[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gambling-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gambling-disorder":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,102,128,157,182,204,228,255,281,308,340,360,377,396,421,441],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":73,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":101},"100641475","qaiax-aihealth4u---ai-public-health-central-microcity-a-re-quantum-ai-agency-aka-ai-city-hall-project-upsto-app-nos-64074526-64063557-63903181-63729428-100641475",false,"NCT07661823","QAIAx (AIhealth4U) - AI Public Health Central: Microcity-A (re Quantum AI Agency Aka AI City Hall Project, UPSTO App Nos. 64\u002F074,526, 64\u002F063,557, 63\u002F903,181, 63\u002F729,428","QAIAx (AIhealth4U) - AI Public Health Central: Microcity-A (re Quantum AI Agency Aka AI City Hall Project, UPSTO App Nos. 64\u002F074,526, 64\u002F063,557, 63\u002F903,181, 63\u002F729,428: A Quantum AI Public Health Agency That Provides Free Public Health Services to Registered and Sponsored Visitors\u002FOccupants for RDT&E Under 28 U.S. Code 1498 (Classified as a PPA Under 10 U.S. Code 129a)","QAIAx","Inclusion Criteria:\n\n* Individuals aged 17 to 99 years old.\n* Referral by a licensed health services professional (e.g., R.N., N.P., Ph.D., M.D.).\n* Referral by a non-profit organization (e.g., 501c3, university, church).\n* Referral by a public agency (e.g., case manager, social worker, parole\u002Fprobation\u002FPTS officer, judge).\n\nExclusion Criteria:\n\n\\* Individuals under 17 or over 99 years of age.",true,"ALL","17 Years","99 Years",{"count":22,"type":23},1000000,"ESTIMATED","INTERVENTIONAL",[26],"NA","BRIEF SUMMARY\n\nA. \"What is the purpose of this study?\"\n\nThis study will test whether the \"AI City Hall Project\" (QAIAx), a quantum artificial intelligence (AI) public health agency, can provide free or low-cost behavioral and mental health services inside self-contained, dome-enclosed communities called \"Microcities\". Researchers want to see if AI-managed public administration, AI humanoid robots, holoportation of human-figures via 'holo-suites' (e.g., AI-119 Kikkeri Holo-Suit; AI-119 Vulcan QM-Ware) and advanced AI mental-health tools can lower housing and care costs, improve mental health outcomes (e.g., particular ecosystems using AI tools among persons with one or more addiction disorders), and be financially sustainable for people on fixed incomes or public assistance.\n\nB. \"What conditions does the study focus on?\"\n\nThe study focuses on adults with:\n\n* Autism spectrum disorders (Asperger's, autism, ADHD, ASD)\n* Substance use disorders (alcohol, opioids, marijuana, cocaine, MDMA\u002Fecstasy, tobacco\u002Fnicotine)\n* Psychiatric conditions (personality disorders, narcissism, gender dysphoria, eating disorders)\n* Behavioral addictions (gambling, sex addiction) and related issues (sex offence history).\n\nC. \"What does the study involve?\"\n\nEligible volunteers live in an omni AI-managed Microcity for up to 24 months. The community is housed in a geodesic dome that contains all daily necessities: housing, food, utilities, healthcare, and public services. Daily life is managed by an AI system (ISAC) and AI humanoid robots, with only occasional human oversight. Participants receive free mental-health treatment that may include AI-driven counselling, virtual-reality therapy (holo-suits), and non-invasive digital \"attitude inoculation\" protocols designed to reduce stress and addiction cravings. All participants also take AI-technology courses as a condition of enrolment. The study does not use any FDA-regulated drug, device, or biologic.\n\n\\*\\*Who can participate?\\*\\*\n\nYou may be able to join if you:\n\n* Are an adult (18 years or older)\n* Have a diagnosis of one of the listed mental-health or addiction disorders\n* Are referred by a licensed health professional (e.g., RN, NP, PhD, MD), a non-profit organisation (e.g., 501(c)(3), university, church), or a public agency (e.g., case manager, social worker, parole\u002Fprobation officer, judge)\n* Are willing to live in a closed, AI-managed community for up to one year and complete AI educational courses.\n\nParticipants who are veterans, receive public assistance (e.g., VA disability, SSDI\u002FSSI, Medicaid, Medicare), or are experiencing homelessness may be prioritised.\n\n\\*\\*Where is the study taking place?\\*\\* The study will be conducted at Microcity sites in the United States and internationally. The first administrative site is in Richmond, Virginia, USA. Additional sites are planned in partner nations, including tribal lands, military installations, and special economic zones.\n\n\\*\\*Who is sponsoring the study?\\*\\* The study is sponsored by \\*\\*Veterans Recovery Network Inc.\\*\\*, a non-profit organization, in collaboration with \\*\\*AI-119 Vulcan Project Research \\& Educational Technology Co. (PRETCO)\\*\\* and an AI legal agency. The study is conducted under U.S. federal research and development authorities (28 U.S.C. §1498; 10 U.S.C. §129a) and is part of a Cooperative Research and Development Agreement (CRADA) with U.S. Special Operations Command (USSOCOM).