[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gastric-emptying-time\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gastric-emptying-time":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100627650","intraoperative-pyloric-balloon-dilatation-to-reduce-delayed-gastric-emptying-after-pppd-100627650",false,"NCT07451392","Intraoperative Pyloric Balloon Dilatation to Reduce Delayed Gastric Emptying After PPPD","Intraoperative Pyloric Balloon Dilatation to Decrease Post PPPD Delayed Gastric Emptying. Does It Help? RCT Study","Inclusion Criteria:\n\n* Adult patients (≥18 years) scheduled for elective PPPD due to tumors of the pancreatic head, distal bile duct, or ampulla of Vater.\n* Patients with no prior history of gastric surgery or severe gastroparesis.\n* Patients with no contraindications to balloon dilatation or intraoperative endoscopic procedures\n\nExclusion Criteria:\n\n* Patients with prior gastric surgery, pyloric stenosis, or history of severe gastroparesis.\n* Patients with severe comorbidities that may preclude safe surgery (ASA class IV or higher).\n* Patients who require emergency surgery or have unresectable disease.\n* Patients with active gastrointestinal bleeding or severe malnutrition","ALL","18 Years",{"count":19,"type":20},70,"ESTIMATED","INTERVENTIONAL",[23],"NA","Pylorus-preserving pancreatoduodenectomy (PPPD) is a standard surgical treatment for tumors of the pancreatic head and surrounding areas. However, it is frequently associated with delayed gastric emptying (DGE), a complication that can lead to nausea, vomiting, and prolonged hospital stays. This study is a randomized controlled trial designed to evaluate if a simple intraoperative maneuver (pneumatic balloon dilatation of the pylorus) can reduce the incidence of early postoperative vomiting and DGE.\n\nParticipants will be randomly assigned to either the intervention group, receiving pyloric dilatation during surgery, or the control group, receiving standard surgery without dilatation. Researchers will monitor postoperative symptoms, gastric emptying function, and overall recovery to determine if this maneuver effectively improves patient outcomes.",[26,27,28],"Delayed Gastric Emptying","Postoperative Nausea and Vomiting","Gastric Emptying Time",[26,30,31,32,33,34],"Pylorus-Preserving Pancreatoduodenectomy","PPPD","Pyloric Balloon Dilatation","Early Postoperative Vomiting","Pylorospasm","NOT_YET_RECRUITING","2026-02-28",{"date":38,"type":39},"2026-03-05","ACTUAL",{"date":41,"type":20},"2026-04",{"date":43,"type":20},"2027-05",{"name":45,"class":46},"Assiut University","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":5},"100600684","phase-4-gastric-emptying-with-metoclopramide-in-glp-1-agonist-patients-undergoing-elective-surgery-100600684","NCT07100691","Gastric Emptying With Metoclopramide in GLP-1 Agonist Patients Undergoing Elective Surgery","Preoperative Metoclopramide to Enhance Gastric Emptying in Patients on Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss: A Randomised Controlled Trial With Ultrasound Assessment","GEM-GLP1RA","Inclusion Criteria:\n\n* Patients taking GLP-1 receptor agonists (for weight loss only)\n* Male and female patients aged 18 years or older\n* Able to provide written informed consent\n* ASA grade I-V\n* Scheduled for elective surgery with an expected overnight hospital stay\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Presence of hiatus hernia\n* History of any gastric surgery\n* Pregnancy\n* Inability to lie in the right lateral decubitus position\n* Patients taking chronic opioids\n* Poorly controlled diabetes (HbA1c \\>69 mmol\u002Fmol)\n* Urgent or emergency surgery, including trauma\n* Diagnosis of Parkinson's disease\n* Allergy or intolerance to metoclopramide",{"count":56,"type":20},80,[58],"PHASE4","This is a multicentre, investigator-blinded, randomised controlled trial evaluating whether the use of oral metoclopramide before surgery can reduce the amount of residual gastric content in patients who are taking glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for weight loss. These medications are known to slow down gastric emptying, which may increase the risk of pulmonary aspiration during anaesthesia. Patients will be randomly assigned to either receive metoclopramide 24 hours before surgery or continue with standard care. The primary outcome will be the presence or absence of residual gastric content on ultrasound before surgery. Secondary outcomes include nausea, vomiting, constipation, and any adverse effects of the medication.",[61,28,62,63],"Pulmonary Aspiration During Anaesthetic Induction","Preoperative Risk Assessment","Obesity (Disorder)",[65,66,67,68,69,70,71,72,73,74],"GLP-1 Receptor Agonist","Metoclopramide","Elective Surgery","Residual Gastric Content","Gastric Ultrasound","Aspiration Risk","Perioperative Management","Obesity Medications","Randomised Controlled Trial","Anaesthesia Safety","2025-08-01",{"date":77,"type":39},"2025-08-06",{"date":79,"type":20},"2025-08",{"date":81,"type":20},"2026-06",{"name":83,"class":46},"Mater Misericordiae University Hospital"]