[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gait-training\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gait-training":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,72,106,152],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100635252","body-weight-supported-and-virtual-reality-gait-training-in-stroke-patients-100635252",false,"NCT07550270","Body Weight-Supported and Virtual Reality Gait Training in Stroke Patients","A Comparative Evaluation of the Effectiveness of Body Weight-Supported Forward and Backward Gait Training Versus Virtual Reality-Assisted Gait Training in Patients With Stroke","Inclusion Criteria:\n\n* Patients experiencing their first-ever stroke\n* Patients with a post-stroke duration of more than 2 weeks\n* Patients with plantar flexor muscle spasticity of the lower extremity less than grade 3 according to the Modified Ashworth Scale (MAS)\n* Patients with a Brunnstrom stage of the lower extremity greater than 2\n* Patients who are able to stand independently or under supervision for at least 2 minutes for standing assessments\n* Patients who are able to walk at least 10 meters independently or under supervision, with or without an assistive device, for walking assessments\n* Patients with sufficient cognitive function to understand study instructions (Mini-Mental State Examination \\[MMSE\\] score \\> 23)\n* Patients with stable medical and psychological conditions\n* Patients who are willing to participate in the study\n\nExclusion Criteria:\n\n* Patients with bilateral hemispheric lesions\n* Patients with severe cardiovascular or musculoskeletal conditions that prevent walking (e.g., fixed ankle contracture)\n* Patients using a permanent urinary catheter, or those with pressure ulcers or urinary and\u002For fecal incontinence\n* Patients with unilateral neglect\n* Patients with neurological conditions other than stroke that may affect balance performance (e.g., Parkinson's disease, epilepsy, meningitis, cerebellar disorders, vertigo, dizziness, polyneuropathy) or musculoskeletal disorders (e.g., severe low back pain, knee disorders)\n* Patients with severe visual, hearing, or speech impairments","ALL","45 Years","75 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of this study is to compare the effects of body weight-supported gait training that includes virtual reality-assisted dual-task applications with body weight-supported forward and backward gait training on functional capacity, gait parameters (such as step length, gait speed, and balance), cognitive functions and psychological status in patients with stroke. The findings of this study are expected to contribute to the development of more effective rehabilitation strategies for improving mobility in patients with stroke",[27,28,29,30],"Stroke","Walking Impairment","Balance","Gait Training",[32,33],"stroke","gait training","RECRUITING","2026-04-19",{"date":37,"type":38},"2026-04-24","ACTUAL",{"date":40,"type":38},"2026-03-26",{"date":42,"type":21},"2026-12",{"name":44,"class":45},"Gaziler Physical Medicine and Rehabilitation Education and Research Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":46},"100599690","optimizing-gait-symmetry-after-stroke-using-mechanical-constraints-and-sensory-feedback-100599690","NCT07087769","Optimizing Gait Symmetry After Stroke Using Mechanical Constraints and Sensory Feedback","Optimizing Post-Stroke Gait Symmetry: Integrating Mechanical Constraints and Sensory Feedback to Enhance Paretic Leg Propulsion","Inclusion Criteria:\n\nAged 20 years or older\n\nFor stroke group: clinical diagnosis of stroke at least 1 month prior to participation\n\nAbility to walk at least 10 meters with or without assistive devices\n\nFor healthy group: able to walk independently without assistive devices\n\nExclusion Criteria:\n\nLife expectancy less than one year\n\nComatose or unable to follow three-step commands\n\nAmputation of any lower limb\n\nPoorly controlled diabetes (e.g., foot ulceration)\n\nBlindness\n\nProgressive neurological disease\n\nMedically unstable condition\n\nSignificant musculoskeletal impairments affecting gait\n\nCongestive heart failure or unstable angina\n\nPeripheral vascular disease\n\nSevere neuropsychiatric conditions (e.g., dementia, cognitive deficits, severe depression)",true,"20 Years",{"count":20,"type":21},[24],"This single-session study aims to evaluate a novel gait training protocol that integrates mechanical constraints and sensory feedback to enhance paretic leg propulsion in individuals post-stroke. The study will include 15 individuals who have experienced a stroke and 15 healthy adults, each aged 20 years or older. Participants will walk on both tied-belt and split-belt