\n\nThis summary describes a planned clinical study. Not all details may be final. Information may change as the study progresses.",[29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72],"Asperger's Disorder","Asperger Disorder","Autism Disorder","Autism","ADHD - Attention Deficit Disorder With Hyperactivity","ADHD","ASD","Alcohol Abuse\u002FDependence","Alcohol Addiction","Alcohol and Other Drug Use Disorders","Alcohol and Other Substance Use Prevention","Gambling Addiction","Gambling Disorder","Sex Abuse","Sex Behavior","Sex Crimes","Sex Disorder","Sex Disorders","Gender Dysphoria, Adult","Eating Behavior Disorders","Narcotic-Related Disorders","Narcotic Addiction","Narcissism","Psychiatric Disorder","Psychedelic Effects in Healthy Volunteers","Psychedelic Experiences","Psychedelic Drug Dependence","Marijuana Use Disorder","Marijuana Abuse and Dependence","Smoking (Tobacco) Addiction","Smoking Among Youth","Smoking Abstinence","Abstinence, Sex","Opiate Substitution Treatment","Opioid Abuse (Disorder)","Opioid Abuse and Addiction","Cocaine Abuse","MDMA ('Ecstasy')","Addiction Disorders","Homeless and Low Incomes People, Refugees","Homelessness","Reliability and Validity","Anger Problems","Child Abuse, Sexual",[74,75,76,77,78,79,80,81,82,83,84,85,86,87,88],"ai city hall project","ai 119","ai119","qaia","qaiax","ai wat","veterans recovery network","veterans","addiction disorder","vulcan","artificial intelligence","agi","military","sex addiction","mental health treatment","NOT_YET_RECRUITING","2026-06-16",{"date":92,"type":93},"2026-06-22","ACTUAL",{"date":95,"type":23},"2026-08-01",{"date":97,"type":23},"2028-12-31",{"name":99,"class":100},"Veterans Recovery Network Inc.","OTHER",1,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":17,"sex":18,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":24,"phases":113,"briefSummary":114,"conditions":115,"keywords":116,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":101},"100610484","effect-of-high-intensity-transcranial-alternating-current-stimulation-on-gambling-disorder-a-randomized-controlled-trial-100610484","NCT07228182","Effect of High-Intensity Transcranial Alternating Current Stimulation on Gambling Disorder: A Randomized Controlled Trial","HITACSRCT-GD","Inclusion Criteria:\n\n* Aged 18-60, male or female, with 9 or more years of education, and able to complete questionnaire evaluation and behavioral tests;\n* Meet DSM-5 (Diagnostic and Statistical Manual of mental disorders，DSM) diagnostic criteria for gambling disorder;\n* Have gambled for at least one year (at least once a week);\n* Normal vision and hearing, or within the normal range after correction;\n* Agree to cooperate in the follow-up evaluation;\n* No metal implantation in the head, no history of nerve problems or head injury, and no skin sensitivity.\n\nExclusion Criteria:\n\n* Have severe cognitive impairment, such as a history of head trauma, -cerebrovascular disease, epilepsy, etc.;\n* Have used drugs promoting cognitive function in the last 6 months;\n* Have impaired intelligence (Intelligence Quotient\\\u003C70);\n* Abuse or dependence of psychoactive substances (except nicotine) in the last 5 years.","18 Years","60 Years",{"count":112,"type":23},60,[26],"The investigators assume that High-intensity transcranial Alternating Current Stimulation (HI-tACS) could improve gambling disorder patients' executive-control function by modulating abnormal neural activity, particularly gamma-band oscillations, which are closely associated with executive-control deficits. This study intends to validate the effect of HI-tACS treatment, which has been discovered in the previous pilot study. A three-month follow-up assessment will be conducted to test the changes in executive-control function and its underlying mechanism.",[41],[117],"High-Intensity Transcranial Alternating Current Stimulation, Gambling disorder.","RECRUITING","2026-06-08",{"date":121,"type":93},"2026-06-10",{"date":123,"type":23},"2026-06-01",{"date":125,"type":23},"2026-12-28",{"name":127,"class":100},"Shanghai Mental Health Center",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":18,"minAge":109,"maxAge":4,"enrollmentInfo":136,"targetDuration":4,"studyType":24,"phases":138,"briefSummary":139,"conditions":140,"keywords":141,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":156},"100398389","virtual-reality-exposure-therapy-for-gambling-disorder-100398389","NCT04467502","Virtual Reality Exposure Therapy for Gambling Disorder","Virtual Reality Exposure Therapy for Gambling Disorder: Randomized Controlled Trial","VIRET-GAD","Inclusion Criteria:\n\n* Seek treatment for GD within one of health care facilities participating in the research (first request for treatment and not patients already receiving treatment for gambling disorder in the care center).\n* Meet a current diagnosis of gambling disorder according to DSM-5 criteria and with a South Oaks Gambling Screen (SOGS) score ≥ 5\n* Meet a casino gambling behavior with a casino gambling frequency ≥ 1 time every two months during the last 12 months\n* Have a sufficient understanding of French for therapy\n* Beneficiary of the French social security system\n* Give an informed consent to participate\n* Willing to comply with all study procedures and duration\n\nExclusion Criteria:\n\n* Visual disturbance making impossible the use of virtual reality equipment (e.g. advanced retinal degeneration, central scotoma, age-related macular degeneration)\n* Pregnant woman\n* Minor or adult under guardianship, conservatorship, under judicial protection, persons deprived of their liberty\n* Balance disorder (e.g. cerebellar disorder, inner ear disorder)\n* Photosensitive epilepsy\n* Refusal to participate",{"count":137,"type":23},124,[26],"Gambling disorder (GD) is recognized as an addictive disorder in the DSM-5. Craving is a core phenomenon in addiction that can lead to relapse in problem gambling for pathological gamblers. Exposure Therapy (ET) focuses on craving in addiction treatment. ET in Cognitive-Behavioral Therapy (CBT) is based on classical conditioning that addresses the association between contextual cues and the craving response. ET helps the patient to reduce craving when faced with cues triggering craving. ET includes in vivo exposure and imaginal exposure. The literature recommends being as close as possible to the context of addiction to facilitate the extinction of craving but in vivo ET is complicated to perform. For GD, in outpatient consultation, bringing a patient to a casino presents obstacles (e.g., time, human and financial cost, agreement with casino for therapy).