[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gastroenterostomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gastroenterostomy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100472995","washed-microbiota-transplantation-for-malnutrition-after-nonphysiological-reconstruction-of-the-upper-gastrointestinal-tract-100472995",false,"NCT05439135","Washed Microbiota Transplantation for Malnutrition After Nonphysiological Reconstruction of the Upper Gastrointestinal Tract","An Open-label, Multicenter, Randomized Clinical Trial for Malnutrition After Nonphysiological Reconstruction of the Upper Gastrointestinal Tract: Washed Microbiota Transplantation Via Mid-gut Tube Versus Colonic Transendoscopic Enteral Tube","Inclusion Criteria:\n\n* Patients undergone nonphysiological reconstruction of the gastrointestinal tract (such as Billroth-II, Roux-en-Y, Child, Whipple reconstruction)\n* Aged over 18 years old;\n* Malnutrition is assessed by Nutritional Risk Screening 2002 score≥3 and Patient Generated Subjective Global Assessment (PG-SGA) score≥4;\n* Written informed consent;\n\nExclusion Criteria:\n\n* Expected survival time \\\u003C 3 months;\n* Still on anti-tumor therapy or it is expected during the visit;\n* Complicated with ascites or edema caused by malnutrition;\n* Known organic gastrointestinal disease (e.g., gastrointestinal infection, inflammatory bowel disease, or radiation enteritis);\n* Undergone other gastrointestinal surgery (e.g., enterectomy, enterostomy, or gastrostomy) except appendectomy or anal fistula surgery;\n* Complicated with contraindications of enteral nutrition such as ileus, active gastrointestinal bleeding, and shock;\n* Cannot tolerate gastroscopy or colonoscopy;\n* Severe comorbidities (e.g., diabetes, cardiopulmonary failure, severe liver or or kidney diseases);\n* Complicated with other wasting diseases (e.g., active tuberculosis, hyperthyroidism, diabetes, HIV, active hepatitis, hip fracture, craniocerebral injury, etc.);\n* A history of anti-infective treatment within 30 days before enrollment; or need anti-infective treatment at the time of enrollment; or unwilling to stop taking drugs that affect gut microbes, such as probiotics;\n* Can not tolerate oral enteral nutrition;\n* Women who are pregnant or breastfeeding;\n* Participating in another clinical trial;\n* Deemed unsuitable for inclusion by the investigators.","ALL","18 Years",{"count":19,"type":20},62,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is a prospective, randomized, multicenter study to evaluate WMT in improving nutritional status in malnourished patients who underwent nonphysiological reconstruction of the upper gastrointestinal tract. In this multicenter trial, sixty-two patients will be enrolled in forteen Chinese sites. Participants will be randomized at a ratio of 1:1 to receive three WMTs through either mid-gut tube or colonic TET. After WMT, each participant will receive free diet plus home enteral nutrition. Home enteral nutrition should last for 2 months at home, with blood, urine and stool samples taken and stored at baseline and 2 months after WMT.",[26,27],"Malnutrition","Gastroenterostomy",[29,30,31,32,33,34,35,36],"washed microbiota transplantation","fecal microbiota transplant","malnutrition","enteral nutrition","cachexia","upper gastrointestinal rerouting surgery","delivery","nonphysiological reconstruction of the upper gastrointestinal tract","RECRUITING","2025-07-06",{"date":40,"type":41},"2025-07-10","ACTUAL",{"date":43,"type":41},"2024-10-20",{"date":45,"type":20},"2025-10-31",{"name":47,"class":48},"The Second Hospital of Nanjing Medical University","OTHER"]