[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gastro-esophageal-reflux-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gastro-esophageal-reflux-disease":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100569390","patient-preferences-for-barretts-esophagus-and-esophageal-cancer-screening-tests-100569390",false,"NCT06693622","Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests","Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests: A Discrete Choice-Based Conjoint Analysis","Inclusion Criteria:\n\n* Provision to sign and date the consent form.\n* Stated willingness to comply with all study procedures and be available for the duration of the study.\n* Individual has 3 or more established risk factors for BE (age \\> 50 years, chronic GERD, male, white race, smoking, obesity, family history of BE\u002FEAC).\n\nExclusion Criteria:\n\n* Unable to consent.\n* Prior diagnosis of BE\u002FEAC.\n* Life limiting comorbidity\u002F disability.\n* Active dementia\u002F cognitive impairment.\n* Incarcerated.",true,"ALL","18 Years","89 Years",{"count":21,"type":22},556,"ESTIMATED","OBSERVATIONAL","This study plans to learn more about what patients think about screening for esophageal cancer (EAC) and Barrett's esophagus (BE); a pre-cancerous condition associated with esophageal cancer. The plan is to use this information to modify screening practices in the United States with the goal to decrease the number of people who die from esophageal cancer.",[26,27],"Gastro Esophageal Reflux Disease","Barrett Esophagus",[29,30,31,32,33],"Gastroesophageal Reflux Disease","Barrett's Esophagus","Barrett's Esophagus Screening","BE","GERD","RECRUITING","2024-11-14",{"date":37,"type":38},"2024-11-18","ACTUAL",{"date":40,"type":38},"2024-11-01",{"date":42,"type":22},"2029-03-01",{"name":44,"class":45},"University of Colorado, Denver","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":46},"100559471","the-effect-of-postural-correction-on-gastroesophageal-reflux-disease-100559471","NCT06564558","The Effect of Postural Correction On Gastroesophageal Reflux Disease","The Effect of Postural Correctional Interventions on the Quality of Life of Patients With Gastroesophageal Reflux Disease.","Inclusion Criteria:\n\n* Ages between 18 and 60.\n* Diagnosed with GERD by a primary medical doctor.\n* Patients with a kyphosis angle greater than 30 degrees.\n* A score of 8 or greater on the Frequency Scale for the Symptoms of GERD (FSSG) which is considered positive.\n\nExclusion Criteria:\n\n* Individuals with recent spinal surgery.\n* Recent spinal trauma in the thoracic or lumbar regions\n* A score less than 8 on the FSSG\n* Having no associated thoracic or thoracolumbar deformity or abnormal alignment.","60 Years",{"count":56,"type":22},30,"INTERVENTIONAL",[59],"NA","The main aim of this randomized controlled trial is to investigate the effects of postural correctional exercises and interventions on the severity of symptoms of gastroesophageal reflux disease (GERD) as well as the quality of life of patients afflicated with this disease. The main questions this study aims to answer is:\n\n1. Do postural correctional exercises reduce the symptoms of GERD?\n2. Do postural correctional exercises improve the quality of life of individuals afflicted with GERD?\n\nThe experimental group in this study will undergo real postural correctional exercises whereas the control group will undergo sham postural correctional interventions and then the two groups will be compared post-treatment based on GERD severity of symptoms as well as quality of life of the patients afflicted with GERD.",[62,26],"Gastro Esophageal Reflux","2024-08-19",{"date":65,"type":38},"2024-08-21",{"date":67,"type":22},"2024-09-01",{"date":69,"type":22},"2025-09-01",{"name":71,"class":45},"Cairo University",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":57,"phases":81,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":98},"100331531","diagnostic-yield-of-post-prandial-esophageal-high-resolution-impedance-manometry-in-patients-with-gastro-esophageal-reflux-disease-symptoms-resistant-to-proton-pump-inhibitor-therapy-100331531","NCT03596476","Diagnostic Yield of Post PRandial Esophageal High Resolution Impedance Manometry in Patients With Gastro-Esophageal Reflux Disease Symptoms Resistant to Proton Pump Inhibitor Therapy","PRIMER","Inclusion Criteria:\n\n* Patient older than 18 years\n* Typical symptoms of GERD (heartburn, regurgitation) at least twice a week despite PPI therapy for at least one month.\n* Reflux Disease Questionnaire (RDQ) score off PPI \\> 3\n* Subject with health insurance\n\nExclusion Criteria:\n\n* Previous esophago-gastric surgery,\n* Previous history of developing esophageal or gastric tumor, esophageal stricture, or esophageal varices\n* Pregnancy (assessment at V0)\n* Contraindication to general anesthesia,\n* Contraindications to the wireless capsule pH-monitoring: pacemakers, implantable cardiac defibrillator,\n* Contraindications to HRIM: inability to tolerate nasal intubation, significant bleeding disorders for which nasal intubation is contraindicated, known esophageal obstruction is preventing the passage of the HRIM probe.\n* Intolerance or allergy to one component of the test meal,\n* Intolerance or allergy to PPI,\n* Inability to give consent,\n* Mentally unbalanced patients, under supervision or guardianship\n* Decline to participate in the study,\n* Participation in another study at the same time",{"count":80,"type":22},330,[59],"Gastro-esophageal reflux disease (GERD) is defined as the reflux of gastric content into the esophagus that causes troublesome symptoms or complications. Nine to 30% of the population suffers from GERD-suggestive symptoms (heartburn, regurgitation, chest pain, chronic couch, sore throat). In the absence of warning signs, proton pump inhibitors (PPI) are prescribed as first-line treatment. However, 20 to 60% of patients are unsatisfied because of persistent symptoms when taking PPI. Causes of persistent symptoms are: erroneous diagnosis of GERD (up to 50% of PPI non-responders), rumination syndrome, excessive weakly acid reflux on PPI due to defective esophago-gastric junction or an excessive number of transient lower esophageal sphincter relaxations (main mechanism of GERD), poor acid secretion inhibition on PPI, and non-compliance to therapy. Complementary examinations are indicated to explain persistent GERD symptoms. Upper gastro-intestinal endoscopy is performed first to rule out an esophageal tumor and to identify erosive esophagitis, a specific sign of GERD. However, it is normal in up to 70% of symptomatic GERD patients. Direct detection of reflux episodes is then requested to confirm GERD. The gold standard for reflux detection is the ambulatory measurement of esophageal pH for 24 to 96 hours using a catheter (catheter-based pH-monitoring) or a capsule clipped into the esophagus (wireless pH-monitoring). Reflux episodes are defined as an esophageal pH \\\u003C 4. Another method of reflux detection is based on liquid and gas detection in the esophagus using pH-impedance monitoring. Recently the combination of impedance and esophageal pressure monitoring, called esophageal high resolution impedance manometry (HRIM) was introduced to simultaneously identify reflux episodes and their mechanisms. It has several advantages over esophageal pH measurement: shorter recording duration (1 or 2 hours post prandial) and identification of reflux mechanisms that might guide the choice of the best therapeutic option.\n\nHypothesis: The 1-hour post prandial esophageal HRIM might be useful to diagnose GERD.",[84],"Gastro-esophageal Reflux Disease",[86,87,88],"Gastro-esophageal reflux","High resolution Impedance Manometry","Resistance to proton pump inhibitors (PPI)","2024-06-25",{"date":91,"type":38},"2024-06-26",{"date":93,"type":38},"2021-05-03",{"date":95,"type":22},"2027-05-03",{"name":97,"class":45},"Hospices Civils de Lyon",7]