\n\nThe study will be to assess the effectiveness of Virtual Reality Exposure Therapy (VRET) in a virtual gambling environment. Various trials show that VRET is no more or less effective than classical ET in CBT but has other advantages for motivation to treatment. This research aims to compare efficacy between CBT with VRET and CBT with imaginal exposure for treatment of GD in a multicenter, randomized, controlled, non-inferiority clinical trial.",[41],[142,143,144,145,146],"Exposure therapy","virtual reality","cognitive behavioral therapy","pathological gambling","CBT","2026-05-11",{"date":149,"type":93},"2026-05-14",{"date":151,"type":93},"2023-07-12",{"date":153,"type":23},"2027-07",{"name":155,"class":100},"University Hospital, Lille",10,{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":17,"sex":18,"minAge":109,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":24,"phases":167,"briefSummary":168,"conditions":169,"keywords":170,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":101},"100282235","contingency-management-as-an-adjunct-treatment-for-rural-and-remote-disordered-gamblers-100282235","NCT02953899","Contingency Management as an Adjunct Treatment for Rural and Remote Disordered Gamblers","Piloting the Addition of Contingency Management to Best Practice Counselling as an Adjunct Treatment for Rural and Remote Disordered Gamblers","Inclusion Criteria:\n\n* capable of providing written consent,\n* received a diagnosis of gambling disorder (American Psychiatric Association, 2013),\n* gambled within the last month,\n* live in a rural or remote location, and\n* speak English\n\nExclusion Criteria:\n\n* Medically unmanaged psychiatric or neurological disorder(s) except for disordered gambling","70 Years",{"count":166,"type":23},54,[26],"The purpose of this project is to pilot contingency management as an adjunct treatment to counselling as usual using internet delivered video-conferencing applications for remote disordered gamblers. This project further investigates the impact of adding contingency management to counselling to improve counselling attendance and retention and uses internet-delivered approaches to assist rural and remote disordered gamblers gain access to counselling treatments.",[41],[171,172,41,173],"Internet","Contingency Management","Rural","2026-05-06",{"date":147,"type":93},{"date":177,"type":93},"2016-11",{"date":179,"type":23},"2026-12-31",{"name":181,"class":100},"University of Lethbridge",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":18,"minAge":109,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":24,"phases":191,"briefSummary":193,"conditions":194,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":101},"100623030","phase-2-psilocybin-assisted-psychotherapy-for-the-treatment-of-gambling-disorder--a-pilot-study-100623030","NCT07391332","Psilocybin AsSisted pSychotherapy for the treatmENt of Gambling disordER : a Pilot Study","PASSENGER","Inclusion Criteria:\n\n* Men and women aged 18 years or older\n* With a confirmed diagnosis of current gambling disorder (diagnostic criteria according to DSM-5), regardless of severity.\n* Able to complete self-assessment questionnaires\n* Willing to start addiction treatment, or for whom treatment already undertaken is not sufficient\n* Willing to undergo a blood test and ECG\n* Written and oral comprehension of French\n* Having signed an informed consent form before any procedure under study\n* Affiliated with a French social security system\n* Women of childbearing age with a negative pregnancy test and highly effective contraception (according to version 1.2 of March 2024 of the CTCG recommendations in Appendix 7)\n* Men of childbearing age using effective contraception (according to version 1.2 of March 2024 of the CTCG recommendations).\n* Negative result on urinary toxicology screening\n* In the case of psychotropic treatment (excluding nicotine replacement therapy): stabilization of dosage or initiation for more than 1 month.\n\nExclusion Criteria:\n\n* Medical conditions that would prevent safe participation in the trial (epilepsy, significantly impaired liver function (TP\\\u003C50%), significantly impaired kidney function (GFR\\\u003C90 mL\u002Fmin), coronary artery disease, history of arrhythmia, heart failure, uncontrolled hypertension, history of stroke, severe asthma, hyperthyroidism, narrow-angle glaucoma, symptomatic prostatic hypertrophy, or bladder neck obstruction).\n* Serious ECG abnormalities (including QTc prolongation = corrected QT)\n* Current or past psychotic or bipolar disorder\n* Other unstable psychiatric disorder\n* Family history (first-degree relatives) of psychotic disorder or type 1 bipolar disorder\n* Current high risk of suicide (according to the MINI 5.0 suicide risk module)\n* History of hallucinogen use disorder or any use in the past year\n* Current alcohol use disorder with a history of withdrawal symptoms\n* Extreme thinness (BMI \\\u003C 16.5) or obesity (BMI \\> 30)\n* Major cognitive impairment (Mini-Mental State Examination score \\\u003C 26)\n* Allergy or hypersensitivity to psilocybin or any of the excipients contained in the investigational drug\n* Taking UGT1A9, UGT1A10, ALDH, or ADH inhibitors\n* Pregnancy or breastfeeding\n* Current protective measures (guardianship and legal protection)\n* Participation in another interventional research protocol involving another psychotherapeutic or pharmacological intervention that may have an impact on clinical progression",{"count":190,"type":23},30,[192],"PHASE2","The PASSENGER project aims to conduct a pilot feasibility study of the implementation of a randomized clinical trial on psilocybin-assisted psychotherapy for the treatment of gambling disorder. Feasibility will be assessed by estimating the ability to retain