treadmills under various training conditions, including backward-directed resistance (applied at the pelvis, ankle, or both) and real-time sensory feedback (visual, auditory, or combined). These interventions will be applied individually and in combination to identify the most effective environment for promoting symmetrical gait patterns. Each session will last approximately two hours. The equipment used is non-invasive, and the risk to participants is minimal.",[27,60,61,62,30],"Split-belt Treadmill","Resistance Exercise","Feedback","2026-03-31",{"date":65,"type":38},"2026-04-01",{"date":67,"type":38},"2025-07-25",{"date":69,"type":21},"2026-12-01",{"name":71,"class":45},"The University of Texas Medical Branch, Galveston",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":79,"maxAge":18,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":46},"100595853","the-effects-of-the-control-strategies-of-wearable-lower-limb-rehabilitation-robots-100595853","NCT07037849","The Effects of the Control Strategies of Wearable Lower Limb Rehabilitation Robots","Effects of Control Strategies in Wearable Lower Limb Rehabilitation Robots","Inclusion Criteria:\n\nStroke patients aged between 18 and 75 years. Patients who are medically stable and able to stand and walk independently for at least 10 meters during rehabilitation.\n\nStroke event occurred at least 3 months ago Patients with impaired lower limb motor function but with some degree of muscle activity in the lower extremities.\n\nPatients without severe cognitive impairment and capable of understanding and following the treatment protocol.\n\nPatients without severe balance or coordination disorders, able to maintain balance and perform gait training with assistive devices.\n\nPatients without lower limb fractures or other serious skeletal issues affecting the lower limbs.\n\nPatients without severe cardiovascular or other serious illnesses and able to tolerate the intensity and duration of rehabilitation therapy.\n\nPatients willing to participate in the study and able to provide written informed consent.\n\nExclusion Criteria:\n\nSevere cognitive impairment that prevents the patient from understanding or complying with the treatment protocol.\n\nSevere balance or coordination disorders that prevent the patient from maintaining balance and participating in gait training, even with assistive devices.\n\nOther serious motor disorders, such as abnormal muscle tone or ataxia, which may interfere with the effectiveness of rehabilitation therapy.\n\nActive cardiovascular disease or other serious systemic illnesses that may affect the patient's safety or treatment outcomes.\n\nLower limb fractures or other serious skeletal issues that may impact the suitability and safety of robot-assisted rehabilitation therapy.\n\nPatients currently receiving other rehabilitation or experimental treatments. Patients with skin ulcers, infections, or other severe skin conditions that may interfere with the use and application of robotic devices.\n\nUnexplained discomfort or pain symptoms that may limit the patient's ability to participate in rehabilitation therapy.\n\nFailure to meet other specific inclusion criteria outlined in the study protocol.","18 Years",{"count":81,"type":21},10,[24],"Post-stroke patients were required to complete a session of robot-assisted training, which involved nine repetitions of 5-meter overground walking (three trials for each of the three controllers) in a rectangular hospital corridor.",[27,30,85],"Gait Disorders",[87,88,89,90,91,92,93,94,95,96],"Robots","Assistive robots","Trajectory","Torque","Force","Robot kinematics","Knee","Limb","Muscles","Hip","2025-06-17",{"date":99,"type":38},"2025-06-26",{"date":101,"type":38},"2024-10-23",{"date":103,"type":21},"2027-04-22",{"name":105,"class":45},"Eighth Affiliated Hospital, Sun Yat-sen University",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":118,"briefSummary":119,"conditions":120,"keywords":130,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":46},"100588304","bci-assisted-scs-exs-for-gait-optimization-100588304","NCT06939660","BCI-Assisted SCS-EXS for Gait Optimization","Spatiotemporal Spinal Cord Stimulation Based on Implantable Brain-machine Interfaces and Exoskeletons for Spinal Cord Injury (BASEGO)","BASEGO","Inclusion Criteria:\n\n* Age 14-65 years, any gender.\n* Clinical diagnosis of spinal cord injury (SCI) due to trauma, inflammation, tumor, vascular disease, or iatrogenic factors, confirmed by medical history, physical examination, and ancillary tests, resulting in lower limb motor dysfunction.\n* SCI diagnosed ≥6 months prior, with ≥1 month of continuous conventional rehabilitation (e.g., physical therapy, acupuncture, hydrotherapy, ≥3 hours daily) without significant improvement in motor function in the past 2 months.