[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gall-stone\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gall-stone":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,68,102,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100593571","laparoendoscopic-rendezvous-for-concomitant-gall-bladder-stones-and-common-bile-duct-stones-100593571",false,"NCT07008170","Laparoendoscopic Rendezvous for Concomitant Gall Bladder Stones and Common Bile Duct Stones","Laparoendoscopic Rendezvous for Difficult Cholecystocholedocholithiasis.","LERV","Inclusion Criteria:\n\n* Patients having stone(s) in the gallbladder and concurrent common bile duct , as determined by MRCP(magnetic resonance cholangiopancreatography) or US.\n* Patients with acute cholecystitis, acute cholangitis, obstructive jaundice, and those with highly suspicious criteria for common bile duct stones, such as dilated CBD( common bile duct ) on US examination \\> 7 mm in diameter without obvious common bile duct stones, high serum bilirubin level, and\u002For high serum alkaline phosphatase level, were also included in this study. (high risk for cholecystocholedocholithiasis)\n* Previous failed ERCP attempt\n* Patients fit for general anesthesia and tolerant of pneumoperitoneum and endoscopic procedures.\n\nExclusion Criteria:\n\n* History of hepatobiliary surgery as choledochoduodenal anastomosis\n* A Previous upper abdominal surgery as total or partial gastric resection.\n* Morbid obesity.\n* Uncorrectable coagulopathy.\n* Patients who refused to give consent.\n* Pregnancy.\n* Suspected malignant biliary stricture or cholangiocarcinoma\n* Severe acute cholangitis with hemodynamic instability or septic shock requiring immediate biliary drainage (may necessitate emergent ERCP or percutaneous drainage first)\n* Impacted CBD stones or stones deemed too large for endoscopic extraction (e.g., \\> 1.5 cm)\n* Severe cardiopulmonary disease significantly increasing operative risk.\n* Intrahepatic bile duct stones with indications for surgery.\n* Patients with choledocholithiasis \\>2 cm or a large number of stones were difficult to remove.","ALL","18 Years","75 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","Chronic calculous cholecystitis in pediatric patients leads to choledocholithiasis in about 12% of cases. These patients require removal of stones from the common bile duct. The most common method of cleaning the common bile duct is endoscopic retrograde cholangiopancreatography, and the standard technique for removing the gallbladder is laparoscopic cholecystectomy. There are different approaches to the treatment of this category of patients: laparoscopic common bile duct exploration (LCBDE), laparoendoscopic rendezvous method (LERV) and one-stage LC( laparoscopic cholecystectomy) after ERCP( endoscopic retrograde cholangiopancreatography).\n\nThe aim of this prospective study is to evaluate the efficacy and safety Laparoendoscopic rendezvous for difficult cholecystocholedocholithiasis.",[28,29,30,31,32],"Gall Stone","Common Bile Duct Calculi","Cholecystitis, Chronic","Choledocholithiasis","Periampullary Diverticula","RECRUITING","2025-06-16",{"date":36,"type":37},"2025-06-19","ACTUAL",{"date":39,"type":37},"2025-06-15",{"date":41,"type":22},"2026-07-15",{"name":43,"class":44},"Minia University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":45},"100568324","genetic-variants-associated-with-the-risk-of-gall-stones-and-cirrhosis-100568324","NCT06679738","Genetic Variants Associated With the Risk of Gall Stones and Cirrhosis.","Inclusion Criteria:\n\n1. Patients \\> 18 years of age.\n2. Who has a GSD diagnosed by USG or have history of cholecystectomy for gall stone disease.\n3. Who is a diagnosed case of cirrhosis by Fibroscan or USG (Cirrhosis including alcohol related cirrhosis, Hepatitis B, Hepatitis C, Wilsons disease, Hemochromatosis are excluded.\n\nExclusion Criteria:\n\n1. Patients who have haemolytic anaemia\n2. Patients who do not consent for genetic study\n3. Patients who has a diagnosed cause for liver disease, including alcohol related cirrhosis, Hepatitis B, Hepatitis C, Wilsons disease, Hemochromatosis.\n4. Inability to provide informed consent.\n5. Cannot understand Hindi or English should be excluded since they will not be able to reply objectively to questionnaire.",{"count":53,"type":22},50,"OBSERVATIONAL","Gall stone disease is more common in patients with cirrhosis. This association has been well established in different studies. Among the various factors which predispose a patient with gall stone disease to have associated liver cirrhosis, genetics also plays an important role.