participants until the end of the protocol. Other objectives of the study will be to generate preliminary efficacy data, identify clinical factors potentially associated with the intensity of the psychedelic experience (which determines the expected therapeutic effect), and conduct a preliminary assessment of the safety of the treatment under study.",[41],"2026-01-29",{"date":197,"type":93},"2026-02-05",{"date":199,"type":23},"2026-04-01",{"date":201,"type":23},"2029-01-01",{"name":203,"class":100},"Nantes University Hospital",{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":11,"sex":18,"minAge":109,"maxAge":4,"enrollmentInfo":211,"targetDuration":4,"studyType":24,"phases":213,"briefSummary":214,"conditions":215,"keywords":217,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":101},"100594181","contingency-management-to-reinforce-attendance-to-cognitive-behavioral-treatment-for-gambling-disorder-100594181","NCT07016100","Contingency Management to Reinforce Attendance to Cognitive Behavioral Treatment for Gambling Disorder","A Randomized Clinical Trial of Contingency Management for Gambling Disorder: Enhancing Treatment Retention and Outcomes","Inclusion Criteria:\n\n1. Adults age 18 or older\n2. Seeking treatment for gambling-related concerns at The Gambling Clinic\n3. Available to meet weekly for eight treatment sessions without a known structural barrier to continuation that could interfere with study conclusions (e.g., planned relocation out of state).\n4. Proficient in English (assumed by request of gambling treatment in English).\n5. Must be physically present in the US.\n\nExclusion Criteria:\n\n1. Minors under the age of 18.\n2. Recent history of psychotic symptoms or suicidal intent\n3. Not proficient in English.\n4. Seeking gambling treatment for someone other than themselves (e.g., a loved one).\n5. Will not be available for a full eight weeks of study participation.\n6. Not physically present in the US.",{"count":212,"type":23},80,[26],"The aim of this study is to conduct a trial to investigate the effectiveness of adding contingency management treatment (CM) to standard care cognitive behavioral therapy (CBT) for the treatment of gambling disorder to increase attendance to treatment. CM will be used to incentivize therapy session attendance with a therapist and engagement in recovery-related engagement with a peer recovery specialist. The proposed research will evaluate whether CM can enhance the overall effectiveness of CBT, the most widely tested treatment for individuals with gambling disorder.",[41,216],"Gambling Problem",[218],"contingency management","2025-06-11",{"date":221,"type":93},"2025-06-15",{"date":223,"type":23},"2025-09-01",{"date":225,"type":23},"2027-04",{"name":227,"class":100},"East Tennessee State University",{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":11,"sex":18,"minAge":109,"maxAge":4,"enrollmentInfo":235,"targetDuration":4,"studyType":24,"phases":237,"briefSummary":238,"conditions":239,"keywords":240,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":101},"100592107","internet-based-versus-synchronous-cognitive-behavioural-therapy-for-patients-with-gambling-disorder-100592107","NCT06989125","Internet-based Versus Synchronous Cognitive Behavioural Therapy for Patients With Gambling Disorder","Internet-based Versus Synchronous Cognitive Behavioural Therapy for Patients With Gambling Disorder: A Non-inferiority Randomized Controlled Trial","Inclusion Criteria:\n\nTo be included patients should:\n\n* fulfil diagnostic criteria for GD (DSM-5).\n* score 4 points or more on the National Opinion Research Centre Screen for Gambling Problems (NODS).\n* be able to read, write, and speak Danish.\n* have IT skills and access to the internet and a computer, smartphone, and\u002For tablet.\n\nExclusion Criteria:\n\nPatients are excluded from participation if they:\n\n* present with severe comorbid somatic disease, cognitive deficits, severe trauma, and\u002For psychiatric disorder (e.g. depression, bipolar disorder, substance abuse, ADHD) that is insufficiently treated at the time of assessment and\u002For is evaluated to constitute a barrier for engaging in or benefitting from treatment.\n* are not willing to engage in internet-delivered treatment or face-to-face cognitive behavioural therapy.\n* do not provide informed consent.\n* are in risk of suicide (indicated by clear intent and\u002For plans).\n* have previously received treatment via or had access to the SpilleFri platform.\n* seek treatment as part of an imminent legal case.\n* only fulfil diagnostic criteria for Gambling Disorder in relation to behaviour such as stock trading or buying and selling cryptocurrency.\n* present with highly unstable social circumstances, which are considered to potentially pose a barrier to engaging in treatment (e.g., homelessness).",{"count":236,"type":23},150,[26],"The aim of this two-armed, randomized controlled trial is to determine if internet-based cognitive behavioural therapy (CBT) is as effective as synchronous CBT (sCBT) for treating Gambling Disorder (GD) in adults. The main question it aims to answer is: Is the effect of the internet-based CBT (\"SpilleFri\") non-inferior to that of synchronous CBT in reducing gambling severity?\n\nThe trial will enroll 150 patients with Gambling Disorder who will be randomized (1:1) to either the experimental condition (12 weeks' treatment with the internet-based treatment \"SpilleFri\") or the active control condition (18 weeks individual sCBT). The primary outcome measure will be based on self-reported GD severity (NODS).\n\nThe trial will be considered effective if SpilleFri is not clinically inferior (within a predefined non-inferiority margin) to sCBT in reducing GD severity at the primary endpoint three months after end-of-treatment.