\n* ASIA Impairment Scale (AIS) grade A, B, or C based on the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI).\n* Good general health with a life expectancy ≥12 months.\n* Mini-Mental State Examination (MMSE) score ≥22.\n* Educational attainment of secondary school or above.\n* Willingness to participate, provide informed consent, and comply with study follow-up.\n\nExclusion Criteria:\n\n* Presence of diseases other than spinal cord injury (SCI) that affect lower limb motor function, including brain diseases (e.g., brain tumor, stroke), lower limb vascular diseases (e.g., lower limb vascular occlusion), peripheral nerve diseases, or lower limb bone diseases (e.g., osteoarthritis, joint contracture).\n* Requires continuous medical interventions (e.g., tracheal intubation, nasogastric feeding) to maintain critical physiological functions (e.g., heartbeat, respiration, swallowing).\n* Congenital or acquired structural abnormalities of the lower limb bones or muscles.\n* Presence of surgical contraindications (e.g., anesthesia-related adverse reactions, coagulation risks, or surgeon's determination of unsuitability for surgery).\n* Presence of active implantable devices except for SCS or BCI devices (e.g., pacemakers, defibrillators, drug infusion pumps, cochlear implants, sacral nerve stimulators).\n* Unable to receive implantable devices due to other disease treatments or investigations, or requires magnetic resonance imaging (MRI) during the device implantation period.\n* MRI shows structural damage \\>50% in motor function areas (precentral and postcentral gyri, ventromedial sensorimotor areas, mid temporal lobe, Broca's area, Wernicke's area, Geschwind's area), or DTI shows damage \\>50% in the posterior limb of the internal capsule.\n* Severe cardiovascular disease: Above level II myocardial ischemia or myocardial infarction, uncontrolled arrhythmias (including QTc interval ≥450 ms in men, ≥470 ms in women), level III-IV heart failure (NYHA classification), or echocardiography showing LVEF \\\u003C50%.\n* Coagulation abnormalities (INR \\>1.5 ULN, PT \\>ULN +4 s, or APTT \\>1.5 ULN), hemorrhagic tendency, or undergoing thrombolytic or anticoagulant therapy.\n* Severe infections within 4 weeks before surgery (requiring IV antibiotics, antifungals, or antivirals) or lumbar soft tissue infections, or unexplained fever \\>38.5℃ during screening or before surgery.\n* HIV infection, acquired immunodeficiency syndrome (AIDS), active tuberculosis, active hepatitis B (HBV DNA ≥500 IU\u002Fml), hepatitis C (positive HCV antibody and detectable HCV-RNA), or co-infection of hepatitis B and C.\n\nSevere cerebrovascular events (including transient ischemic attack, cerebral hemorrhage, cerebral infarction), deep vein thrombosis, or pulmonary embolism within 12 months before enrollment.\n\n* Metastatic malignancies or untreated malignant tumors.\n* Major surgery or severe traumatic injuries, fractures, or ulcers within 4 weeks before enrollment.\n* Addictive habits such as drug abuse or alcoholism.\n* History of psychotropic drug abuse that is not controllable or presence of mental disorders, including major psychiatric illnesses (e.g., depression \\[BDI score \\>20\\], anxiety, obsessive-compulsive disorder, schizophrenia, autism, chronic sleep disorders, consciousness disorders).\n* Pregnant, breastfeeding, planning to conceive, or women of childbearing potential without reliable contraception.\n* Participation in other clinical trials within the past month.\n* Cognitive impairments or poor compliance from subjects, family members, or caregivers, or inability to complete at least 12 months of follow-up and rehabilitation training.\n* Other conditions that increase the risk of study participation or device use, as determined by the investigator.","14 Years","65 Years",{"count":117,"type":21},3,[24],"The goal of this clinical trial is to evaluate the safety and technical feasibility of a novel brain-machine interface (BCI)-assisted spinal cord stimulation (SCS) and exoskeleton (EXS) system in patients with spinal cord injury (SCI). The primary aim is to determine whether the BCI-SCS-EXS system can safely and effectively improve lower limb motor function and quality of life in individuals with chronic SCI.\n\nParticipant Population:\n\nAdults aged 14-65 years (sex\u002Fgender not limited). Patients with chronic SCI (≥6 months post-injury) classified as ASIA A, B, or C.\n\nIndividuals with stable health status, MMSE ≥22, and secondary education or above.\n\nPrimary Questions:\n\n1. Is the BCI-SCS-EXS system safe and technically feasible for SCI rehabilitation?