\n\nThis study aims to do a genetic panel-based analysis of genes which are involved in cholestasis to find any association between liver cirrhosis and gall stone disease.\n\nPatients with history of gall stone or history of cholecystectomy done for gall stone disease will be evaluated for the presence of liver cirrhosis by fibroscan and ultrasonography. Those patients with cirrhosis and without cirrhosis will undergo a panel based genetic test for the common cholestasis genes and multivariate analysis will be done for variants associated with lithogenesis and cirrhosis.",[57,28],"Liver Cirrhosis","NOT_YET_RECRUITING","2024-11-06",{"date":61,"type":37},"2024-11-07",{"date":63,"type":22},"2024-11-10",{"date":65,"type":22},"2025-12-31",{"name":67,"class":44},"Institute of Liver and Biliary Sciences, India",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":76,"targetDuration":78,"studyType":54,"phases":4,"briefSummary":79,"conditions":80,"keywords":87,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100553047","algerian-cholecystectomy-outcomes-and-determinants-study-al-cods-100553047","NCT06481007","ALgerian Cholecystectomy Outcomes and Determinants Study (AL-CODS)","Algerian Cholecystectomy Outcomes and Determinants Study","AL-CODS","Inclusion Criteria:\n\n* Patients aged 18 years and older.\n* Undergoing cholecystectomy.\n* Surgery performed in public or private hospitals in Algeria.\n* Surgery performed from January 1, 2025, to June 30, 2025.\n\nExclusion Criteria:\n\n* Patients younger than 18 years.\n* Patients refusing to participate.\n* Cholecystectomy performed for Gallbladder cancer.\n* Cholecystectomy performed outside the inclusion period.\n* Cholecystectomies performed in conjunction with other major surgeries.",{"count":77,"type":22},500,"1 Month","Cholecystectomy, the surgical removal of the gallbladder, is a common procedure performed to treat benign gallbladder diseases such as cholelithiasis (gallstones), cholecystitis (inflammation of the gallbladder), and biliary dyskinesia. While generally considered safe, this surgery can be associated with significant morbidity and mortality, particularly in certain populations or healthcare settings. Understanding these outcomes and the factors influencing them is crucial for improving patient care and surgical practices.\n\nIn Algeria, the healthcare landscape presents unique challenges and opportunities for evaluating surgical outcomes. Limited studies have specifically focused on the morbidity and mortality associated with cholecystectomy in this context. This study aims to fill that gap by providing comprehensive data on 30-day postoperative outcomes following cholecystectomy for benign gallbladder diseases in Algeria. Such data is essential for benchmarking current practices, identifying areas for improvement, and ultimately enhancing patient safety and surgical efficacy.",[81,82,28,83,84,85,86],"Cholecystectomy","Adults","Polyps","Pancreatitis Biliary","Gallbladder Dyskinesia","Cholecystitis",[88,81,89,90,91,92],"Algeria","mortality","morbidity","30 days","determinants","2024-06-26",{"date":95,"type":37},"2024-07-01",{"date":97,"type":22},"2025-01-01",{"date":99,"type":22},"2025-07-02",{"name":101,"class":44},"University of Oran 1",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":45},"100495536","influence-of-gut-microbiome-in-gallstone-disease-100495536","NCT05732480","Influence of Gut Microbiome in Gallstone Disease","Understanding Changes in the Gut Microbiome in Patients With Gallstone Disease and Its Impact on Patient Outcomes","Inclusion Criteria:\n\n* All adults (age \\>18 years of age) patients diagnosed with gallstone disease following confirmatory imaging at an East Kent University Foundation Trust Hospital. Patients of any gender, ethnicity or socio-economic background are eligible as well as pregnant women. Patients undergoing both open and laparoscopic cholecystectomy will be included.\n\nExclusion Criteria:\n\n* Patients less than 18 years of age and patients who do not have capacity to consent to involvement in the study.",{"count":110,"type":22},75,"The goal of this prospective observational study is to explore the role of the gut microbiome in patients with gallstone disease.\n\nThe main question\\[s\\] it aims to answer are:\n\n* if there is a relationship between the gut microbiome and the development of complications associated with gallstone disease (such as pancreatitis and acute cholecystitis)\n* if there are changes in the gut microbiome following cholecystectomy and the relationship with patient outcomes.