\n\nIn addition to evaluating the effectiveness of the treatments, the study will conduct an exploratory analysis of the impact of each condition on secondary outcomes (changes in gambling behavior, relationship quality, and symptoms of anxiety, depression, and emotional distress). Similarly, an exploratory analysis of process variables (gambling-related self-efficacy, maladaptive gambling cognitions, emotion regulation difficulties, and gambling urge) will be conducted across conditions and clinical subgroups.\n\nParticipants will:\n\n* Engage in nine structured modules of either internet-based CBT or sCBT\n* Complete self-reported questionnaires on gambling severity and secondary symptoms at eight time points\n* Have the option for up to three additional support sessions with a psychologist",[41],[241,242,243,244,245],"Gambling Disorder treatment","Internet-based treatment","Cognitive behavioral therapy","Non-inferiority trial","Randomized controlled trial","2025-05-16",{"date":248,"type":93},"2025-05-25",{"date":250,"type":93},"2025-02-24",{"date":252,"type":23},"2027-06",{"name":254,"class":100},"Aarhus University Hospital",{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":11,"sex":18,"minAge":109,"maxAge":4,"enrollmentInfo":262,"targetDuration":4,"studyType":264,"phases":4,"briefSummary":265,"conditions":266,"keywords":267,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":276,"leadSponsor":278,"locationsCount":280},"100591524","modeling-clinical-outcomes-in-gambling-addiction-100591524","NCT06981546","Modeling Clinical Outcomes in Gambling Addiction","MOGADOR","Inclusion Criteria:\n\n* Patient, male or female, over 18 years old, consulting in one of the participating centers.\n* DSM-5 criteria for gambling disorder at inclusion: at least 4 criteria present in the 12 months preceding the study.\n* First treatment for gambling disorder or no treatment in the last 6 months (initiation or re-initiation of care).\n\nExclusion Criteria:\n\n* Unable to be reached by phone.\n* Unable to use the internet.\n* Patient under antiparkinsonian treatment of the dopaminergic family.\n* Being treated with a drug that may trigger\u002Fincrease symptoms of gambling disorder (e.g. dopamine agonist).\n* Subject under guardianship.",{"count":263,"type":23},268,"OBSERVATIONAL","Gambling disorder (GD) is recognized as an addictive disorder. Financial consequences of GD are often dramatic, inducing professional, familial, legal and medical repercussions and particularly mental health consequences.\n\nMOGADOR is a longitudinal, multicentric, prospective, prognostic study, which aims to identify factors predicting the evolution of french patients with GD in care centers particularly involved in the management of GD. The main goal will focus on evolution of DSM-5 (Diagnostic and Statistical Manual of Mental Disorder 5th edition) GD criteria during the first year of follow-up. The prognostic factors will be collected at base-line and they will be considered to influence the long-term prognosis of patients.\n\nFor patients suffering of GD, our main hypothesis is that initial factors like individual socio-demographic characteristics, clinical psychiatric profiles, addiction comorbidities, and behaviour are associated with the clinical prognosis (total remission of DSM-5 criteria of GD at 12 months).\n\nMOGADOR will be the first study, aiming to model prognostic aspects of GB in populations specially monitored for this disorder.",[41],[268,269,270,271],"Gambling disorders","Modeling outcomes","Socio-demographic Characteristics","Clinical psychiatric profiles","2025-05-13",{"date":274,"type":93},"2025-05-20",{"date":223,"type":23},{"date":277,"type":23},"2030-09-01",{"name":279,"class":100},"Hospices Civils de Lyon",9,{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":17,"sex":18,"minAge":288,"maxAge":4,"enrollmentInfo":289,"targetDuration":4,"studyType":24,"phases":291,"briefSummary":292,"conditions":293,"keywords":295,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":4},"100555881","beliefs-about-mental-health-treatment---gambling-addiction-study-in-colorado-100555881","NCT06517849","Beliefs About Mental Health Treatment - Gambling Addiction Study in Colorado","The Stanford Gambling Addiction Therapy Study (SGATS) in Colorado","Inclusion Criteria:\n\n* must reside in Colorado\n* must be English-speaking\n\nExclusion Criteria:\n\n* does not reside in Colorado\n* is not English-speaking","21 Years",{"count":290,"type":23},375,[26],"Many people with mental health conditions do not seek treatment, and it is unclear what exactly prevents people from taking up treatment. The goal of this interventional study is to learn about how people think about cognitive behavioral therapy (CBT) for gambling disorders. The main questions it aims to answer are:\n\n* Do people have incorrect beliefs about the net benefits of CBT? If yes, which beliefs are those, and how much do people underestimate or overestimate the benefits?\n* Is a small monetary incentive (that participants receive conditional on trying out CBT) helpful in increasing take-up of CBT?\n\nApart from these questions, the researchers will also study how well CBT works to treat gambling disorders.\n\nParticipants will be asked to complete two surveys over four months and might be offered a modest monetary incentive for doing (free) CBT if they are in the treatment group. Researchers will compare that treatment group to a control group. Participants in the control group will have access to free CBT and do the same two surveys as those in the treatment group, but will not receive the monetary incentive.",[41,216,294],"Mental Health Issue",[296,297,298],"Beliefs","Bias","Incentive","2025-04-12",{"date":301,"type":93},"2025-04-16",{"date":303,"type":23},"2025-06",{"date":305,"type":23},"2026-03",{"name":307,"class":100},"Stanford University",{"id":309,"slug":310,"hasResults":11,"nctId":311,"briefTitle":312,"officialTitle":313,"acronym":4,"eligibilityCriteria":314,"healthyVolunteers":17,"sex":18,"minAge":288,"maxAge":4,"enrollmentInfo":315,"targetDuration":4,"studyType":24,"phases":316,"briefSummary":317,"conditions":318,"keywords":322,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":4},"100565436","theory-based-intervention-for-promoting-responsible-gambling-among-college-students-100565436","NCT06642155","Theory-based Intervention for Promoting Responsible Gambling Among College Students","Testing the Efficacy of ResponsiblePlay©: MTM-Based Intervention for Responsible Gambling for College Students","Inclusion Criteria:\n\n* Must be at least 21 years old.