\n2. Does the system improve lower limb motor function and quality of life in SCI patients?\n\nInterventions:\n\nParticipants will undergo the following procedures:\n\nPhase I (Implantation):\n\nBCI implantation: ECoG electrodes placed over the motor cortex to decode lower limb movement intent.\n\nSCS electrode implantation: 5-6-5 paddle electrodes at T11-L2 for targeted spinal cord stimulation.\n\nPhase II (System Calibration):\n\nBCI-SCS synchronization: Calibration of decoded motor intent to trigger SCS parameters.\n\nSCS-EXO synchronization: Integration of SCS pulses with exoskeleton-assisted gait training.\n\nPhase III (Rehabilitation):\n\nDaily BCI-SCS-EXS training sessions (60 minutes, 5 times\u002Fweek for 1 year). Adaptive adjustments to stimulation parameters and exoskeleton support based on performance.\n\nRemote monitoring of device performance and emergency intervention for technical issues.\n\nOutcome Measures:\n\nPrimary: Safety (adverse events, device performance, synchronization metrics). Secondary: Efficacy (motor function, neurophysiological function, quality of life).\n\nEthics and Safety:\n\nInformed consent will be obtained from all participants. Adverse events will be monitored and reported according to CTCAE 5.0 guidelines.\n\nParticipant confidentiality will be strictly maintained. This study will provide foundational evidence for the safety and feasibility of the BCI-SCS-EXO system, paving the way for future randomized controlled trials in SCI rehabilitation.",[121,122,123,124,125,126,127,128,30,129],"Spinal Cord Injuries (SCI)","Spinal Cord Injury, Chronic","Spinal Cord Injury","Spinal Cord Injury Cervical","Spinal Cord Injury Thoracic","Spinal Cord Injury (Quadraplegia)","Motor Impairment","Motor Deficits","Gait Impairment",[131,132,133,134,135,136,137,138,139,140,141,142],"Brain-computer interface","Spianl cord stimulation","Exoskeleton","Rehabilitation","Spinal cord injury","Motor dysfunction","BCI","Brain-spinal interface","BSI","Brain-machine interface","Gait training","Neural plasticity","2025-05-14",{"date":145,"type":38},"2025-05-20",{"date":147,"type":38},"2025-04-23",{"date":149,"type":21},"2027-04-30",{"name":151,"class":45},"Xuanwu Hospital, Beijing",{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":16,"minAge":79,"maxAge":18,"enrollmentInfo":158,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":161,"conditions":162,"keywords":164,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":46},"100559435","effect-on-gait-pattern-during-robot-assisted-gait-training-ragt-of-end-effector-type-in-burn-patients-100559435","NCT06564090","Effect on Gait Pattern During Robot Assisted Gait Training (RAGT) of End-effector Type in Burn Patients","Inclusion Criteria:\n\n* Patients who underwent split thickness skin graft (STSG) at Hangang Sacred Heart Hospital\n* with full or virtually full thickness involvement ( \\>50% of the body surface area of the lower extremity)\n* aged \\>18 years\n* with ≤ 1 functional ambulation category (FAC) score of ≤3 were included in this study.\n\nExclusion Criteria:\n\n* who had fourth-degree burns (involving muscles, tendons, and bone injuries)\n* severe communication disorders due to intellectual impairment and psychologic problems\n* body weight \\> 135kg or height \\>195cm\n* physical status that could limit physical therapy (severe deformity or contracture of limbs, open wounds, or pressure ulcers, severe osteoporosis).",{"count":159,"type":21},60,[24],"This study aimed to investigate gait pattern and muscles power improvement of patient with gait disturbance caused by burns after end-effector type robot (Morning Walk®)-assited gait training (RAGT). This study randomly assigned 36 patients to one of two group : 30 minutes of Morning Walk® training with 30 minutes conventional physiotherapy (RAGT group) or 60 minutes of conventional physiotherapy (CON group). Five training sessions per week were given for 8 weeks. The primary outcomes were gait performance and muscles powers, which were assessed by the functional ambulation category (FAC) and the manual muscles test (MMT), respectively. The secondary outcomes included 6-minute walking test (6MWT), gait kinematic and spatiotemporal gait parameters. The results of this study is anticipated that the patients with gait disturbance receiving the RAGT might improve greater in gait performance and normal gait patterns that those trained with conventional physiotherapy.",[163,30,134],"Burns",[165,166,167],"burns","gait pattern","robot assisted gait training","2024-08-19",{"date":170,"type":38},"2024-08-21",{"date":172,"type":38},"2023-08-15",{"date":174,"type":21},"2024-12-30",{"name":176,"class":45},"Hangang Sacred Heart Hospital"]