusion Criteria:\n\n* Age between 18 and 70 years.\n* History of a first-ever stroke occurring at least 6 months before enrollment.\n* Independence in personal activities of daily living (e.g., dressing, undressing, and using the toilet).\n* Ability to take a few steps indoors without a walking aid and without supervision; use of an orthosis is permitted.\n\nExclusion Criteria:\n\n* Unstable cardiovascular disease or exercise-induced epilepsy.\n* Insufficient cognitive ability to participate in group-based training, including the capacity to understand, follow, and maintain verbal instructions during exercise tasks.\n* Blood pressure \\>140\u002F90 mmHg at the first visit.","ALL","18 Years","70 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn whether combining moderate to high intensity aerobic exercise with constraint-induced movement therapy (CI therapy) can improve walking ability in adults who have had a stroke. The study will also learn if telerehabilitation at home can support long-term recovery after intensive rehabilitation.\n\nThe main questions this study aims to answer are:\n\n* Does moderate to high intensity aerobic exercise before CI therapy improve walking ability, balance and lower extremity function in people with long-lasting gait difficulties after stroke?\n* Does CI therapy alone lead to similar or different improvements in walking ability, balance or lower extremity function?\n* Does telerehabilitation help participants maintain or further improve their function after the intensive rehabilitation period?\n\nResearchers will compare two groups. One group will receive 4 weeks of CI therapy, 5 days per week, plus 20 minutes of moderate-to-high-intensity aerobic exercise before the rehabilitation session on 3 of these days, and the other group will receive 4 weeks of CI therapy, 5 days per week, without preparatory aerobic exercise.\n\nAfter the completion of CI therapy, all participants will be offered an individualized 8-week telerehabilitation program to follow at home. They will use a mobile application to report physical activity and follow instructions for telerehabilitation.\n\nAll participants will complete two assessment visits (about 3 hours each), 1-2 weeks before and 1-2 weeks after CI therapy. They will also complete questionnaires electronically after the telerehabilitation program.\n\nDaily activity will be measured twice during the study: once during a week after the intensive rehabilitation and once during a week after the telerehabilitation program. A small movement sensor worn on the thigh will be used. The sensor is attached with a soft strap or an adhesive patch and is comfortable to wear all day. The sensor shows how much a person walks, stands, or sits in everyday life. It is light, does not disturb normal activities, and only collects movement information for the study. An instruction sheet will be included to make it easy to use.",[27,28,29,30,31,32],"Stroke","Rehabilitation","Rehabilitation Outcome","Aerobic Exercise","Telerehabilitation","Gait Impairment in Stroke Patients",[34,35,36],"Aerobic exercise, stroke rehabilitation, constraint-induced movement therapy","telerehabilitation","gait impairment","NOT_YET_RECRUITING","2026-06-11",{"date":40,"type":41},"2026-06-16","ACTUAL",{"date":43,"type":21},"2026-08-01",{"date":45,"type":21},"2029-06-30",{"name":47,"class":48},"The Swedish School of Sport and Health Sciences","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100638270","walking-and-thinking---brain-activity-during-complex-walking-in-stroke-100638270","NCT07624630","Walking and Thinking - Brain Activity During Complex Walking in Stroke","Inclusion Criteria:\n\n* 18 years or older\n* with a stroke ≥6 months confirmed by a clinical diagnosis\n* with the ability to walk with or without a walking aid for ≥ 5 min\n\nExclusion Criteria:\n\n* Individuals post stroke with cognitive impairment\n* severe neglect\n* global aphasia affecting the ability to provide written informed consent\n* severe perceptual problems or severe freezing of gait",{"count":20,"type":21},"OBSERVATIONAL","Everyday life requires individuals to function in complex environments and perform tasks that involve the integration of motor and cognitive abilities. However, stroke often leads to impairments in motor-cognitive interaction, which can negatively affect mobility, balance, attention, and the ability to live independently. Although motor-cognitive performance has been identified as an important rehabilitation target after stroke, limited knowledge exists regarding the underlying brain function associated with these difficulties and how rehabilitation and exercise interventions can best address them.\n\nImproving treatment for motor-cognitive difficulties after stroke, such as dual-task walking and navigation, remains a major challenge. An important step is developing assessment methods that accurately capture these impairments in ecologically valid settings that reflect real-world mobility demands. The investigators therefore aim to explore brain function during complex walking after stroke by investigating motor-cognitive performance and its neural correlates during three walking conditions: dual-task walking, navigation, and a combination of both. Non-invasive measures of brain activity using functional near-infrared spectroscopy (fNIRS) together with advanced real-time gait analysis will be used to better understand how stroke affects motor-cognitive functioning during complex walking tasks.",[27,59,60,32],"Aging","Neuro-Degenerative Disease",[27,62,63,64,65,66],"Dual task walking","navigated walking","motor-cognitive interference","funtional Near Infrared Spectroscopy (fNIRS)","brain funtion","RECRUITING","2026-06-01",{"date":70,"type":41},"2026-06-03",{"date":43,"type":21},{"date":73,"type":21},"2027-07-01",{"name":75,"class":48},"Karolinska Institutet",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":76},"100595565","spatiotemporal-gait-parameters-of-healthy-and-stroke-patients-during-overground-treadmill-and-body-weight-supported-treadmill-walking-100595565","NCT07034105","Spatiotemporal Gait Parameters of Healthy and Stroke Patients During Overground, Treadmill, and Body Weight Supported Treadmill Walking","Variability in Spatiotemporal Gait Parameters of Stroke Patients Across Overground, Self Paced Treadmill, and Body-Weight Supported Treadmill Walking","Inclusion Criteria:\n\n* Participants must be between 18 to 75 years old.\n* More than 1- month post stroke patient.\n* Participants must be able to walk with or without assistance.\n* Patients including both the male and female.\n* Participants must be able to provide informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Severe cognitive or communicative disorders.\n* Significant joint malposition.\n* Psychological, cognitive dysfunction, and any other neuromuscular problem.\n* Pregnant women will be excluded to avoid any potential risks to the mother and fetus.\n* Unstable cardiovascular disease like congenital heart disease, deep vein thrombosis, coronary heart disease, previous history of heart attack or heart failure.","75 Years",{"count":86,"type":21},25,[24],"Gait impairments following a stroke significantly hinder mobility and quality of life, emphasizing the need for precise assessment methods to guide effective rehabilitation strategies. This study evaluates the variability and reliability of spatiotemporal gait parameters across three walking modalities: overground walking, treadmill walking, and body-weight-supported treadmill walking. Using a counterbalanced design, all participants undergo gait analysis in each modality to ensure unbiased and reliable comparisons.\n\nThe study also incorporates a locally developed, cost-effective Body Weight Support System (BWSS) to address the limitations of accessibility in resource-constrained settings. By identifying how different modalities influence gait variability and reliability, this research aims to optimize rehabilitation outcomes and demonstrate the feasibility of implementing affordable gait analysis tools in clinical practice.",[32],[91,92,93],"Gait Analysis","Spatiotemporal Parameters","Body Weight Support System (BWSS)","2025-06-14",{"date":96,"type":41},"2025-06-24",{"date":98,"type":41},"2024-06-12",{"date":100,"type":21},"2026-02-11",{"name":102,"class":48},"Bangladesh University of Engineering and Technology"]