\n* Must be a enrolled UNLV student.\n* Must engage in gambling activities.\n* Must have a score of 3 or higher on the Problem Gambling Severity Index (PGSI), indicating at-risk or problem gambling behavior.\n\nExclusion Criteria:\n\n* Participants currently receiving treatment for gambling disorders.\n* Individuals with cognitive impairments that would affect their ability to provide consent or participate in the intervention.\n* Individuals who are not fluent in English (since the intervention materials and assessments will be conducted in English).",{"count":112,"type":23},[26],"The goal of this clinical trial is to learn if the RESPONSIBLEPLAY© intervention helps promote responsible gambling behaviors in University of Nevada, Las Vegas (UNLV) students aged 21 and older who have a Problem Gambling Severity Index (PGSI) score of 3 or higher. The main questions it aims to answer are:\n\nDoes the intervention reduce harmful gambling behaviors? Does the intervention increase responsible gambling practices? Researchers will compare participants receiving the RESPONSIBLEPLAY© intervention with those receiving a knowledge-based intervention to see if the RESPONSIBLEPLAY© intervention is more effective.\n\nParticipants will:\n\nAttend three face-to-face sessions on responsible gambling over three weeks. Complete surveys before, after, and eight weeks after the intervention to track their progress.",[319,320,321,41],"Problem Gambling","Pathological Gambling","Behavioral Addiction",[323,324,319,320,325,326,327,328,329,330],"Responsible Gambling","College Students","Behavioral Interventions","Health Behavior Change","Multi-theory Model (MTM)","Randomized Controlled Trial (RCT)","Public Health Intervention","Gambling Disorder Prevention","2024-10-16",{"date":333,"type":93},"2024-10-18",{"date":335,"type":23},"2024-11",{"date":337,"type":23},"2025-04",{"name":339,"class":100},"University of Nevada, Las Vegas",{"id":341,"slug":342,"hasResults":11,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":11,"sex":18,"minAge":109,"maxAge":347,"enrollmentInfo":348,"targetDuration":4,"studyType":24,"phases":349,"briefSummary":350,"conditions":351,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":358,"locationsCount":4},"100562079","repetitive-transcranial-magnetic-stimulation-rtms-and-cognitive-behavioral-therapy-cbt-for-gambling-disorder-100562079","NCT06598501","Repetitive Transcranial Magnetic Stimulation (rTMS) and Cognitive Behavioral Therapy (CBT) for Gambling Disorder","Repetitive Transcranial Magnetic Stimulation (rTMS) and Cognitive Behavioral Therapy (CBT) in the Management of Gambling Disorder in Indonesia: a Pilot and Feasibility Study","Inclusion Criteria:\n\n* Subjects with pathological gambling (SOGS score ≥ 5)\n* Subjects aged 18-70 years old\n* Subjects who understand Bahasa Indonesia\n* Subjects who agree to participate and receive treatment\n\nExclusion Criteria:\n\n* Subjects with history of psychotic disorder and personality disorder according to ICD-11\n* Subjects with severe neurological disorder comorbidities, which cause seizure or loss of consciousness\n* Subjects with intellectual disability\n* Subjects with history of neurostimulation\n* Subjects with history of medical implant\n* Subjects currently or expecting pregnancy\n* Subjects fulfilling diagnostic criteria of substance use disorder in the last 6 months","59 Years",{"count":156,"type":23},[26],"Treatment options for gambling disorder (GD) remain limited, with no pharmacotherapy proven effective. As of date, cognitive behavioral therapy (CBT) is the preferred therapy for GD, but the improvements often require months to show, highlighting the need for a more comprehensive therapy. Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment modality in alleviating craving. Studies have shown potential benefit of combining both CBT and rTMS in substance addiction, but not in GD. Thus, this study aims to determine the feasibility and efficacy of rTMS and CBT combination therapy in the management of GD in Indonesia.",[41],"2024-09-14",{"date":354,"type":93},"2024-09-19",{"date":356,"type":23},"2024-10",{"date":337,"type":23},{"name":359,"class":100},"Indonesia University",{"id":361,"slug":362,"hasResults":11,"nctId":363,"briefTitle":364,"officialTitle":365,"acronym":4,"eligibilityCriteria":366,"healthyVolunteers":11,"sex":18,"minAge":109,"maxAge":347,"enrollmentInfo":367,"targetDuration":4,"studyType":24,"phases":368,"briefSummary":369,"conditions":370,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":371,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":376,"locationsCount":101},"100530081","repetitive-transcranial-magnetic-stimulation-rtms-in-the-treatment-of-gambling-disorder-in-indonesia-100530081","NCT06182137","Repetitive Transcranial Magnetic Stimulation (rTMS) in The Treatment of Gambling Disorder in Indonesia","Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in The Treatment of Gambling Disorder in Indonesia: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Subjects with pathological gambling (SOGS score ≥ 5)\n* Subjects aged 18-59 years old\n* Subjects who understand Bahasa Indonesia\n* Subjects who agree to participate and receive