\n\nParticipants will be asked to provide stool samples at fixed time points (recruitment, pre- and post-cholecystectomy if applicable and at 6 months and 3 years. They will also be asked to provide stool samples if they represent to hospital with complications associated with their gallstone disease.",[28,113,114,115],"Gall Stones, Common Bile Duct","Pancreatitis","Acute Cholecystitis","2024-02-22",{"date":118,"type":37},"2024-02-23",{"date":120,"type":37},"2023-05-30",{"date":122,"type":22},"2026-11-13",{"name":124,"class":125},"East Kent Hospitals University NHS Foundation Trust","OTHER_GOV",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":133,"enrollmentInfo":134,"targetDuration":135,"studyType":54,"phases":4,"briefSummary":136,"conditions":137,"keywords":143,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":4},"100508172","the-construction-of-clinical-database-and-multiomics-biobank-based-on-a-multicentral-prospective-cohort-of-benign-and-malignant-biliary-tract-diseases-100508172","NCT05896956","The Construction of Clinical Database and Multiomics Biobank Based on a Multicentral Prospective Cohort of Benign and Malignant Biliary Tract Diseases","The Construction of Clinical Database and Multiomics Biobank Based on a Multicentral Prospective Cohort of Benign and Malignant Biliary Tract Diseases 胆道系统良恶性肿瘤前瞻性登记队列数据库与多组学生物样本库建设","Inclusion Criteria:\n\n1. Sign informed consent, have good compliance, and be willing to accept follow-up and provide blood samples.\n2. Age 18-74 years old, gender is not limited.\n3. Clinical diagnosis of benign and malignant tumors of the biliary system, including unoperated patients preliminarily diagnosed as benign and malignant tumors of the biliary tract according to the results of imaging examinations and laboratory tests, or pathological examination of patients treated with surgery confirmed as benign and malignant tumors of the gallbladder.\n4. The primary tumor is located in the extrahepatic bile duct, intrahepatic bile duct, gallbladder floor, gallbladder body, gallbladder neck or gallbladder duct.\n5. Karnofsky performance score greater than 50.\n\nExclusion Criteria:\n\n1. Patients with biliary malignant tumors, biliary malignant tumor foci are not primary lesions.\n2. Patients with biliary malignant tumors, combined with serious central nervous system diseases, respiratory diseases, autoimmune diseases, chronic renal insufficiency and other diseases, long-term use of immunosuppressants, combined with serious uncontrolled infections.\n3. Patients with biliary malignant tumors, who also have active cardiovascular and cerebrovascular diseases, have cerebrovascular accidents, myocardial infarction, unstable angina pectoris, or grade II. or above congestive heart failure according to the standards of the New York Heart Association, and require serious arrhythmias requiring drug treatment.\n4. Patients with biliary malignant tumors, women of childbearing age who have a positive blood pregnancy test or have not had a pregnancy test, pregnant or breastfeeding women.\n5. The patient is participating in other therapeutic clinical trials where treatment measures cannot be clarified or treatment information cannot be collected.","74 Years",{"count":77,"type":22},"2 Years","The aim of the study is to establishing a standardized biobank and a clinical information database for patients with benign and malignant tumors of the biliary system. With follow-up plans and advanced multiomics technology, a multiomics database for patients with benign and malignant tumors of the biliary tract will be further established. Based on the above work, real-world clinical research on the diagnosis and treatment of biliary tract tumors is about to be carried out, and a high-standard cohort research foundation is laid for precision therapy based on multiomics characteristics and molecular typing of biliary tract tumors.",[138,139,140,141,142,28],"Biliary Tract Diseases","Gallbladder Cancer","Extrahepatic Bile Duct Cancer","Intrahepatic Cholangiocarcinoma","Biliary Tract Neoplasms",[144,145,146,147,148],"biliary tract diseases","gallbladder cancer","biliary tract neoplasms","biliary tract cancer","cohort study","2023-06-01",{"date":151,"type":37},"2023-06-09",{"date":153,"type":22},"2023-07-01",{"date":155,"type":22},"2027-06-30",{"name":157,"class":44},"RenJi Hospital"]