treatment\n\nExclusion Criteria:\n\n* Subjects with history of psychotic disorder, personality disorder, or sleep disorder according to ICD-11\n* Subjects with history of neurostimulation\n* Subjects with history of medical implant\n* Subjects with history of severe neurological disorder, which causes seizure or loss of consciousness\n* Subjects with intellectual disability\n* Subjects with endocrinological disorders\n* Subjects with contraindication during prior MR or other related procedures\n* Subjects who are currently or expecting pregnancy\n* Subjects with history of substance use in the last 6 months",{"count":190,"type":23},[26],"Research has shown that cognitive-behavioral therapy (CBT) is an effective treatment for gambling disorder. Several studies had also been done to evaluate the effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) in addiction management, particularly in alleviating craving. A randomised controlled trial (RCT) of 30 subjects would be conducted to evaluate the effectiveness of transmodalistic therapy with a combination of rTMS and CBT for online gambling disorder.",[41],{"date":354,"type":93},{"date":373,"type":23},"2024-12",{"date":375,"type":23},"2025-12",{"name":359,"class":100},{"id":378,"slug":379,"hasResults":11,"nctId":380,"briefTitle":381,"officialTitle":382,"acronym":4,"eligibilityCriteria":383,"healthyVolunteers":11,"sex":384,"minAge":109,"maxAge":110,"enrollmentInfo":385,"targetDuration":4,"studyType":24,"phases":386,"briefSummary":387,"conditions":388,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":389,"lastUpdatePostDateStruct":390,"startDateStruct":392,"completionDateStruct":393,"leadSponsor":395,"locationsCount":101},"100552002","effects-of-transcranial-temporal-interference-stimulation-on-risky-decision-making-and-impulse-control-in-gambling-disorder-100552002","NCT06467422","Effects of Transcranial Temporal Interference Stimulation on Risky Decision-making and Impulse Control in Gambling Disorder","Exploring the Role and Neural Mechanisms of Transcranial Temporal Interference Stimulation Modulating the Dorsal Anterior Cingulate Cortex on Risky Decision-making and Impulse Control in Gambling Disorder","Inclusion Criteria:\n\n* Aged 18-60, male or female, right handed;\n* With 9 or more years of education, and able to cooperate in completing the questionnaire assessment and behavioural tests.\n* Meets the DSM-5 diagnostic criteria for gambling addiction;\n* Previous gambling behaviour of not less than 1 year's duration (at least one gambling session per week or more);\n* Normal or corrected normal vision and hearing;\n* Agrees to cooperate in completing the follow-up assessment;\n* No history of neurological problems or head injury; and no skin sensitivity.\n* Agree to cooperate in completing the follow-up assessment;\n* No metal implantation in the head, no history of neurological problems or head injury, and no skin sensitivity.\n\nExclusion Criteria:\n\n* Suffering from severe cognitive dysfunction, such as a history of head trauma, cerebrovascular disease, epilepsy, etc., use of cognitive-promoting medications in the last 6 months;\n* Other psychoactive substance abuse or dependence in the last 5 years (except nicotine).","MALE",{"count":190,"type":23},[26],"The purpose of this research is to investigate the effect of transcranial temporal interference stimulation (tTIS) targeting the dorsal anterior cingulate cortex in patients with gambling disorder.",[41],"2024-06-20",{"date":391,"type":93},"2024-06-21",{"date":389,"type":23},{"date":394,"type":23},"2025-06-01",{"name":127,"class":100},{"id":397,"slug":398,"hasResults":11,"nctId":399,"briefTitle":400,"officialTitle":401,"acronym":4,"eligibilityCriteria":402,"healthyVolunteers":11,"sex":18,"minAge":109,"maxAge":403,"enrollmentInfo":404,"targetDuration":4,"studyType":24,"phases":406,"briefSummary":407,"conditions":408,"keywords":409,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":411,"lastUpdatePostDateStruct":412,"startDateStruct":414,"completionDateStruct":416,"leadSponsor":418,"locationsCount":101},"100506312","theta-burst-stimulation-for-gambling-disorder-100506312","NCT05872750","Theta Burst Stimulation for Gambling Disorder","Rolling Deep With Gambling Disorder: From Building up of Scales, Biomarkers to Therapeutic Innovation","Inclusion Criteria:\n\n1. age between 18 and 65 years;\n2. fulfilling at least 4 of the Diagnostic and Statistical Manual version 5 (DSM-5) criteria of gambling disorder for at least 12-month assessed by the Structured Clinical Interview\n\nExclusion Criteria:\n\n1. Inability to provide informed consent or comprehend the study procedure;\n2. A major psychiatric illness that required chronic psychotropic medication or inpatient treatment, including schizophrenia spectrum disorder, bipolar spectrum disorder, and major depressive disorder with psychotic features.\n3. A current DSM-5 diagnosis of substance use disorder except nicotine use disorder or the use of one to two low-potency benzodiazepine tablets for sleep impairment;\n4. Have known preexisting noise-induced hearing loss, concurrent treatment with ototoxic medications, or with cochlear implants.\n5. Unstable medical illness, including malignancy, uncontrolled diabetes mellitus, unstable cardiac disease or recent myocardial infarction, or cerebrovascular or cardiovascular risk factors that require intensive medical management\n6. On medications known to lower seizure threshold (e.g., TCA, bupropion, clozapine)\n7. Implants controlled by physiological signals, including pacemaker, implantable cardioverter defibrillator, cochlear implant.\n8. Metallic objects in the head, including stenting, suture.\n9. Elevated risk of seizure due to traumatic brain history, seizure history, and head trauma, intracranial lesion, and alcohol or benzodiazepines withdrawal syndrome, stimulant intoxication.","65 Years",{"count":405,"type":23},75,[26],"The goal of this clinical trial is to investigate the efficacy of theta burst stimulation in individuals with gambling disorder. The main goal is to compare the severity of gambling problems following 2 weeks of intervention between active group and sham group. Participants will be randomized into active and sham group. The severity of gambling problems are assessed by self-reported questionaires.",[41],[410,41],"theta burst stimulation","2023-05-14",{"date":413,"type":93},"2023-05-24",{"date":415,"type":93},"2023-04-17",{"date":417,"type":23},"2026-06",{"name":419,"class":420},"Taipei City Hospital","OTHER_GOV",{"id":422,"slug":423,"hasResults":11,"nctId":424,"briefTitle":425,"officialTitle":426,"acronym":4,"eligibilityCriteria":427,"healthyVolunteers":11,"sex":18,"minAge":428,"maxAge":403,"enrollmentInfo":429,"targetDuration":4,"studyType":24,"phases":430,"briefSummary":431,"conditions":432,"keywords":433,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":439,"leadSponsor":440,"locationsCount":101},"100504928","the-effect-of-theta-burst-stimulation-on-serum-bdnf-100504928","NCT05854706","The Effect of Theta-burst Stimulation on Serum BDNF","Antidepressant Effect of Prolonged Intermittent Theta-burst Stimulation on Serum Brain-derived Neurotrophic Factor Levels of Patients With Depression: A Randomized, Double-Blind, Sham-Controlled Study","Inclusion Criteria:\n\n1. age between 20 and 65 years;\n2. fulfilling the Diagnostic and Statistical Manual version 5 (DSM-5) criteria of Major depressive disorder assessed by the Structured Clinical Interview\n\nExclusion Criteria:\n\n1. Inability to provide informed consent or comprehend the study procedure;\n2. A major psychiatric illness including schizophrenia spectrum disorder, bipolar spectrum disorder, and major depressive disorder with psychotic features.\n3. A current DSM-5 diagnosis of substance use disorder except nicotine use disorder or the use of one to two low-potency benzodiazepine tablets for sleep impairment;\n4. Have known preexisting noise-induced hearing loss, concurrent treatment with ototoxic medications, or with cochlear implants.\n5. Unstable medical illness, including malignancy, uncontrolled diabetes mellitus, unstable cardiac disease or recent myocardial infarction, or cerebrovascular or cardiovascular risk factors that require intensive medical management\n6. On medications known to lower seizure threshold (e.g., TCA, bupropion, clozapine)\n7. Implants controlled by physiological signals, including pacemaker, implantable cardioverter defibrillator, cochlear implant.\n8. Metallic objects in the head, including stenting, suture.\n9. Elevated risk of seizure due to traumatic brain history, seizure history, and head trauma, intracranial lesion, and alcohol or benzodiazepines withdrawal syndrome, stimulant intoxication.","20 Years",{"count":112,"type":23},[26],"The goal of this clinical trial is to investigate the effect of theta burst stimulation for depression and serum brain-derived neurotrophic factor (BDNF) in individuals with major depression. The main question it aims to answer is whether 10 sessions of theta burst stimulation can influence the serum level of BDNF.\n\nParticipants will be randomized into active group and sham group. Researchers will compare the level of BDNF in these groups.",[41],[434],"Brain-Derived Neurotrophic Factor, Theta Burst Stimulation","2023-05-02",{"date":437,"type":93},"2023-05-11",{"date":415,"type":93},{"date":417,"type":23},{"name":419,"class":420},{"id":442,"slug":443,"hasResults":11,"nctId":444,"briefTitle":445,"officialTitle":445,"acronym":446,"eligibilityCriteria":447,"healthyVolunteers":11,"sex":18,"minAge":109,"maxAge":403,"enrollmentInfo":448,"targetDuration":4,"studyType":24,"phases":450,"briefSummary":452,"conditions":453,"keywords":454,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":456,"lastUpdatePostDateStruct":457,"startDateStruct":459,"completionDateStruct":461,"leadSponsor":463,"locationsCount":101},"100337120","phase-3-modulating-inhibitory-control-networks-in-gambling-disorder-with-theta-burst-stimulation-100337120","NCT03669315","Modulating Inhibitory Control Networks in Gambling Disorder With Theta Burst Stimulation","TMS-GD","Inclusion Criteria:\n\n1. DSM-5 diagnosis of Gambling Disorder\n2. Age between 18 and 65 years\n\nExclusion Criteria:\n\n1. any additional current psychiatric comorbidity, except for nicotine addiction;\n2. a lifetime DSM-5 diagnosis of schizophrenia or other psychotic syndromes, substance dependence or substance abuse, including alcohol, bipolar I or II disorder, mental disorder due to a general medical condition;\n3. serious suicide risk;\n4. illness duration less than two years;\n5. hospitalization in the last 6 months;\n6. the inability to receive TMS because of metallic implants, or history of seizures (personal or family history of seizure in first degree relatives);\n7. any major medical disease;\n8. pregnancy or nursing of an infant;\n9. the inability or refusal to provide written informed consent.",{"count":449,"type":23},40,[451],"PHASE3","In this project the investigators propose a randomized double-blind placebo-controlled design in which 40 patients with GD will receive active or sham cTBS to the pre-SMA for 2 weeks. The investigators will combine TMS, multimodal structural and functional MRI and behavioral measures in order to identify circuit-level mechanisms of action and therapeutic targets (connectivity changes that explain clinical improvement) and assess the efficacy of TMS in modulating inhibitory control and symptom severity in this population.",[41],[41,455],"Transcranial Magnetic Stimulation","2018-09-11",{"date":458,"type":93},"2018-09-13",{"date":460,"type":93},"2018-05-20",{"date":462,"type":23},"2019-12-01",{"name":464,"class":100},"CNS Onlus"]